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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731438
Species: Homo sapiens
RGD Object: Gene
Symbol: MYC
Name: MYC proto-oncogene, bHLH transcription factor
Acc ID: CHEBI:85990
Term: panobinostat
Definition: A hydroxamic acid obtained by formal condensation of the carboxy group of (2E)-3-[4-({[2-(2-methylindol-3-yl)ethyl]amino}methyl)phenyl]prop-2-enoic acid with the amino group of hydroxylamine. A histone deacetylase inhibitor used (as its lactate salt) in combination with bortezomib and dexamethasone for the treatment of multiple myeloma.
Chemical ID: MESH:C496932
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MYCdecreases expressionEXP 6480464CTDpanobinostat results in decreased expression of MYC proteinPMID:24435446
MYCmultiple interactionsEXP 6480464CTD(+)-JQ1 compound promotes the reaction [panobinostat results in decreased expression of MYC protein]; [panobinostat co-treated with (+)-JQ1 compound] results in decreased expression of MYC protein; panobinostat promotes the reaction [(+)-JQ1 compound results in decreased expression of MYC protein]; panobinostat promotes the reaction [SRT2183 results in decreased expression of MYC protein]PMID:23681230 PMID:24435446
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