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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731438
Species: Homo sapiens
RGD Object: Gene
Symbol: MYC
Name: MYC proto-oncogene, bHLH transcription factor
Acc ID: CHEBI:15365
Term: acetylsalicylic acid
Definition: A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
Chemical ID: MESH:D001241
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MYCdecreases expressionEXP 6480464CTDAspirin results in decreased expression of MYC mRNA; Aspirin results in decreased expression of MYC proteinPMID:11906190 PMID:16878161 PMID:21721879
MYCincreases expressionEXP 6480464CTDAspirin results in increased expression of MYC mRNAPMID:20457246
MYCmultiple interactionsEXP 6480464CTDCTNNB1 affects the reaction [Aspirin results in decreased expression of MYC protein]PMID:16878161
MYCdecreases expressionISOMyc (Rattus norvegicus)6480464CTDAspirin results in decreased expression of MYC mRNAPMID:12800193
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