TP53 (tumor protein p53) - Rat Genome Database

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Gene: TP53 (tumor protein p53) Homo sapiens
Symbol: TP53
Name: tumor protein p53
RGD ID: 70502
HGNC Page HGNC:11998
Description: Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; enzyme binding activity; and nucleic acid binding activity. Involved in several processes, including intracellular signal transduction; regulation of apoptotic process; and regulation of nucleobase-containing compound metabolic process. Acts upstream of with a negative effect on regulation of cell cycle G2/M phase transition. Acts upstream of or within several processes, including ER overload response; cellular response to glucose starvation; and intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. Located in several cellular components, including centrosome; nuclear lumen; and transcription repressor complex. Part of transcription regulator complex. Colocalizes with nuclear body. Implicated in several diseases, including Li-Fraumeni syndrome (multiple); carcinoma (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and open-angle glaucoma (multiple). Biomarker of several diseases, including carcinoma (multiple); hematologic cancer (multiple); oral mucosa leukoplakia; oral submucous fibrosis; and serous cystadenocarcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: antigen NY-CO-13; BCC7; BMFS5; cellular tumor antigen p53; FLJ92943; LFS1; mutant p53 protein; mutant tumor protein 53; P53; p53 antigen; p53 transformation suppressor; p53 tumor suppressor; phosphoprotein p53; transformation-related protein 53; TRP53; truncated p53 protein; tumor protein 53; tumor suppressor p53; tumor suppressor TP53; tumor supressor p53
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38177,668,421 - 7,687,490 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl177,661,779 - 7,687,538 (-)EnsemblGRCh38hg38GRCh38
GRCh37177,571,739 - 7,590,808 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36177,512,445 - 7,531,642 (-)NCBINCBI36Build 36hg18NCBI36
Build 34177,512,463 - 7,531,642NCBI
Celera177,598,099 - 7,617,224 (-)NCBICelera
Cytogenetic Map17p13.1NCBI
HuRef177,465,169 - 7,484,283 (-)NCBIHuRef
CHM1_1177,580,866 - 7,600,003 (-)NCBICHM1_1
T2T-CHM13v2.0177,572,544 - 7,591,594 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)