Myc (myelocytomatosis oncogene) - Rat Genome Database

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Gene: Myc (myelocytomatosis oncogene) Mus musculus
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Symbol: Myc
Name: myelocytomatosis oncogene
RGD ID: 10940
MGI Page MGI
Description: Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and ubiquitin protein ligase binding activity. Involved in several processes, including branching involved in ureteric bud morphogenesis; positive regulation of macromolecule biosynthetic process; and positive regulation of metanephric cap mesenchymal cell proliferation. Acts upstream of or within several processes, including animal organ development; regulation of apoptotic process; and regulation of transcription by RNA polymerase II. Located in several cellular components, including euchromatin; nuclear body; and perinuclear region of cytoplasm. Part of Myc-Max complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Used to study Burkitt lymphoma; autosomal dominant polycystic kidney disease; breast cancer; hepatocellular carcinoma; and pancreatic carcinoma. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); demyelinating disease; hematologic cancer (multiple); prostate cancer (multiple); and urinary bladder cancer. Orthologous to human MYC (MYC proto-oncogene, bHLH transcription factor).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AU016757; bHLHe3; bHLHe39; c-myc; c-myc proto-oncogene; myc proto-oncogene protein; Myc2; N; Niard; Nird; transcription factor p64
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391561,857,190 - 61,862,210 (+)NCBIGRCm39mm39
GRCm39 Ensembl1561,857,240 - 61,862,223 (+)Ensembl
GRCm381561,985,341 - 61,990,361 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1561,985,391 - 61,990,374 (+)EnsemblGRCm38mm10GRCm38
MGSCv371561,816,896 - 61,821,916 (+)NCBIGRCm37mm9NCBIm37
MGSCv361561,815,052 - 61,820,027 (+)NCBImm8
Celera1563,490,745 - 63,495,748 (+)NCBICelera
Cytogenetic Map15D1NCBI
cM Map1526.19NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Aberrant Crypt Foci  (ISO)
acute kidney failure  (IEP)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
acute promyelocytic leukemia  (ISO)
adenocarcinoma  (ISO)
Alcoholic Liver Diseases  (IMP,ISO)
angiosarcoma  (ISO)
Animal Disease Models  (ISO)
autosomal dominant polycystic kidney disease  (IEA,IEP,ISO)
autosomal recessive polycystic kidney disease  (IEP)
B-lymphoblastic leukemia/lymphoma  (IMP)
breast cancer  (IEA,ISO)
Breast Neoplasms  (IEP,ISO)
Burkitt lymphoma  (IAGP,IEA,ISO)
carcinoma  (ISO)
Cardiomegaly  (ISO)
Carotid Artery Injuries  (ISO)
Chromosome Breakage  (ISO)
chronic lymphocytic leukemia  (ISO)
clear cell renal cell carcinoma  (ISO)
cleft lip  (ISO)
cleft palate  (ISO)
Colonic Neoplasms  (ISO)
Colorectal Neoplasms  (ISO)
coronary restenosis  (ISO)
COVID-19  (ISO)
demyelinating disease  (ISO)
diffuse large B-cell lymphoma  (ISO)
disease of cellular proliferation  (ISO)
Disease Progression  (ISO)
Ductal Carcinoma  (ISO)
Endometrial Neoplasms  (ISO)
esophageal carcinoma  (ISO)
Esophageal Neoplasms  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Liver Neoplasms  (ISO)
fatty liver disease  (ISO)
glioblastoma  (ISO)
Hemorrhagic Shock  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (IEA,IMP,ISO)
hyperparathyroidism  (ISO)
hypertrophic cardiomyopathy  (ISO)
Kidney Reperfusion Injury  (ISO)
Left Ventricular Hypertrophy  (ISO)
leiomyoma  (ISO)
liver cirrhosis  (IEP)
Liver Injury  (ISO)
Liver Neoplasms  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
Lung Reperfusion Injury  (ISO)
lung small cell carcinoma  (IMP)
Mammary Neoplasms, Experimental  (IEP)
medulloblastoma  (ISO)
Merkel cell carcinoma  (ISO)
myelodysplastic syndrome  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
nephroblastoma  (IEP,ISO)
neuroblastoma  (ISO)
neuroectodermal tumor  (ISO)
non-Hodgkin lymphoma  (ISO)
obesity  (ISO)
osteoporosis  (ISO)
osteosarcoma  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (IMP,ISO)
pancreatic carcinoma  (IEA)
polycystic kidney disease  (IMP,ISO)
polycystic kidney disease 1  (IEP,ISO)
primary ovarian insufficiency  (ISO)
prolactinoma  (ISO)
prostate adenocarcinoma  (ISO)
prostate cancer  (ISO)
prostate carcinoma in situ  (IMP)
prostatic hypertrophy  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary hypertension  (ISO)
renal cell carcinoma  (ISO)
renal fibrosis  (IEP)
rhabdoid cancer  (ISO)
skin melanoma  (ISO)
Sporadic Papillary Renal Cell Carcinoma  (ISO)
squamous cell carcinoma  (ISO)
Stomach Neoplasms  (ISO)
thyroid gland cancer  (IEP)
thyroid gland papillary carcinoma  (ISO)
Transplant Rejection  (ISO)
trichorhinophalangeal syndrome type I  (ISO)
urinary bladder cancer  (IDA,ISO)
Uterine Cervical Neoplasms  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-epicatechin-3-O-gallate  (EXP)
(+)-schisandrin B  (ISO)
(-)-anisomycin  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(-)-selegiline  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(R)-lipoic acid  (ISO)
(R)-noradrenaline  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-colchicine  (ISO)
(S)-nicotine  (EXP,ISO)
1'-acetoxychavicol acetate  (ISO)
1,1-dichloroethene  (EXP)
1,2,4-trimethylbenzene  (ISO)
1,2-dichlorobenzene  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1,3-benzothiazole-2-thiol  (ISO)
1,4-dichlorobenzene  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (ISO)
1-nitropyrene  (EXP)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
1D-myo-inositol 1,4,5-trisphosphate  (ISO)
2'-(4-ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-D  (EXP)
2,4-dinitrotoluene  (ISO)
2-acetamidofluorene  (ISO)
2-butoxyethanol  (EXP)
2-hydroxy-17beta-estradiol  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methyl-2-[4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propanoic acid  (ISO)
2-nitrofluorene  (ISO)
2-nitrotoluene  (ISO)
26-hydroxycholesterol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3'-diindolylmethane  (EXP,ISO)
3-aminobenzamide  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxy-17beta-estradiol  (ISO)
4-Hydroxy-N-desmethyltamoxifen  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (EXP,ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-azacytidine  (ISO)
5-bromo-2'-deoxyuridine  (EXP)
5-fluorouracil  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
7beta-aminocephalosporanic acid  (ISO)
8-Br-cAMP  (ISO)
8-bromo-3',5'-cyclic GMP  (ISO)
acetaldehyde  (EXP)
acetohydrazide  (EXP)
acetylleucyl-leucyl-norleucinal  (ISO)
acetylsalicylic acid  (ISO)
aconitine  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
actinomycin D  (EXP,ISO)
adenosine  (ISO)
Aeroplysinin 1  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
AH23848  (ISO)
alachlor  (EXP)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (ISO)
allethrin  (ISO)
alpha-hexachlorocyclohexane  (ISO)
alpha-naphthoflavone  (ISO)
alpha-pinene  (ISO)
amifostine  (ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
ammonium hexachloroplatinate  (ISO)
amsacrine  (ISO)
androstane  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aprepitant  (ISO)
aristolochic acid  (ISO)
arsenic acid  (ISO)
arsenic trichloride  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
Asimicin  (EXP)
aspartame  (EXP)
atorvastatin calcium  (ISO)
atrazine  (ISO)
Azaspiracid  (ISO)
bathocuproine disulfonic acid  (ISO)
benazepril  (ISO)
benzamide  (ISO)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzoates  (ISO)
benzoic acid  (ISO)
benzylpenicillin  (EXP)
berberine  (ISO)
beryllium difluoride  (EXP)
beryllium sulfate  (ISO)
betulin  (ISO)
betulinic acid  (ISO)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (EXP)
bleomycin A5  (ISO)
bortezomib  (ISO)
bromobenzene  (ISO)
bromochloroacetic acid  (ISO)
bromodichloromethane  (EXP,ISO)
bromoform  (EXP)
bucladesine  (ISO)
budesonide  (EXP)
bufalin  (ISO)
busulfan  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (ISO)
butyric acid  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
caffeine  (ISO)
calcein am  (ISO)
calcitriol  (ISO)
calcium dichloride  (ISO)
calmidazolium  (EXP)
camptothecin  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
captan  (EXP)
carbamazepine  (ISO)
carbofuran  (ISO)
carbon nanotube  (EXP,ISO)
carbonyl sulfide  (ISO)
carboplatin  (ISO)
carvedilol  (ISO)
catechol  (ISO)
celastrol  (EXP,ISO)
celecoxib  (ISO)
chalcone  (ISO)
chelerythrine  (ISO)
CHIR 99021  (ISO)
chlorambucil  (ISO)
Chlorodibromomethane  (EXP)
chloroform  (EXP,ISO)
chlorohydrocarbon  (ISO)
chloropicrin  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
choline  (EXP)
chromium(6+)  (EXP,ISO)
ciglitazone  (ISO)
ciguatoxin CTX1B  (EXP)
Cinobufagin  (ISO)
cisplatin  (ISO)
clofarabine  (ISO)
clofibrate  (EXP,ISO)
clotrimazole  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
crocin-1  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (ISO)
curcumin  (EXP,ISO)
cyanamide  (ISO)
cycloheximide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyproterone acetate  (ISO)
D-glucose  (EXP,ISO)
daidzein  (ISO)
DDE  (ISO)
DDT  (EXP,ISO)
deguelin  (EXP,ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
Destruxin B  (ISO)
dexamethasone  (ISO)
dextran sulfate  (EXP)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
diarylheptanoid  (ISO)
diazinon  (EXP,ISO)
dibenziodolium  (ISO)
dibenzoylmethane  (ISO)
dibromoacetic acid  (EXP)
Dibromoacetonitrile  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (EXP)
diclofenac  (ISO)
dicrotophos  (ISO)
dieldrin  (ISO)
diethylstilbestrol  (EXP,ISO)
dihydroartemisinin  (ISO)
Dimaprit  (ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (ISO)
diosgenin  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
emodin  (ISO)
endosulfan  (EXP,ISO)
enzalutamide  (ISO)
epichlorohydrin  (ISO)
erythromycin estolate  (ISO)
estra-1,3,5(10)-triene-3,16beta-diol  (ISO)
estriol  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
eugenol  (EXP)
everolimus  (ISO)
Evodiamine  (ISO)
fenofibrate  (EXP,ISO)
fenthion  (ISO)
fipronil  (ISO)
fluoranthene  (EXP)
fluoxetine  (ISO)
flusilazole  (EXP)
flutamide  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
fructose  (ISO)
fucoidan  (ISO)
fulvestrant  (EXP,ISO)
furan  (EXP,ISO)
gamma-aminobutyric acid  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gamma-linolenic acid  (ISO)
gamma-tocopherol  (EXP)
gefitinib  (ISO)
gemcitabine  (EXP,ISO)
gemfibrozil  (EXP)
genistein  (EXP,ISO)
gentamycin  (ISO)
glucaric acid  (EXP)
glucose  (EXP,ISO)
glutathione  (ISO)
Glutethimide  (ISO)
glycerol  (ISO)
glycidol  (ISO)
glycine betaine  (ISO)
glyphosate  (ISO)
guanosine  (ISO)
guggulsterone  (ISO)
GW 4064  (ISO)
GW 7647  (EXP)
harmine  (ISO)
hemin  (ISO)
heparin  (ISO)
hesperetin  (ISO)
hexachlorophene  (ISO)
hexamethylene diisocyanate  (ISO)
hexanal  (ISO)
Honokiol  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
hydroxamic acid  (ISO)
indirubin  (EXP)
indole-3-methanol  (ISO)
indometacin  (ISO)
ionomycin  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
iron(III) nitrilotriacetate  (ISO)
isoprenaline  (EXP,ISO)
ketamine  (ISO)
KT 5823  (ISO)
L-ascorbic acid  (EXP)
L-methionine  (EXP)
lead nitrate  (EXP)
leflunomide  (ISO)
letrozole  (ISO)
limonene  (EXP,ISO)
linalool  (ISO)
linuron  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (ISO)
lithium chloride  (EXP,ISO)
losartan  (ISO)
lupeol  (EXP)
m-xylene  (ISO)
mancozeb  (EXP,ISO)
maneb  (EXP)
masoprocol  (ISO)
Matrine  (ISO)
mebendazole  (ISO)
memantine  (ISO)
menadione  (ISO)
mercury atom  (EXP,ISO)
mercury dichloride  (ISO)
mercury(0)  (EXP,ISO)
meso-tetrakis(N-methyl-4-pyridyl)porphine(4+)  (ISO)
mestranol  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methotrexate  (EXP,ISO)
methoxyacetic acid  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
metoprolol  (ISO)
microcystin-LR  (EXP,ISO)
mifepristone  (EXP,ISO)
mitoxantrone  (ISO)
ML-7  (ISO)
monensin A  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
myricetin  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-dimethylaniline  (ISO)
N-(6-acetamidohexyl)acetamide  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-butyl-N-(4-hydroxybutyl)nitrosamine  (EXP)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-methyl-N-nitrosourea  (EXP,ISO)
N-methylnicotinate  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
N-nitrosomorpholine  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
nafenopin  (ISO)
naloxone  (ISO)
naphthalene  (EXP)
naphthalenes  (ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (ISO)
nickel subsulfide  (ISO)
nickel sulfate  (EXP,ISO)
niclosamide  (ISO)
nicotinamide  (EXP)
nicotine  (EXP,ISO)
nifedipine  (ISO)
nitrofurazone  (ISO)
nitroprusside  (ISO)
Nodularin  (ISO)
NS-398  (ISO)
o-anisidine  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
oleanolic acid  (EXP,ISO)
oridonin  (ISO)
ortho-Aminoazotoluene  (EXP)
ouabain  (ISO)
oxaliplatin  (ISO)
oxidopamine  (ISO)
ozone  (EXP,ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
PD 0325901  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
pevonedistat  (ISO)
phenethyl isothiocyanate  (ISO)
phenformin  (ISO)
phenobarbital  (EXP,ISO)
phenol  (ISO)
phenylhydrazine  (EXP)
phenytoin  (EXP,ISO)
PhIP  (EXP,ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phorone  (ISO)
phosgene  (EXP)
picene  (ISO)
pinosylvin  (ISO)
piperonyl butoxide  (EXP,ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
platycodin D  (ISO)
poly(I:C)  (ISO)
ponatinib  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP,ISO)
promegestone  (ISO)
promethazine  (ISO)
propiconazole  (EXP)
propylparaben  (ISO)
prostaglandin D2  (ISO)
prostaglandin E2  (ISO)
pterostilbene  (ISO)
puerarin  (ISO)
putrescine  (ISO)
pyrrolidine dithiocarbamate  (ISO)
pyrvinium  (ISO)
quartz  (ISO)
quercetin  (ISO)
quinacrine  (ISO)
quinapril hydrochloride  (ISO)
quinidine  (ISO)
quinolone  (ISO)
quizartinib  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
ranitidine  (ISO)
reactive oxygen species  (ISO)
Rebamipide  (ISO)
reserpine  (EXP,ISO)
resveratrol  (EXP,ISO)
ribavirin  (ISO)
riboflavin  (ISO)
ritonavir  (ISO)
rotenone  (EXP,ISO)
ruxolitinib  (ISO)
saccharin  (EXP)
Salinomycin  (ISO)
salvianolic acid B  (EXP)
SB 431542  (ISO)
Securinine  (ISO)
selenium atom  (ISO)
selumetinib  (EXP)
serpentine asbestos  (ISO)
sertraline  (ISO)
silibinin  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sirtinol  (ISO)
sodium arsenite  (EXP,ISO)
sodium chromate  (ISO)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
Soman  (EXP,ISO)
sorafenib  (ISO)
staurosporine  (ISO)
styrene oxide  (ISO)
SU6656  (ISO)
succimer  (EXP)
succinic acid  (ISO)
sulfates  (ISO)
sulforaphane  (EXP)
sulfur dioxide  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (EXP,ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
Tanshinone I  (EXP,ISO)
taurocholic acid  (EXP,ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
teniposide  (ISO)
terbufos  (ISO)
terbutylazine  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thapsigargin  (ISO)
theaflavin  (EXP)
theophylline  (ISO)
thifluzamide  (ISO)
thioacetamide  (ISO)
thiophenes  (ISO)
thiram  (ISO)
thymidine  (ISO)
thymol  (EXP)
thymol sulfate(1-)  (EXP)
thymoquinone  (ISO)
tiazofurine  (ISO)
titanium dioxide  (EXP)
tocopherol  (EXP)
toxaphene  (EXP)
trametinib  (ISO)
trans-chalcone  (ISO)
trans-pinosylvin  (ISO)
Tributyltin oxide  (ISO)
trichloroacetic acid  (EXP)
trichloroethene  (EXP,ISO)
trichostatin A  (EXP,ISO)
triclosan  (EXP)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
Triptolide  (EXP,ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
undecane  (ISO)
urethane  (EXP,ISO)
uridine  (ISO)
valproic acid  (EXP,ISO)
vemurafenib  (ISO)
vincaleukoblastine  (ISO)
vincristine  (ISO)
vinyl carbamate  (EXP)
vorinostat  (ISO)
WIN 55212-2  (EXP)
WR-1065  (ISO)
xanthohumol  (ISO)
zearalenone  (ISO)
zerumbone  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity involved in apoptotic process  (IDA)
amino acid transport  (ISO)
B cell apoptotic process  (IMP)
branching involved in ureteric bud morphogenesis  (IMP)
canonical Wnt signaling pathway involved in negative regulation of apoptotic process  (IGI)
canonical Wnt signaling pathway involved in positive regulation of apoptotic process  (IGI)
cell population proliferation  (ISO)
cellular iron ion homeostasis  (ISO)
cellular response to angiotensin  (ISO)
cellular response to arsenite(3-)  (ISO)
cellular response to carbohydrate stimulus  (ISO)
cellular response to cycloheximide  (ISO)
cellular response to cytokine stimulus  (ISO)
cellular response to dimethyl sulfoxide  (ISO)
cellular response to DNA damage stimulus  (IDA,ISO)
cellular response to endothelin  (ISO)
cellular response to epidermal growth factor stimulus  (ISO)
cellular response to estrogen stimulus  (ISO)
cellular response to fibroblast growth factor stimulus  (ISO)
cellular response to growth hormone stimulus  (ISO)
cellular response to hydrostatic pressure  (ISO)
cellular response to hypoxia  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to interferon-alpha  (IDA)
cellular response to interferon-gamma  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to lectin  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to phorbol 13-acetate 12-myristate  (ISO)
cellular response to platelet-derived growth factor stimulus  (ISO)
cellular response to prolactin  (ISO)
cellular response to putrescine  (ISO)
cellular response to retinoic acid  (ISO)
cellular response to testosterone stimulus  (ISO)
cellular response to UV  (ISO)
cellular response to xenobiotic stimulus  (IDA,ISO)
chromatin remodeling  (ISO)
chromosome organization  (ISO)
detection of mechanical stimulus involved in sensory perception of sound  (IMP)
DNA-templated transcription, initiation  (ISO)
ERK1 and ERK2 cascade  (ISO)
G0 to G1 transition  (ISO)
G1/S transition of mitotic cell cycle  (ISO)
glucose metabolic process  (ISO)
hypothalamus development  (ISO)
in utero embryonic development  (ISO)
inner mitochondrial membrane organization  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage  (IDA,IMP)
lactic acid secretion  (ISO)
liver regeneration  (ISO)
MAPK cascade  (ISO)
middle ear morphogenesis  (IMP)
negative regulation of apoptotic process  (ISO)
negative regulation of cell death  (ISO)
negative regulation of cell division  (ISO)
negative regulation of fibroblast proliferation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of glucose import  (ISO)
negative regulation of monocyte differentiation  (ISO)
negative regulation of protein binding  (IDA)
negative regulation of stress-activated MAPK cascade  (ISO)
negative regulation of transcription by RNA polymerase II  (IDA,ISO)
ovarian follicle development  (ISO)
ovulation  (ISO)
pigmentation  (IMP)
positive regulation of apoptotic signaling pathway  (IDA,IMP)
positive regulation of ATP biosynthetic process  (ISO)
positive regulation of B cell apoptotic process  (IGI)
positive regulation of catalytic activity  (IMP)
positive regulation of cell cycle  (ISO)
positive regulation of cell population proliferation  (IBA,IDA,IGI,ISO)
positive regulation of cellular respiration  (ISO)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
positive regulation of DNA binding  (ISO)
positive regulation of DNA biosynthetic process  (ISO)
positive regulation of DNA methylation  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of glial cell proliferation  (ISO)
positive regulation of glycolytic process  (ISO)
positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator  (ISO)
positive regulation of mesenchymal cell proliferation  (IMP)
positive regulation of metanephric cap mesenchymal cell proliferation  (IMP)
positive regulation of miRNA transcription  (ISO)
positive regulation of mitochondrial membrane potential  (ISO)
positive regulation of oxidative phosphorylation  (ISO)
positive regulation of response to DNA damage stimulus  (ISO)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of telomerase activity  (IMP)
positive regulation of transcription by RNA polymerase II  (IDA,IMP,ISO)
positive regulation of transcription initiation from RNA polymerase II promoter  (IDA)
positive regulation of transcription, DNA-templated  (IDA,ISO)
protein processing  (IMP)
protein-DNA complex disassembly  (ISO)
pyruvate transport  (ISO)
re-entry into mitotic cell cycle  (ISO)
regulation of apoptotic process  (IDA,IMP)
regulation of cell cycle process  (ISO)
regulation of gene expression  (IDA,ISO)
regulation of mitotic cell cycle  (ISO)
regulation of oxidative phosphorylation  (ISO)
regulation of somatic stem cell population maintenance  (IDA)
regulation of telomere maintenance  (ISO)
regulation of transcription by RNA polymerase II  (IBA)
regulation of transcription, DNA-templated  (IDA,IGI,ISO)
response to alkaloid  (IMP)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to gamma radiation  (ISO)
response to human chorionic gonadotropin  (ISO)
response to radiation  (IDA,IMP)
response to wounding  (ISO)
response to xenobiotic stimulus  (ISO)
skeletal muscle cell differentiation  (IMP)
skeletal system morphogenesis  (IMP)
transcription by RNA polymerase II  (ISO)
transcription, DNA-templated  (ISO)
transformation of host cell by virus  (ISO)
Wnt signaling pathway  (IDA)

Cellular Component

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Additional References at PubMed
PMID:1283123   PMID:1333116   PMID:1349587   PMID:1354638   PMID:1358803   PMID:1371961   PMID:1386365   PMID:1401899   PMID:1404614   PMID:1459449   PMID:1515224   PMID:1535334  
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PMID:1733847