Gene: MIR26A2 (microRNA 26a-2) Homo sapiens
Analyze
Symbol:
MIR26A2
Name:
microRNA 26a-2
Description:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type:
ncrna
RefSeq Status:
PROVISIONAL
Also known as:
mir-26a-2; MIRN26A2
Orthologs:
Allele / Splice:
See ClinVar data
Latest Assembly:
GRCh38 - Human Genome Assembly GRCh38
Position:
Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 Ensembl 12 57,824,609 - 57,824,692 (-) Ensembl GRCh38 hg38 GRCh38 GRCh38 12 57,824,609 - 57,824,692 (-) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh37 12 58,218,392 - 58,218,475 (-) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 12 56,504,658 - 56,504,741 (-) NCBI NCBI36 hg18 NCBI36 Celera 12 57,876,312 - 57,876,395 (-) NCBI Cytogenetic Map 12 q14.1 NCBI HuRef 12 55,255,357 - 55,255,440 (-) NCBI HuRef CHM1_1 12 58,186,151 - 58,186,234 (-) NCBI CHM1_1
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Gene-Chemical Interaction Annotations
References - curated
References - uncurated
Genomics
Comparative Map Data
MIR26A2 Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 Ensembl 12 57,824,609 - 57,824,692 (-) Ensembl GRCh38 hg38 GRCh38 GRCh38 12 57,824,609 - 57,824,692 (-) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh37 12 58,218,392 - 58,218,475 (-) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 12 56,504,658 - 56,504,741 (-) NCBI NCBI36 hg18 NCBI36 Celera 12 57,876,312 - 57,876,395 (-) NCBI Cytogenetic Map 12 q14.1 NCBI HuRef 12 55,255,357 - 55,255,440 (-) NCBI HuRef CHM1_1 12 58,186,151 - 58,186,234 (-) NCBI CHM1_1
Mir26a-2 Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 Ensembl 10 126,995,530 - 126,995,613 (+) Ensembl GRCm38 mm10 GRCm38 GRCm38 10 126,995,530 - 126,995,613 (+) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 10 126,432,586 - 126,432,669 (+) NCBI GRCm37 mm9 NCBIm37 Celera 10 129,387,492 - 129,387,575 (+) NCBI Celera Cytogenetic Map 10 D3 NCBI
MIR26A-2
MIR26A
miRNA Target Status
Confirmed Targets
HMGA2 hsa-miR-26a-5p Mirtarbase external_info Luciferase reporter assay Functional MTI 17563749 HMGA1 hsa-miR-26a-5p Mirtarbase external_info Luciferase reporter assay//Western blot Functional MTI 22245693 CCNE2 hsa-miR-26a-5p Mirtarbase external_info Luciferase reporter assay//Western blot Functional MTI 19524505 ESR1 hsa-miR-26a-5p Mirtarbase external_info Luciferase reporter assay Functional MTI 21610700 CDK6 hsa-miR-26a-5p Mirtarbase external_info Luciferase reporter assay//Western blot Functional MTI 22210897 CDK8 hsa-miR-26a-5p Mirtarbase external_info Western blot Non-Functional MTI 18713946 LIF hsa-miR-26a-5p Mirtarbase external_info ELISA Non-Functional MTI (Weak) 19011087 PTEN hsa-miR-26a-5p Mirtarbase external_info Western blot//Luciferase reporter assay Functional MTI 19487573 PTEN hsa-miR-26a-5p Mirtarbase external_info Luciferase reporter assay//Western blot Functional MTI 20216554 PTEN hsa-miR-26a-5p Mirtarbase external_info GFP reporter assay//Luciferase reporter assay//Wes Functional MTI 20080666 EZH2 hsa-miR-26a-5p Mirtarbase external_info Luciferase reporter assay//Western blot Functional MTI 18713946 EZH2 hsa-miR-26a-5p Mirtarbase external_info Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 20478051 EZH2 hsa-miR-26a-5p Mirtarbase external_info Immunohistochemistry//qRT-PCR//Western blot Functional MTI 21199804 EZH2 hsa-miR-26a-5p Mirtarbase external_info Immunohistochemistry//Luciferase reporter assay//q Functional MTI 20952513 EZH2 hsa-miR-26a-5p Mirtarbase external_info Reporter assay Functional MTI 18281287 PLAG1 hsa-miR-26a-5p Mirtarbase external_info Luciferase reporter assay//Microarray//Reporter as Functional MTI 16461460 SERBP1 hsa-miR-26a-5p Mirtarbase external_info Immunoprecipitaion//Luciferase reporter assay//Wes Functional MTI 17637574 SMAD1 hsa-miR-26a-5p Mirtarbase external_info Western blot Functional MTI 20857419 SMAD1 hsa-miR-26a-5p Mirtarbase external_info RNase mapping analysis//Western blot//Reporter ass Functional MTI 17922609 SMAD1 hsa-miR-26a-5p Mirtarbase external_info Luciferase reporter assay Functional MTI 14697198 SMAD1 hsa-miR-26a-5p Mirtarbase external_info Luciferase reporter assay//Western blot//Reporter Functional MTI 18197755 SMAD1 hsa-miR-26a-5p Mirtarbase external_info Luciferase reporter assay Functional MTI 23028144 RB1 hsa-miR-26a-5p Mirtarbase external_info Luciferase reporter assay//Microarray//qRT-PCR//We Functional MTI 23108995 MYC hsa-miR-26a-5p Mirtarbase external_info Western blot Non-Functional MTI 19524505 IFNB1 hsa-miR-26a-5p Mirtarbase external_info ELISA//Luciferase reporter assay//qRT-PCR Functional MTI 20130213 GSK3B hsa-miR-26a-5p Mirtarbase external_info Luciferase reporter assay//Microarray//qRT-PCR//We Functional MTI 20525681 CPEB2 hsa-miR-26a-5p Mirtarbase external_info Luciferase reporter assay//Northern blot//qRT-PCR Functional MTI 20660482 CPEB3 hsa-miR-26a-5p Mirtarbase external_info CLASH Functional MTI (Weak) 23622248 ABCA1 hsa-miR-26a-5p Mirtarbase external_info Immunoblot//Luciferase reporter assay//qRT-PCR Functional MTI 22673513 E2F7 hsa-miR-26a-5p Mirtarbase external_info ChIP-seq//Immunoblot//Immunofluorescence// Functional MTI (Weak) 23096114 GDAP1 hsa-miR-26a-5p Mirtarbase external_info Immunofluorescence//In situ hybridization//Lucifer Functional MTI 20827281 NOS2 hsa-miR-26a-5p Mirtarbase external_info qRT-PCR//Western blot Functional MTI 23338972 IL6 hsa-miR-26a-5p Mirtarbase external_info Luciferase reporter assay Functional MTI 23389848 MCL1 hsa-miR-26a-5p Mirtarbase external_info Western blot Functional MTI 23750239 SMAD1 hsa-miR-26a-5p Tarbase external_info Reporter Gene POSITIVE IL6 hsa-miR-26a-5p OncomiRDB external_info NA NA 23389848 NOS2 hsa-miR-26a-5p OncomiRDB external_info NA NA 23338972 BAG4 hsa-miR-26a-5p OncomiRDB external_info NA NA 23190898 PTEN hsa-miR-26a-5p OncomiRDB external_info NA NA 22885155 GSK3B hsa-miR-26a-5p OncomiRDB external_info NA NA 22484120 HMGA1 hsa-miR-26a-5p OncomiRDB external_info NA NA 22245693 CDK6 hsa-miR-26a-5p OncomiRDB external_info NA NA 22210897 ESR1 hsa-miR-26a-5p OncomiRDB external_info NA NA 21610700 EZH2 hsa-miR-26a-5p OncomiRDB external_info NA NA 21368858 EZH2 hsa-miR-26a-5p OncomiRDB external_info NA NA 21199804 MTDH hsa-miR-26a-5p OncomiRDB external_info NA NA 20952513 PTEN hsa-miR-26a-5p OncomiRDB external_info NA NA 20080666 CCND2 hsa-miR-26a-5p OncomiRDB external_info NA NA 19524505 PTEN hsa-miR-26a-5p OncomiRDB external_info NA NA 19487573 EZH2 hsa-miR-26a-5p OncomiRDB external_info NA NA 18713946 SYCE1 hsa-miR-26a-2-3p Mirtarbase external_info CLASH Functional MTI (Weak) 23622248 
Gene-Chemical Interaction Annotations
