RGD Reference Report - Activation of the proto-oncogene c-myc and c-fos by c-ras: involvement of polyamines. - Rat Genome Database

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Activation of the proto-oncogene c-myc and c-fos by c-ras: involvement of polyamines.

Authors: Tabib, A  Bachrach, U 
Citation: Tabib A and Bachrach U, Biochem Biophys Res Commun. 1994 Jul 29;202(2):720-7.
RGD ID: 10059622
Pubmed: PMID:8048943   (View Abstract at PubMed)
DOI: DOI:10.1006/bbrc.1994.1990   (Journal Full-text)

Rat kidney cells infected with a temperature-sensitive mutant of Kirsten sarcoma virus (Ki-MSV ts 371) expressed Ki-Ras at 37 degrees C but not at 42 degrees C. This expression of the oncogene was accompanied by an increase in the activity of ornithine decarboxylase (ODC) and the accumulation of putrescine. Elevation of cellular polyamine content triggered the transcription of c-myc and c-fos. alpha-Difluoromethylornithine, a specific inhibitor of ODC, prevented the transcription of c-myc in cells grown at 37 degrees C. Putrescine, at physiological concentrations, triggered the transcription of c-myc and c-fos in cells grown at 42 degrees C, when Ki-ras was not expressed. It has been suggested that polyamines participate in a cascade of events leading to the communication between membrane-bound and nuclear oncogene products. These findings may attribute a new function to the naturally occurring polyamines.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cellular response to putrescine  IEP 10059622 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Myc  (MYC proto-oncogene, bHLH transcription factor)


Additional Information