Mir34a (microRNA 34a) - Rat Genome Database

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Gene: Mir34a (microRNA 34a) Mus musculus
Analyze
Symbol: Mir34a
Name: microRNA 34a
RGD ID: 1608206
MGI Page MGI
Description: Involved in several processes, including bone resorption; cellular response to leukemia inhibitory factor; and osteoclast development. Is expressed in several structures, including brain; branchial arch; otocyst; and somite. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human MIR34A (microRNA 34a).
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: Mir; mir-34a; Mirn34a; mmu-mir-; mmu-mir-34a
RGD Orthologs
Human
Rat
Dog
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394150,152,911 - 150,153,012 (+)NCBIGRCm39mm39
GRCm39 Ensembl4150,152,911 - 150,153,012 (+)Ensembl
GRCm384150,068,454 - 150,068,555 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4150,068,454 - 150,068,555 (+)EnsemblGRCm38mm10GRCm38
MGSCv374149,442,563 - 149,442,664 (+)NCBIGRCm37mm9NCBIm37
Celera4152,344,303 - 152,344,404 (+)NCBICelera
Cytogenetic Map4E2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-citrinin  (ISO)
1,3,5-trinitro-1,3,5-triazinane  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-acetamidofluorene  (ISO)
3,7-dihydropurine-6-thione  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-D-galactose  (ISO)
aristolochic acid  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzene  (EXP)
benzo[a]pyrene  (EXP)
bisphenol A  (ISO)
bleomycin A2  (ISO)
buta-1,3-diene  (EXP)
Butylbenzyl phthalate  (ISO)
camptothecin  (ISO)
cannabidiol  (EXP)
chenodeoxycholic acid  (ISO)
chlorendic acid  (ISO)
choline  (EXP)
cisplatin  (EXP,ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
ethanol  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
furan  (ISO)
galactose  (ISO)
genistein  (ISO)
hydrogen peroxide  (ISO)
irinotecan  (ISO)
L-methionine  (EXP)
lipopolysaccharide  (ISO)
lithium atom  (ISO)
lithium chloride  (ISO)
lithium hydride  (ISO)
mercaptopurine  (ISO)
methapyrilene  (ISO)
mitomycin C  (ISO)
monuron  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
NAD zwitterion  (EXP)
NAD(+)  (EXP)
NMN zwitterion  (EXP)
ochratoxin A  (EXP)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
propanal  (ISO)
purine-6-thiol  (ISO)
quercetin  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
sevoflurane  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP)
sulforaphane  (EXP)
tamoxifen  (ISO)
titanium dioxide  (ISO)
tributyl phosphate  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

Additional References at PubMed
PMID:12554860   PMID:12919684   PMID:16381832   PMID:16462742   PMID:17369397   PMID:17554337   PMID:17604727   PMID:17875987   PMID:18594913   PMID:18723672   PMID:18835850   PMID:19345099  
PMID:19727952   PMID:19895913   PMID:20090763   PMID:20185821   PMID:20215419   PMID:20413612   PMID:20439489   PMID:20548288   PMID:20558326   PMID:20598588   PMID:20668074   PMID:20689156  
PMID:20805985   PMID:21037258   PMID:21067520   PMID:21267068   PMID:21423204   PMID:21553024   PMID:21690328   PMID:21718763   PMID:21822254   PMID:21831840   PMID:21857907   PMID:21931765  
PMID:22020437   PMID:22064828   PMID:22102825   PMID:22115756   PMID:22160687   PMID:22160706   PMID:22297810   PMID:22436728   PMID:22483937   PMID:22561871   PMID:22564414   PMID:22701667  
PMID:22841474   PMID:22844244   PMID:22988100   PMID:23029150   PMID:23047694   PMID:23239859   PMID:23426265   PMID:23462268   PMID:23646144   PMID:23778113   PMID:23796712   PMID:23834033  
PMID:24129179   PMID:24147106   PMID:24401748   PMID:24421386   PMID:24532687   PMID:24587330   PMID:24630988   PMID:24642471   PMID:24752729   PMID:24759152   PMID:24780820   PMID:24829923  
PMID:24899310   PMID:24967703   PMID:24973144   PMID:25078608   PMID:25107369   PMID:25123309   PMID:25182532   PMID:25322725   PMID:25348795   PMID:25400756   PMID:25489229   PMID:25526086  
PMID:25638533   PMID:25751060   PMID:26082557   PMID:26100857   PMID:26126715   PMID:26282218   PMID:26330104   PMID:26406385   PMID:26438731   PMID:26459758   PMID:26493107   PMID:26572867  
PMID:26577528   PMID:26661155   PMID:26718338   PMID:26802970   PMID:26833183   PMID:26849305   PMID:26871287   PMID:26902416   PMID:26902620   PMID:26935288   PMID:26949937   PMID:27026110  
PMID:27297797   PMID:27635790   PMID:27707753   PMID:27789474   PMID:27979858   PMID:28082412   PMID:28185128   PMID:28199987   PMID:28250026   PMID:28263817   PMID:28273432   PMID:28303901  
PMID:28321785   PMID:28363996   PMID:28485501   PMID:28533191   PMID:28639625   PMID:28668331   PMID:28817812   PMID:28923932   PMID:28981097   PMID:29079808   PMID:29128099   PMID:29162670  
PMID:29175286   PMID:29187903   PMID:29289683   PMID:29378298   PMID:29417477   PMID:29424794   PMID:29523084   PMID:29637443   PMID:29700282   PMID:29704100   PMID:29764990   PMID:29957876  
PMID:30026277   PMID:30030567   PMID:30042416   PMID:30093634   PMID:30365981   PMID:30543324   PMID:30659149   PMID:30667374   PMID:30770339   PMID:30793480   PMID:30853453   PMID:30867288  
PMID:30872089   PMID:30898698   PMID:30922079   PMID:30930169   PMID:31026620   PMID:31139863   PMID:31247197   PMID:31294899   PMID:31296380   PMID:31308031   PMID:31376385   PMID:31482401  
PMID:31487267   PMID:31604677   PMID:32094435   PMID:32178735   PMID:32507765   PMID:32541781   PMID:32542395   PMID:32585876   PMID:33034147   PMID:33098868   PMID:33581076  


Genomics

Comparative Map Data
Mir34a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394150,152,911 - 150,153,012 (+)NCBIGRCm39mm39
GRCm39 Ensembl4150,152,911 - 150,153,012 (+)Ensembl
GRCm384150,068,454 - 150,068,555 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4150,068,454 - 150,068,555 (+)EnsemblGRCm38mm10GRCm38
MGSCv374149,442,563 - 149,442,664 (+)NCBIGRCm37mm9NCBIm37
Celera4152,344,303 - 152,344,404 (+)NCBICelera
Cytogenetic Map4E2NCBI
MIR34A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl19,151,668 - 9,151,777 (-)EnsemblGRCh38hg38GRCh38
GRCh3819,151,668 - 9,151,777 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3719,211,727 - 9,211,836 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3619,134,313 - 9,134,422 (-)NCBINCBI36hg18NCBI36
Celera18,321,161 - 8,321,270 (-)NCBI
Cytogenetic Map1p36.22NCBI
HuRef18,362,551 - 8,362,660 (-)NCBIHuRef
CHM1_119,201,981 - 9,202,090 (-)NCBICHM1_1
Mir34a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25160,533,002 - 160,533,103 (+)NCBI
Rnor_6.0 Ensembl5167,092,491 - 167,092,592 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.05167,092,491 - 167,092,592 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05170,733,242 - 170,733,343 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera5158,795,110 - 158,795,211 (+)NCBICelera
Cytogenetic Map5q36NCBI
MIR34A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1562,485,832 - 62,485,897 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl562,485,832 - 62,485,897 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha562,502,877 - 62,502,942 (-)NCBI
ROS_Cfam_1.0562,712,027 - 62,712,092 (-)NCBI
UMICH_Zoey_3.1562,710,061 - 62,710,126 (-)NCBI
UNSW_CanFamBas_1.0562,573,923 - 62,573,988 (-)NCBI
UU_Cfam_GSD_1.0562,978,341 - 62,978,406 (-)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301452Elsgp1_melevated serum gp70 1 (mouse)Not determined4121615338155615442Mouse
1300933Cdcs9_mcytokine deficiency colitis susceptibility 9 (mouse)Not determined4125504302156508116Mouse
1301815Sles2_msystemic lupus erythmatosus suppressor 2 (mouse)Not determined495069342150592401Mouse
1301823Bmd7_mbone mineral density 7 (mouse)Not determined489063832151570093Mouse
1301525Lmb1_mlupus in MRL and B6 F2 cross (mouse)Not determined4124371164150592401Mouse
1301584Lrdg2_mlight induced retinal degeneration 2 (mouse)Not determined4129572018151570093Mouse
1301964Bw8q2_mbody weight at 8 weeks QTL 2 (mouse)Not determined4120137122154137225Mouse
1301982Pltiq1_mphospholipid transfer protein inducibility QTL 1 (mouse)Not determined4124893970156508116Mouse
1302078Sluc21_msusceptibility to lung cancer 21 (mouse)Not determined4117673830151673964Mouse
1302102Bis1_mbeta-carboline-induced seizures 1 (mouse)Not determined4120137122154137225Mouse
1300780Cocrb16_mcocaine related behavior 16 (mouse)Not determined4138859268156508116Mouse
1300803Sluc6_msusceptibility to lung cancer 6 (mouse)Not determined4120946694154946840Mouse
1300858Tafat_mtally ho associated mesenteric fat pad weight (mouse)Not determined4124893970156508116Mouse
1300874Gasa2_mgastritis type A susceptibility locus 2 (mouse)Not determined4132926037156508116Mouse
1300621Tpnr1_mthermal pain response 1 (mouse)Not determined4125504302156508116Mouse
1300537Ap3q_malcohol preference 3 QTL (mouse)Not determined4134569994156508116Mouse
1300553Athsq1_matherosclerosis susceptibility QTL 1 (mouse)Not determined4137890537151570093Mouse
1301108Scon2_msucrose consumption 2 (mouse)Not determined4134569994156508116Mouse
4141180Ssic1_msusceptibility to small intestinal cancer 1 (mouse)Not determined120946694154946840Mouse
4141184Tb2r1_mTGF-beta2 responsiveness 1 (mouse)Not determined137946694150592401Mouse
1301267Bcmd2_mB cell maturation defect 2 (mouse)Not determined4133427367150704994Mouse
4142139Adip12_madiposity 12 (mouse)Not determined4124893970156508116Mouse
10043985Stheal12_msoft tissue heal 12 (mouse)Not determined4121615338155615442Mouse
10043996Gct5_mgranulosa cell tumorigenesis 5 (mouse)Not determined4128057656156508116Mouse
10045620Heal22_mwound healing/regeneration 22 (mouse)Not determined4125504302156508116Mouse
10412210Cypr6_mcytokine production 6 (mouse)Not determined4120890537154890684Mouse
4142481Gct1_mgranulosa cell tumorigenesis 1 (mouse)Not determined4128057656156508116Mouse
4142493Femwf13_mfemur work to failure 13 (mouse)Not determined116427367150427471Mouse
4142061Chlq16_mcirculating hormone level QTL 16 (mouse)Not determined4121615338155615442Mouse
4142077Ignpq2_mIgA nephropathy QTL 2 (mouse)Not determined4133592276156508116Mouse
14746982Manh56_mmandible shape 56 (mouse)4118088606152088606Mouse
13503348Bntq18_mbone traits QTL 18 (mouse)4120890537154890684Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155600000Mouse
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156183778Mouse
26884445Sklq7_mskull length QTL 7, 10 week (mouse)468100000150800000Mouse
10755531Lymph3_mlymphocyte differential 3 (mouse)4124826172156508116Mouse
11533916Mts1_mmammary tumor susceptibility 1 (mouse)4125562755156508116Mouse

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Notch1mmu-miR-34a-5pMirtarbaseexternal_infoELISA//Immunofluorescence//Luciferase reporter assFunctional MTI22483937
Actbmmu-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI18835850
Bcl2mmu-miR-34a-5pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI19683563
Dll1mmu-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI21931765
Foxp1mmu-miR-34a-5pMirtarbaseexternal_infoWestern blotFunctional MTI20598588
Foxp1mmu-miR-34a-5pTarbaseexternal_infoWesternblitPOSITIVE
Aregmmu-miR-34a-5pOncomiRDBexternal_infoNANA23145211
Notch1mmu-miR-34a-5pOncomiRDBexternal_infoNANA23085450
Fosl1mmu-miR-34a-5pOncomiRDBexternal_infoNANA23001043
Ccl22mmu-miR-34a-5pOncomiRDBexternal_infoNANA22975373
Arhgap1mmu-miR-34a-5pOncomiRDBexternal_infoNANA22850877
Pdgframmu-miR-34a-5pOncomiRDBexternal_infoNANA22750848
Notch1mmu-miR-34a-5pOncomiRDBexternal_infoNANA22684561
Bcl2mmu-miR-34a-5pOncomiRDBexternal_infoNANA22623155
Pdgframmu-miR-34a-5pOncomiRDBexternal_infoNANA22479456
Metmmu-miR-34a-5pOncomiRDBexternal_infoNANA22457788
Impdh1mmu-miR-34a-5pOncomiRDBexternal_infoNANA22301190
Nol3mmu-miR-34a-5pOncomiRDBexternal_infoNANA22235332
Fosl1mmu-miR-34a-5pOncomiRDBexternal_infoNANA22198213
Nol3mmu-miR-34a-5pOncomiRDBexternal_infoNANA22159222
Snai1mmu-miR-34a-5pOncomiRDBexternal_infoNANA22134354
Arafmmu-miR-34a-5pOncomiRDBexternal_infoNANA22102825
Snai1mmu-miR-34a-5pOncomiRDBexternal_infoNANA22024162
Dll1mmu-miR-34a-5pOncomiRDBexternal_infoNANA21931765
Msi1mmu-miR-34a-5pOncomiRDBexternal_infoNANA21881409
Axlmmu-miR-34a-5pOncomiRDBexternal_infoNANA21814748
Notch1mmu-miR-34a-5pOncomiRDBexternal_infoNANA21743299
Cdk6mmu-miR-34a-5pOncomiRDBexternal_infoNANA21702042
Mycnmmu-miR-34a-5pOncomiRDBexternal_infoNANA21654684
Foxp1mmu-miR-34a-5pOncomiRDBexternal_infoNANA21460242
Aregmmu-miR-34a-5pOncomiRDBexternal_infoNANA21343391
Axlmmu-miR-34a-5pOncomiRDBexternal_infoNANA21317930
Nol3mmu-miR-34a-5pOncomiRDBexternal_infoNANA21297663
Cd44mmu-miR-34a-5pOncomiRDBexternal_infoNANA21240262
Yy1mmu-miR-34a-5pOncomiRDBexternal_infoNANA21182263
Magea2mmu-miR-34a-5pOncomiRDBexternal_infoNANA21177782
E2f3mmu-miR-34a-5pOncomiRDBexternal_infoNANA20889924
Sirt1mmu-miR-34a-5pOncomiRDBexternal_infoNANA20687223
Sirt1mmu-miR-34a-5pOncomiRDBexternal_infoNANA20470934
Notch1mmu-miR-34a-5pOncomiRDBexternal_infoNANA20351093
Metmmu-miR-34a-5pOncomiRDBexternal_infoNANA19773441
Nol3mmu-miR-34a-5pOncomiRDBexternal_infoNANA19696787
Metmmu-miR-34a-5pOncomiRDBexternal_infoNANA19029026
Metmmu-miR-34a-5pOncomiRDBexternal_infoNANA19006648
Sirt1mmu-miR-34a-5pOncomiRDBexternal_infoNANA18834855
Bcl2mmu-miR-34a-5pOncomiRDBexternal_infoNANA18803879
Sirt1mmu-miR-34a-5pOncomiRDBexternal_infoNANA18755897
Cdk6mmu-miR-34a-5pOncomiRDBexternal_infoNANA18719384
Bcl2mmu-miR-34a-5pOncomiRDBexternal_infoNANA18505919
Mycnmmu-miR-34a-5pOncomiRDBexternal_infoNANA18504438
Ccnd1mmu-miR-34a-5pOncomiRDBexternal_infoNANA18406353
Bcl2mmu-miR-34a-5pOncomiRDBexternal_infoNANA17656095
E2f3mmu-miR-34a-5pOncomiRDBexternal_infoNANA17297439
Sirt1mmu-miR-34a-3pMirecordsexternal_infoNANA20424141
Bcl2mmu-miR-34a-3pMirecordsexternal_infoNANA21415464

Predicted Targets
Summary Value
Count of predictions:28608
Count of gene targets:11803
Count of transcripts:20688
Interacting mature miRNAs:mmu-miR-34a-3p, mmu-miR-34a-5p
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000083559
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl4150,068,454 - 150,068,555 (+)Ensembl
RefSeq Acc Id: NR_029751
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394150,152,911 - 150,153,012 (+)NCBI
GRCm384150,068,454 - 150,068,555 (+)ENTREZGENE
MGSCv374149,442,563 - 149,442,664 (+)RGD
Celera4152,344,303 - 152,344,404 (+)RGD
cM Map4 ENTREZGENE
Sequence:
Promoters
RGD ID:6885592
Promoter ID:EPDNEW_M6247
Type:single initiation site
Name:Mir34a_1
Description:Mus musculus microRNA 34a , microRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384150,068,540 - 150,068,600EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3619363 AgrOrtholog
Ensembl Genes ENSMUSG00000065493 Ensembl, ENTREZGENE
Ensembl Transcript ENSMUST00000083559 ENTREZGENE
MGD MGI:3619363 ENTREZGENE
miRBase MI0000584 ENTREZGENE
NCBI Gene 723848 ENTREZGENE
PhenoGen Mir34a PhenoGen
RNAcentral URS000030BD69 RNACentral
  URS00005E520A RNACentral
  URS000075E272 RNACentral