TP53 (tumor protein p53) - Rat Genome Database

Name: TP53
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: TP53 (tumor protein p53) Homo sapiens

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Symbol:

TP53

Name:

tumor protein p53

RGD ID:

70502

HGNC Page

HGNC:11998

Description:

Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; enzyme binding activity; and nucleic acid binding activity. Involved in several processes, including intracellular signal transduction; regulation of apoptotic process; and regulation of nucleobase-containing compound metabolic process. Acts upstream of with a negative effect on regulation of cell cycle G2/M phase transition. Acts upstream of or within several processes, including cellular response to glucose starvation; intracellular signal transduction; and positive regulation of transcription by RNA polymerase II. Located in several cellular components, including centrosome; nuclear lumen; and transcription repressor complex. Part of chromatin and transcription regulator complex. Implicated in several diseases, including Li-Fraumeni syndrome (multiple); carcinoma (multiple); hematologic cancer (multiple); open-angle glaucoma (multiple); and pancreatic cancer (multiple). Biomarker of several diseases, including carcinoma (multiple); graft-versus-host disease; hematologic cancer (multiple); oral mucosa leukoplakia; and oral submucous fibrosis.

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

antigen NY-CO-13; BCC7; BMFS5; cellular tumor antigen p53; FLJ92943; LFS1; mutant p53 protein; mutant tumor protein 53; P53; p53 antigen; p53 transformation suppressor; p53 tumor suppressor; phosphoprotein p53; transformation-related protein 53; TRP53; truncated p53 protein; tumor protein 53; tumor suppressor p53; tumor suppressor TP53; tumor supressor p53

RGD Orthologs

Alliance Orthologs

More Info

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More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Mus musculus (house mouse):	Trp53 (transformation related protein 53)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Tp53 (tumor protein p53)	HGNC	EggNOG, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Chinchilla lanigera (long-tailed chinchilla):	Tp53 (tumor protein p53)	NCBI	Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):	TP53 (tumor protein p53)	NCBI	Ortholog
Canis lupus familiaris (dog):	TP53 (tumor protein p53)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tp53 (tumor protein p53)	NCBI	Ortholog
Sus scrofa (pig):	TP53 (tumor protein p53)	HGNC	EggNOG, Ensembl, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Chlorocebus sabaeus (green monkey):	TP53 (tumor protein p53)	NCBI	Ortholog
Heterocephalus glaber (naked mole-rat):	Tp53 (tumor protein p53)	NCBI	Ortholog
Other homologs ²
Rattus norvegicus (Norway rat):	Glis2 (GLIS family zinc finger 2)	HGNC	OMA
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Tp53 (tumor protein p53)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Mus musculus (house mouse):	Trp53 (transformation related protein 53)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	tp53 (tumor protein p53)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid\|ZFIN)
Drosophila melanogaster (fruit fly):	p53	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	tp53	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus laevis (African clawed frog):	tp53.L	Alliance	DIOPT (Xenbase)
Xenopus laevis (African clawed frog):	tp53.S	Alliance	DIOPT (Xenbase)

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	7,668,421 - 7,687,490 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	7,661,779 - 7,687,546 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	7,571,739 - 7,590,808 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	7,512,445 - 7,531,642 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	17	7,512,463 - 7,531,642	NCBI
Celera	17	7,598,099 - 7,617,224 (-)	NCBI		Celera
Cytogenetic Map	17	p13.1	NCBI
HuRef	17	7,465,169 - 7,484,283 (-)	NCBI		HuRef
CHM1_1	17	7,580,866 - 7,600,003 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	17	7,572,544 - 7,591,594 (-)	NCBI		T2T-CHM13v2.0

JBrowse:

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Model

Annotation Click to see Annotation Detail View

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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