AR (androgen receptor) - Rat Genome Database
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Gene: AR (androgen receptor) Homo sapiens
Symbol: AR
Name: androgen receptor
RGD ID: 735652
Description: Exhibits several functions, including ATPase binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and transcription factor binding activity. Involved in several processes, including cellular response to hormone stimulus; cellular response to testosterone stimulus; and regulation of macromolecule biosynthetic process. Localizes to cytoplasm; nuclear lumen; and protein-containing complex. Implicated in several diseases, including attention deficit hyperactivity disorder; conduct disorder; disorder of sexual development (multiple); reproductive organ cancer (multiple); and spinal muscular atrophy (multiple). Biomarker of ductal carcinoma in situ; hypospadias; invasive ductal carcinoma; and prostate cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AIS; androgen nuclear receptor variant 2; androgen receptor splice variant 4b; AR8; DHTR; dihydrotestosterone receptor; HUMARA; HYSP1; KD; Kennedy disease; NR3C4; nuclear receptor subfamily 3 group C member 4; SBMA; SMAX1; spinal and bulbar muscular atrophy; testicular feminization; TFM
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 EnsemblX67,544,021 - 67,730,619 (+)EnsemblGRCh38hg38GRCh38
GRCh38X67,544,021 - 67,730,619 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X66,763,874 - 66,950,461 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X66,680,599 - 66,860,844 (+)NCBINCBI36hg18NCBI36
Build 34X66,571,703 - 66,727,140NCBI
CeleraX67,112,960 - 67,293,967 (+)NCBI
Cytogenetic MapXq12NCBI
HuRefX60,592,006 - 60,778,929 (+)NCBIHuRef
CHM1_1X66,656,369 - 66,842,989 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
alopecia  (EXP)
androgen insensitivity syndrome  (EXP,IAGP,ISO)
astrocytoma  (EXP)
attention deficit hyperactivity disorder  (IAGP)
autistic disorder  (EXP,IAGP)
Breast Neoplasms  (EXP)
Castration-Resistant Prostatic Neoplasms  (EXP)
conduct disorder  (IAGP)
coronary artery disease  (IEA)
cryptorchidism  (IAGP)
Denys-Drash syndrome  (ISO)
ductal carcinoma in situ  (IEP)
endocrine system disease  (IAGP)
endometrial cancer  (IAGP)
endometriosis  (IAGP)
Experimental Diabetes Mellitus  (ISO)
Fabry disease  (ISO)
Familial Prostate Cancer  (IAGP)
Female Infertility  (EXP)
genetic disease  (IAGP)
gestational diabetes  (EXP)
hepatocellular carcinoma  (EXP)
hypertension  (EXP,ISO)
hypospadias  (IAGP,IEA,IEP)
Hypospadias 1, X-Linked  (IAGP)
Insulin Resistance  (EXP,IAGP,IDA)
invasive ductal carcinoma  (IEP)
Kennedy's disease  (IAGP,IMP)
Knee Osteoarthritis  (IAGP)
leiomyoma  (IAGP)
leukemia  (EXP)
Lung Neoplasms  (EXP)
Male Breast Neoplasms  (EXP,IEP)
male infertility  (EXP)
male reproductive system disease  (EXP)
Mammary Neoplasms, Experimental  (ISO)
Mayer-Rokitansky-Kuster-Hauser syndrome  (IAGP)
multicentric Castleman disease  (IAGP)
Neoplasm Recurrence, Local  (EXP)
obesity  (IAGP,IEA,ISS)
oppositional defiant disorder  (IAGP)
osteoporosis  (ISO)
Osteoporotic Fractures  (IAGP)
partial androgen insensitivity syndrome  (IAGP)
polycystic ovary syndrome  (IAGP)
Postmenopausal Osteoporosis  (IAGP)
prostate adenocarcinoma  (ISO)
prostate cancer  (IAGP,IDA,IEP,ISO)
Prostate Cancer, Somatic  (IAGP)
prostate carcinoma in situ  (EXP)
prostatic hypertrophy  (ISO)
Prostatic Neoplasms  (EXP,ISO)
Sarcopenia  (ISO)
spinal muscular atrophy  (IAGP)
syndromic X-linked intellectual disability Lubs type  (IAGP)
type 2 diabetes mellitus  (ISS)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-nootkatone  (EXP)
(-)-Arctigenin  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
(20R)-17,20-dihydroxypregn-4-en-3-one  (EXP)
(20S)-ginsenoside Rg3  (EXP)
(E)-thiamethoxam  (EXP)
(R)-linalyl acetate  (EXP)
(S)-duloxetine hydrochloride  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2,3,6,7,8-Hexachlorodibenzodioxin  (EXP)
1,4-dithiothreitol  (ISO)
1-Hydroxypyrene  (EXP)
1-methylphenanthrene  (ISO)
1-naphthaldehyde  (ISO)
1-naphthol  (ISO)
1-naphthyl isothiocyanate  (EXP)
1-nitropyrene  (EXP)
10H-phenothiazine  (EXP)
11-deoxycorticosterone  (EXP)
11-deoxycortisol  (EXP)
11beta,21-Dihydroxypregn-4-ene-3,20-dione 21-acetate  (EXP)
15-acetyldeoxynivalenol  (EXP)
16-alpha,17-Epoxypregn-4-ene-3,20-dione  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17alpha-hydroxyprogesterone  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
2,2',3,3',6,6'-hexachlorobiphenyl  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',4,4'-tetrachlorobiphenyl  (EXP,ISO)
2,2',4,5'-Tetrabromodiphenyl ether  (EXP)
2,2',4,5-tetrachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,2-(2-Chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene  (EXP,ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3',5-trichlorobiphenyl  (EXP)
2,3,3',4,4',5,5'-Heptachlorobiphenyl  (EXP)
2,3,3',4,4',5-Hexachlorobiphenyl  (EXP)
2,3,4,3',4'-Pentachlorobiphenyl  (EXP)
2,3,4,4'-tetrachlorobiphenyl  (EXP)
2,3,4,5-Tetrachloro-4'-biphenylol  (ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP)
2,3,5,6-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4'-dichlorobiphenyl  (EXP,ISO)
2,4-D  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2,4-dichlorophenol  (EXP,ISO)
2,4-Dihydroxybenzophenone  (ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2,6-dichlorobiphenyl  (EXP)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (EXP)
2-chlorobiphenyl  (EXP)
2-hydroxy-17beta-estradiol  (ISO)
2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester  (EXP)
2-hydroxypropanoic acid  (EXP)
2-naphthol  (ISO)
2-sec-butylphenol  (ISO)
2-tert-butylhydroquinone  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3'-Dichlorobenzidine  (EXP)
3,3'-diindolylmethane  (EXP)
3,3'-Dimethoxybenzidine  (EXP)
3,5-dichlorobiphenyl  (EXP)
3,6-diaminoacridine  (EXP)
3-acetyldeoxynivalenol  (EXP)
3-chlorophenol  (ISO)
3-phenoxybenzoic acid  (EXP)
4'-epidoxorubicin  (EXP)
4'-hydroxydiclofenac  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-Dichlorobenzophenone  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (EXP)
4-chloro-2-methylphenol  (ISO)
4-chloro-m-cresol  (EXP,ISO)
4-hexylbenzene-1,3-diol  (EXP)
4-hydroxy-17beta-estradiol  (ISO)
4-Hydroxybenzophenone  (ISO)
4-hydroxychalcone  (ISO)
4-nitrophenol  (ISO)
4-nonylphenol  (EXP,ISO)
4-octylphenol  (EXP,ISO)
4-tert-butylphenol  (ISO)
4-tert-Octylphenol  (EXP,ISO)
5-aza-2'-deoxycytidine  (EXP)
5-azacytidine  (EXP)
5-chloro-7-iodoquinolin-8-ol  (EXP)
5alpha-Androstan-17beta-ol  (ISO)
6-propyl-2-thiouracil  (ISO)