MIR34C (microRNA 34c) - Rat Genome Database

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Gene: MIR34C (microRNA 34c) Homo sapiens
Analyze
Symbol: MIR34C
Name: microRNA 34c
RGD ID: 1348685
HGNC Page HGNC
Description: Predicted to act upstream of or within several processes, including cellular response to forskolin; cellular response to leukemia inhibitory factor; and embryonic brain development. Predicted to be part of RISC complex. Biomarker of Parkinson's disease.
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: mir-34c; MIRN34C; miRNA34C
RGD Orthologs
Mouse
Rat
Dog
Pig
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl11111,513,439 - 111,513,515 (+)EnsemblGRCh38hg38GRCh38
GRCh3811111,513,439 - 111,513,515 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711111,384,164 - 111,384,240 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611110,889,373 - 110,889,449 (+)NCBINCBI36hg18NCBI36
Celera11108,537,353 - 108,537,429 (+)NCBI
Cytogenetic Map11q23.1NCBI
HuRef11107,308,362 - 107,308,438 (+)NCBIHuRef
CHM1_111111,267,259 - 111,267,335 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

Additional References at PubMed
PMID:12919684   PMID:16381832   PMID:17554337   PMID:17604727   PMID:18451145   PMID:18519671   PMID:19461653   PMID:19536169   PMID:19632201   PMID:20198305   PMID:20212154   PMID:20309940  
PMID:20924086   PMID:21037258   PMID:21321636   PMID:21351256   PMID:21600876   PMID:21610744   PMID:21946562   PMID:21976504   PMID:21976676   PMID:22047961   PMID:22074923   PMID:22082000  
PMID:22844323   PMID:23047694   PMID:23155254   PMID:23183747   PMID:23298640   PMID:23423488   PMID:23504554   PMID:23516510   PMID:23525472   PMID:23720736   PMID:23805317   PMID:23922103  
PMID:23935875   PMID:24337371   PMID:24479666   PMID:24482044   PMID:24559316   PMID:24573638   PMID:24637697   PMID:24686393   PMID:24802328   PMID:24811488   PMID:24945256   PMID:24970812  
PMID:25064703   PMID:25190019   PMID:25190020   PMID:25201524   PMID:25213795   PMID:25227823   PMID:25273528   PMID:25326793   PMID:25370690   PMID:25475831   PMID:25541488   PMID:25611392  
PMID:25647415   PMID:25658980   PMID:25894979   PMID:26051092   PMID:26097561   PMID:26126715   PMID:26170125   PMID:26250586   PMID:26261507   PMID:26320502   PMID:26402112   PMID:26402809  
PMID:26674205   PMID:26704889   PMID:26722462   PMID:26975503   PMID:27576168   PMID:27577964   PMID:27704267   PMID:27808368   PMID:27835575   PMID:27886674   PMID:27983526   PMID:27993935  
PMID:28069384   PMID:28075441   PMID:28105423   PMID:28106538   PMID:28153728   PMID:28263709   PMID:28277300   PMID:28363996   PMID:28415817   PMID:28431233   PMID:28461137   PMID:28512015  
PMID:28540980   PMID:28661068   PMID:28886318   PMID:29039021   PMID:29077234   PMID:29576507   PMID:29654165   PMID:29703249   PMID:29744877   PMID:29975106   PMID:30096129   PMID:30096777  
PMID:30334298   PMID:30373654   PMID:30426533   PMID:30537410   PMID:30935968   PMID:30942424   PMID:31023029   PMID:31376385   PMID:31430761   PMID:31432176   PMID:31446795   PMID:31554925  
PMID:31915008   PMID:32053576   PMID:32080912   PMID:32083300   PMID:32089626   PMID:32092796   PMID:32157741   PMID:32166848   PMID:32228202   PMID:32317629   PMID:32319382   PMID:32353411  
PMID:32446383   PMID:32458967   PMID:32502545   PMID:32572919   PMID:32586280   PMID:32705492   PMID:33190281   PMID:33300051   PMID:33370525   PMID:33377704   PMID:33396625   PMID:33501502  
PMID:33786631   PMID:34038763  


Genomics

Comparative Map Data
MIR34C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl11111,513,439 - 111,513,515 (+)EnsemblGRCh38hg38GRCh38
GRCh3811111,513,439 - 111,513,515 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711111,384,164 - 111,384,240 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611110,889,373 - 110,889,449 (+)NCBINCBI36hg18NCBI36
Celera11108,537,353 - 108,537,429 (+)NCBI
Cytogenetic Map11q23.1NCBI
HuRef11107,308,362 - 107,308,438 (+)NCBIHuRef
CHM1_111111,267,259 - 111,267,335 (+)NCBICHM1_1
Mir34c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39951,014,334 - 51,014,410 (-)NCBIGRCm39mm39
GRCm39 Ensembl951,014,334 - 51,014,410 (-)Ensembl
GRCm38951,103,034 - 51,103,110 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl951,103,034 - 51,103,110 (-)EnsemblGRCm38mm10GRCm38
MGSCv37950,911,139 - 50,911,215 (-)NCBIGRCm37mm9NCBIm37
Celera948,389,544 - 48,389,620 (-)NCBICelera
Cytogenetic Map9A5.3NCBI
Mir34c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2851,409,726 - 51,409,802 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl851,409,726 - 51,409,802 (-)Ensembl
Rnor_6.0855,492,024 - 55,492,100 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl855,492,024 - 55,492,100 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0854,088,381 - 54,088,457 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera850,956,167 - 50,956,243 (-)NCBICelera
Cytogenetic Map8q23NCBI
MIR34C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1521,558,106 - 21,558,160 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha521,479,748 - 21,479,802 (-)NCBI
ROS_Cfam_1.0521,583,762 - 21,583,816 (-)NCBI
UMICH_Zoey_3.1521,644,859 - 21,644,913 (-)NCBI
UNSW_CanFamBas_1.0521,544,830 - 21,544,884 (-)NCBI
UU_Cfam_GSD_1.0521,593,815 - 21,593,869 (-)NCBI
MIR34C-1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl939,280,278 - 39,280,357 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1939,280,278 - 39,280,357 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2944,166,873 - 44,166,952 (-)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
NOTCH1hsa-miR-34c-5pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//qRT-PCR//WeFunctional MTI22498974
MYBhsa-miR-34c-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)19461653
METhsa-miR-34c-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19461653
METhsa-miR-34c-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI20198305
METhsa-miR-34c-5pMirtarbaseexternal_infoMicroarray//Western blot//RTPCRFunctional MTI20924086
METhsa-miR-34c-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22419847
E2F3hsa-miR-34c-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI18768788
HNF4Ahsa-miR-34c-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22232426
MYCNhsa-miR-34c-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI22020437
NOTCH4hsa-miR-34c-5pMirtarbaseexternal_infoEMSA//Luciferase reporter assay//Western blotFunctional MTI22074923
ULBP2hsa-miR-34c-5pMirtarbaseexternal_infoFlow//Luciferase reporter assay//Western blotFunctional MTI22102694
BCL2hsa-miR-34c-5pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI18803879
ZAP70hsa-miR-34c-5pMirtarbaseexternal_infoImmunoblot//Luciferase reporter assayFunctional MTI21205967
MAPThsa-miR-34c-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23423488
UNGhsa-miR-34c-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23228472
MYChsa-miR-34c-5pMirecordsexternal_info{changed}NA20212154
FOSL1hsa-miR-34c-5pOncomiRDBexternal_infoNANA23001043
METhsa-miR-34c-5pOncomiRDBexternal_infoNANA22419847
BMFhsa-miR-34c-5pOncomiRDBexternal_infoNANA22370637
SNAI1hsa-miR-34c-5pOncomiRDBexternal_infoNANA22134354
NOTCH4hsa-miR-34c-5pOncomiRDBexternal_infoNANA22074923
SNAI1hsa-miR-34c-5pOncomiRDBexternal_infoNANA22024162
MYCNhsa-miR-34c-5pOncomiRDBexternal_infoNANA21654684
ARhsa-miR-34c-5pOncomiRDBexternal_infoNANA21343391
ZAP70hsa-miR-34c-5pOncomiRDBexternal_infoNANA21205967
METhsa-miR-34c-5pOncomiRDBexternal_infoNANA20198305
METhsa-miR-34c-5pOncomiRDBexternal_infoNANA19074879
BCL2hsa-miR-34c-5pOncomiRDBexternal_infoNANA18803879
BCL2hsa-miR-34c-5pOncomiRDBexternal_infoNANA17656095
NOTCH3hsa-miR-34c-3pMirecordsexternal_info{changed}NA18803879
BCL2hsa-miR-34c-3pMirecordsexternal_infoNANA18803879

Predicted Targets
Summary Value
Count of predictions:41717
Count of gene targets:15449
Count of transcripts:33529
Interacting mature miRNAs:hsa-miR-34c-3p, hsa-miR-34c-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 1 2 13 12
Low 16 3 10 2 19 4 45 8 27 11 74 85 4 1 1
Below cutoff 5 3 4 12 1 7 19 17 4 15 17 1 1 2

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000384831
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11111,513,439 - 111,513,515 (+)Ensembl
RefSeq Acc Id: NR_029840
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811111,513,439 - 111,513,515 (+)NCBI
GRCh3711111,384,164 - 111,384,240 (+)RGD
Celera11108,537,353 - 108,537,429 (+)RGD
HuRef11107,308,362 - 107,308,438 (+)ENTREZGENE
CHM1_111111,267,259 - 111,267,335 (+)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11q22.1-25(chr11:100348599-135040246)x3 copy number gain See cases [RCV000053638] Chr11:100348599..135040246 [GRCh38]
Chr11:100219331..134910140 [GRCh37]
Chr11:99724541..134415350 [NCBI36]
Chr11:11q22.1-25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11q13.4-23.3(chr11:71588805-116680918)x3 copy number gain not provided [RCV000683374] Chr11:71588805..116680918 [GRCh37]
Chr11:11q13.4-23.3
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11q14.1-23.2(chr11:80053454-113316236)x1 copy number loss not provided [RCV000737595] Chr11:80053454..113316236 [GRCh37]
Chr11:11q14.1-23.2
pathogenic
GRCh37/hg19 11q22.3-23.3(chr11:104101411-116680918)x1 copy number loss not provided [RCV000848741] Chr11:104101411..116680918 [GRCh37]
Chr11:11q22.3-23.3
pathogenic
GRCh37/hg19 11q23.1-23.3(chr11:110969076-114578509)x1 copy number loss not provided [RCV000848936] Chr11:110969076..114578509 [GRCh37]
Chr11:11q23.1-23.3
uncertain significance
GRCh37/hg19 11q22.3-23.2(chr11:103320065-114349787)x1 copy number loss not provided [RCV001006439] Chr11:103320065..114349787 [GRCh37]
Chr11:11q22.3-23.2
pathogenic
NC_000011.9:g.(?_111171709)_(111965694_?)del deletion Carney-Stratakis syndrome [RCV001032115] Chr11:111171709..111965694 [GRCh37]
Chr11:11q23.1
pathogenic
GRCh37/hg19 11q22.3-23.3(chr11:105699599-114524876)x1 copy number loss not provided [RCV001006445] Chr11:105699599..114524876 [GRCh37]
Chr11:11q22.3-23.3
pathogenic
Single allele deletion Intellectual disability [RCV001293382] Chr11:118359328..118372573 [GRCh37]
Chr11:11p15.3-q23.3
pathogenic
NC_000011.9:g.(?_111171709)_(111965694_?)dup duplication Carney-Stratakis syndrome [RCV001300223] Chr11:111171709..111965694 [GRCh37]
Chr11:11q23.1
uncertain significance
NC_000011.9:g.(?_94153285)_(111965700_?)del deletion Ataxia-telangiectasia syndrome [RCV001389105] Chr11:94153285..111965700 [GRCh37]
Chr11:11q21-23.1
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:31637 AgrOrtholog
COSMIC MIR34C COSMIC
Ensembl Genes ENSG00000207562 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000384831 ENTREZGENE
GTEx ENSG00000207562 GTEx
HGNC ID HGNC:31637 ENTREZGENE
Human Proteome Map MIR34C Human Proteome Map
miRBase MI0000743 ENTREZGENE
NCBI Gene 407042 ENTREZGENE
OMIM 611375 OMIM
PharmGKB PA164722677 PharmGKB
RNAcentral URS00002C7B2B RNACentral
  URS00002C7C59 RNACentral
  URS000075E7C8 RNACentral