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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731438
Species: Homo sapiens
RGD Object: Gene
Symbol: MYC
Name: MYC proto-oncogene, bHLH transcription factor
Acc ID: CHEBI:7719
Term: ochratoxin A
Definition: A phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid (ochratoxin alpha). It is among the most widely occurring food-contaminating mycotoxins, produced by Aspergillus ochraceus, Aspergillus carbonarius and Penicillium verrucosum.
Chemical ID: MESH:C025589
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MYCdecreases expressionEXP 6480464CTDochratoxin A results in decreased expression of MYC mRNAPMID:17316727 PMID:30763683 PMID:31154016
MYCincreases expressionISOMyc (Mus musculus)6480464CTDochratoxin A results in increased expression of MYC mRNAPMID:28710020
MYCincreases expressionISOMyc (Rattus norvegicus)6480464CTDochratoxin A results in increased expression of MYC mRNAPMID:16251485 PMID:19237604 PMID:19717638 PMID:37162024
MYCmultiple interactionsISOMyc (Mus musculus)6480464CTDsulforaphane inhibits the reaction [ochratoxin A results in increased expression of MYC mRNA]PMID:28710020
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