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Gene: MIRLET7F1 (microRNA let-7f-1) Homo sapiens
Symbol: MIRLET7F1
Name: microRNA let-7f-1
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
Also known as: let-7f-1; LET7F1; MIRNLET7F1
Mus musculus (house mouse) : Mirlet7f-1 (microRNA let7f-1)  MGI  Alliance
Canis lupus familiaris (dog) : MIRLET7F (microRNA let-7f)
Sus scrofa (pig) : MIRLET7F-2 (microRNA let-7f-2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl994,176,347 - 94,176,433 (+)EnsemblGRCh38hg38GRCh38
GRCh38994,176,347 - 94,176,433 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37996,938,629 - 96,938,715 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36995,978,449 - 95,978,535 (+)NCBINCBI36hg18NCBI36
Celera967,380,185 - 67,380,271 (+)NCBI
Cytogenetic Map9q22.32NCBI
HuRef966,616,308 - 66,616,394 (+)NCBIHuRef
CHM1_1997,085,474 - 97,085,560 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Clinical Variants

Additional Information

External Database Links
More on MIRLET7F1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1350549
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.