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Gene: E2F1 (E2F transcription factor 1) Homo sapiens
Symbol: E2F1
Name: E2F transcription factor 1
Description: Exhibits DNA-binding transcription factor activity, RNA polymerase II-specific; proximal promoter sequence-specific DNA binding activity; and transcription factor binding activity. Involved in several processes, including intrinsic apoptotic signaling pathway in response to DNA damage; positive regulation of fibroblast proliferation; and regulation of RNA metabolic process. Localizes to the centrosome and nucleus. Implicated in lung non-small cell carcinoma; lung small cell carcinoma; lung squamous cell carcinoma; pancreatic adenocarcinoma; and pancreatic ductal adenocarcinoma. Biomarker of several diseases, including chronic myeloid leukemia; lung cancer (multiple); malignant glioma (multiple); neurodegenerative disease (multiple); and viral encephalitis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: E2F-1; PBR3; PRB-binding protein E2F-1; RBAP-1; RBAP1; RBBP-3; RBBP3; RBP3; retinoblastoma-associated protein 1; retinoblastoma-binding protein 3; transcription factor E2F1
Mus musculus (house mouse) : E2f1 (E2F transcription factor 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : E2f1 (E2F transcription factor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : E2f1 (E2F transcription factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : E2F1 (E2F transcription factor 1)
Canis lupus familiaris (dog) : E2F1 (E2F transcription factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : E2f1 (E2F transcription factor 1)
Sus scrofa (pig) : E2F1 (E2F transcription factor 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382033,675,477 - 33,686,385 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372032,263,292 - 32,274,210 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362031,727,150 - 31,737,854 (-)NCBINCBI36hg18NCBI36
Build 342031,727,149 - 31,737,854NCBI
Celera2029,016,324 - 29,027,242 (-)NCBI
Cytogenetic Map20q11.22NCBI
HuRef2029,049,266 - 29,060,184 (-)NCBIHuRef
CHM1_12032,164,384 - 32,175,302 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on E2F1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 730923
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.