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Gene: TP53 (tumor protein p53) Homo sapiens
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Symbol: TP53
Name: tumor protein p53
Description: This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: antigen NY-CO-13; BCC7; BMFS5; cellular tumor antigen p53; FLJ92943; LFS1; mutant p53 protein; mutant tumor protein 53; P53; p53 antigen; p53 transformation suppressor; p53 tumor suppressor; phosphoprotein p53; transformation-related protein 53; TRP53; truncated p53 protein; tumor protein 53; tumor suppressor p53; tumor suppressor TP53; tumor supressor p53
Orthologs:
Mus musculus (house mouse) : Trp53 (transformation related protein 53)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tp53 (tumor protein p53)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tp53 (tumor protein p53)
Pan paniscus (bonobo/pygmy chimpanzee) : TP53 (tumor protein p53)
Canis lupus familiaris (dog) : TP53 (tumor protein p53)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tp53 (tumor protein p53)
Sus scrofa (pig) : TP53 (tumor protein p53)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38177,668,402 - 7,687,550 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37177,571,720 - 7,590,868 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36177,512,445 - 7,531,642 (-)NCBINCBI36hg18NCBI36
Build 34177,512,463 - 7,531,642NCBI
Celera177,598,099 - 7,617,224 (-)NCBI
Cytogenetic Map17p13.1NCBI
HuRef177,465,169 - 7,484,283 (-)NCBIHuRef
CHM1_1177,580,866 - 7,600,003 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model