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Gene: MAP2K1 (mitogen-activated protein kinase kinase 1) Homo sapiens
Symbol: MAP2K1
Name: mitogen-activated protein kinase kinase 1
Description: Exhibits several functions, including protein C-terminus binding activity; protein kinase activity; and scaffold protein binding activity. Involved in several processes, including positive regulation of macromolecule metabolic process; protein phosphorylation; and regulation of protein heterodimerization activity. Localizes to the cytosol; endoplasmic reticulum; and plasma membrane. Implicated in cardiofaciocutaneous syndrome; malignant glioma; pancreatic adenocarcinoma; renal cell carcinoma; and small intestine adenocarcinoma. Biomarker of breast cancer; ovarian carcinoma; pancreatic adenocarcinoma; and renal cell carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CFC3; dual specificity mitogen-activated protein kinase kinase 1; ERK activator kinase 1; MAP kinase kinase 1; MAPK/ERK kinase 1; MAPKK 1; MAPKK1; MEK 1; MEK1; mitogen activated protein kinase kinase 1; MKK1; PRKMK1; protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1)
Mus musculus (house mouse) : Map2k1 (mitogen-activated protein kinase kinase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Map2k1 (mitogen activated protein kinase kinase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Map2k1 (mitogen-activated protein kinase kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : MAP2K1 (mitogen-activated protein kinase kinase 1)
Canis lupus familiaris (dog) : MAP2K1 (mitogen-activated protein kinase kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Map2k1 (mitogen-activated protein kinase kinase 1)
Sus scrofa (pig) : MAP2K1 (mitogen-activated protein kinase kinase 1)
more info ...
Related Pseudogenes: MAP2K1P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381566,386,873 - 66,491,544 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371566,679,182 - 66,783,882 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361564,466,679 - 64,570,936 (+)NCBINCBI36hg18NCBI36
Build 341564,466,678 - 64,570,935NCBI
Celera1543,568,908 - 43,673,089 (+)NCBI
Cytogenetic Map15q22.31NCBI
HuRef1543,515,493 - 43,620,002 (+)NCBIHuRef
CHM1_11566,797,173 - 66,901,898 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on MAP2K1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732023
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.