BIRC3 (baculoviral IAP repeat containing 3) - Rat Genome Database

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Gene: BIRC3 (baculoviral IAP repeat containing 3) Homo sapiens
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Symbol: BIRC3
Name: baculoviral IAP repeat containing 3
RGD ID: 732624
HGNC Page HGNC:591
Description: Enables ubiquitin-protein transferase activity. Involved in positive regulation of protein ubiquitination; regulation of apoptotic process; and regulation of necroptotic process. Located in cytosol and nucleoplasm. Implicated in MALT lymphoma; colorectal carcinoma; esophagus adenocarcinoma; hepatocellular carcinoma; and lung non-small cell carcinoma. Biomarker of carcinoma (multiple); gastrointestinal system cancer (multiple); and non-alcoholic steatohepatitis.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AIP1; API2; apoptosis inhibitor 2; baculoviral IAP repeat-containing 3; baculoviral IAP repeat-containing protein 3; c-IAP2; cellular inhibitor of apoptosis 2; CIAP2; HAIP1; HIAP1; IAP homolog C; IAP-1; inhibitor of apoptosis protein 1; MALT2; mammalian IAP homolog C; MIHC; RING finger protein 49; RING-type E3 ubiquitin transferase BIRC3; RNF49; TNFR2-TRAF signaling complex protein; TNFR2-TRAF-signaling complex protein 1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811102,317,484 - 102,339,403 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl11102,317,450 - 102,339,403 (+)EnsemblGRCh38hg38GRCh38
GRCh3711102,188,215 - 102,210,134 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611101,693,404 - 101,713,675 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411101,693,403 - 101,713,674NCBI
Celera1199,349,739 - 99,370,012 (+)NCBICelera
Cytogenetic Map11q22.2NCBI
HuRef1198,114,738 - 98,136,703 (+)NCBIHuRef
CHM1_111102,071,142 - 102,093,097 (+)NCBICHM1_1
T2T-CHM13v2.011102,319,603 - 102,341,520 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
(aminomethyl)phosphonic acid  (EXP)
1'-acetoxychavicol acetate  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
1-nitropyrene  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-amino-4-(3-nitrophenyl)-3-cyano-7-(dimethylamino)-4H-chromene  (EXP)
2-butoxyethanol  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (EXP)
2-hydroxypropanoic acid  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-iodobenzyl-5'-N-methylcarboxamidoadenosine  (EXP)
3-methylcholanthrene  (ISO)
3-phenylprop-2-enal  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-aminopyridine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenol  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-fluorouracil  (EXP)
5Z-7-oxozeaenol  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrolein  (EXP)
actinomycin D  (EXP)
adenosine  (EXP)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (EXP)
alvocidib  (EXP)
ammonium chloride  (ISO)
andrographolide  (EXP)
antirheumatic drug  (EXP)
apigenin  (EXP)
aprepitant  (EXP)
aristolochic acid  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenous acid  (EXP)
Bardoxolone methyl  (EXP)
beauvericin  (EXP)
benzene  (EXP)
benzene-1,2,4-triol  (EXP)
benzo[a]pyrene  (EXP)
benzo[a]pyrene diol epoxide I  (EXP)
beta-naphthoflavone  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (EXP)
bryostatin 1  (EXP)
butanal  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
calcitriol  (EXP)
carbon monoxide  (EXP)
carbon nanotube  (ISO)
cefaloridine  (ISO)
CGP 52608  (EXP)
chrysazin  (EXP)
cisplatin  (EXP,ISO)
cladribine  (EXP)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
crocidolite asbestos  (EXP)
crotonaldehyde  (EXP)
cryptolepine  (EXP)
curcumin  (EXP,ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
dexamethasone  (EXP,ISO)
diallyl disulfide  (EXP)
Diallyl sulfide  (EXP)
diarsenic trioxide  (EXP)
dichloromethane  (EXP)
dicrotophos  (EXP)
dieldrin  (ISO)
diethyl maleate  (ISO)
dioxygen  (EXP)
disodium selenite  (EXP)
dorsomorphin  (EXP)
doxorubicin  (EXP)
endosulfan  (ISO)
entinostat  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP)
ethylbenzene  (EXP)
etoposide  (EXP)
Evodiamine  (EXP)
fenofibrate  (EXP)
fluoranthene  (ISO)
flutamide  (ISO)
folic acid  (EXP)
fulvestrant  (EXP)
furan  (ISO)
gamma-aminobutyric acid  (ISO)
gamma-hexachlorocyclohexane  (EXP)
gastrin-17  (EXP)
gemcitabine  (EXP,ISO)
Genipin  (ISO)
gentamycin  (ISO)
gliotoxin  (EXP)
glutathione  (EXP)
gold atom  (EXP)
gold(0)  (EXP)
graphite  (ISO)
guggulsterone  (EXP)
homocysteine  (EXP)
hydrogen cyanide  (ISO)
hydrogen peroxide  (EXP)
hydroquinone  (EXP)
ibrutinib  (EXP)
indole-3-methanol  (EXP)
indometacin  (EXP)
irinotecan  (ISO)
isoflurane  (ISO)
isoliquiritigenin  (EXP)
L-ascorbic acid  (EXP)
lead diacetate  (ISO)
leflunomide  (EXP)
leptomycin B  (EXP)
linalool  (EXP)
lipopolysaccharide  (EXP,ISO)
lobaplatin  (EXP)
lonafarnib  (EXP)
LY294002  (EXP)
lysophosphatidylethanolamine  (EXP)
melittin  (EXP)
mercury atom  (EXP)
mercury(0)  (EXP)
methotrexate  (EXP)
methoxyacetic acid  (EXP)
methyl methanesulfonate  (EXP)
methylparaben  (EXP)
methylseleninic acid  (EXP)
microcystin-LR  (EXP)
Mitotane  (ISO)
morin  (EXP)
N,N'-(hexane-1,6-diyl)bis(1-\{(2S)-2-cyclohexyl-2-[(N-methyl-L-alanyl)amino]acetyl\}-L-prolyl-beta-phenyl-L-phenylalaninamide)  (EXP)
N-acetyl-L-cysteine  (EXP)
N-acetylsphingosine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
N-palmitoyl-S-[2,3-bis(palmitoyloxy)propyl]-Cys-Ser-Lys-Lys-Lys-Lys  (EXP)
N-tosyl-L-phenylalanyl chloromethyl ketone  (EXP)
nickel atom  (EXP)
nickel dichloride  (EXP,ISO)
nickel sulfate  (EXP)
nitric oxide  (EXP,ISO)
o-xylene  (EXP)
obeticholic acid  (EXP)
ochratoxin A  (EXP)
oxaliplatin  (ISO)
p-menthan-3-ol  (EXP)
paclitaxel  (EXP)
paracetamol  (ISO)
paraquat  (EXP,ISO)
PCB138  (ISO)
PD 0325901  (EXP)
pentanal  (EXP)
Pentoxifylline  (EXP)
perfluorodecanoic acid  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
phenethyl caffeate  (EXP)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
pioglitazone  (EXP)
pirinixic acid  (ISO)
potassium atom  (EXP)
potassium chromate  (EXP)
potassium cyanide  (ISO)
progesterone  (EXP)
propanal  (EXP)
prostaglandin E2  (EXP)
pyrrolidine dithiocarbamate  (EXP)
quercetin  (EXP)
rac-lactic acid  (EXP)
raloxifene  (EXP)
reactive oxygen species  (EXP)
resveratrol  (EXP)
rotenone  (EXP)
rottlerin  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
SB 431542  (EXP)
silicon dioxide  (EXP,ISO)
simvastatin  (EXP)
SM-164  (EXP)
sodium arsenite  (EXP)
sorafenib  (EXP)
staurosporine  (EXP)
succimer  (EXP,ISO)
sulforaphane  (EXP)
sulindac  (EXP)
sulindac sulfide  (EXP)
tacrolimus hydrate  (ISO)
tamoxifen  (EXP)
Tanshinone I  (EXP)
tephrosin  (EXP)
testosterone  (EXP,ISO)
thapsigargin  (EXP)
thimerosal  (EXP)
thioacetamide  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
topotecan  (ISO)
tributylstannane  (EXP)
Tributyltin oxide  (EXP,ISO)
trichloroethene  (EXP)
trichostatin A  (EXP)
Triptolide  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (EXP,ISO)
valproic acid  (EXP)
vancomycin  (ISO)
vincaleukoblastine  (EXP)
vincristine  (EXP)
vitamin E  (EXP)
vorinostat  (EXP)
wortmannin  (EXP)
zerumbone  (EXP)
zinc atom  (EXP)
zinc protoporphyrin  (EXP)
zinc(0)  (EXP)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IDA,IEA)
cytosol  (IDA,TAS)
membrane raft  (IEA,ISO)
nucleoplasm  (IDA)
nucleus  (IBA,IDA,IEA)
protein-containing complex  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Guggulsterone induces apoptosis in colon cancer cells and inhibits tumor growth in murine colorectal cancer xenografts. An MJ, etal., Cancer Lett. 2009 Jun 28;279(1):93-100. doi: 10.1016/j.canlet.2009.01.026. Epub 2009 Feb 18.
2. [Association of cellular inhibitor of apoptosis protein-2 expression with clinical outcomes of hepatocellular carcinoma]. Bi M, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2012 Jun;32(7):1020-5, 1030.
3. Identification of microRNA-124 in regulation of Hepatocellular carcinoma through BIRC3 and the NF-κB pathway. Cao J, etal., J Cancer. 2018 Jul 30;9(17):3006-3015. doi: 10.7150/jca.25956. eCollection 2018.
4. Cytoplasmic HuR expression: correlation with cellular inhibitors of apoptosis protein-2 expression and clinicopathologic factors in oral squamous cell carcinoma cells. Cha JD, etal., Head Neck. 2014 Aug;36(8):1168-75. doi: 10.1002/hed.23431. Epub 2014 Jan 16.
5. Additive effects of C(2)-ceramide on paclitaxel-induced premature senescence of human lung cancer cells. Chen JY, etal., Life Sci. 2010 Sep 11;87(11-12):350-7. doi: 10.1016/j.lfs.2010.06.017. Epub 2010 Jul 17.
6. Expression of inhibitor of apoptosis family proteins in human oral squamous cell carcinogenesis. Chen YK, etal., Head Neck. 2011 Jul;33(7):985-98. doi: 10.1002/hed.21582. Epub 2010 Oct 21.
7. Lobaplatin induces pyroptosis through regulating cIAP1/2, Ripoptosome and ROS in nasopharyngeal carcinoma. Chen Z, etal., Biochem Pharmacol. 2020 Jul;177:114023. doi: 10.1016/j.bcp.2020.114023. Epub 2020 May 13.
8. Tumor necrosis factor. Chu WM, Cancer Lett. 2013 Jan 28;328(2):222-5. doi: 10.1016/j.canlet.2012.10.014. Epub 2012 Oct 22.
9. Clinical Positioning of the IAP Antagonist Tolinapant (ASTX660) in Colorectal Cancer. Crawford N, etal., Mol Cancer Ther. 2021 Sep;20(9):1627-1639. doi: 10.1158/1535-7163.MCT-20-1050. Epub 2021 Aug 13.
10. A critical role for cellular inhibitor of protein 2 (cIAP2) in colitis-associated colorectal cancer and intestinal homeostasis mediated by the inflammasome and survival pathways. Dagenais M, etal., Mucosal Immunol. 2016 Jan;9(1):146-58. doi: 10.1038/mi.2015.46. Epub 2015 Jun 3.
11. Death receptor 5 (DR5) and a 5-gene apoptotic biomarker panel with significant differential diagnostic potential in colorectal cancer. Devetzi M, etal., Sci Rep. 2016 Nov 9;6:36532. doi: 10.1038/srep36532.
12. Cellular inhibitor of apoptosis proteins prevent clearance of hepatitis B virus. Ebert G, etal., Proc Natl Acad Sci U S A. 2015 May 5;112(18):5797-802. doi: 10.1073/pnas.1502390112. Epub 2015 Apr 20.
13. New insight into BIRC3: A novel prognostic indicator and a potential therapeutic target for liver cancer. Fu PY, etal., J Cell Biochem. 2019 Apr;120(4):6035-6045. doi: 10.1002/jcb.27890. Epub 2018 Oct 28.
14. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
15. Gene signature based on B cell predicts clinical outcome of radiotherapy and immunotherapy for patients with lung adenocarcinoma. Han L, etal., Cancer Med. 2020 Dec;9(24):9581-9594. doi: 10.1002/cam4.3561. Epub 2020 Oct 24.
16. Transcriptome profiling and genome-wide DNA binding define the differential role of fenretinide and all-trans RA in regulating the death and survival of human hepatocellular carcinoma Huh7 cells. Hu Y, etal., Biochem Pharmacol. 2013 Apr 1;85(7):1007-17. doi: 10.1016/j.bcp.2013.01.023. Epub 2013 Feb 8.
17. cIAP2 promotes gallbladder cancer invasion and lymphangiogenesis by activating the NF-κB pathway. Jiang X, etal., Cancer Sci. 2017 Jun;108(6):1144-1156. doi: 10.1111/cas.13236. Epub 2017 May 31.
18. cIAP2 via NF-κB signalling affects cell proliferation and invasion in hepatocellular carcinoma. Jiang XJ, etal., Life Sci. 2021 Feb 1;266:118867. doi: 10.1016/j.lfs.2020.118867. Epub 2020 Dec 10.
19. Expression parameters of the inhibitors of apoptosis cIAP1 and cIAP2 in renal cell carcinomas and their prognostic relevance. Kempkensteffen C, etal., Int J Cancer. 2007 Mar 1;120(5):1081-6.
20. t(11;18)(q21;q21) translocation as predictive marker for non-responsiveness to salvage thalidomide therapy in patients with marginal zone B-cell lymphoma with gastric involvement. Kuo SH, etal., Cancer Chemother Pharmacol. 2011 Dec;68(6):1387-95. doi: 10.1007/s00280-011-1631-y. Epub 2011 Apr 5.
21. Haem oxygenase-1 plays a central role in NNK-mediated lung carcinogenesis. Li MY, etal., Eur Respir J. 2008 Oct;32(4):911-23. doi: 10.1183/09031936.00064508. Epub 2008 May 28.
22. Comprehensive molecular characterization of inhibitors of apoptosis proteins (IAPs) for therapeutic targeting in cancer. Liang J, etal., BMC Med Genomics. 2020 Jan 21;13(1):7. doi: 10.1186/s12920-020-0661-x.
23. Toll-like receptor 2 stimulation promotes colorectal cancer cell growth via PI3K/Akt and NF-κB signaling pathways. Liu YD, etal., Int Immunopharmacol. 2018 Jun;59:375-383. doi: 10.1016/j.intimp.2018.04.033. Epub 2018 Apr 24.
24. Concomitant activation of caspase-9 and down-regulation of IAP proteins as a mechanism of apoptotic death in HepG2, T47D and HCT-116 cells upon exposure to a derivative from 4-aryl-4H-chromenes family. Mahdavi M, etal., Biomed Pharmacother. 2011 Jun;65(3):175-82. doi: 10.1016/j.biopha.2011.03.001. Epub 2011 Apr 8.
25. Combined analysis of cell growth and apoptosis-regulating proteins in HPVs associated anogenital tumors. Mitsuishi T, etal., BMC Cancer. 2010 Mar 27;10:118. doi: 10.1186/1471-2407-10-118.
26. Overexpression of cIAP2 contributes to 5-FU resistance and a poor prognosis in oral squamous cell carcinoma. Nagata M, etal., Br J Cancer. 2011 Oct 25;105(9):1322-30. doi: 10.1038/bjc.2011.387. Epub 2011 Sep 27.
27. Alcoholic hepatitis versus non-alcoholic steatohepatitis: Levels of expression of some proteins involved in tumorigenesis. Nguyen L, etal., Exp Mol Pathol. 2018 Feb;104(1):45-49. doi: 10.1016/j.yexmp.2017.12.007. Epub 2018 Jan 4.
28. Gene signature distinguishes patients with chronic ulcerative colitis harboring remote neoplastic lesions. Pekow J, etal., Inflamm Bowel Dis. 2013 Mar;19(3):461-70. doi: 10.1097/MIB.0b013e3182802bac.
29. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
30. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
31. TAK1-regulated expression of BIRC3 predicts resistance to preoperative chemoradiotherapy in oesophageal adenocarcinoma patients. Piro G, etal., Br J Cancer. 2015 Sep 15;113(6):878-85. doi: 10.1038/bjc.2015.283. Epub 2015 Aug 20.
32. An apoptosis-independent role of SMAC in tumor suppression. Qiu W, etal., Oncogene. 2013 May 9;32(19):2380-9. doi: 10.1038/onc.2012.265. Epub 2012 Jul 2.
33. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
34. API2-MALT1 chimeric transcript is a predictive marker for the responsiveness of H. pylori eradication treatment in low-grade gastric MALT lymphoma. Sugiyama T, etal., Gastroenterology. 2001 Jun;120(7):1884-5. doi: 10.1053/gast.2001.25305.
35. Genetic variants of BIRC3 and NRG1 in the NLRP3 inflammasome pathway are associated with non-small cell lung cancer survival. Tang D, etal., Am J Cancer Res. 2020 Aug 1;10(8):2582-2595. eCollection 2020.
36. Functional mismatch repair and inactive p53 drive sensitization of colorectal cancer cells to irinotecan via the IAP antagonist BV6. Tomicic MT, etal., Arch Toxicol. 2019 Aug;93(8):2265-2277. doi: 10.1007/s00204-019-02513-7. Epub 2019 Jul 9.
37. CircDOCK1 suppresses cell apoptosis via inhibition of miR‑196a‑5p by targeting BIRC3 in OSCC. Wang L, etal., Oncol Rep. 2018 Mar;39(3):951-966. doi: 10.3892/or.2017.6174. Epub 2017 Dec 28.
38. Identification of cyclin B1 and Sec62 as biomarkers for recurrence in patients with HBV-related hepatocellular carcinoma after surgical resection. Weng L, etal., Mol Cancer. 2012 Jun 8;11:39. doi: 10.1186/1476-4598-11-39.
39. cIAP2 upregulated by E6 oncoprotein via epidermal growth factor receptor/phosphatidylinositol 3-kinase/AKT pathway confers resistance to cisplatin in human papillomavirus 16/18-infected lung cancer. Wu HH, etal., Clin Cancer Res. 2010 Nov 1;16(21):5200-10. doi: 10.1158/1078-0432.CCR-10-0020. Epub 2010 Oct 19.
40. The LEF1/CYLD axis and cIAPs regulate RIP1 deubiquitination and trigger apoptosis in selenite-treated colorectal cancer cells. Wu P, etal., Cell Death Dis. 2014 Feb 27;5:e1085. doi: 10.1038/cddis.2014.13.
41. LCL161 increases paclitaxel-induced apoptosis by degrading cIAP1 and cIAP2 in NSCLC. Yang C, etal., J Exp Clin Cancer Res. 2016 Sep 30;35(1):158. doi: 10.1186/s13046-016-0435-7.
42. Helicobacter pylori Eradication Downregulates Cellular Inhibitor of Apoptosis Protein 2 in Gastric Carcinogenesis. Yoon H, etal., Gut Liver. 2017 Jan 15;11(1):79-86. doi: 10.5009/gnl15585.
43. Fusobacterium nucleatum promotes chemoresistance to 5-fluorouracil by upregulation of BIRC3 expression in colorectal cancer. Zhang S, etal., J Exp Clin Cancer Res. 2019 Jan 10;38(1):14. doi: 10.1186/s13046-018-0985-y.
44. Increased HMGB1 expression correlates with higher expression of c-IAP2 and pERK in colorectal cancer. Zhang W, etal., Medicine (Baltimore). 2019 Jan;98(3):e14069. doi: 10.1097/MD.0000000000014069.
45. Evironmental pollutant perfluorodecanoic acid upregulates cIAP2 to suppress gastric cell senescence. Zhang Z, etal., Oncol Rep. 2019 Feb;41(2):981-988. doi: 10.3892/or.2018.6856. Epub 2018 Nov 9.
Additional References at PubMed
PMID:8548810   PMID:8552191   PMID:8643514   PMID:8938457   PMID:8943045   PMID:9384571   PMID:9545235   PMID:9642260   PMID:9705938   PMID:9892732   PMID:10233894   PMID:10610122  
PMID:10753917   PMID:10797013   PMID:10862606   PMID:10929712   PMID:11066071   PMID:11084335   PMID:11466612   PMID:11562359   PMID:11583623   PMID:11604410   PMID:11724934   PMID:11906213  
PMID:11907583   PMID:11960389   PMID:12082024   PMID:12161039   PMID:12243753   PMID:12393423   PMID:12477932   PMID:12525502   PMID:12539042   PMID:12571250   PMID:12651604   PMID:12651874  
PMID:12815069   PMID:12865429   PMID:12867425   PMID:12926068   PMID:14527959   PMID:14562112   PMID:14685266   PMID:14708638   PMID:14960576   PMID:15023888   PMID:15037009   PMID:15069192  
PMID:15078890   PMID:15175157   PMID:15183896   PMID:15218035   PMID:15353805   PMID:15363040   PMID:15489334   PMID:15494311   PMID:15598810   PMID:15665297   PMID:15696476   PMID:15845643  
PMID:15856013   PMID:15861135   PMID:15982633   PMID:16123224   PMID:16142363   PMID:16189514   PMID:16282325   PMID:16339151   PMID:16356540   PMID:16395399   PMID:16395405   PMID:16467195  
PMID:16510124   PMID:16547522   PMID:16701639   PMID:16761316   PMID:16775419   PMID:16799641   PMID:16813569   PMID:16891304   PMID:16983704   PMID:16984419   PMID:17069460   PMID:17133355  
PMID:17179183   PMID:17613533   PMID:17626072   PMID:17927572   PMID:17972100   PMID:17993464   PMID:18195037   PMID:18216531   PMID:18566024   PMID:18570872   PMID:18621737   PMID:18676680  
PMID:18768389   PMID:18775313   PMID:18784070   PMID:18931663   PMID:18939944   PMID:18953427   PMID:19008929   PMID:19011619   PMID:19029953   PMID:19060847   PMID:19170196   PMID:19223549  
PMID:19234489   PMID:19243308   PMID:19302291   PMID:19336370   PMID:19358671   PMID:19416853   PMID:19464198   PMID:19625176   PMID:19690564   PMID:19692168   PMID:19698783   PMID:19763917  
PMID:19810754   PMID:19815541   PMID:19913121   PMID:19923725   PMID:20063052   PMID:20078866   PMID:20079017   PMID:20097753   PMID:20237496   PMID:20385093   PMID:20447407   PMID:20453000  
PMID:20547836   PMID:20562859   PMID:20576118   PMID:20628086   PMID:20651737   PMID:20691152   PMID:20855536   PMID:20863547   PMID:20888210   PMID:20940148   PMID:20957035   PMID:21048031  
PMID:21113135   PMID:21116278   PMID:21152357   PMID:21229359   PMID:21273489   PMID:21331077   PMID:21393245   PMID:21447281   PMID:21628460   PMID:21653699   PMID:21737330   PMID:21795072  
PMID:21817100   PMID:21849505   PMID:21865390   PMID:21869827   PMID:21873635   PMID:21881048   PMID:21931591   PMID:21963223   PMID:21988832   PMID:22068233   PMID:22083956   PMID:22195745  
PMID:22403404   PMID:22434933   PMID:22493164   PMID:22607974   PMID:22902369   PMID:23007157   PMID:23032264   PMID:23052480   PMID:23243274   PMID:23250032   PMID:23259674   PMID:23364796  
PMID:23453969   PMID:23524849   PMID:23535732   PMID:23543740   PMID:23558524   PMID:23612708   PMID:23770847   PMID:23867815   PMID:23871895   PMID:23918987   PMID:23972990   PMID:24008361  
PMID:24008839   PMID:24194568   PMID:24266799   PMID:24349465   PMID:24371121   PMID:24425875   PMID:24464131   PMID:24552816   PMID:24584352   PMID:24595242   PMID:24633224   PMID:24841289  
PMID:25046208   PMID:25065467   PMID:25113061   PMID:25241761   PMID:25246529   PMID:25260751   PMID:25273171   PMID:25275296   PMID:25394657   PMID:25494483   PMID:25513960   PMID:25549803  
PMID:25565375   PMID:25569716   PMID:25681446   PMID:25692408   PMID:25911380   PMID:25996949   PMID:26077759   PMID:26513451   PMID:26612615   PMID:26815504   PMID:26819056   PMID:26888114  
PMID:26969755   PMID:27070702   PMID:27074575   PMID:27248820   PMID:27304223   PMID:27420950   PMID:27476169   PMID:27534557   PMID:27810922   PMID:28244869   PMID:28635396   PMID:28839258  
PMID:29191979   PMID:29378181   PMID:29518103   PMID:29545793   PMID:30385739   PMID:30420664   PMID:30487125   PMID:30670910   PMID:30948266   PMID:31215169   PMID:31371416   PMID:31540997  
PMID:32015491   PMID:32026660   PMID:32028675   PMID:32053868   PMID:32322338   PMID:32382056   PMID:32553630   PMID:32968279   PMID:33435582   PMID:33469115   PMID:33526051   PMID:33599891  
PMID:33608556   PMID:33737574   PMID:33961781   PMID:34244476   PMID:34839354   PMID:34853447   PMID:34914932   PMID:34942311   PMID:34971648   PMID:34997070   PMID:35008722   PMID:35022505  
PMID:35039877   PMID:35218437   PMID:35287655   PMID:35985688  


Genomics

Comparative Map Data
BIRC3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811102,317,484 - 102,339,403 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl11102,317,450 - 102,339,403 (+)EnsemblGRCh38hg38GRCh38
GRCh3711102,188,215 - 102,210,134 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611101,693,404 - 101,713,675 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411101,693,403 - 101,713,674NCBI
Celera1199,349,739 - 99,370,012 (+)NCBICelera
Cytogenetic Map11q22.2NCBI
HuRef1198,114,738 - 98,136,703 (+)NCBIHuRef
CHM1_111102,071,142 - 102,093,097 (+)NCBICHM1_1
T2T-CHM13v2.011102,319,603 - 102,341,520 (+)NCBIT2T-CHM13v2.0
Birc3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3997,848,698 - 7,873,199 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl97,848,700 - 7,873,187 (-)EnsemblGRCm39 Ensembl
GRCm3897,847,468 - 7,873,205 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl97,848,699 - 7,873,186 (-)EnsemblGRCm38mm10GRCm38
MGSCv3797,848,699 - 7,873,170 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3697,849,220 - 7,873,545 (-)NCBIMGSCv36mm8
Celera95,240,413 - 5,264,652 (-)NCBICelera
Cytogenetic Map9A1NCBI
Birc3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.285,000,844 - 5,028,470 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl85,000,845 - 5,015,802 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx88,960,993 - 8,975,854 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.087,258,675 - 7,273,532 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.085,260,542 - 5,275,505 (-)NCBIRnor_WKY
Rnor_6.086,048,590 - 6,076,828 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl86,048,969 - 6,076,598 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.086,047,454 - 6,075,236 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.484,682,202 - 4,696,856 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.184,682,202 - 4,696,856 (-)NCBI
Celera86,558,921 - 6,573,882 (-)NCBICelera
Cytogenetic Map8q11NCBI
Birc3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554125,628,973 - 5,643,410 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554125,624,865 - 5,643,520 (+)NCBIChiLan1.0ChiLan1.0
BIRC3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.111100,763,274 - 100,785,194 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11100,763,274 - 100,785,194 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01197,269,778 - 97,290,112 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
BIRC3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1529,324,893 - 29,343,322 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl529,325,331 - 29,337,240 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha529,274,261 - 29,286,176 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0529,377,538 - 29,396,454 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl529,377,570 - 29,395,969 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1529,434,557 - 29,446,661 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0529,292,001 - 29,303,913 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0529,466,940 - 29,478,850 (-)NCBIUU_Cfam_GSD_1.0
Birc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494785,977,221 - 85,992,462 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365515,544,065 - 5,556,555 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365515,544,047 - 5,556,550 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BIRC3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl933,003,276 - 33,020,242 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1933,003,570 - 33,020,252 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2936,951,995 - 36,969,108 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BIRC3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1193,692,239 - 93,711,905 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604332,150,453 - 32,171,737 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Birc3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624878523,300 - 536,062 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624878516,750 - 541,475 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in BIRC3
3 total Variants
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR34Ahsa-miR-34a-5pMirtarbaseexternal_infoMicroarray//Northern blotFunctional MTI (Weak)17540599

Predicted Target Of
Summary Value
Count of predictions:1210
Count of miRNA genes:738
Interacting mature miRNAs:821
Transcripts:ENST00000263464, ENST00000526421, ENST00000527309, ENST00000527336, ENST00000528940, ENST00000532808
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
G43312  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711102,208,323 - 102,208,423UniSTSGRCh37
Build 3611101,713,533 - 101,713,633RGDNCBI36
Celera1199,369,870 - 99,369,970RGD
Cytogenetic Map11q22UniSTS
HuRef1198,134,891 - 98,134,991UniSTS
G60088  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711102,208,323 - 102,208,422UniSTSGRCh37
Build 3611101,713,533 - 101,713,632RGDNCBI36
Celera1199,369,870 - 99,369,969RGD
Cytogenetic Map11q22UniSTS
HuRef1198,134,891 - 98,134,990UniSTS
TNG Radiation Hybrid Map1147238.0UniSTS
PMC166414P2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711102,195,663 - 102,195,856UniSTSGRCh37
Build 3611101,700,873 - 101,701,066RGDNCBI36
Celera1199,357,209 - 99,357,402RGD
Cytogenetic Map11q22UniSTS
HuRef1198,122,232 - 98,122,425UniSTS
PMC229255P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711102,206,822 - 102,207,817UniSTSGRCh37
Build 3611101,712,032 - 101,713,027RGDNCBI36
Celera1199,368,369 - 99,369,364RGD
Cytogenetic Map11q22UniSTS
HuRef1198,133,390 - 98,134,385UniSTS
SHGC-31347  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711102,194,944 - 102,195,093UniSTSGRCh37
Build 3611101,700,154 - 101,700,303RGDNCBI36
Celera1199,356,490 - 99,356,639RGD
Cytogenetic Map11q22UniSTS
HuRef1198,121,513 - 98,121,662UniSTS
GeneMap99-G3 RH Map114482.0UniSTS
RH79205  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711102,208,173 - 102,208,305UniSTSGRCh37
Build 3611101,713,383 - 101,713,515RGDNCBI36
Celera1199,369,720 - 99,369,852RGD
Cytogenetic Map11q22UniSTS
HuRef1198,134,741 - 98,134,873UniSTS
GeneMap99-GB4 RH Map11348.76UniSTS
A007H38  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711102,208,223 - 102,208,363UniSTSGRCh37
Build 3611101,713,433 - 101,713,573RGDNCBI36
Celera1199,369,770 - 99,369,910RGD
Cytogenetic Map11q22UniSTS
HuRef1198,134,791 - 98,134,931UniSTS
GeneMap99-GB4 RH Map11348.76UniSTS
SGC33804  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711102,195,973 - 102,196,099UniSTSGRCh37
Build 3611101,701,183 - 101,701,309RGDNCBI36
Celera1199,357,519 - 99,357,645RGD
Cytogenetic Map11q22UniSTS
HuRef1198,122,542 - 98,122,668UniSTS
GeneMap99-GB4 RH Map11350.78UniSTS
Whitehead-RH Map11467.2UniSTS
NCBI RH Map11897.1UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 1 1
Medium 1247 366 318 264 1244 185 1149 276 658 179 317 774 90 344 819
Low 1185 2560 1391 348 654 268 2960 1825 2158 228 1122 800 82 1 859 1926 4 2
Below cutoff 5 64 15 11 44 11 230 93 903 11 18 31 3 1 43

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_065365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_182962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024448467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA805622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AA873008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF070674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF178945 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF233684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI880555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP000942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY764389 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC027485 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC037420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE907592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG569841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ718651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU428906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX415415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX475964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HI574220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HI574222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L43346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L49432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U37546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U45878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000263464   ⟹   ENSP00000263464
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11102,317,484 - 102,339,403 (+)Ensembl
RefSeq Acc Id: ENST00000526421   ⟹   ENSP00000501119
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11102,317,484 - 102,337,705 (+)Ensembl
RefSeq Acc Id: ENST00000527309   ⟹   ENSP00000431718
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11102,317,484 - 102,337,061 (+)Ensembl
RefSeq Acc Id: ENST00000527336
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11102,336,521 - 102,337,291 (+)Ensembl
RefSeq Acc Id: ENST00000528940
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11102,317,502 - 102,322,128 (+)Ensembl
RefSeq Acc Id: ENST00000532808   ⟹   ENSP00000432907
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11102,317,563 - 102,339,403 (+)Ensembl
RefSeq Acc Id: ENST00000615299   ⟹   ENSP00000481903
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11102,317,450 - 102,339,394 (+)Ensembl
RefSeq Acc Id: ENST00000673846   ⟹   ENSP00000501181
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11102,317,494 - 102,337,259 (+)Ensembl
RefSeq Acc Id: NM_001165   ⟹   NP_001156
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811102,317,484 - 102,339,403 (+)NCBI
GRCh3711102,188,181 - 102,210,134 (+)NCBI
Build 3611101,693,404 - 101,713,675 (+)NCBI Archive
HuRef1198,114,738 - 98,136,703 (+)NCBI
CHM1_111102,071,142 - 102,093,097 (+)NCBI
T2T-CHM13v2.011102,319,603 - 102,341,520 (+)NCBI
Sequence:
RefSeq Acc Id: NM_182962   ⟹   NP_892007
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811102,317,484 - 102,339,403 (+)NCBI
GRCh3711102,188,181 - 102,210,134 (+)NCBI
Build 3611101,693,404 - 101,713,675 (+)NCBI Archive
HuRef1198,114,738 - 98,136,703 (+)NCBI
CHM1_111102,071,142 - 102,093,097 (+)NCBI
T2T-CHM13v2.011102,319,603 - 102,341,520 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001156   ⟸   NM_001165
- UniProtKB: Q9UP46 (UniProtKB/Swiss-Prot),   Q13489 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_892007   ⟸   NM_182962
- UniProtKB: Q9UP46 (UniProtKB/Swiss-Prot),   Q13489 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000501181   ⟸   ENST00000673846
RefSeq Acc Id: ENSP00000432907   ⟸   ENST00000532808
RefSeq Acc Id: ENSP00000481903   ⟸   ENST00000615299
RefSeq Acc Id: ENSP00000501119   ⟸   ENST00000526421
RefSeq Acc Id: ENSP00000263464   ⟸   ENST00000263464
RefSeq Acc Id: ENSP00000431718   ⟸   ENST00000527309
Protein Domains
CARD   RING-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q13489-F1-model_v2 AlphaFold Q13489 1-604 view protein structure

Promoters
RGD ID:6788523
Promoter ID:HG_KWN:14034
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000393201,   NM_001165,   NM_182962
Position:
Human AssemblyChrPosition (strand)Source
Build 3611101,692,486 - 101,693,557 (+)MPROMDB
RGD ID:6788521
Promoter ID:HG_KWN:14035
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   Jurkat,   K562,   Lymphoblastoid
Transcripts:UC009YXB.1
Position:
Human AssemblyChrPosition (strand)Source
Build 3611101,696,781 - 101,701,232 (+)MPROMDB
RGD ID:7221907
Promoter ID:EPDNEW_H16698
Type:initiation region
Name:BIRC3_1
Description:baculoviral IAP repeat containing 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H16697  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811102,317,484 - 102,317,544EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11q22.1-22.2(chr11:102130109-102368261)x3 copy number gain See cases [RCV000051934] Chr11:102130109..102368261 [GRCh38]
Chr11:102000840..102238992 [GRCh37]
Chr11:101506050..101744202 [NCBI36]
Chr11:11q22.1-22.2
uncertain significance
GRCh38/hg38 11q14.1-22.3(chr11:78232836-106779420)x1 copy number loss See cases [RCV000052710] Chr11:78232836..106779420 [GRCh38]
Chr11:77943882..106650146 [GRCh37]
Chr11:77621530..106155356 [NCBI36]
Chr11:11q14.1-22.3
pathogenic
GRCh38/hg38 11q14.1-22.2(chr11:85242847-102920097)x1 copy number loss See cases [RCV000052711] Chr11:85242847..102920097 [GRCh38]
Chr11:84953891..102738968 [GRCh37]
Chr11:84631539..102296037 [NCBI36]
Chr11:11q14.1-22.2
pathogenic
GRCh38/hg38 11q22.1-25(chr11:100348599-135040246)x3 copy number gain See cases [RCV000053638] Chr11:100348599..135040246 [GRCh38]
Chr11:100219331..134910140 [GRCh37]
Chr11:99724541..134415350 [NCBI36]
Chr11:11q22.1-25
pathogenic
GRCh38/hg38 11q22.1-22.3(chr11:98357901-106059146)x1 copy number loss See cases [RCV000136574] Chr11:98357901..106059146 [GRCh38]
Chr11:98228629..105929873 [GRCh37]
Chr11:97733839..105435083 [NCBI36]
Chr11:11q22.1-22.3
pathogenic
GRCh38/hg38 11q22.1-22.3(chr11:101452984-104044105)x3 copy number gain See cases [RCV000136846] Chr11:101452984..104044105 [GRCh38]
Chr11:101323715..103914833 [GRCh37]
Chr11:100828925..103420043 [NCBI36]
Chr11:11q22.1-22.3
pathogenic
GRCh38/hg38 11q14.3-22.3(chr11:91086659-109595582)x1 copy number loss See cases [RCV000138038] Chr11:91086659..109595582 [GRCh38]
Chr11:90819827..109466308 [GRCh37]
Chr11:90459475..108971518 [NCBI36]
Chr11:11q14.3-22.3
pathogenic
GRCh37/hg19 11q22.1-22.2(chr11:102064452-102249344)x3 copy number gain See cases [RCV000240116] Chr11:102064452..102249344 [GRCh37]
Chr11:11q22.1-22.2
uncertain significance
GRCh37/hg19 11p13-q25(chr11:32799481-134938470)x3 copy number gain MISSED ABORTION [RCV002282973] Chr11:32799481..134938470 [GRCh37]
Chr11:11p13-q25
pathogenic
GRCh37/hg19 11q14.2-22.3(chr11:88152458-109414650)x1 copy number loss See cases [RCV000510457] Chr11:88152458..109414650 [GRCh37]
Chr11:11q14.2-22.3
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11q22.1-22.3(chr11:98515900-104970876)x1 copy number loss See cases [RCV000511844] Chr11:98515900..104970876 [GRCh37]
Chr11:11q22.1-22.3
likely pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11q13.4-23.3(chr11:71588805-116680918)x3 copy number gain not provided [RCV000683374] Chr11:71588805..116680918 [GRCh37]
Chr11:11q13.4-23.3
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11q14.1-23.2(chr11:80053454-113316236)x1 copy number loss not provided [RCV000737595] Chr11:80053454..113316236 [GRCh37]
Chr11:11q14.1-23.2
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
NM_001165.5(BIRC3):c.1663A>C (p.Arg555=) single nucleotide variant not provided [RCV000905866] Chr11:102336950 [GRCh38]
Chr11:102207681 [GRCh37]
Chr11:11q22.2
benign
NM_001165.5(BIRC3):c.1202G>A (p.Arg401Lys) single nucleotide variant not provided [RCV000953293] Chr11:102331119 [GRCh38]
Chr11:102201850 [GRCh37]
Chr11:11q22.2
likely benign
NM_001165.5(BIRC3):c.261A>G (p.Lys87=) single nucleotide variant not provided [RCV000956994] Chr11:102324770 [GRCh38]
Chr11:102195501 [GRCh37]
Chr11:11q22.2
benign
NC_000011.9:g.(?_94153285)_(111965700_?)del deletion Ataxia-telangiectasia syndrome [RCV001389105] Chr11:94153285..111965700 [GRCh37]
Chr11:11q21-23.1
pathogenic
Single allele deletion Intellectual disability [RCV001293382] Chr11:118359328..118372573 [GRCh37]
Chr11:11p15.3-q23.3
pathogenic
GRCh37/hg19 11q14.1-23.3(chr11:85422071-118022671)x1 copy number loss not provided [RCV001832892] Chr11:85422071..118022671 [GRCh37]
Chr11:11q14.1-23.3
uncertain significance
NC_000011.9:g.(?_101323686)_(103349981_?)del deletion Jeune thoracic dystrophy [RCV001942288]|not provided [RCV001942287] Chr11:101323686..103349981 [GRCh37]
Chr11:11q22.1-22.3
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:591 AgrOrtholog
COSMIC BIRC3 COSMIC
Ensembl Genes ENSG00000023445 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000263464 ENTREZGENE
  ENSP00000263464.4 UniProtKB/Swiss-Prot
  ENSP00000431718.2 UniProtKB/TrEMBL
  ENSP00000432907 ENTREZGENE
  ENSP00000432907.1 UniProtKB/Swiss-Prot
  ENSP00000481903.1 UniProtKB/Swiss-Prot
  ENSP00000501119.1 UniProtKB/Swiss-Prot
  ENSP00000501181.1 UniProtKB/TrEMBL
Ensembl Transcript ENST00000263464 ENTREZGENE
  ENST00000263464.9 UniProtKB/Swiss-Prot
  ENST00000526421.6 UniProtKB/Swiss-Prot
  ENST00000527309.2 UniProtKB/TrEMBL
  ENST00000532808 ENTREZGENE
  ENST00000532808.5 UniProtKB/Swiss-Prot
  ENST00000615299.4 UniProtKB/Swiss-Prot
  ENST00000673846.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000023445 GTEx
HGNC ID HGNC:591 ENTREZGENE
Human Proteome Map BIRC3 Human Proteome Map
InterPro BIR_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:330 UniProtKB/Swiss-Prot
NCBI Gene 330 ENTREZGENE
OMIM 601721 OMIM
Pfam BIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA25360 PharmGKB
PROSITE BIR_REPEAT_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BIR_REPEAT_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A669KBC7_HUMAN UniProtKB/TrEMBL
  BIRC3_HUMAN UniProtKB/Swiss-Prot
  H0YCJ5_HUMAN UniProtKB/TrEMBL
  L8E7L9_HUMAN UniProtKB/TrEMBL
  Q13489 ENTREZGENE
  Q9UP46 ENTREZGENE
UniProt Secondary Q16628 UniProtKB/Swiss-Prot
  Q9HC27 UniProtKB/Swiss-Prot
  Q9UP46 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-16 BIRC3  baculoviral IAP repeat containing 3  BIRC3  baculoviral IAP repeat containing 3  Symbol and/or name change 5135510 APPROVED
2011-08-10 BIRC3  baculoviral IAP repeat containing 3  BIRC3  baculoviral IAP repeat containing 3  Symbol and/or name change 5135510 APPROVED
2011-07-27 BIRC3  baculoviral IAP repeat containing 3  BIRC3  baculoviral IAP repeat-containing 3  Symbol and/or name change 5135510 APPROVED