MIR145 (microRNA 145) - Rat Genome Database

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Gene: MIR145 (microRNA 145) Homo sapiens
Analyze
Symbol: MIR145
Name: microRNA 145
RGD ID: 1353686
HGNC Page HGNC:31532
Description: Enables mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Involved in several processes, including negative regulation of cardiac muscle cell apoptotic process; negative regulation of gene expression; and negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Acts upstream of or within positive regulation of cellular response to hypoxia. Located in extracellular exosome. Biomarker of several diseases, including artery disease (multiple); biliary atresia; cerebral infarction; gastrointestinal system cancer (multiple); and liver cirrhosis.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: miR-145; MIRN145; miRNA145
RGD Orthologs
Mouse
Rat
Dog
Pig
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385149,430,646 - 149,430,733 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5149,430,646 - 149,430,733 (+)EnsemblGRCh38hg38GRCh38
GRCh375148,810,209 - 148,810,296 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365148,790,401 - 148,790,488 (+)NCBINCBI36Build 36hg18NCBI36
Celera5144,892,189 - 144,892,276 (+)NCBICelera
Cytogenetic Map5q32NCBI
HuRef5143,956,545 - 143,956,632 (+)NCBIHuRef
CHM1_15148,242,644 - 148,242,731 (+)NCBICHM1_1
T2T-CHM13v2.05149,965,492 - 149,965,579 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (ISS)
angiotensin-activated signaling pathway  (ISS)
aorta smooth muscle tissue morphogenesis  (ISO,ISS)
cardiac vascular smooth muscle cell differentiation  (ISO)
cellular response to amino acid stimulus  (ISO)
cellular response to estrogen stimulus  (ISO)
cellular response to ethanol  (ISO)
cellular response to hydroperoxide  (ISO)
cellular response to leukemia inhibitory factor  (ISO)
ectodermal cell differentiation  (IDA)
establishment or maintenance of cell type involved in phenotypic switching  (ISS)
hematopoietic stem cell proliferation  (ISO)
long-term synaptic potentiation  (ISO)
mesodermal cell differentiation  (IDA)
miRNA-mediated gene silencing by inhibition of translation  (IDA)
miRNA-mediated gene silencing by mRNA destabilization  (IDA,IMP)
miRNA-mediated post-transcriptional gene silencing  (IDA,IEA)
myofibroblast differentiation  (ISS)
negative regulation of angiogenesis  (IDA)
negative regulation of cardiac muscle cell apoptotic process  (IDA,ISS)
negative regulation of cardiac muscle hypertrophy  (ISS)
negative regulation of cell migration  (IDA)
negative regulation of cellular response to transforming growth factor beta stimulus  (IGI)
negative regulation of cholesterol efflux  (IDA)
negative regulation of epithelial to mesenchymal transition  (IDA)
negative regulation of extracellular matrix assembly  (IGI,IMP)
negative regulation of inflammatory response  (IDA)
negative regulation of interleukin-16 production  (IDA)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISS)
negative regulation of SMAD protein signal transduction  (IMP)
negative regulation of smooth muscle cell proliferation  (ISS)
negative regulation of somatic stem cell division  (IDA)
negative regulation of somatic stem cell population maintenance  (IDA)
negative regulation of transforming growth factor beta receptor signaling pathway  (IGI)
negative regulation of vascular associated smooth muscle cell dedifferentiation  (ISS)
positive regulation of canonical Wnt signaling pathway  (ISS)
positive regulation of cardiac vascular smooth muscle cell differentiation  (ISS)
positive regulation of cellular response to hypoxia  (IDA)
positive regulation of fibroblast migration  (ISS)
positive regulation of interleukin-10 production  (IDA)
positive regulation of macrophage activation  (IDA)
positive regulation of macrophage differentiation  (IDA)
positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching  (ISO)
regulation of collagen biosynthetic process  (ISS)
regulation of ERK1 and ERK2 cascade  (ISS)
regulation of phenotypic switching  (ISS)
regulation of smooth muscle contraction  (ISS)
response to alkaloid  (ISO)
response to ischemia  (ISO)
retina layer formation  (ISO)
transforming growth factor beta receptor signaling pathway  (ISO)
vascular associated smooth muscle cell differentiation  (ISS)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. MiR-145 facilitates proliferation and migration of endothelial progenitor cells and recanalization of arterial thrombosis in cerebral infarction mice via JNK signal pathway. Chen R, etal., Int J Clin Exp Pathol. 2015 Oct 1;8(10):13770-6. eCollection 2015.
2. Long noncoding RNA myocardial infarction associated transcript promotes the development of thoracic aortic by targeting microRNA-145 via the PI3K/Akt signaling pathway. Chen S, etal., J Cell Biochem. 2019 Sep;120(9):14405-14413. doi: 10.1002/jcb.28695. Epub 2019 Apr 15.
3. MicroRNA-145, a novel smooth muscle cell phenotypic marker and modulator, controls vascular neointimal lesion formation. Cheng Y, etal., Circ Res. 2009 Jul 17;105(2):158-66. doi: 10.1161/CIRCRESAHA.109.197517. Epub 2009 Jun 18.
4. miR-145 attenuates cardiac fibrosis through the AKT/GSK-3β/β-catenin signaling pathway by directly targeting SOX9 in fibroblasts. Cui S, etal., J Cell Biochem. 2021 Feb;122(2):209-221. doi: 10.1002/jcb.29843. Epub 2020 Sep 5.
5. Circulatory microRNA-145 expression is increased in cerebral ischemia. Gan CS, etal., Genet Mol Res. 2012 Jan 27;11(1):147-52. doi: 10.4238/2012.January.27.1.
6. Plasma Levels of microRNA-145 Are Associated with Severity of Coronary Artery Disease. Gao H, etal., PLoS One. 2015 May 4;10(5):e0123477. doi: 10.1371/journal.pone.0123477. eCollection 2015.
7. Long noncoding RNA MALAT1 mediates cardiac fibrosis in experimental postinfarct myocardium mice model. Huang S, etal., J Cell Physiol. 2019 Mar;234(3):2997-3006. doi: 10.1002/jcp.27117. Epub 2018 Aug 26.
8. MicroRNA-145 post-transcriptionally regulates the expression and function of P-glycoprotein in intestinal epithelial cells. Ikemura K, etal., Mol Pharmacol. 2013 Feb;83(2):399-405. doi: 10.1124/mol.112.081844. Epub 2012 Nov 19.
9. Circular RNA Sirtuin1 represses pulmonary artery smooth muscle cell proliferation, migration and autophagy to ameliorate pulmonary hypertension via targeting microRNA-145-5p/protein kinase-B3 axis. Jing X, etal., Bioengineered. 2022 Apr;13(4):8759-8771. doi: 10.1080/21655979.2022.2036302.
10. Associations Between miRNAs and Two Different Cancers: Breast and Colon. Kundaktepe BP, etal., Cancer Manag Res. 2020 Feb 7;12:871-879. doi: 10.2147/CMAR.S227628. eCollection 2020.
11. P38 MAPK Signaling Pathway Mediates Angiotensin II-Induced miR143/145 Gene Cluster Downregulation during Aortic Dissection Formation. Li B, etal., Ann Vasc Surg. 2017 Apr;40:262-273. doi: 10.1016/j.avsg.2016.09.016. Epub 2017 Feb 4.
12. Investigation of the clinical significance and prognostic value of microRNA-145 in human hepatocellular carcinoma. Li P, etal., Medicine (Baltimore). 2018 Dec;97(51):e13715. doi: 10.1097/MD.0000000000013715.
13. MicroRNA-145 protects cardiomyocytes against hydrogen peroxide (H(2)O(2))-induced apoptosis through targeting the mitochondria apoptotic pathway. Li R, etal., PLoS One. 2012;7(9):e44907. doi: 10.1371/journal.pone.0044907. Epub 2012 Sep 18.
14. Regulatory Mechanism of MicroRNA-145 in the Pathogenesis of Acute Aortic Dissection. Li T, etal., Yonsei Med J. 2019 Apr;60(4):352-359. doi: 10.3349/ymj.2019.60.4.352.
15. Selection and Application of Tissue microRNAs for Nonendoscopic Diagnosis of Barrett's Esophagus. Li X, etal., Gastroenterology. 2018 Sep;155(3):771-783.e3. doi: 10.1053/j.gastro.2018.05.050. Epub 2018 Jun 12.
16. Effects of flavonoids on MicroRNA 145 regulation through Klf4 and myocardin in neointimal formation in vitro and in vivo. Lin CM, etal., J Nutr Biochem. 2018 Feb;52:27-35. doi: 10.1016/j.jnutbio.2017.08.016. Epub 2017 Sep 14.
17. Correlation between miR-21 and miR-145 and the incidence and prognosis of colorectal cancer. Liu Q, etal., J BUON. 2018 Jan-Feb;23(1):29-35.
18. Over-expression of microRNA-145 drives alterations in β-adrenergic signaling and attenuates cardiac remodeling in heart failure post myocardial infarction. Liu Z, etal., Aging (Albany NY). 2020 Jun 18;12(12):11603-11622. doi: 10.18632/aging.103320. Epub 2020 Jun 18.
19. MicroRNA-145 Protects against Myocardial Ischemia Reperfusion Injury via CaMKII-Mediated Antiapoptotic and Anti-Inflammatory Pathways. Liu Z, etal., Oxid Med Cell Longev. 2019 Sep 10;2019:8948657. doi: 10.1155/2019/8948657. eCollection 2019.
20. Overexpression of MicroRNA-145 Promotes Ascending Aortic Aneurysm Media Remodeling through TGF-β1. Pei H, etal., Eur J Vasc Endovasc Surg. 2015 Jan;49(1):52-9. doi: 10.1016/j.ejvs.2014.10.018.
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Overexpression of microRNA-145 in atherosclerotic plaques from hypertensive patients. Santovito D, etal., Expert Opin Ther Targets. 2013 Mar;17(3):217-23. doi: 10.1517/14728222.2013.745512. Epub 2013 Jan 23.
23. miR-145-5p attenuates inflammatory response and apoptosis in myocardial ischemia-reperfusion injury by inhibiting (NADPH) oxidase homolog 1. Tan L, etal., Exp Anim. 2021 Aug 6;70(3):311-321. doi: 10.1538/expanim.20-0160. Epub 2021 Mar 4.
24. Clinicopathological significance of microRNA-31, -143 and -145 expression in colorectal cancer. Wang CJ, etal., Dis Markers. 2009;26(1):27-34. doi: 10.3233/DMA-2009-0601.
25. Long noncoding RNA H19 suppresses cardiac hypertrophy through the MicroRNA-145-3p/SMAD4 axis. Wang H, etal., Bioengineered. 2022 Feb;13(2):3826-3839. doi: 10.1080/21655979.2021.2017564.
26. LncRNA TUG1 Promotes Apoptosis, Invasion, and Angiogenesis of Retinal Endothelial Cells in Retinopathy of Prematurity via MiR-145-5p. Wang Y, etal., Front Med (Lausanne). 2022 Apr 4;9:803214. doi: 10.3389/fmed.2022.803214. eCollection 2022.
27. MicroRNA-145 is involved in endothelial cell dysfunction and acts as a promising biomarker of acute coronary syndrome. Wu S, etal., Eur J Med Res. 2020 Mar 17;25(1):2. doi: 10.1186/s40001-020-00403-8.
28. The miR-143/145 cluster reverses the regulation effect of KLF5 in smooth muscle cells with proliferation and contractility in intracranial aneurysm. Xu J, etal., Gene. 2018 Dec 30;679:266-273. doi: 10.1016/j.gene.2018.09.010. Epub 2018 Sep 7.
29. MicroRNA-145-5p targeting of TRIM2 mediates the apoptosis of retinal ganglion cells via the PI3K/AKT signaling pathway in glaucoma. Xu K, etal., J Gene Med. 2021 Nov;23(11):e3378. doi: 10.1002/jgm.3378. Epub 2021 Aug 10.
30. Downregulation of microRNA-145 may contribute to liver fibrosis in biliary atresia by targeting ADD3. Ye Y, etal., PLoS One. 2017 Sep 13;12(9):e0180896. doi: 10.1371/journal.pone.0180896. eCollection 2017.
31. Downregulation of miR143/145 gene cluster expression promotes the aortic media degeneration process via the TGF-β1 signaling pathway. Zhang M and Wang Z, Am J Transl Res. 2019 Jan 15;11(1):370-378. eCollection 2019.
32. Circulating MicroRNA-145 is Associated with Acute Myocardial Infarction and Heart Failure. Zhang M, etal., Chin Med J (Engl). 2017 5th Jan 2017;130(1):51-56. doi: 10.4103/0366-6999.196573.
33. Hypermethylation of the Micro-RNA 145 Promoter Is the Key Regulator for NLRP3 Inflammasome-Induced Activation and Plaque Formation. Zhong W, etal., JACC Basic Transl Sci. 2018 Sep 19;3(5):604-624. doi: 10.1016/j.jacbts.2018.06.004. eCollection 2018 Oct.
34. MicroRNA-145 inhibits hepatic stellate cell activation and proliferation by targeting ZEB2 through Wnt/β-catenin pathway. Zhou DD, etal., Mol Immunol. 2016 Jul;75:151-60. doi: 10.1016/j.molimm.2016.05.018. Epub 2016 Jun 9.
Additional References at PubMed
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PMID:20332243   PMID:20370992   PMID:20382729   PMID:20525177   PMID:20588276   PMID:20687965   PMID:20717966   PMID:20737575   PMID:20809117   PMID:20818426   PMID:20889907   PMID:21037258  
PMID:21092188   PMID:21111732   PMID:21159816   PMID:21218087   PMID:21258769   PMID:21289483   PMID:21349819   PMID:21351259   PMID:21360565   PMID:21453382   PMID:21479367   PMID:21496429  
PMID:21557394   PMID:21647377   PMID:21673106   PMID:21685392   PMID:21701675   PMID:21712382   PMID:21836381   PMID:21873545   PMID:21900452   PMID:21943005   PMID:21945499   PMID:22093444  
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PMID:32588730   PMID:32602617   PMID:32623445   PMID:32633367   PMID:32654289   PMID:32706759   PMID:32708433   PMID:32772636   PMID:32788878   PMID:32822848   PMID:32826455   PMID:32856736  
PMID:32869851   PMID:32918701   PMID:32945355   PMID:32948220   PMID:32985219   PMID:33021154   PMID:33037180   PMID:33081171   PMID:33174029   PMID:33285775   PMID:33307836   PMID:33342777  
PMID:33349227   PMID:33385444   PMID:33393324   PMID:33414420   PMID:33416179   PMID:33416186   PMID:33419459   PMID:33453148   PMID:33484447   PMID:33501702   PMID:33507687   PMID:33517563  
PMID:33527765   PMID:33537874   PMID:33616623   PMID:33650661   PMID:33715582   PMID:33728339   PMID:33728345   PMID:33734580   PMID:33824281   PMID:33825830   PMID:33870836   PMID:33956301  
PMID:33980135   PMID:34027799   PMID:34043125   PMID:34115321   PMID:34119822   PMID:34143694   PMID:34149728   PMID:34233586   PMID:34238129   PMID:34238213   PMID:34345210   PMID:34381015  
PMID:34424263   PMID:34551209   PMID:34554391   PMID:34586738   PMID:34617877   PMID:34631898   PMID:34678319   PMID:34686504   PMID:34715591   PMID:34728027   PMID:34738631   PMID:34767671  
PMID:34860147   PMID:34888652   PMID:34913063   PMID:34918978   PMID:34943951   PMID:34944484   PMID:35001875   PMID:35156321   PMID:35163550   PMID:35302725   PMID:35340746   PMID:35451796  
PMID:35468468   PMID:35474406   PMID:35478113   PMID:35597494   PMID:35615948   PMID:35616620   PMID:35729462   PMID:35749663   PMID:35753017   PMID:35754140   PMID:35772782   PMID:35778952  
PMID:35778962   PMID:35809311   PMID:35818240   PMID:35820565   PMID:35836107   PMID:35901327   PMID:35936390   PMID:35968984   PMID:35975529   PMID:35980523   PMID:36071121   PMID:36214767  
PMID:36327671   PMID:36329419   PMID:36348305   PMID:36370492   PMID:36435763   PMID:36499676   PMID:36533675   PMID:36621158   PMID:36635458   PMID:36648259   PMID:36653507   PMID:36670490  
PMID:36722155   PMID:37167274   PMID:37175410   PMID:37213158   PMID:37264620   PMID:37442529   PMID:37619484   PMID:37950842   PMID:38127107   PMID:38139440   PMID:38211336   PMID:38287826  
PMID:38353742   PMID:38396844   PMID:38400818   PMID:38834101   PMID:38965401  


Genomics

Comparative Map Data
MIR145
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385149,430,646 - 149,430,733 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5149,430,646 - 149,430,733 (+)EnsemblGRCh38hg38GRCh38
GRCh375148,810,209 - 148,810,296 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365148,790,401 - 148,790,488 (+)NCBINCBI36Build 36hg18NCBI36
Celera5144,892,189 - 144,892,276 (+)NCBICelera
Cytogenetic Map5q32NCBI
HuRef5143,956,545 - 143,956,632 (+)NCBIHuRef
CHM1_15148,242,644 - 148,242,731 (+)NCBICHM1_1
T2T-CHM13v2.05149,965,492 - 149,965,579 (+)NCBIT2T-CHM13v2.0
Mir145a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391861,780,896 - 61,780,965 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1861,780,896 - 61,780,965 (-)EnsemblGRCm39 Ensembl
GRCm381861,647,825 - 61,647,894 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1861,647,825 - 61,647,894 (-)EnsemblGRCm38mm10GRCm38
MGSCv371861,807,479 - 61,807,548 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1862,930,620 - 62,930,689 (-)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1834.64NCBI
Mir145
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81857,369,983 - 57,370,070 (-)NCBIGRCr8
mRatBN7.21855,099,640 - 55,099,727 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1855,099,640 - 55,099,727 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1857,193,356 - 57,193,443 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01857,907,967 - 57,908,054 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01855,723,506 - 55,723,593 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01856,969,907 - 56,969,994 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1856,969,907 - 56,969,994 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01856,198,820 - 56,198,907 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1853,250,138 - 53,250,225 (-)NCBICelera
Cytogenetic Map18q12.1NCBI
MIR145
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1459,533,128 - 59,533,210 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl459,533,128 - 59,533,210 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha459,298,427 - 59,298,509 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0460,015,687 - 60,015,769 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl460,015,687 - 60,015,769 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1459,802,584 - 59,802,666 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0459,917,043 - 59,917,125 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0460,447,590 - 60,447,672 (-)NCBIUU_Cfam_GSD_1.0
MIR145
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2150,580,126 - 150,580,211 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12150,580,126 - 150,580,211 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22157,346,127 - 157,346,212 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in MIR145
1 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 5q23.3-33.2(chr5:130860928-155321811)x3 copy number gain See cases [RCV000051193] Chr5:130860928..155321811 [GRCh38]
Chr5:130196621..154701371 [GRCh37]
Chr5:130224520..154681564 [NCBI36]
Chr5:5q23.3-33.2		 pathogenic
GRCh38/hg38 5q21.3-33.2(chr5:106619588-156124387)x1 copy number loss See cases [RCV000053524] Chr5:106619588..156124387 [GRCh38]
Chr5:105955289..155551397 [GRCh37]
Chr5:105983188..155483975 [NCBI36]
Chr5:5q21.3-33.2		 pathogenic
GRCh38/hg38 5q23.3-33.2(chr5:129847794-153353546)x3 copy number gain See cases [RCV000138808] Chr5:129847794..153353546 [GRCh38]
Chr5:129183487..152733106 [GRCh37]
Chr5:129211386..152713299 [NCBI36]
Chr5:5q23.3-33.2		 pathogenic
GRCh38/hg38 5q31.3-32(chr5:141089988-149530678)x3 copy number gain See cases [RCV000139504] Chr5:141089988..149530678 [GRCh38]
Chr5:140469572..148910241 [GRCh37]
Chr5:140449756..148890434 [NCBI36]
Chr5:5q31.3-32		 pathogenic
GRCh37/hg19 5q15-35.3(chr5:94844077-178830410)x3 copy number gain not provided [RCV000487658] Chr5:94844077..178830410 [GRCh37]
Chr5:5q15-35.3		 likely benign
GRCh37/hg19 5q23.3-33.3(chr5:130125085-157574910)x3 copy number gain See cases [RCV000449349] Chr5:130125085..157574910 [GRCh37]
Chr5:5q23.3-33.3		 pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789) copy number gain See cases [RCV000510723] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
GRCh37/hg19 5q21.3-35.3(chr5:106716357-180687338)x3 copy number gain See cases [RCV000448245] Chr5:106716357..180687338 [GRCh37]
Chr5:5q21.3-35.3		 pathogenic
GRCh37/hg19 5q31.3-32(chr5:141113273-149154835)x1 copy number loss See cases [RCV000510497] Chr5:141113273..149154835 [GRCh37]
Chr5:5q31.3-32		 pathogenic
GRCh37/hg19 5p15.1-q35.2(chr5:17628741-176575720)x1 copy number loss See cases [RCV000511978] Chr5:17628741..176575720 [GRCh37]
Chr5:5p15.1-q35.2		 pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789)x3 copy number gain See cases [RCV000512039] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
NC_000005.9:g.(?_86400000)_(154000000_?)del deletion Familial adenomatous polyposis 1 [RCV004561496]|Hereditary cancer-predisposing syndrome [RCV000554476] Chr5:86400000..154000000 [GRCh37]
Chr5:5q14.3-33.2		 pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:25328-180693344)x3 copy number gain not provided [RCV000744323] Chr5:25328..180693344 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:13648-180905029)x3 copy number gain not provided [RCV000744317] Chr5:13648..180905029 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
Single allele deletion Neurodevelopmental disorder [RCV000787436] Chr5:14685137..149511942 [GRCh37]
Chr5:5p15.2-q32		 uncertain significance
NR_029686.1(MIR145):n.18C>A single nucleotide variant MIR145-related multisystemic smooth muscle dysfunction [RCV002280373] Chr5:149430663 [GRCh38]
Chr5:148810226 [GRCh37]
Chr5:5q32		 uncertain significance
GRCh37/hg19 5q31.3-32(chr5:140424333-148985999)x3 copy number gain not provided [RCV000848228] Chr5:140424333..148985999 [GRCh37]
Chr5:5q31.3-32		 uncertain significance
GRCh37/hg19 5q23.3-33.3(chr5:130125085-157574910) copy number gain not specified [RCV002053526] Chr5:130125085..157574910 [GRCh37]
Chr5:5q23.3-33.3		 pathogenic
NC_000005.9:g.(?_147774340)_(149681936_?)del deletion not provided [RCV003116332] Chr5:147774340..149681936 [GRCh37]
Chr5:5q32		 uncertain significance
GRCh37/hg19 5q32(chr5:147164969-149315489)x1 copy number loss not provided [RCV002473891] Chr5:147164969..149315489 [GRCh37]
Chr5:5q32		 pathogenic
miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
BNIP3hsa-miR-145-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI20332243
SOX2hsa-miR-145-5pMirtarbaseexternal_infoFACS//Flow//GFP reporter assay//In situ hybridizatFunctional MTI19409607
SOX2hsa-miR-145-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23541921
MUC1hsa-miR-145-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI20407606
MUC1hsa-miR-145-5pMirtarbaseexternal_infoImmunohistochemistry//Luciferase reporter assay//qFunctional MTI19996288
MYO6hsa-miR-145-5pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI20353999
CDKN1Ahsa-miR-145-5pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotNon-Functional MTI20190813
ERGhsa-miR-145-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23480797
ITGB8hsa-miR-145-5pMirtarbaseexternal_infoImmunofluorescence//Luciferase reporter assay//qRTFunctional MTI21701675
STAT1hsa-miR-145-5pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blot//Functional MTI20098684
YES1hsa-miR-145-5pMirtarbaseexternal_infoReporter assay;MicroarrayFunctional MTI21351259
CBFBhsa-miR-145-5pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Microarray//ReFunctional MTI19915607
CBFBhsa-miR-145-5pMirtarbaseexternal_infoLuciferase reporter assayNon-Functional MTI20737575
IRS1hsa-miR-145-5pMirtarbaseexternal_infoLuciferase reporter assay//Northern blot//qRT-PCR/Functional MTI17827156
IRS1hsa-miR-145-5pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI19391107
IRS1hsa-miR-145-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22431718
IRS1hsa-miR-145-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI23201159
PARP8hsa-miR-145-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI15131085
VEGFAhsa-miR-145-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI22472569
TMOD3hsa-miR-145-5pMirtarbaseexternal_infoLuciferase reporter assay//Reporter assay;OtherNon-Functional MTI15131085
HOXA9hsa-miR-145-5pMirtarbaseexternal_infoGFP reporter assay//qRT-PCR//Western blotNon-Functional MTI18474618
FSCN1hsa-miR-145-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI20160723
FSCN1hsa-miR-145-5pMirtarbaseexternal_infoWestern blotNon-Functional MTI21218087
FSCN1hsa-miR-145-5pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//qRT-PCR//WeFunctional MTI21351259
FSCN1hsa-miR-145-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blot//Functional MTI20198616
FSCN1hsa-miR-145-5pMirtarbaseexternal_infoReporter assayFunctional MTI21258769
MYChsa-miR-145-5pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI19202062
MYChsa-miR-145-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI21092188
FLI1hsa-miR-145-5pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI20382729
FLI1hsa-miR-145-5pMirtarbaseexternal_infoLuciferase reporter assay//Northern blot//qRT-PCR/Functional MTI20737575
FLI1hsa-miR-145-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI21217773
DFFAhsa-miR-145-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI20687965
IFNB1hsa-miR-145-5pMirtarbaseexternal_infoELISA//Luciferase reporter assay//qRT-PCRFunctional MTI20130213
TIRAPhsa-miR-145-5pMirtarbaseexternal_infoImmunoprecipitaion//Western blot//CommunoprecipitaFunctional MTI19898489
POU5F1hsa-miR-145-5pMirtarbaseexternal_infoImmunofluorescence//qRT-PCRFunctional MTI (Weak)22486352
POU5F1hsa-miR-145-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI21496429
KRT7hsa-miR-145-5pMirtarbaseexternal_infoImmunoblot//qRT-PCRNon-Functional MTI (Weak)19378336
PPM1Dhsa-miR-145-5pMirtarbaseexternal_infoImmunoblot//Luciferase reporter assayNon-Functional MTI20668064
ROBO2hsa-miR-145-5pMirtarbaseexternal_infoIn situ hybridization//Luciferase reporter assay//Functional MTI21276775
SERPINE1hsa-miR-145-5pMirtarbaseexternal_infoImmunoblot//Luciferase reporter assay//qRT-PCR//WeFunctional MTI22108519
SWAP70hsa-miR-145-5pMirtarbaseexternal_infoReporter assay;Western blot;qRT-PCRFunctional MTI21360565
NEDD9hsa-miR-145-5pMirtarbaseexternal_infoImmunofluorescence//Immunohistochemistry//qRT-PCR/Functional MTI22869051
NEDD9hsa-miR-145-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23355420
PAK4hsa-miR-145-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI22766504
DDX17hsa-miR-145-5pMirtarbaseexternal_infoLuciferase reporter assay//Northern blot//qRT-PCR/Functional MTI22876303
ILKhsa-miR-145-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI23104321
CCN2hsa-miR-145-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23390502
SOCS7hsa-miR-145-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23392170
MDM2hsa-miR-145-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22330136
ADAM17hsa-miR-145-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23441135
CDH2hsa-miR-145-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI22370644
HDAC2hsa-miR-145-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23499894
RTKNhsa-miR-145-5pMirtarbaseexternal_infoReporter assay;Western blot;qRT-PCR;OtherFunctional MTI19360360
F11Rhsa-miR-145-5pMirtarbaseexternal_infoReporter assayFunctional MTI20818426
MYO5Ahsa-miR-145-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22895360
TMOD3hsa-miR-145-5pTarbaseexternal_infoReporter GeneNEGATIVE
IRS1hsa-miR-145-5pTarbaseexternal_infoReporter GenePOSITIVE
APH1Ahsa-miR-145-5pTarbaseexternal_infoMicroarrayPOSITIVE
FSCN1hsa-miR-145-5pTarbaseexternal_infoqPCRPOSITIVE
FSCN1hsa-miR-145-5pTarbaseexternal_infoWesternblitPOSITIVE
RTKNhsa-miR-145-5pTarbaseexternal_infoqPCRNEGATIVE
RTKNhsa-miR-145-5pTarbaseexternal_infoOtherPOSITIVE
SOX2hsa-miR-145-5pTarbaseexternal_infoWesternblitNEGATIVE
ADAM17hsa-miR-145-5pOncomiRDBexternal_infoNANA23441135
SOCS7hsa-miR-145-5pOncomiRDBexternal_infoNANA23392170
NEDD9hsa-miR-145-5pOncomiRDBexternal_infoNANA23355420
NRAShsa-miR-145-5pOncomiRDBexternal_infoNANA23201159
CD44hsa-miR-145-5pOncomiRDBexternal_infoNANA23128394
ILKhsa-miR-145-5pOncomiRDBexternal_infoNANA23104321
ZEB2hsa-miR-145-5pOncomiRDBexternal_infoNANA22908280
PAK4hsa-miR-145-5pOncomiRDBexternal_infoNANA22766504
NRAShsa-miR-145-5pOncomiRDBexternal_infoNANA22592534
VEGFAhsa-miR-145-5pOncomiRDBexternal_infoNANA22472569
FSCN1hsa-miR-145-5pOncomiRDBexternal_infoNANA22457808
IRS1hsa-miR-145-5pOncomiRDBexternal_infoNANA22431718
CDH2hsa-miR-145-5pOncomiRDBexternal_infoNANA22370644
MDM2hsa-miR-145-5pOncomiRDBexternal_infoNANA22330136
POU5F1hsa-miR-145-5pOncomiRDBexternal_infoNANA22285547
SERPINE1hsa-miR-145-5pOncomiRDBexternal_infoNANA22108519
RPS6KB1hsa-miR-145-5pOncomiRDBexternal_infoNANA21917858
FSCN1hsa-miR-145-5pOncomiRDBexternal_infoNANA21723890
POU5F1hsa-miR-145-5pOncomiRDBexternal_infoNANA21496429
POU5F1hsa-miR-145-5pOncomiRDBexternal_infoNANA21479367
POU5F1hsa-miR-145-5pOncomiRDBexternal_infoNANA21365617
FSCN1hsa-miR-145-5pOncomiRDBexternal_infoNANA21351259
FSCN1hsa-miR-145-5pOncomiRDBexternal_infoNANA21258769
FLI1hsa-miR-145-5pOncomiRDBexternal_infoNANA21217773
KRAShsa-miR-145-5pOncomiRDBexternal_infoNANA21159816
MYChsa-miR-145-5pOncomiRDBexternal_infoNANA21092188
MYChsa-miR-145-5pOncomiRDBexternal_infoNANA21075312
F11Rhsa-miR-145-5pOncomiRDBexternal_infoNANA20818426
FLI1hsa-miR-145-5pOncomiRDBexternal_infoNANA20737575
MYO6hsa-miR-145-5pOncomiRDBexternal_infoNANA20353999
BNIP3hsa-miR-145-5pOncomiRDBexternal_infoNANA20332243
FSCN1hsa-miR-145-5pOncomiRDBexternal_infoNANA20160723
YES1hsa-miR-145-5pOncomiRDBexternal_infoNANA20098684
MUC1hsa-miR-145-5pOncomiRDBexternal_infoNANA19996288
CBFBhsa-miR-145-5pOncomiRDBexternal_infoNANA19915607
ESR1hsa-miR-145-5pOncomiRDBexternal_infoNANA19730444
RTKNhsa-miR-145-5pOncomiRDBexternal_infoNANA19360360
MYChsa-miR-145-5pOncomiRDBexternal_infoNANA19202062
IRS1hsa-miR-145-5pOncomiRDBexternal_infoNANA17827156
PARP8hsa-miR-145-3pMirecordsexternal_infoNANA15131085
IRS1hsa-miR-145-3pMirecordsexternal_info{unchanged}NA17827156
MYChsa-miR-145-3pMirecordsexternal_info{changed}NA19202062
CCNA2hsa-miR-145-3pMirecordsexternal_infoNANA19996289
CBFBhsa-miR-145-3pMirecordsexternal_info{changed}NA19915607
IGF1Rhsa-miR-145-3pMirecordsexternal_infoNANA19502786
KRT7hsa-miR-145-3pMirecordsexternal_infoNANA19378336
RTKNhsa-miR-145-3pMirecordsexternal_info{changed}NA19360360
SOX9hsa-miR-145-3pMirecordsexternal_info{changed}NA22102413

Predicted Targets
Summary Value
Count of predictions:31777
Count of gene targets:11592
Count of transcripts:23248
Interacting mature miRNAs:hsa-miR-145-3p, hsa-miR-145-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357314AASTH54_HAllergic/atopic asthma related QTL 54 (human)3.560.0003Reversible airflow obstructiontotal serum IgE5135892246150155845Human


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
862 2129 1628 1823 1551 585 1031 204 403 67 1247 3642 3938 1082 430 1016 732 137

Sequence


Ensembl Acc Id: ENST00000384967
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5149,430,646 - 149,430,733 (+)Ensembl
RefSeq Acc Id: NR_029686
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385149,430,646 - 149,430,733 (+)NCBI
GRCh375148,810,209 - 148,810,296 (+)ENTREZGENE
HuRef5143,956,545 - 143,956,632 (+)ENTREZGENE
CHM1_15148,242,644 - 148,242,731 (+)NCBI
T2T-CHM13v2.05149,965,492 - 149,965,579 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:31532 AgrOrtholog
COSMIC MIR145 COSMIC
Ensembl Genes ENSG00000276365 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000384967 ENTREZGENE
GTEx ENSG00000276365 GTEx
HGNC ID HGNC:31532 ENTREZGENE
Human Proteome Map MIR145 Human Proteome Map
miRBase MI0000461 ENTREZGENE
NCBI Gene 406937 ENTREZGENE
OMIM 611795 OMIM
PharmGKB PA164722494 PharmGKB
RNAcentral URS00004F4657 RNACentral
  URS0000527F89 RNACentral
  URS000052F380 RNACentral