RGD Reference Report - Alcohol increases c-myc mRNA and protein in skeletal and cardiac muscle. - Rat Genome Database

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Alcohol increases c-myc mRNA and protein in skeletal and cardiac muscle.

Authors: Paice, AG  Hesketh, JE  Towner, P  Hirako, M  Peters, TJ  Preedy, VR 
Citation: Paice AG, etal., Metabolism. 2002 Oct;51(10):1285-90.
RGD ID: 10059625
Pubmed: PMID:12370848   (View Abstract at PubMed)

The pathogenic mechanisms responsible for alcohol-induced muscle disease are unknown, although it is possible that increased proto-oncogene expression may be the causative process. Therefore, we investigated the responses of skeletal muscle c-myc protein and mRNA to a standard acute ethanol dosage regimen (75 mmol/kg/body weight [BW]) for 2.5 to 24 hours. Comparative studies were made on the heart. Acute ethanol administration in vivo led to an increase in c-myc proto-oncogene mRNA in rat skeletal and cardiac muscle. The changes in c-myc mRNA were mirrored by increases in the c-myc protein as demonstrated by immunohistochemistry. The changes in the c-myc protein were localized to the myonuclei, with no corresponding changes seen in the interstitial cell nuclei. This is the first report of altered proto-oncogene expression in muscle in response to ethanol. Increased c-myc mRNA and protein may reflect adaptive changes, a stress response, or another uncharacterized cellular adaptation.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MycRatresponse to ethanol  IEP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Myc  (MYC proto-oncogene, bHLH transcription factor)


Additional Information