Myc (MYC proto-oncogene, bHLH transcription factor) - Rat Genome Database

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Gene: Myc (MYC proto-oncogene, bHLH transcription factor) Heterocephalus glaber
Analyze
Symbol: Myc
Name: MYC proto-oncogene, bHLH transcription factor
RGD ID: 18925401
Description: ENCODES a protein that exhibits cis-regulatory region sequence-specific DNA binding (ortholog); core promoter sequence-specific DNA binding (ortholog); DNA binding (ortholog); INVOLVED IN acinar cell proliferation (ortholog); amino acid transport (ortholog); B cell apoptotic process (ortholog); PARTICIPATES IN ceramide signaling pathway; interleukin-2 signaling pathway; interleukin-6 signaling pathway; ASSOCIATED WITH Aberrant Crypt Foci (ortholog); acute kidney failure (ortholog); acute lymphoblastic leukemia (ortholog); FOUND IN axon (ortholog); chromatin (ortholog); euchromatin (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: myc proto-oncogene protein; v-myc avian myelocytomatosis viral oncogene homolog
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473527,780,037 - 27,784,806 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473527,780,338 - 27,784,714 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Aberrant Crypt Foci  (ISO)
acute kidney failure  (ISO)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
acute promyelocytic leukemia  (ISO)
adenocarcinoma  (ISO)
Alcoholic Liver Diseases  (ISO)
angiosarcoma  (ISO)
Animal Disease Models  (ISO)
atherosclerosis  (ISO)
autosomal dominant polycystic kidney disease  (ISO)
autosomal recessive polycystic kidney disease  (ISO)
B-lymphoblastic leukemia/lymphoma  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Burkitt lymphoma  (ISO)
carcinoma  (ISO)
Cardiomegaly  (ISO)
Carotid Artery Injuries  (ISO)
cholesteatoma of middle ear  (ISO)
Chromosome Breakage  (ISO)
chronic lymphocytic leukemia  (ISO)
clear cell renal cell carcinoma  (ISO)
cleft lip  (ISO)
cleft palate  (ISO)
Colonic Neoplasms  (ISO)
Colorectal Neoplasms  (ISO)
coronary restenosis  (ISO)
COVID-19  (ISO)
demyelinating disease  (ISO)
diffuse large B-cell lymphoma  (ISO)
disease of cellular proliferation  (ISO)
Disease Progression  (ISO)
Ductal Carcinoma  (ISO)
Endometrial Neoplasms  (ISO)
esophageal carcinoma  (ISO)
Esophageal Neoplasms  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Mammary Neoplasms  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
Hemorrhagic Shock  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
Hodgkin's lymphoma  (ISO)
hyperparathyroidism  (ISO)
hypertrophic cardiomyopathy  (ISO)
Kidney Reperfusion Injury  (ISO)
Left Ventricular Hypertrophy  (ISO)
leiomyoma  (ISO)
liver cirrhosis  (ISO)
Liver Injury  (ISO)
Liver Neoplasms  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
Lung Reperfusion Injury  (ISO)
lung small cell carcinoma  (ISO)
medulloblastoma  (ISO)
Merkel cell carcinoma  (ISO)
myelodysplastic syndrome  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
nephroblastoma  (ISO)
neuroblastoma  (ISO)
neuroectodermal tumor  (ISO)
non-Hodgkin lymphoma  (ISO)
obesity  (ISO)
osteoporosis  (ISO)
osteosarcoma  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
polycystic kidney disease  (ISO)
polycystic kidney disease 1  (ISO)
primary ovarian insufficiency  (ISO)
prolactinoma  (ISO)
prostate adenocarcinoma  (ISO)
prostate cancer  (ISO)
prostate carcinoma in situ  (ISO)
prostatic hypertrophy  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary hypertension  (ISO)
renal cell carcinoma  (ISO)
renal fibrosis  (ISO)
rhabdoid cancer  (ISO)
skin melanoma  (ISO)
Sporadic Papillary Renal Cell Carcinoma  (ISO)
squamous cell carcinoma  (ISO)
steatotic liver disease  (ISO)
Stomach Neoplasms  (ISO)
thyroid cancer  (ISO)
thyroid gland papillary carcinoma  (ISO)
Transplant Rejection  (ISO)
trichorhinophalangeal syndrome type I  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acinar cell proliferation  (ISO)
amino acid transport  (ISO)
B cell apoptotic process  (ISO)
branching involved in ureteric bud morphogenesis  (ISO)
cell population proliferation  (ISO)
cellular response to angiotensin  (ISO)
cellular response to arsenite(3-)  (ISO)
cellular response to carbohydrate stimulus  (ISO)
cellular response to cycloheximide  (ISO)
cellular response to cytokine stimulus  (ISO)
cellular response to dimethyl sulfoxide  (ISO)
cellular response to endothelin  (ISO)
cellular response to epidermal growth factor stimulus  (ISO)
cellular response to estrogen stimulus  (ISO)
cellular response to fibroblast growth factor stimulus  (ISO)
cellular response to growth hormone stimulus  (ISO)
cellular response to hydrostatic pressure  (ISO)
cellular response to hypoxia  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to interferon-alpha  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to lectin  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to phorbol 13-acetate 12-myristate  (ISO)
cellular response to platelet-derived growth factor stimulus  (ISO)
cellular response to prolactin  (ISO)
cellular response to putrescine  (ISO)
cellular response to retinoic acid  (ISO)
cellular response to testosterone stimulus  (ISO)
cellular response to type II interferon  (ISO)
cellular response to UV  (ISO)
cellular response to xenobiotic stimulus  (ISO)
chromatin remodeling  (ISO)
chromosome organization  (ISO)
detection of mechanical stimulus involved in sensory perception of sound  (ISO)
DNA damage response  (ISO)
DNA-templated transcription  (ISO)
DNA-templated transcription initiation  (ISO)
ERK1 and ERK2 cascade  (ISO)
G0 to G1 transition  (ISO)
G1/S transition of mitotic cell cycle  (ISO)
glucose metabolic process  (ISO)
hypothalamus development  (ISO)
in utero embryonic development  (ISO)
inner mitochondrial membrane organization  (ISO)
intracellular iron ion homeostasis  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage  (ISO)
lactic acid secretion  (ISO)
liver regeneration  (ISO)
MAPK cascade  (ISO)
middle ear morphogenesis  (ISO)
myoblast proliferation  (ISO)
myotube differentiation  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cell division  (ISO)
negative regulation of epithelial cell apoptotic process  (ISO)
negative regulation of fibroblast proliferation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of gene expression via chromosomal CpG dinucleotide methylation  (ISO)
negative regulation of glucose import  (ISO)
negative regulation of monocyte differentiation  (ISO)
negative regulation of stress-activated MAPK cascade  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transcription initiation by RNA polymerase II  (ISO)
NK T cell proliferation  (ISO)
ovarian follicle development  (ISO)
pigmentation  (ISO)
positive regulation of acinar cell proliferation  (ISO)
positive regulation of apoptotic signaling pathway  (ISO)
positive regulation of ATP biosynthetic process  (ISO)
positive regulation of B cell apoptotic process  (ISO)
positive regulation of cell cycle  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cellular respiration  (ISO)
positive regulation of DNA binding  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of glial cell proliferation  (ISO)
positive regulation of glycolytic process  (ISO)
positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator  (ISO)
positive regulation of mesenchymal cell proliferation  (ISO)
positive regulation of metanephric cap mesenchymal cell proliferation  (ISO)
positive regulation of miRNA transcription  (ISO)
positive regulation of mitochondrial membrane potential  (ISO)
positive regulation of oxidative phosphorylation  (ISO)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription initiation by RNA polymerase II  (ISO)
protein processing  (ISO)
protein-DNA complex disassembly  (ISO)
pyruvate transport  (ISO)
re-entry into mitotic cell cycle  (ISO)
regulation of apoptotic process  (ISO)
regulation of cell cycle process  (ISO)
regulation of DNA-templated transcription  (ISO)
regulation of gene expression  (ISO)
regulation of mitotic cell cycle  (ISO)
regulation of oxidative phosphorylation  (ISO)
regulation of somatic stem cell population maintenance  (ISO)
regulation of telomere maintenance  (ISO)
response to alkaloid  (ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to gamma radiation  (ISO)
response to human chorionic gonadotropin  (ISO)
response to radiation  (ISO)
response to xenobiotic stimulus  (ISO)
skeletal muscle cell differentiation  (ISO)
skeletal system morphogenesis  (ISO)
transcription by RNA polymerase II  (ISO)
transformation of host cell by virus  (ISO)
Wnt signaling pathway  (ISO)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Myc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473527,780,037 - 27,784,806 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473527,780,338 - 27,784,714 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
MYC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388127,735,434 - 127,742,951 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8127,735,434 - 127,742,951 (+)EnsemblGRCh38hg38GRCh38
GRCh378128,747,680 - 128,755,197 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368128,817,498 - 128,822,856 (+)NCBINCBI36Build 36hg18NCBI36
Build 348128,817,685 - 128,822,853NCBI
Celera8124,928,812 - 124,934,177 (+)NCBICelera
Cytogenetic Map8q24.21NCBI
HuRef8124,069,829 - 124,075,195 (+)NCBIHuRef
CHM1_18128,788,551 - 128,793,916 (+)NCBICHM1_1
T2T-CHM13v2.08128,862,888 - 128,870,405 (+)NCBIT2T-CHM13v2.0
Myc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391561,857,190 - 61,862,210 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1561,857,240 - 61,862,223 (+)EnsemblGRCm39 Ensembl
GRCm381561,985,341 - 61,990,361 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1561,985,391 - 61,990,374 (+)EnsemblGRCm38mm10GRCm38
MGSCv371561,816,896 - 61,821,916 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361561,815,052 - 61,820,027 (+)NCBIMGSCv36mm8
Celera1563,490,745 - 63,495,748 (+)NCBICelera
Cytogenetic Map15D1NCBI
cM Map1526.19NCBI
Myc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8795,483,105 - 95,488,031 (+)NCBIGRCr8
mRatBN7.2793,593,705 - 93,598,633 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl793,593,705 - 93,598,630 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx795,416,828 - 95,421,746 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0797,619,124 - 97,624,042 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0797,498,652 - 97,503,571 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07102,586,313 - 102,591,240 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7102,586,313 - 102,591,240 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07103,157,452 - 103,162,379 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4798,953,142 - 98,958,060 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1798,987,371 - 98,992,287 (+)NCBI
Celera790,263,903 - 90,268,823 (+)NCBICelera
Cytogenetic Map7q33NCBI
Myc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554612,714,022 - 2,718,982 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554612,714,022 - 2,718,872 (+)NCBIChiLan1.0ChiLan1.0
MYC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27145,127,238 - 145,132,177 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18120,636,992 - 120,641,918 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08124,387,561 - 124,393,551 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18127,130,877 - 127,136,861 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8127,131,512 - 127,136,863 (+)Ensemblpanpan1.1panPan2
MYC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11325,200,772 - 25,205,309 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1325,200,577 - 25,205,309 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1325,169,176 - 25,173,718 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01325,544,697 - 25,549,239 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1325,539,647 - 25,549,749 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11325,260,451 - 25,264,991 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01325,374,618 - 25,379,158 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01325,629,077 - 25,633,621 (+)NCBIUU_Cfam_GSD_1.0
Myc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530313,054,869 - 13,059,826 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647020,480,829 - 20,485,965 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647020,480,844 - 20,485,955 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl412,455,122 - 12,461,078 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1412,455,141 - 12,460,360 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2412,778,452 - 12,783,667 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap4p13NCBI
MYC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18122,282,989 - 122,288,392 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8122,282,630 - 122,288,384 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603917,837,088 - 17,843,111 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_004837959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AHKG01011422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSHGLT00000009758   ⟹   ENSHGLP00000009651
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462473527,780,037 - 27,784,806 (-)Ensembl
RefSeq Acc Id: XM_004837959   ⟹   XP_004838016
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473527,780,338 - 27,784,714 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004838016 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004838016   ⟸   XM_004837959
RefSeq Acc Id: ENSHGLP00000009651   ⟸   ENSHGLT00000009758


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000006922 Ensembl
NCBI Gene Myc ENTREZGENE