VEGFA (vascular endothelial growth factor A)

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Gene: VEGFA (vascular endothelial growth factor A) Homo sapiens

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Symbol:

VEGFA

Name:

vascular endothelial growth factor A

RGD ID:

731072

HGNC Page

HGNC:12680

Description:

Enables several functions, including fibronectin binding activity; heparin binding activity; and signaling receptor binding activity. Involved in several processes, including positive regulation of cell migration; positive regulation of macromolecule metabolic process; and positive regulation of signal transduction. Acts upstream of or within several processes, including branching involved in blood vessel morphogenesis; cellular response to hypoxia; and positive regulation of endothelial cell proliferation. Located in several cellular components, including adherens junction; cell surface; and secretory granule. Part of VEGF-A complex. Implicated in several diseases, including autoimmune disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); hypertension (multiple); and reproductive organ cancer (multiple). Biomarker of several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); inflammatory bowel disease (multiple); and respiratory system cancer (multiple).

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

L-VEGF; MGC70609; MVCD1; vascular endothelial growth factor; vascular endothelial growth factor A, long form; vascular endothelial growth factor A121; vascular endothelial growth factor A165; vascular permeability factor; VEGF; VEGF-A; VPF

RGD Orthologs

Alliance Orthologs

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Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

NCBI Annotation Information:

Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in cytokine storm inflammatory response.

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	43,770,211 - 43,786,487 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	43,770,184 - 43,786,487 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	43,737,948 - 43,754,224 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	43,845,931 - 43,862,202 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	43,845,923 - 43,860,314	NCBI
Celera	6	45,289,570 - 45,305,849 (+)	NCBI		Celera
Cytogenetic Map	6	p21.1	NCBI
HuRef	6	43,458,106 - 43,474,385 (+)	NCBI		HuRef
CHM1_1	6	43,741,412 - 43,757,691 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	6	43,599,724 - 43,616,002 (+)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

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Imported Disease Annotations - ClinVar

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Imported Disease Annotations - OMIM