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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731438
Species: Homo sapiens
RGD Object: Gene
Symbol: MYC
Name: MYC proto-oncogene, bHLH transcription factor
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MYCaffects expressionEXP 6480464CTDTretinoin affects the expression of MYC proteinPMID:16054129
MYCdecreases expressionEXP 6480464CTDTretinoin results in decreased expression of MYC mRNA; Tretinoin results in decreased expression of MYC proteinPMID:12875902 PMID:15498508 PMID:15770638 PMID:16054129 PMID:16140955 PMID:17218384 PMID:17229153 PMID:17318229 PMID:17453147 PMID:20945414 PMID:21924320 PMID:23724009 PMID:23830798 PMID:30093655 PMID:33167477 PMID:34058077
MYCmultiple interactionsEXP 6480464CTD[Arsenic Trioxide co-treated with Tretinoin] results in decreased expression of MYC protein; Arsenic Trioxide promotes the reaction [Tretinoin results in decreased expression of MYC protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Tretinoin results in decreased expression of MYC protein]; Thiophenes analog promotes the reaction [Tretinoin results in decreased expression of MYC mRNA]; Tretinoin affects the reaction [SET protein affects the expression of MYC protein]; Tretinoin promotes the reaction [Arsenic Trioxide results in decreased expression of MYC protein]PMID:16140955 PMID:20945414 PMID:30093655 PMID:34058077
MYCdecreases expressionISOMyc (Mus musculus)6480464CTDTretinoin results in decreased expression of MYC mRNAPMID:16604517 PMID:16788091
MYCdecreases expressionISOMyc (Rattus norvegicus)6480464CTDTretinoin results in decreased expression of MYC proteinPMID:1917145
MYCincreases expressionISOMyc (Mus musculus)6480464CTDTretinoin results in increased expression of MYC mRNAPMID:26272751
MYCmultiple interactionsISOMyc (Mus musculus)6480464CTDNR2C1 protein affects the reaction [Tretinoin results in increased expression of MYC protein]PMID:17389641
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