Myc (MYC proto-oncogene, bHLH transcription factor) - Rat Genome Database

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Gene: Myc (MYC proto-oncogene, bHLH transcription factor) Chinchilla lanigera
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Symbol: Myc
Name: MYC proto-oncogene, bHLH transcription factor
RGD ID: 8954249
Description: ENCODES a protein that exhibits cis-regulatory region sequence-specific DNA binding (ortholog); core promoter sequence-specific DNA binding (ortholog); DNA binding (ortholog); INVOLVED IN activation of cysteine-type endopeptidase activity involved in apoptotic process (ortholog); amino acid transport (ortholog); B cell apoptotic process (ortholog); PARTICIPATES IN ceramide signaling pathway; interleukin-2 signaling pathway; interleukin-6 signaling pathway; ASSOCIATED WITH Aberrant Crypt Foci (ortholog); acute kidney failure (ortholog); acute lymphoblastic leukemia (ortholog); FOUND IN axon (ortholog); chromatin (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: v-myc avian myelocytomatosis viral oncogene homolog
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554612,714,022 - 2,718,982 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554612,714,022 - 2,718,872 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Aberrant Crypt Foci  (ISO)
acute kidney failure  (ISO)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
acute promyelocytic leukemia  (ISO)
adenocarcinoma  (ISO)
Alcoholic Liver Diseases  (ISO)
angiosarcoma  (ISO)
Animal Disease Models  (ISO)
autosomal dominant polycystic kidney disease  (ISO)
autosomal recessive polycystic kidney disease  (ISO)
B-lymphoblastic leukemia/lymphoma  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Burkitt lymphoma  (ISO)
carcinoma  (ISO)
Cardiomegaly  (ISO)
Carotid Artery Injuries  (ISO)
Chromosome Breakage  (ISO)
chronic lymphocytic leukemia  (ISO)
clear cell renal cell carcinoma  (ISO)
cleft lip  (ISO)
cleft palate  (ISO)
Colonic Neoplasms  (ISO)
Colorectal Neoplasms  (ISO)
coronary restenosis  (ISO)
COVID-19  (ISO)
demyelinating disease  (ISO)
diffuse large B-cell lymphoma  (ISO)
disease of cellular proliferation  (ISO)
Disease Progression  (ISO)
Ductal Carcinoma  (ISO)
Endometrial Neoplasms  (ISO)
esophageal carcinoma  (ISO)
Esophageal Neoplasms  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Liver Neoplasms  (ISO)
fatty liver disease  (ISO)
glioblastoma  (ISO)
Hemorrhagic Shock  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
hyperparathyroidism  (ISO)
hypertrophic cardiomyopathy  (ISO)
Kidney Reperfusion Injury  (ISO)
Left Ventricular Hypertrophy  (ISO)
leiomyoma  (ISO)
liver cirrhosis  (ISO)
Liver Injury  (ISO)
Liver Neoplasms  (ISO)
lung adenocarcinoma  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
Lung Reperfusion Injury  (ISO)
lung small cell carcinoma  (ISO)
Mammary Neoplasms, Experimental  (ISO)
medulloblastoma  (ISO)
Merkel cell carcinoma  (ISO)
myelodysplastic syndrome  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
nephroblastoma  (ISO)
neuroblastoma  (ISO)
neuroectodermal tumor  (ISO)
non-Hodgkin lymphoma  (ISO)
obesity  (ISO)
osteoporosis  (ISO)
osteosarcoma  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
polycystic kidney disease  (ISO)
polycystic kidney disease 1  (ISO)
primary ovarian insufficiency  (ISO)
prolactinoma  (ISO)
prostate adenocarcinoma  (ISO)
prostate cancer  (ISO)
prostate carcinoma in situ  (ISO)
prostatic hypertrophy  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary hypertension  (ISO)
renal cell carcinoma  (ISO)
renal fibrosis  (ISO)
rhabdoid cancer  (ISO)
skin melanoma  (ISO)
Sporadic Papillary Renal Cell Carcinoma  (ISO)
squamous cell carcinoma  (ISO)
Stomach Neoplasms  (ISO)
thyroid gland cancer  (ISO)
thyroid gland papillary carcinoma  (ISO)
Transplant Rejection  (ISO)
trichorhinophalangeal syndrome type I  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
amino acid transport  (ISO)
B cell apoptotic process  (ISO)
branching involved in ureteric bud morphogenesis  (ISO)
canonical Wnt signaling pathway involved in negative regulation of apoptotic process  (ISO)
canonical Wnt signaling pathway involved in positive regulation of apoptotic process  (ISO)
cell population proliferation  (ISO)
cellular iron ion homeostasis  (ISO)
cellular response to angiotensin  (ISO)
cellular response to arsenite(3-)  (ISO)
cellular response to carbohydrate stimulus  (ISO)
cellular response to cycloheximide  (ISO)
cellular response to cytokine stimulus  (ISO)
cellular response to dimethyl sulfoxide  (ISO)
cellular response to DNA damage stimulus  (ISO)
cellular response to drug  (ISO)
cellular response to endothelin  (ISO)
cellular response to epidermal growth factor stimulus  (ISO)
cellular response to estrogen stimulus  (ISO)
cellular response to fibroblast growth factor stimulus  (ISO)
cellular response to growth hormone stimulus  (ISO)
cellular response to hydrostatic pressure  (ISO)
cellular response to hypoxia  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to interferon-alpha  (ISO)
cellular response to interferon-gamma  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to lectin  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to phorbol 13-acetate 12-myristate  (ISO)
cellular response to platelet-derived growth factor stimulus  (ISO)
cellular response to prolactin  (ISO)
cellular response to putrescine  (ISO)
cellular response to retinoic acid  (ISO)
cellular response to testosterone stimulus  (ISO)
cellular response to UV  (ISO)
chromatin remodeling  (ISO)
chromosome organization  (ISO)
detection of mechanical stimulus involved in sensory perception of sound  (ISO)
DNA-templated transcription, initiation  (ISO)
ERK1 and ERK2 cascade  (ISO)
flavonoid metabolic process  (ISO)
fungal-type cell wall polysaccharide metabolic process  (ISO)
G0 to G1 transition  (ISO)
glucose metabolic process  (ISO)
hypothalamus development  (ISO)
in utero embryonic development  (ISO)
inner mitochondrial membrane organization  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage  (ISO)
lactic acid secretion  (ISO)
liver regeneration  (ISO)
MAPK cascade  (ISO)
middle ear morphogenesis  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cell death  (ISO)
negative regulation of cell division  (ISO)
negative regulation of fibroblast proliferation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of glucose import  (ISO)
negative regulation of monocyte differentiation  (ISO)
negative regulation of protein binding  (ISO)
negative regulation of stress-activated MAPK cascade  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
ovarian follicle development  (ISO)
ovulation  (ISO)
pigmentation  (ISO)
positive regulation of apoptotic signaling pathway  (ISO)
positive regulation of ATP biosynthetic process  (ISO)
positive regulation of B cell apoptotic process  (ISO)
positive regulation of catalytic activity  (ISO)
positive regulation of cell cycle  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cellular respiration  (ISO)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
positive regulation of DNA binding  (ISO)
positive regulation of DNA biosynthetic process  (ISO)
positive regulation of DNA methylation  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of glial cell proliferation  (ISO)
positive regulation of glycolytic process  (ISO)
positive regulation of mesenchymal cell proliferation  (ISO)
positive regulation of metanephric cap mesenchymal cell proliferation  (ISO)
positive regulation of mitochondrial membrane potential  (ISO)
positive regulation of oxidative phosphorylation  (ISO)
positive regulation of response to DNA damage stimulus  (ISO)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of telomerase activity  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription initiation from RNA polymerase II promoter  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
protein processing  (ISO)
protein-DNA complex disassembly  (ISO)
pyruvate transport  (ISO)
re-entry into mitotic cell cycle  (ISO)
regulation of apoptotic process  (ISO)
regulation of cell cycle  (ISO)
regulation of gene expression  (ISO)
regulation of mitotic cell cycle  (ISO)
regulation of oxidative phosphorylation  (ISO)
regulation of somatic stem cell population maintenance  (ISO)
regulation of telomere maintenance  (ISO)
regulation of transcription, DNA-templated  (ISO)
response to alkaloid  (ISO)
response to drug  (ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to gamma radiation  (ISO)
response to human chorionic gonadotropin  (ISO)
response to radiation  (ISO)
response to wounding  (ISO)
skeletal muscle cell differentiation  (ISO)
skeletal system morphogenesis  (ISO)
transcription by RNA polymerase II  (ISO)
transcription, DNA-templated  (ISO)
transformation of host cell by virus  (ISO)
Wnt signaling pathway  (ISO)

Cellular Component

References


Genomics

Comparative Map Data
Myc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554612,714,022 - 2,718,982 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554612,714,022 - 2,718,872 (+)NCBIChiLan1.0ChiLan1.0
MYC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl8127,735,434 - 127,742,951 (+)EnsemblGRCh38hg38GRCh38
GRCh388127,735,434 - 127,742,951 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh378128,747,680 - 128,755,197 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368128,817,498 - 128,822,856 (+)NCBINCBI36hg18NCBI36
Build 348128,817,685 - 128,822,853NCBI
Celera8124,928,812 - 124,934,177 (+)NCBI
Cytogenetic Map8q24.21NCBI
HuRef8124,069,829 - 124,075,195 (+)NCBIHuRef
CHM1_18128,788,551 - 128,793,916 (+)NCBICHM1_1
Myc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391561,857,190 - 61,862,210 (+)NCBIGRCm39mm39
GRCm39 Ensembl1561,857,240 - 61,862,223 (+)Ensembl
GRCm381561,985,341 - 61,990,361 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1561,985,391 - 61,990,374 (+)EnsemblGRCm38mm10GRCm38
MGSCv371561,816,896 - 61,821,916 (+)NCBIGRCm37mm9NCBIm37
MGSCv361561,815,052 - 61,820,027 (+)NCBImm8
Celera1563,490,745 - 63,495,748 (+)NCBICelera
Cytogenetic Map15D1NCBI
cM Map1526.19NCBI
Myc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2793,593,705 - 93,598,633 (+)NCBI
Rnor_6.0 Ensembl7102,586,313 - 102,591,240 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.07102,586,313 - 102,591,240 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07103,157,452 - 103,162,379 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4798,953,142 - 98,958,060 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1798,987,371 - 98,992,287 (+)NCBI
Celera790,263,903 - 90,268,823 (+)NCBICelera
Cytogenetic Map7q33NCBI
MYC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.18127,130,877 - 127,136,861 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8127,131,512 - 127,136,863 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v08124,387,561 - 124,393,551 (+)NCBIMhudiblu_PPA_v0panPan3
MYC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11325,200,772 - 25,205,309 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1325,200,577 - 25,205,309 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1325,169,176 - 25,173,718 (+)NCBI
ROS_Cfam_1.01325,544,697 - 25,549,239 (+)NCBI
UMICH_Zoey_3.11325,260,451 - 25,264,991 (+)NCBI
UNSW_CanFamBas_1.01325,374,618 - 25,379,158 (+)NCBI
UU_Cfam_GSD_1.01325,629,077 - 25,633,621 (+)NCBI
Myc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530313,054,869 - 13,059,826 (-)NCBI
SpeTri2.0NW_00493647020,480,844 - 20,485,955 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl412,455,119 - 12,461,078 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1412,455,141 - 12,460,360 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2412,778,452 - 12,783,667 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap4p13NCBI
MYC
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18122,282,989 - 122,288,392 (+)NCBI
ChlSab1.1 Ensembl8122,282,630 - 122,288,384 (+)Ensembl
Myc
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473527,780,338 - 27,784,714 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000001237   ⟹   ENSCLAP00000001196
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554612,714,022 - 2,718,982 (+)Ensembl
RefSeq Acc Id: XM_005397989   ⟹   XP_005398046
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554612,714,022 - 2,718,872 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005398046 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005398046   ⟸   XM_005397989
- Sequence:
RefSeq Acc Id: ENSCLAP00000001196   ⟸   ENSCLAT00000001237


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000000909 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000001196 ENTREZGENE
Ensembl Transcript ENSCLAT00000001237 ENTREZGENE
NCBI Gene Myc ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-08 Myc  MYC proto-oncogene, bHLH transcription factor    v-myc avian myelocytomatosis viral oncogene homolog  Symbol and/or name change 5135510 APPROVED