Max (MYC associated factor X) - Rat Genome Database

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Gene: Max (MYC associated factor X) Rattus norvegicus
Analyze
Symbol: Max
Name: MYC associated factor X
RGD ID: 621101
Description: Enables DNA-binding transcription factor activity; identical protein binding activity; and sequence-specific DNA binding activity. Involved in several processes, including regulation of gene expression; response to peptide hormone; and retina development in camera-type eye. Located in PML body and dendrite. Human ortholog(s) of this gene implicated in lung small cell carcinoma and pheochromocytoma. Orthologous to human MAX (MYC associated factor X); PARTICIPATES IN mitogen activated protein kinase signaling pathway; small cell lung carcinoma pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC124611; myc-associated factor X
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Max-ps1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86101,369,989 - 101,395,333 (-)NCBIGRCr8
mRatBN7.2695,636,859 - 95,662,204 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl695,636,858 - 95,662,137 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx696,033,070 - 96,056,884 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0696,331,618 - 96,355,431 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0695,760,430 - 95,784,244 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0699,984,260 - 100,011,460 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl699,984,260 - 100,011,388 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06109,378,844 - 109,403,792 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4699,529,905 - 99,553,851 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1699,533,360 - 99,557,307 (-)NCBI
Celera694,056,185 - 94,080,083 (-)NCBICelera
Cytogenetic Map6q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Involvement of c-myc and max in CNS beta-endorphin modulation of hepatic ornithine decarboxylase responsiveness to insulin in rat pups. Bartolome JV, etal., Life Sci. 1999;64(5):PL87-91.
2. Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts. Berg T, etal., Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3830-5. Epub 2002 Mar 12.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. The nerve growth factor-responsive PC12 cell line does not express the Myc dimerization partner Max. Hopewell R and Ziff EB, Mol Cell Biol. 1995 Jul;15(7):3470-8.
5. Molecular cloning and sequencing of rat Max cDNA: castration-induced expression of the 2 kb transcript in male accessory sex organs of rats. Izawa M Biochim Biophys Acta 1993 Dec 14;1216(3):492-4.
6. c-Myc and ChREBP regulate glucose-mediated expression of the L-type pyruvate kinase gene in INS-1-derived 832/13 cells. Jason Collier J, etal., Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E48-56. Epub 2007 Mar 6.
7. Induction of a novel histone deacetylase 1/c-Myc/Mnt/Max complex formation is implicated in parity-induced refractoriness to mammary carcinogenesis. Matsuoka Y, etal., Cancer Sci. 2008 Feb;99(2):309-15.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. Early nuclear exclusion of the transcription factor max is associated with retinal ganglion cell death independent of caspase activity. Petrs-Silva H, etal., J Cell Physiol. 2004 Feb;198(2):179-87.
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. Abelson interacting protein 1 (Abi-1) is essential for dendrite morphogenesis and synapse formation. Proepper C, etal., EMBO J. 2007 Mar 7;26(5):1397-409. Epub 2007 Feb 15.
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. MAX inactivation in small cell lung cancer disrupts MYC-SWI/SNF programs and is synthetic lethal with BRG1. Romero OA, etal., Cancer Discov. 2014 Mar;4(3):292-303. doi: 10.1158/2159-8290.CD-13-0799. Epub 2013 Dec 20.
17. Induction of max by adrenomedullin and calcitonin gene-related peptide antagonizes endothelial apoptosis. Shichiri M, etal., Mol Endocrinol. 1999 Aug;13(8):1353-63.
18. c-Myc localization within the nucleus: evidence for association with the PML nuclear body. Smith KP, etal., J Cell Biochem. 2004 Dec 15;93(6):1282-96.
19. Expression and subcellular localization of the Myc superfamily proteins: c-Myc, Max, Mad1 and Mxi1 in the epiphyseal plate cartilage chondrocytes of growing rats. Wang Y, etal., Cell Mol Biol (Noisy-le-grand). 1997 Mar;43(2):175-88.
Additional References at PubMed
PMID:8425219   PMID:8521822   PMID:9399572   PMID:10601024   PMID:12477932   PMID:12837246   PMID:12970171   PMID:15358760   PMID:15960975   PMID:16150871   PMID:16171389   PMID:18601921  
PMID:20197614   PMID:22770845   PMID:26070438   PMID:35103748  


Genomics

Comparative Map Data
Max
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86101,369,989 - 101,395,333 (-)NCBIGRCr8
mRatBN7.2695,636,859 - 95,662,204 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl695,636,858 - 95,662,137 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx696,033,070 - 96,056,884 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0696,331,618 - 96,355,431 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0695,760,430 - 95,784,244 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0699,984,260 - 100,011,460 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl699,984,260 - 100,011,388 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06109,378,844 - 109,403,792 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4699,529,905 - 99,553,851 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1699,533,360 - 99,557,307 (-)NCBI
Celera694,056,185 - 94,080,083 (-)NCBICelera
Cytogenetic Map6q24NCBI
MAX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381465,006,101 - 65,102,695 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1465,006,174 - 65,102,695 (-)EnsemblGRCh38hg38GRCh38
GRCh371465,472,819 - 65,569,413 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361464,542,645 - 64,638,980 (-)NCBINCBI36Build 36hg18NCBI36
Build 341464,542,644 - 64,638,980NCBI
Celera1445,527,481 - 45,623,823 (-)NCBICelera
Cytogenetic Map14q23.3NCBI
HuRef1445,642,154 - 45,738,669 (-)NCBIHuRef
CHM1_11465,411,018 - 65,507,560 (-)NCBICHM1_1
T2T-CHM13v2.01459,210,965 - 59,307,534 (-)NCBIT2T-CHM13v2.0
Max
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391276,984,045 - 77,009,123 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1276,984,043 - 77,008,975 (-)EnsemblGRCm39 Ensembl
GRCm381276,937,269 - 76,962,323 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1276,937,269 - 76,962,201 (-)EnsemblGRCm38mm10GRCm38
MGSCv371278,038,256 - 78,063,235 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361277,856,109 - 77,881,025 (-)NCBIMGSCv36mm8
Celera1278,019,503 - 78,044,521 (-)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1233.78NCBI
Max
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554664,816,568 - 4,842,659 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554664,816,568 - 4,842,659 (+)NCBIChiLan1.0ChiLan1.0
MAX
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21566,113,395 - 66,216,485 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11465,329,908 - 65,432,998 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01445,588,366 - 45,683,828 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11464,467,753 - 64,562,671 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1464,535,120 - 64,562,671 (-)Ensemblpanpan1.1panPan2
MAX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1839,441,216 - 39,465,703 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl839,380,686 - 39,465,959 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha839,133,226 - 39,157,709 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0839,664,047 - 39,688,532 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl839,603,427 - 39,688,561 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1839,284,778 - 39,309,267 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0839,357,282 - 39,381,777 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0839,716,473 - 39,740,975 (-)NCBIUU_Cfam_GSD_1.0
Max
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864065,435,802 - 65,462,758 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364958,728,940 - 8,755,799 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364958,728,941 - 8,755,742 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAX
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl789,142,969 - 89,168,201 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1789,142,966 - 89,168,265 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2795,519,256 - 95,544,583 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAX
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12442,288,891 - 42,314,711 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2442,291,106 - 42,314,605 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605330,463,237 - 30,488,861 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Max
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473435,925,827 - 35,952,375 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Max
59 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:746
Count of miRNA genes:267
Interacting mature miRNAs:322
Transcripts:ENSRNOT00000010954, ENSRNOT00000041442
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)645790088104200226Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)657730540104085867Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)657730540104085867Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)658632962103632962Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)661747639106747639Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
1641904Alcrsp4Alcohol response QTL 4response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)667262953112262953Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)671201409116201409Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)672202632115200186Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)672202632117202632Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)673463459109394713Rat
2293837Kiddil1Kidney dilation QTL 13.7kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)681132889104393926Rat
2293842Kiddil3Kidney dilation QTL 34.3kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)681132889104393926Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)682523650110548006Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)683190345106747639Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
1300076Glom8Glomerulus QTL 870.000000009kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)689762877106752806Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat

Markers in Region
D6Got122  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2695,646,538 - 95,646,660 (+)MAPPERmRatBN7.2
Rnor_6.0699,995,804 - 99,995,925NCBIRnor6.0
Rnor_5.06109,388,151 - 109,388,272UniSTSRnor5.0
RGSC_v3.4699,538,348 - 99,538,470RGDRGSC3.4
RGSC_v3.4699,538,349 - 99,538,470UniSTSRGSC3.4
RGSC_v3.1699,541,805 - 99,541,926RGD
Celera694,064,677 - 94,064,798UniSTS
RH 3.4 Map6673.4RGD
RH 3.4 Map6673.4UniSTS
Cytogenetic Map6q24UniSTS
BI277538  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2652,947,739 - 52,948,041 (+)MAPPERmRatBN7.2
mRatBN7.2695,636,962 - 95,637,145 (+)MAPPERmRatBN7.2
Rnor_6.0699,984,365 - 99,984,547NCBIRnor6.0
Rnor_6.0655,706,624 - 55,706,925NCBIRnor6.0
Rnor_5.0665,321,005 - 65,321,306UniSTSRnor5.0
Rnor_5.06109,378,949 - 109,379,131UniSTSRnor5.0
RGSC_v3.4654,941,318 - 54,941,619UniSTSRGSC3.4
RGSC_v3.4699,528,751 - 99,528,933UniSTSRGSC3.4
Celera694,055,031 - 94,055,213UniSTS
Celera652,090,030 - 52,090,333UniSTS
RH 3.4 Map6669.3UniSTS
Cytogenetic Map6q16UniSTS
Cytogenetic Map6q24UniSTS
RH128859  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2695,636,903 - 95,637,083 (+)MAPPERmRatBN7.2
Rnor_6.0699,984,306 - 99,984,485NCBIRnor6.0
Rnor_5.06109,378,890 - 109,379,069UniSTSRnor5.0
RGSC_v3.4699,528,692 - 99,528,871UniSTSRGSC3.4
Celera694,054,972 - 94,055,151UniSTS
Cytogenetic Map6q24UniSTS
AI237355  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2652,949,383 - 52,949,578 (+)MAPPERmRatBN7.2
Rnor_6.0655,708,268 - 55,708,458NCBIRnor6.0
RH 3.4 Map6362.7UniSTS
Cytogenetic Map6q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 35 49 33 19 33 1 4 74 32 39 11 1
Low 8 8 8 8 7 7 3 2 7
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001411963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_022210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_177987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_177988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_177989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_593084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC099778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D14447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D14448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000010954   ⟹   ENSRNOP00000010954
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl695,636,858 - 95,662,128 (-)Ensembl
Rnor_6.0 Ensembl699,984,260 - 100,011,388 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000041442   ⟹   ENSRNOP00000040275
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl699,985,519 - 100,011,226 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000083286   ⟹   ENSRNOP00000072268
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl699,985,519 - 100,011,226 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000106817   ⟹   ENSRNOP00000086002
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl695,636,862 - 95,662,137 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000107085   ⟹   ENSRNOP00000082617
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl695,636,862 - 95,662,137 (-)Ensembl
RefSeq Acc Id: NM_001411963   ⟹   NP_001398892
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86101,369,989 - 101,395,290 (-)NCBI
mRatBN7.2695,636,859 - 95,662,161 (-)NCBI
RefSeq Acc Id: NM_022210   ⟹   NP_071546
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86101,369,989 - 101,395,290 (-)NCBI
mRatBN7.2695,636,859 - 95,662,161 (-)NCBI
Rnor_6.0699,985,519 - 100,011,226 (-)NCBI
Rnor_5.06109,378,844 - 109,403,792 (-)NCBI
RGSC_v3.4699,529,905 - 99,553,851 (-)RGD
Celera694,056,185 - 94,080,083 (-)RGD
Sequence:
RefSeq Acc Id: NR_177987
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86101,369,989 - 101,395,290 (-)NCBI
mRatBN7.2695,636,859 - 95,662,161 (-)NCBI
RefSeq Acc Id: NR_177988
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86101,369,989 - 101,395,290 (-)NCBI
mRatBN7.2695,636,859 - 95,662,161 (-)NCBI
RefSeq Acc Id: NR_177989
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86101,369,989 - 101,395,290 (-)NCBI
mRatBN7.2695,636,859 - 95,662,161 (-)NCBI
RefSeq Acc Id: XM_063262440   ⟹   XP_063118510
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86101,369,989 - 101,395,333 (-)NCBI
RefSeq Acc Id: XM_063262441   ⟹   XP_063118511
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86101,369,989 - 101,395,001 (-)NCBI
RefSeq Acc Id: XM_063262442   ⟹   XP_063118512
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86101,369,989 - 101,395,325 (-)NCBI
RefSeq Acc Id: XR_593084
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86101,371,268 - 101,395,333 (-)NCBI
mRatBN7.2695,638,138 - 95,662,204 (-)NCBI
Rnor_6.0699,985,511 - 100,011,460 (-)NCBI
Sequence:
RefSeq Acc Id: NP_071546   ⟸   NM_022210
- Peptide Label: isoform 1
- UniProtKB: P52164 (UniProtKB/Swiss-Prot),   A6HCC6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000040275   ⟸   ENSRNOT00000041442
RefSeq Acc Id: ENSRNOP00000072268   ⟸   ENSRNOT00000083286
RefSeq Acc Id: ENSRNOP00000010954   ⟸   ENSRNOT00000010954
RefSeq Acc Id: ENSRNOP00000086002   ⟸   ENSRNOT00000106817
RefSeq Acc Id: ENSRNOP00000082617   ⟸   ENSRNOT00000107085
RefSeq Acc Id: NP_001398892   ⟸   NM_001411963
- Peptide Label: isoform 2
- UniProtKB: A6HCC5 (UniProtKB/TrEMBL),   A0A8I5ZV85 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118510   ⟸   XM_063262440
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063118512   ⟸   XM_063262442
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063118511   ⟸   XM_063262441
- Peptide Label: isoform X2
Protein Domains
bHLH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P52164-F1-model_v2 AlphaFold P52164 1-160 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694690
Promoter ID:EPDNEW_R5208
Type:initiation region
Name:Max_1
Description:MYC associated factor X
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06100,011,404 - 100,011,464EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621101 AgrOrtholog
BioCyc Gene G2FUF-37040 BioCyc
Ensembl Genes ENSRNOG00000008049 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055020110 UniProtKB/Swiss-Prot
  ENSRNOG00060022495 UniProtKB/Swiss-Prot
  ENSRNOG00065017509 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000010954 ENTREZGENE
  ENSRNOT00000010954.6 UniProtKB/TrEMBL
  ENSRNOT00000106817 ENTREZGENE
  ENSRNOT00000106817.1 UniProtKB/Swiss-Prot
  ENSRNOT00000107085.1 UniProtKB/TrEMBL
  ENSRNOT00055034386 UniProtKB/Swiss-Prot
  ENSRNOT00060039188 UniProtKB/Swiss-Prot
  ENSRNOT00065029299 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7933028 IMAGE-MGC_LOAD
InterPro bHLH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  bZIP_sf UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:60661 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:124611 IMAGE-MGC_LOAD
NCBI Gene 60661 ENTREZGENE
PANTHER PROTEIN MAX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10328 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB MAX RGD
PhenoGen Max PhenoGen
PROSITE BHLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008049 RatGTEx
  ENSRNOG00055020110 RatGTEx
  ENSRNOG00060022495 RatGTEx
  ENSRNOG00065017509 RatGTEx
SMART HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP HLH, helix-loop-helix DNA-binding domain UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  SSF57959 UniProtKB/TrEMBL
UniProt A0A8I5ZV85 ENTREZGENE, UniProtKB/TrEMBL
  A6HCC4_RAT UniProtKB/TrEMBL
  A6HCC5 ENTREZGENE, UniProtKB/TrEMBL
  A6HCC6 ENTREZGENE, UniProtKB/TrEMBL
  MAX_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q499S8_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-24 Max  MYC associated factor X  Max  Max protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Max  Max protein    Max  Name updated 1299863 APPROVED
2002-08-07 Max  Max      Symbol and Name status set to provisional 70820 PROVISIONAL