SNAI1 (snail family transcriptional repressor 1) - Rat Genome Database

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Gene: SNAI1 (snail family transcriptional repressor 1) Homo sapiens
Symbol: SNAI1
Name: snail family transcriptional repressor 1
RGD ID: 1347076
HGNC Page HGNC:11128
Description: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; E-box binding activity; and kinase binding activity. Involved in several processes, including negative regulation of response to DNA damage stimulus; regulation of bicellular tight junction assembly; and regulation of cellular biosynthetic process. Located in cytosol; nuclear lumen; and pericentric heterochromatin. Biomarker of oral mucosa leukoplakia.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: dJ710H13.1; SLUGH2; SNA; SNAH; SNAIL; snail 1 homolog; snail 1 zinc finger protein; snail 1, zinc finger protein; snail family zinc finger 1; snail homolog 1; SNAIL1; zinc finger protein SNAI1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: SNAI1P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382049,982,980 - 49,988,886 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2049,982,980 - 49,988,886 (+)EnsemblGRCh38hg38GRCh38
GRCh372048,599,517 - 48,605,423 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362048,032,934 - 48,038,830 (+)NCBINCBI36hg18NCBI36
Build 342048,032,933 - 48,038,825NCBI
Celera2045,304,074 - 45,309,984 (+)NCBI
Cytogenetic Map20q13.13NCBI
HuRef2045,348,282 - 45,354,192 (+)NCBIHuRef
CHM1_12048,504,120 - 48,510,030 (+)NCBICHM1_1
T2T-CHM13v2.02051,752,473 - 51,758,373 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(+)-schisandrin B  (EXP,ISO)
(+)-Tetrandrine  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
(20S)-ginsenoside Rg3  (EXP)
(R)-carnitine  (ISO)
(S)-naringenin  (EXP)
(S)-nicotine  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dithiothreitol  (EXP)
1-chloro-2,4-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-Dihydroxybenzophenone  (EXP)
2-ethylhexan-1-ol  (ISO)
2-hydroxypropanoic acid  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3'-diindolylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-tert-Octylphenol  (EXP)
5-aza-2'-deoxycytidine  (EXP)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (EXP)
acrolein  (EXP)
acteoside  (EXP)
aldehydo-D-glucose  (EXP)
aldosterone  (EXP)
all-trans-retinoic acid  (EXP,ISO)
alpha-pinene  (EXP)
aluminium atom  (EXP)
aluminium(0)  (EXP)
AM-251  (EXP)
ammonium chloride  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antirheumatic drug  (EXP)
antroquinonol  (EXP)
aristolochic acid  (EXP,ISO)
Aroclor 1254  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (EXP)
arsenous acid  (EXP)
bafilomycin A1  (EXP)
benzo[a]pyrene  (EXP)
Benzo[k]fluoranthene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
butanal  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
carbon nanotube  (EXP,ISO)
celecoxib  (EXP)
chloroquine  (ISO)
choline  (ISO)
chromium(6+)  (EXP)
chrysin  (EXP)
ciprofloxacin  (EXP)
cisplatin  (EXP)
cobalt dichloride  (EXP)
colforsin daropate hydrochloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP)
crocidolite asbestos  (EXP)
curcumin  (EXP)
cyclosporin A  (EXP,ISO)
cytochalasin D  (EXP)
D-glucose  (EXP)
decabromodiphenyl ether  (EXP)
deguelin  (EXP)
delphinidin  (EXP)
dexamethasone  (EXP)
dextran sulfate  (ISO)
diallyl disulfide  (EXP)
diallyl trisulfide  (EXP)
diarsenic trioxide  (EXP)
diazinon  (EXP)
dibutyl phthalate  (ISO)
dinophysistoxin 1  (EXP)
dioxygen  (EXP)
disulfiram  (EXP)
doxorubicin  (EXP,ISO)
embelin  (EXP)
endosulfan  (EXP,ISO)
eplerenone  (EXP)
ergosta-4,6,8(14),22-tetraen-3-one  (EXP)
erlotinib hydrochloride  (EXP)
ethanol  (ISO)
fludioxonil  (EXP)
folic acid  (ISO)
formaldehyde  (EXP)
fulvestrant  (EXP,ISO)
furan  (ISO)
galaxolide  (EXP)
genistein  (EXP)
gentamycin  (ISO)
gingerol  (EXP)
Ginkgoic acid  (EXP)
glucose  (EXP)
hydrogen peroxide  (EXP)
Indeno[1,2,3-cd]pyrene  (EXP)
Iodine aqueous  (EXP)
jaspamide  (EXP)
L-1,4-dithiothreitol  (EXP)
L-methionine  (ISO)
lapatinib  (EXP)
leflunomide  (EXP)
Licochalcone B  (EXP)
lipopolysaccharide  (ISO)
lithium chloride  (EXP,ISO)
losartan  (EXP)
luteolin  (EXP)
LY294002  (EXP)
mangiferin  (EXP)
menadione  (EXP)
methylisothiazolinone  (EXP)
microcystin-LR  (EXP)
mifepristone  (EXP)
MK-2206  (EXP,ISO)
N-acetyl-L-cysteine  (EXP)
N-methyl-N-nitrosourea  (ISO)
nickel dichloride  (EXP)
nickel sulfate  (EXP)
niclosamide  (EXP,ISO)
nicotine  (EXP,ISO)
Nonylphenol  (EXP)
oridonin  (EXP)
ouabain  (EXP)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
p-tert-Amylphenol  (EXP)
Pachymic acid  (EXP,ISO)
paracetamol  (ISO)
paraquat  (ISO)
patulin  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phenol red  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
pirinixic acid  (ISO)
potassium chromate  (EXP)
propiconazole  (EXP)
pterostilbene  (EXP)
quercetin  (EXP,ISO)
rac-lactic acid  (EXP)
radon atom  (EXP,ISO)
radon(0)  (EXP,ISO)
reparixin  (EXP)
resveratrol  (EXP)
retinyl acetate  (ISO)
ridaforolimus  (EXP)
rotenone  (EXP)
Salinomycin  (EXP)
sanguinarine  (EXP)
SB 203580  (EXP)
SB 431542  (EXP,ISO)
sclareol  (EXP)
serpentine asbestos  (EXP)
silver atom  (EXP)
silver(0)  (EXP)
sirolimus  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sorafenib  (EXP)
stattic  (EXP)
sulforaphane  (ISO)
tacrolimus hydrate  (EXP,ISO)
tamoxifen  (EXP)
tebuconazole  (EXP)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetraethylenepentamine  (EXP,ISO)
tetraphene  (EXP)
thioacetamide  (ISO)
thymoquinone  (EXP)
titanium dioxide  (ISO)
tolfenamic acid  (EXP)
topotecan  (ISO)
trichostatin A  (EXP)
triclosan  (EXP)
urethane  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component


References - curated
# Reference Title Reference Citation
1. LINC00689 participates in proliferation, chemoresistance and metastasis via miR-31-5p/YAP/β-catenin axis in colorectal cancer. Du YL, etal., Exp Cell Res. 2020 Oct 1;395(1):112176. doi: 10.1016/j.yexcr.2020.112176. Epub 2020 Jul 16.
2. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
3. Ginkgolic acid (GA) suppresses gastric cancer growth by inducing apoptosis and suppressing STAT3/JAK2 signaling regulated by ROS. Liang JR and Yang H, Biomed Pharmacother. 2020 May;125:109585. doi: 10.1016/j.biopha.2019.109585. Epub 2020 Feb 25.
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Snail and Axin2 expression predict the malignant transformation of oral leukoplakia. Zhang X, etal., Oral Oncol. 2017 Oct;73:48-55. doi: 10.1016/j.oraloncology.2017.08.004. Epub 2017 Aug 12.
Additional References at PubMed
PMID:10543399   PMID:10585766   PMID:10655587   PMID:10773451   PMID:11245431   PMID:11780052   PMID:11912130   PMID:12082640   PMID:12161443   PMID:12477932   PMID:12632084   PMID:12668723  
PMID:12832491   PMID:14507651   PMID:14673164   PMID:15026811   PMID:15075229   PMID:15286702   PMID:15302935   PMID:15314165   PMID:15448698   PMID:15467754   PMID:15489334   PMID:15631989  
PMID:15647282   PMID:15712635   PMID:15742334   PMID:15836774   PMID:16096638   PMID:16169460   PMID:16203744   PMID:16207734   PMID:16328348   PMID:16344560   PMID:16502042   PMID:16568079  
PMID:16858414   PMID:16936774   PMID:17060462   PMID:17072303   PMID:17296734   PMID:17353931   PMID:17545014   PMID:17616667   PMID:17692821   PMID:17724139   PMID:17914115   PMID:17952120  
PMID:18026186   PMID:18043286   PMID:18089802   PMID:18234959   PMID:18256147   PMID:18321996   PMID:18331720   PMID:18347060   PMID:18469861   PMID:18519590   PMID:18554584   PMID:18559496  
PMID:18676743   PMID:18691339   PMID:18799618   PMID:18832382   PMID:19004823   PMID:19010907   PMID:19046938   PMID:19107228   PMID:19124656   PMID:19198871   PMID:19245592   PMID:19269083  
PMID:19274049   PMID:19347028   PMID:19381684   PMID:19386897   PMID:19411070   PMID:19412634   PMID:19440385   PMID:19502595   PMID:19533388   PMID:19604315   PMID:19604397   PMID:19641025  
PMID:19651985   PMID:19695091   PMID:19784072   PMID:19789323   PMID:19795442   PMID:19802011   PMID:19821482   PMID:19860811   PMID:19861116   PMID:19887480   PMID:19915148   PMID:19923321  
PMID:19955572   PMID:20018240   PMID:20089328   PMID:20091050   PMID:20121949   PMID:20128911   PMID:20138990   PMID:20150431   PMID:20166136   PMID:20211142   PMID:20348013   PMID:20385133  
PMID:20389281   PMID:20397042   PMID:20403241   PMID:20421926   PMID:20489148   PMID:20514449   PMID:20534591   PMID:20562920   PMID:20576520   PMID:20620220   PMID:20628624   PMID:20634891  
PMID:20823140   PMID:20851575   PMID:20947514   PMID:20951801   PMID:20952218   PMID:20953189   PMID:20957493   PMID:20959806   PMID:21088236   PMID:21225336   PMID:21300290   PMID:21315410  
PMID:21315411   PMID:21317430   PMID:21321977   PMID:21324165   PMID:21360437   PMID:21448462   PMID:21454664   PMID:21478114   PMID:21577210   PMID:21617757   PMID:21633953   PMID:21638011  
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PMID:21952048   PMID:21963453   PMID:22006115   PMID:22024162   PMID:22028892   PMID:22128911   PMID:22131135   PMID:22134354   PMID:22158034   PMID:22246525   PMID:22248055   PMID:22267549  
PMID:22276203   PMID:22307688   PMID:22344746   PMID:22349639   PMID:22382019   PMID:22393371   PMID:22406531   PMID:22408413   PMID:22471493   PMID:22471696   PMID:22514743   PMID:22562246  
PMID:22562247   PMID:22580338   PMID:22580609   PMID:22586581   PMID:22629832   PMID:22745173   PMID:22791710   PMID:22820858   PMID:22903530   PMID:22923499   PMID:22974478   PMID:23011797  
PMID:23029563   PMID:23052737   PMID:23054398   PMID:23075682   PMID:23076049   PMID:23185371   PMID:23196056   PMID:23246564   PMID:23254865   PMID:23261431   PMID:23261444   PMID:23288509  
PMID:23342249   PMID:23431386   PMID:23435375   PMID:23449453   PMID:23454378   PMID:23496980   PMID:23510993   PMID:23522088   PMID:23524585   PMID:23582741   PMID:23611780   PMID:23644467  
PMID:23677639   PMID:23707238   PMID:23761168   PMID:23783653   PMID:23788111   PMID:23791009   PMID:23791882   PMID:23792447   PMID:23799116   PMID:23807662   PMID:23831330   PMID:23850675  
PMID:23856093   PMID:23891091   PMID:23900729   PMID:23973669   PMID:23979441   PMID:24001613   PMID:24022665   PMID:24081672   PMID:24085291   PMID:24106276   PMID:24126595   PMID:24154725  
PMID:24157836   PMID:24203464   PMID:24209753   PMID:24239292   PMID:24242829   PMID:24293287   PMID:24333218   PMID:24354880   PMID:24356933   PMID:24357458   PMID:24365974   PMID:24384091  
PMID:24402192   PMID:24410631   PMID:24424718   PMID:24489910   PMID:24503443   PMID:24561623   PMID:24565133   PMID:24607896   PMID:24610352   PMID:24638100   PMID:24648349   PMID:24675890  
PMID:24699649   PMID:24721928   PMID:24724096   PMID:24760275   PMID:24859886   PMID:24861866   PMID:24878522   PMID:24903147   PMID:24916398   PMID:24944064   PMID:24947186   PMID:24959930  
PMID:24999604   PMID:25003810   PMID:25019394   PMID:25041364   PMID:25055044   PMID:25059120   PMID:25078145   PMID:25088797   PMID:25122124   PMID:25124796   PMID:25164016   PMID:25172658  
PMID:25178837   PMID:25203322   PMID:25277775   PMID:25280941   PMID:25303734   PMID:25314079   PMID:25326810   PMID:25405790   PMID:25416956   PMID:25483191   PMID:25488750   PMID:25504116  
PMID:25547433   PMID:25607597   PMID:25608841   PMID:25639869   PMID:25640309   PMID:25681470   PMID:25784376   PMID:25832584   PMID:25869072   PMID:25893292   PMID:25938539   PMID:25961453  
PMID:25964055   PMID:25971970   PMID:25975373   PMID:25982273   PMID:26062664   PMID:26110567   PMID:26161782   PMID:26186194   PMID:26198055   PMID:26219900   PMID:26235880   PMID:26302187  
PMID:26305619   PMID:26307032   PMID:26321866   PMID:26336990   PMID:26362312   PMID:26498709   PMID:26510265   PMID:26527679   PMID:26549030   PMID:26571812   PMID:26617790   PMID:26648419  
PMID:26684241   PMID:26701730   PMID:26711268   PMID:26764010   PMID:26771232   PMID:26781944   PMID:26794444   PMID:26840564   PMID:26845447   PMID:26988558   PMID:27057280   PMID:27076520  
PMID:27113480   PMID:27129171   PMID:27171242   PMID:27184007   PMID:27188792   PMID:27191258   PMID:27322434   PMID:27363667   PMID:27409172   PMID:27452518   PMID:27455254   PMID:27461247  
PMID:27473084   PMID:27481218   PMID:27495232   PMID:27503928   PMID:27504909   PMID:27554601   PMID:27566588   PMID:27579892   PMID:27588479   PMID:27596137   PMID:27705942   PMID:27706642  
PMID:27749822   PMID:27755964   PMID:27793090   PMID:27807072   PMID:27829223   PMID:27851965   PMID:27855404   PMID:27863213   PMID:27878251   PMID:27894095   PMID:27956702   PMID:27995335  
PMID:28057716   PMID:28067227   PMID:28077400   PMID:28146149   PMID:28176759   PMID:28177890   PMID:28198361   PMID:28215642   PMID:28232080   PMID:28247164   PMID:28256591   PMID:28259904  
PMID:28296173   PMID:28299321   PMID:28334716   PMID:28335789   PMID:28339614   PMID:28349782   PMID:28400282   PMID:28424413   PMID:28431572   PMID:28442786   PMID:28459992   PMID:28466868  
PMID:28473536   PMID:28498415   PMID:28514442   PMID:28550287   PMID:28570750   PMID:28586004   PMID:28611395   PMID:28631560   PMID:28648644   PMID:28687755   PMID:28691764   PMID:28718374  
PMID:28778796   PMID:28803067   PMID:28806534   PMID:28849004   PMID:28892081   PMID:28912889   PMID:28925484   PMID:29032338   PMID:29059170   PMID:29101499   PMID:29117943   PMID:29155818  
PMID:29162839   PMID:29230000   PMID:29233829   PMID:29241546   PMID:29269046   PMID:29304493   PMID:29305973   PMID:29309923   PMID:29331416   PMID:29352246   PMID:29355657   PMID:29363574  
PMID:29374328   PMID:29385656   PMID:29415155   PMID:29427661   PMID:29431637   PMID:29434190   PMID:29445189   PMID:29475734   PMID:29488603   PMID:29513927   PMID:29559747   PMID:29601127  
PMID:29619372   PMID:29661250   PMID:29703902   PMID:29705809   PMID:29729076   PMID:29755680   PMID:29789583   PMID:29844345   PMID:29845196   PMID:29859299   PMID:29880891   PMID:29937187  
PMID:29945959   PMID:30021884   PMID:30058095   PMID:30094882   PMID:30099830   PMID:30132886   PMID:30165191   PMID:30189360   PMID:30216111   PMID:30219228   PMID:30272327   PMID:30321593  
PMID:30341688   PMID:30365089   PMID:30429463   PMID:30451989   PMID:30473218   PMID:30483750   PMID:30502437   PMID:30535480   PMID:30569152   PMID:30617305   PMID:30631151   PMID:30631154  
PMID:30664186   PMID:30664792   PMID:30679596   PMID:30679767   PMID:30684287   PMID:30690667   PMID:30736337   PMID:30770102   PMID:30770873   PMID:30772441   PMID:30793610   PMID:30798422  
PMID:30818851   PMID:30874360   PMID:30927556   PMID:30975732   PMID:31000195   PMID:31006800   PMID:31055699   PMID:31061416   PMID:31071459   PMID:31081061   PMID:31086816   PMID:31106370  
PMID:31114028   PMID:31131047   PMID:31131753   PMID:31165775   PMID:31209060   PMID:31221586   PMID:31239073   PMID:31243371   PMID:31266817   PMID:31311807   PMID:31383647   PMID:31391555  
PMID:31393789   PMID:31463973   PMID:31515488   PMID:31622717   PMID:31666207   PMID:31746377   PMID:31774615   PMID:31814518   PMID:31814570   PMID:31827075   PMID:31887300   PMID:31910234  
PMID:31911859   PMID:31970942   PMID:31982456   PMID:31998374   PMID:32011531   PMID:32096174   PMID:32124938   PMID:32277674   PMID:32296183   PMID:32306523   PMID:32319576   PMID:32319591  
PMID:32329192   PMID:32354171   PMID:32369597   PMID:32441446   PMID:32456793   PMID:32472219   PMID:32494626   PMID:32500474   PMID:32536816   PMID:32610184   PMID:32657545   PMID:32716347  
PMID:32736710   PMID:32742193   PMID:32784485   PMID:32824297   PMID:32828273   PMID:32867821   PMID:32945534   PMID:32973332   PMID:33099085   PMID:33132158   PMID:33162808   PMID:33166992  
PMID:33221433   PMID:33313663   PMID:33364200   PMID:33383483   PMID:33391500   PMID:33414422   PMID:33432364   PMID:33450239   PMID:33478150   PMID:33605548   PMID:33823623   PMID:33852841  
PMID:33880590   PMID:33897885   PMID:33961781   PMID:34026424   PMID:34040386   PMID:34214845   PMID:34242623   PMID:34249081   PMID:34265287   PMID:34335956   PMID:34335957   PMID:34347983  
PMID:34379517   PMID:34537302   PMID:34568024   PMID:34571852   PMID:34597678   PMID:34642464   PMID:34741724   PMID:34808498   PMID:34855201   PMID:34872023   PMID:34939898   PMID:35066576  
PMID:35075245   PMID:35163593   PMID:35300562   PMID:35434126   PMID:35506169   PMID:35541899   PMID:35562515   PMID:35563463   PMID:35595735   PMID:35605663   PMID:35739527  


Comparative Map Data
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382049,982,980 - 49,988,886 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2049,982,980 - 49,988,886 (+)EnsemblGRCh38hg38GRCh38
GRCh372048,599,517 - 48,605,423 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362048,032,934 - 48,038,830 (+)NCBINCBI36hg18NCBI36
Build 342048,032,933 - 48,038,825NCBI
Celera2045,304,074 - 45,309,984 (+)NCBI
Cytogenetic Map20q13.13NCBI
HuRef2045,348,282 - 45,354,192 (+)NCBIHuRef
CHM1_12048,504,120 - 48,510,030 (+)NCBICHM1_1
T2T-CHM13v2.02051,752,473 - 51,758,373 (+)NCBI
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm392167,380,115 - 167,384,734 (+)NCBIGRCm39mm39
GRCm39 Ensembl2167,380,115 - 167,384,734 (+)Ensembl
GRCm382167,538,195 - 167,542,814 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2167,538,195 - 167,542,814 (+)EnsemblGRCm38mm10GRCm38
MGSCv372167,363,727 - 167,368,314 (+)NCBIGRCm37mm9NCBIm37
MGSCv362167,229,432 - 167,234,019 (+)NCBImm8
Celera2173,478,489 - 173,483,072 (+)NCBICelera
Cytogenetic Map2H3NCBI
cM Map287.33NCBI
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.23156,248,479 - 156,252,969 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl3156,248,485 - 156,252,969 (+)Ensembl
Rnor_6.03164,274,710 - 164,279,199 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3164,274,710 - 164,279,378 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03170,425,898 - 170,430,387 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43158,676,980 - 158,681,471 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13158,583,924 - 158,586,727 (+)NCBI
Celera3154,827,543 - 154,832,032 (+)NCBICelera
Cytogenetic Map3q42NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554458,231,924 - 8,237,996 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554458,232,084 - 8,237,893 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.12047,384,818 - 47,390,738 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2047,384,818 - 47,390,733 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02046,321,075 - 46,328,865 (+)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12436,498,343 - 36,503,623 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2436,498,062 - 36,503,628 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2435,741,546 - 35,747,503 (+)NCBI
ROS_Cfam_1.02437,204,007 - 37,209,960 (+)NCBI
ROS_Cfam_1.0 Ensembl2437,204,036 - 37,209,945 (+)Ensembl
UMICH_Zoey_3.12436,445,442 - 36,451,401 (+)NCBI
UNSW_CanFamBas_1.02436,578,693 - 36,584,651 (+)NCBI
UU_Cfam_GSD_1.02437,122,272 - 37,128,230 (+)NCBI
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024408640189,002,837 - 189,012,567 (-)NCBI
SpeTri2.0NW_0049365144,456,498 - 4,462,436 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1751,546,477 - 51,552,499 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11751,546,446 - 51,552,498 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1213,988,059 - 13,993,780 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl213,988,024 - 13,993,746 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605062,416,997 - 62,422,718 (-)NCBIVero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247905,509,311 - 5,515,266 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046247905,509,541 - 5,515,240 (-)NCBIHetGla_female_1.0hetGla2

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID

Predicted Target Of
Summary Value
Count of predictions:467
Count of miRNA genes:385
Interacting mature miRNAs:404
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
Medium 615 1367 1036 83 403 64 1817 324 808 117 389 1296 22 997 982 3
Low 1806 1372 674 527 1125 388 2456 1774 2831 289 1058 304 148 207 1730 1
Below cutoff 11 242 13 12 378 12 81 94 69 12 1 8 76


Nucleotide Sequences
RefSeq Transcripts NM_005985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF125377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF131208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF155233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF177731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ245657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ245658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ245659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL121712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC012910 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI822180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA972913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HI422754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT583904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000244050   ⟹   ENSP00000244050
RefSeq Status:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2049,982,980 - 49,988,886 (+)Ensembl
RefSeq Acc Id: NM_005985   ⟹   NP_005976
RefSeq Status: REVIEWED
Human AssemblyChrPosition (strand)Source
GRCh382049,982,980 - 49,988,886 (+)NCBI
GRCh372048,599,513 - 48,605,423 (+)ENTREZGENE
Build 362048,032,934 - 48,038,830 (+)NCBI Archive
HuRef2045,348,282 - 45,354,192 (+)ENTREZGENE
CHM1_12048,504,120 - 48,510,030 (+)NCBI
T2T-CHM13v2.02051,752,473 - 51,758,373 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_005976   ⟸   NM_005985
- UniProtKB: Q9UHH7 (UniProtKB/Swiss-Prot),   O95863 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000244050   ⟸   ENST00000244050

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O95863-F1-model_v2 AlphaFold O95863 1-264 view protein structure

RGD ID:6799082
Promoter ID:HG_KWN:39787
SO ACC ID:SO:0000170
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid
Human AssemblyChrPosition (strand)Source
Build 362048,032,461 - 48,033,057 (+)MPROMDB
RGD ID:13207249
Promoter ID:EPDNEW_H27203
Type:multiple initiation site
Description:snail family transcriptional repressor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Human AssemblyChrPosition (strand)Source
GRCh382049,982,980 - 49,983,040EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 20q13.13-13.2(chr20:49731076-51202566)x1 copy number loss See cases [RCV000052767] Chr20:49731076..51202566 [GRCh38]
Chr20:48347613..49819103 [GRCh37]
Chr20:47781020..49252510 [NCBI36]
GRCh38/hg38 20q13.13-13.2(chr20:49947237-55875406)x3 copy number gain See cases [RCV000053037] Chr20:49947237..55875406 [GRCh38]
Chr20:48563774..54450462 [GRCh37]
Chr20:47997181..53883869 [NCBI36]
GRCh38/hg38 20q13.12-13.33(chr20:44787704-64277321)x3 copy number gain See cases [RCV000053035] Chr20:44787704..64277321 [GRCh38]
Chr20:43416345..62908674 [GRCh37]
Chr20:42849759..62379118 [NCBI36]
GRCh38/hg38 20p13-q13.33(chr20:99557-64277321)x3 copy number gain See cases [RCV000135859] Chr20:99557..64277321 [GRCh38]
Chr20:80198..62908674 [GRCh37]
Chr20:28198..62379118 [NCBI36]
GRCh37/hg19 20q13.13-13.2(chr20:47682662-49884981)x1 copy number loss See cases [RCV000167570] Chr20:47682662..49884981 [GRCh37]
likely pathogenic
GRCh37/hg19 20q13.13-13.2(chr20:47627844-52045480)x1 copy number loss See cases [RCV000511555] Chr20:47627844..52045480 [GRCh37]
GRCh37/hg19 20q13.13-13.2(chr20:47726521-50427649)x1 copy number loss See cases [RCV000511416] Chr20:47726521..50427649 [GRCh37]
likely pathogenic
GRCh37/hg19 20p13-q13.33(chr20:61569-62915555)x3 copy number gain See cases [RCV000510832] Chr20:61569..62915555 [GRCh37]
GRCh37/hg19 20p13-q13.33(chr20:61569-62915555) copy number gain See cases [RCV000512450] Chr20:61569..62915555 [GRCh37]
Single allele duplication not provided [RCV000677941] Chr20:46962638..50647699 [GRCh37]
uncertain significance
GRCh37/hg19 20p13-q13.33(chr20:63244-62948788)x3 copy number gain not provided [RCV000741058] Chr20:63244..62948788 [GRCh37]
GRCh37/hg19 20p13-q13.33(chr20:63244-62961294)x3 copy number gain not provided [RCV000741059] Chr20:63244..62961294 [GRCh37]
GRCh37/hg19 20p13-q13.33(chr20:63244-62912463)x3 copy number gain not provided [RCV000741057] Chr20:63244..62912463 [GRCh37]
NM_005985.4(SNAI1):c.197C>T (p.Ala66Val) single nucleotide variant not provided [RCV000948053] Chr20:49983938 [GRCh38]
Chr20:48600475 [GRCh37]

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:11128 AgrOrtholog
Ensembl Genes ENSG00000124216 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000244050 ENTREZGENE
  ENSP00000244050.2 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000244050 ENTREZGENE
  ENST00000244050.3 UniProtKB/Swiss-Prot
GTEx ENSG00000124216 GTEx
Human Proteome Map SNAI1 Human Proteome Map
InterPro Znf_C2H2_sf UniProtKB/Swiss-Prot
  Znf_C2H2_type UniProtKB/Swiss-Prot
KEGG Report hsa:6615 UniProtKB/Swiss-Prot
OMIM 604238 OMIM
Pfam zf-C2H2 UniProtKB/Swiss-Prot
PharmGKB PA35977 PharmGKB
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot
SMART ZnF_C2H2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57667 UniProtKB/Swiss-Prot
  SNAI1_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary B2R842 UniProtKB/Swiss-Prot
  Q9P113 UniProtKB/Swiss-Prot
  Q9UBP7 UniProtKB/Swiss-Prot
  Q9UHH7 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-10 SNAI1  snail family transcriptional repressor 1  SNAI1  snail family zinc finger 1  Symbol and/or name change 5135510 APPROVED
2013-06-04 SNAI1  snail family zinc finger 1  SNAI1  snail homolog 1 (Drosophila)  Symbol and/or name change 5135510 APPROVED