MIR26A2 (microRNA 26a-2) - Rat Genome Database

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Gene: MIR26A2 (microRNA 26a-2) Homo sapiens
Analyze
Symbol: MIR26A2
Name: microRNA 26a-2
RGD ID: 1345037
HGNC Page HGNC:31611
Description: Enables mRNA 3'-UTR binding activity and mRNA base-pairing post-transcriptional repressor activity. Involved in several processes, including cellular response to growth factor stimulus; regulation of gene expression; and regulation of signal transduction. Located in extracellular space. Part of extracellular vesicle.
Type: ncrna
RefSeq Status: PROVISIONAL
Previously known as: mir-26a-2; MIRN26A2
RGD Orthologs
Mouse
Dog
Pig
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381257,824,609 - 57,824,692 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1257,824,609 - 57,824,692 (-)EnsemblGRCh38hg38GRCh38
GRCh371258,218,392 - 58,218,475 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361256,504,658 - 56,504,741 (-)NCBINCBI36hg18NCBI36
Celera1257,876,312 - 57,876,395 (-)NCBI
Cytogenetic Map12q14.1NCBI
HuRef1255,255,357 - 55,255,440 (-)NCBIHuRef
CHM1_11258,186,151 - 58,186,234 (-)NCBICHM1_1
T2T-CHM13v2.01257,792,978 - 57,793,061 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to lipopolysaccharide  (ISO)
cellular response to mechanical stimulus  (ISO)
central nervous system myelin maintenance  (ISS)
embryo implantation  (ISO)
long-term synaptic potentiation  (ISO)
miRNA-mediated gene silencing  (IDA,IEA,ISO)
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (IDA)
negative regulation of BMP signaling pathway  (IDA)
negative regulation of cell cycle G1/S phase transition  (IDA)
negative regulation of cell migration  (IDA)
negative regulation of cell migration involved in sprouting angiogenesis  (IDA)
negative regulation of cell population proliferation  (IDA)
negative regulation of cholesterol efflux  (ISS)
negative regulation of cytokine production involved in inflammatory response  (IDA)
negative regulation of DNA-binding transcription factor activity  (IDA)
negative regulation of G1/S transition of mitotic cell cycle  (IDA,ISO)
negative regulation of heart rate  (ISS)
negative regulation of interleukin-17 production  (ISS)
negative regulation of interleukin-6 production  (IDA,ISS)
negative regulation of interleukin-6-mediated signaling pathway  (IDA)
negative regulation of inward rectifier potassium channel activity  (ISS)
negative regulation of MAPK cascade  (IDA)
negative regulation of neuroinflammatory response  (ISS)
negative regulation of nitric-oxide synthase activity  (IDA)
negative regulation of protein phosphorylation  (ISO)
negative regulation of vascular associated smooth muscle cell differentiation  (IDA)
positive regulation of canonical Wnt signaling pathway  (IDA)
positive regulation of vascular associated smooth muscle cell migration  (IMP)
positive regulation of vascular associated smooth muscle cell proliferation  (IMP)
regulation of atrial cardiac muscle cell membrane depolarization  (ISS)
response to bacterium  (ISO)
response to wounding  (ISO)
transforming growth factor beta receptor signaling pathway  (IDA)
vascular endothelial growth factor signaling pathway  (IDA)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11679670   PMID:14573789   PMID:15183728   PMID:15325244   PMID:15978578   PMID:16381832   PMID:17604727   PMID:17616659   PMID:18713946   PMID:18766170   PMID:20660482   PMID:20857419  
PMID:21037258   PMID:22673513   PMID:23389848   PMID:23543060   PMID:24047927   PMID:24375761   PMID:24935220   PMID:25203061   PMID:25252958   PMID:25362566   PMID:25613580   PMID:26063197  
PMID:26087181   PMID:26587974   PMID:26646931   PMID:26733151   PMID:27025651   PMID:27252421   PMID:28079894   PMID:28602162   PMID:28798470   PMID:29908280   PMID:29967294   PMID:30066905  
PMID:30272373   PMID:30542439   PMID:30657563   PMID:30756482   PMID:31063232   PMID:31143769   PMID:31210329   PMID:31229922   PMID:31234552   PMID:31298396   PMID:31493868   PMID:31615875  
PMID:31696481   PMID:31789414   PMID:31907356   PMID:32193289   PMID:32265934   PMID:32453410   PMID:32950535   PMID:32955094   PMID:33429910   PMID:33761638   PMID:33931763   PMID:34059575  
PMID:34185112   PMID:34438336   PMID:35073820   PMID:35094634   PMID:35484165  


Genomics

Comparative Map Data
MIR26A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381257,824,609 - 57,824,692 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1257,824,609 - 57,824,692 (-)EnsemblGRCh38hg38GRCh38
GRCh371258,218,392 - 58,218,475 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361256,504,658 - 56,504,741 (-)NCBINCBI36hg18NCBI36
Celera1257,876,312 - 57,876,395 (-)NCBI
Cytogenetic Map12q14.1NCBI
HuRef1255,255,357 - 55,255,440 (-)NCBIHuRef
CHM1_11258,186,151 - 58,186,234 (-)NCBICHM1_1
T2T-CHM13v2.01257,792,978 - 57,793,061 (-)NCBI
Mir26a-2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910126,831,399 - 126,831,482 (+)NCBIGRCm39mm39
GRCm39 Ensembl10126,831,399 - 126,831,482 (+)Ensembl
GRCm3810126,995,530 - 126,995,613 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10126,995,530 - 126,995,613 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710126,432,586 - 126,432,669 (+)NCBIGRCm37mm9NCBIm37
Celera10129,387,492 - 129,387,575 (+)NCBICelera
Cytogenetic Map10D3NCBI
MIR26A-2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1101,880,513 - 1,880,572 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl101,880,513 - 1,880,572 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha101,943,019 - 1,943,078 (-)NCBI
ROS_Cfam_1.0101,889,492 - 1,889,551 (-)NCBI
UMICH_Zoey_3.1101,866,978 - 1,867,037 (-)NCBI
UNSW_CanFamBas_1.0102,109,197 - 2,109,256 (-)NCBI
UU_Cfam_GSD_1.0102,233,891 - 2,233,950 (-)NCBI
MIR26A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl523,112,744 - 23,112,827 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1523,112,744 - 23,112,827 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
HMGA2hsa-miR-26a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI17563749
HMGA1hsa-miR-26a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI22245693
CCNE2hsa-miR-26a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI19524505
ESR1hsa-miR-26a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI21610700
CDK6hsa-miR-26a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI22210897
CDK8hsa-miR-26a-5pMirtarbaseexternal_infoWestern blotNon-Functional MTI18713946
LIFhsa-miR-26a-5pMirtarbaseexternal_infoELISANon-Functional MTI (Weak)19011087
PTENhsa-miR-26a-5pMirtarbaseexternal_infoWestern blot//Luciferase reporter assayFunctional MTI19487573
PTENhsa-miR-26a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI20216554
PTENhsa-miR-26a-5pMirtarbaseexternal_infoGFP reporter assay//Luciferase reporter assay//WesFunctional MTI20080666
EZH2hsa-miR-26a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI18713946
EZH2hsa-miR-26a-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI20478051
EZH2hsa-miR-26a-5pMirtarbaseexternal_infoImmunohistochemistry//qRT-PCR//Western blotFunctional MTI21199804
EZH2hsa-miR-26a-5pMirtarbaseexternal_infoImmunohistochemistry//Luciferase reporter assay//qFunctional MTI20952513
EZH2hsa-miR-26a-5pMirtarbaseexternal_infoReporter assayFunctional MTI18281287
PLAG1hsa-miR-26a-5pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//Reporter asFunctional MTI16461460
SERBP1hsa-miR-26a-5pMirtarbaseexternal_infoImmunoprecipitaion//Luciferase reporter assay//WesFunctional MTI17637574
SMAD1hsa-miR-26a-5pMirtarbaseexternal_infoWestern blotFunctional MTI20857419
SMAD1hsa-miR-26a-5pMirtarbaseexternal_infoRNase mapping analysis//Western blot//Reporter assFunctional MTI17922609
SMAD1hsa-miR-26a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI14697198
SMAD1hsa-miR-26a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blot//Reporter Functional MTI18197755
SMAD1hsa-miR-26a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23028144
RB1hsa-miR-26a-5pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//qRT-PCR//WeFunctional MTI23108995
MYChsa-miR-26a-5pMirtarbaseexternal_infoWestern blotNon-Functional MTI19524505
IFNB1hsa-miR-26a-5pMirtarbaseexternal_infoELISA//Luciferase reporter assay//qRT-PCRFunctional MTI20130213
GSK3Bhsa-miR-26a-5pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//qRT-PCR//WeFunctional MTI20525681
CPEB2hsa-miR-26a-5pMirtarbaseexternal_infoLuciferase reporter assay//Northern blot//qRT-PCRFunctional MTI20660482
CPEB3hsa-miR-26a-5pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
ABCA1hsa-miR-26a-5pMirtarbaseexternal_infoImmunoblot//Luciferase reporter assay//qRT-PCRFunctional MTI22673513
E2F7hsa-miR-26a-5pMirtarbaseexternal_infoChIP-seq//Immunoblot//Immunofluorescence//Functional MTI (Weak)23096114
GDAP1hsa-miR-26a-5pMirtarbaseexternal_infoImmunofluorescence//In situ hybridization//LuciferFunctional MTI20827281
NOS2hsa-miR-26a-5pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI23338972
IL6hsa-miR-26a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23389848
MCL1hsa-miR-26a-5pMirtarbaseexternal_infoWestern blotFunctional MTI23750239
SMAD1hsa-miR-26a-5pTarbaseexternal_infoReporter GenePOSITIVE
IL6hsa-miR-26a-5pOncomiRDBexternal_infoNANA23389848
NOS2hsa-miR-26a-5pOncomiRDBexternal_infoNANA23338972
BAG4hsa-miR-26a-5pOncomiRDBexternal_infoNANA23190898
PTENhsa-miR-26a-5pOncomiRDBexternal_infoNANA22885155
GSK3Bhsa-miR-26a-5pOncomiRDBexternal_infoNANA22484120
HMGA1hsa-miR-26a-5pOncomiRDBexternal_infoNANA22245693
CDK6hsa-miR-26a-5pOncomiRDBexternal_infoNANA22210897
ESR1hsa-miR-26a-5pOncomiRDBexternal_infoNANA21610700
EZH2hsa-miR-26a-5pOncomiRDBexternal_infoNANA21368858
EZH2hsa-miR-26a-5pOncomiRDBexternal_infoNANA21199804
MTDHhsa-miR-26a-5pOncomiRDBexternal_infoNANA20952513
PTENhsa-miR-26a-5pOncomiRDBexternal_infoNANA20080666
CCND2hsa-miR-26a-5pOncomiRDBexternal_infoNANA19524505
PTENhsa-miR-26a-5pOncomiRDBexternal_infoNANA19487573
EZH2hsa-miR-26a-5pOncomiRDBexternal_infoNANA18713946
SYCE1hsa-miR-26a-2-3pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248

Predicted Targets
Summary Value
Count of predictions:27381
Count of gene targets:9602
Count of transcripts:18886
Interacting mature miRNAs:hsa-miR-26a-2-3p, hsa-miR-26a-5p
Prediction methods:Microtar, Miranda, Pita, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 1 1 2 2 3 3 2 1 1
Low 237 257 162 50 363 46 634 167 328 158 390 280 11 116 327 3
Below cutoff 165 223 64 14 76 7 388 234 268 29 100 67 7 117 254 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000385054
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1257,824,609 - 57,824,692 (-)Ensembl
RefSeq Acc Id: NR_029847
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381257,824,609 - 57,824,692 (-)NCBI
GRCh371258,218,392 - 58,218,475 (-)RGD
Celera1257,876,312 - 57,876,395 (-)RGD
HuRef1255,255,357 - 55,255,440 (-)ENTREZGENE
CHM1_11258,186,151 - 58,186,234 (-)NCBI
T2T-CHM13v2.01257,792,978 - 57,793,061 (-)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 12q13.3-14.2(chr12:57013355-63042498)x1 copy number loss See cases [RCV000052813] Chr12:57013355..63042498 [GRCh38]
Chr12:57407139..63436278 [GRCh37]
Chr12:55693406..61722545 [NCBI36]
Chr12:12q13.3-14.2		 pathogenic
GRCh38/hg38 12q13.3-14.1(chr12:57041158-60273934)x1 copy number loss See cases [RCV000052814] Chr12:57041158..60273934 [GRCh38]
Chr12:57434942..60667715 [GRCh37]
Chr12:55721209..58953982 [NCBI36]
Chr12:12q13.3-14.1		 pathogenic
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:1-133851895)x3 copy number gain See cases [RCV000258805] Chr12:1..133851895 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic|likely pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)x3 copy number gain See cases [RCV000510482] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902) copy number gain See cases [RCV000511643] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:191619-133777645)x3 copy number gain not provided [RCV000750246] Chr12:191619..133777645 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:621220-133779118)x3 copy number gain not provided [RCV000750253] Chr12:621220..133779118 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12q13.2-14.1(chr12:55552371-62126304)x3 copy number gain not provided [RCV001006505] Chr12:55552371..62126304 [GRCh37]
Chr12:12q13.2-14.1		 pathogenic
GRCh37/hg19 12q13.3-14.1(chr12:57582163-59031979)x1 copy number loss not provided [RCV001006506] Chr12:57582163..59031979 [GRCh37]
Chr12:12q13.3-14.1		 likely pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:31611 AgrOrtholog
COSMIC MIR26A2 COSMIC
Ensembl Genes ENSG00000207789 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000385054 ENTREZGENE
GTEx ENSG00000207789 GTEx
HGNC ID HGNC:31611 ENTREZGENE
Human Proteome Map MIR26A2 Human Proteome Map
miRBase MI0000750 ENTREZGENE
NCBI Gene 407016 ENTREZGENE
OMIM 613057 OMIM
PharmGKB PA164722619 PharmGKB
RNAcentral URS000015D23B RNACentral
  URS000019B0F7 RNACentral
  URS000075C1BF RNACentral