AR (androgen receptor) - Rat Genome Database
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Gene: AR (androgen receptor) Sus scrofa
Analyze
Symbol: AR
Name: androgen receptor
RGD ID: 14067307
Description: ENCODES a protein that exhibits androgen binding (ortholog); androgen receptor binding (ortholog); beta-catenin binding (ortholog); INVOLVED IN activation of prostate induction by androgen receptor signaling pathway (ortholog); androgen receptor signaling pathway (ortholog); animal organ formation (ortholog); PARTICIPATES IN altered androgen signaling pathway; androgen signaling pathway; forkhead class A signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); alopecia (ortholog); androgen insensitivity syndrome (ortholog); FOUND IN axon (ortholog); chromatin (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: androgen receptor (dihydrotestosterone receptor, testicular feminization, spinal and bulbar muscular atrophy, Kennedy disease); androgen receptor AR; dihydrotestosterone receptor; NR3C4; nuclear receptor subfamily 3 group C member 4; SBMA
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX53,609,176 - 53,805,578 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X53,609,113 - 53,806,778 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X60,313,281 - 60,504,529 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig CytomapXq11-q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
alopecia  (ISO)
androgen insensitivity syndrome  (ISO)
attention deficit hyperactivity disorder  (ISO)
autistic disorder  (ISO)
Breast Neoplasms  (ISO)
Castration-Resistant Prostatic Neoplasms  (ISO)
conduct disorder  (ISO)
cryptorchidism  (ISO)
Denys-Drash syndrome  (ISO)
ductal carcinoma in situ  (ISO)
endometrial cancer  (ISO)
endometriosis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Fabry disease  (ISO)
Familial Prostate Cancer  (ISO)
Female Infertility  (ISO)
genetic disease  (ISO)
gestational diabetes  (ISO)
hepatocellular carcinoma  (ISO)
hypertension  (ISO)
hypospadias  (ISO)
Hypospadias 1, X-Linked  (ISO)
Insulin Resistance  (ISO)
invasive ductal carcinoma  (ISO)
Kennedy's disease  (ISO)
Knee Osteoarthritis  (ISO)
leiomyoma  (ISO)
leukemia  (ISO)
Lung Neoplasms  (ISO)
Male Breast Neoplasms  (ISO)
male infertility  (ISO)
male reproductive system disease  (ISO)
malignant astrocytoma  (ISO)
Mammary Neoplasms, Experimental  (ISO)
Mayer-Rokitansky-Kuster-Hauser syndrome  (ISO)
multicentric Castleman disease  (ISO)
Neoplasm Recurrence, Local  (ISO)
obesity  (ISO)
oppositional defiant disorder  (ISO)
osteoporosis  (ISO)
Osteoporotic Fractures  (ISO)
partial androgen insensitivity syndrome  (ISO)
polycystic ovary syndrome  (ISO)
Postmenopausal Osteoporosis  (ISO)
prostate adenocarcinoma  (ISO)
prostate cancer  (ISO)
Prostate Cancer, Somatic  (ISO)
prostate carcinoma in situ  (ISO)
prostatic hypertrophy  (ISO)
Prostatic Neoplasms  (ISO)
Sarcopenia  (ISO)
spinal muscular atrophy  (ISO)
syndromic X-linked intellectual disability Lubs type  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of prostate induction by androgen receptor signaling pathway  (IEA,ISO)
androgen receptor signaling pathway  (IEA,ISO,ISS)
animal organ formation  (IEA,ISO)
cellular process  (ISO)
cellular response to estrogen stimulus  (IEA)
cellular response to follicle-stimulating hormone stimulus  (ISO)
cellular response to steroid hormone stimulus  (ISO)
cellular response to testosterone stimulus  (IEA,ISO)
copulation  (ISO)
epithelial cell differentiation involved in prostate gland development  (IEA,ISO)
epithelial cell morphogenesis  (IEA,ISO)
fertilization  (ISO)
in utero embryonic development  (IEA,ISO)
intracellular estrogen receptor signaling pathway  (IEA)
intracellular receptor signaling pathway  (ISS)
intracellular steroid hormone receptor signaling pathway  (IBA)
lateral sprouting involved in mammary gland duct morphogenesis  (IEA,ISO)
Leydig cell differentiation  (IEA,ISO)
male courtship behavior  (ISO)
male genitalia morphogenesis  (IEA,ISO)
male gonad development  (IBA,ISO)
male sex differentiation  (ISO)
male somatic sex determination  (IEA,ISO)
mammary gland alveolus development  (IEA,ISO)
morphogenesis of an epithelial fold  (IEA,ISO)
multicellular organism growth  (IEA,ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of epithelial cell proliferation  (IEA,ISO)
negative regulation of extrinsic apoptotic signaling pathway  (IEA,ISS)
negative regulation of integrin biosynthetic process  (IEA,ISS)
negative regulation of transcription by RNA polymerase II  (IEA)
negative regulation of transcription, DNA-templated  (ISO)
positive regulation of cell differentiation  (IEA)
positive regulation of cell population proliferation  (ISS)
positive regulation of epithelial cell proliferation involved in prostate gland development  (IEA,ISO)
positive regulation of gene expression  (IEA,ISS)
positive regulation of insulin-like growth factor receptor signaling pathway  (IEA,ISO)
positive regulation of integrin biosynthetic process  (IEA)
positive regulation of intracellular estrogen receptor signaling pathway  (IEA,ISO)
positive regulation of MAPK cascade  (IEA,ISO)
positive regulation of NF-kappaB transcription factor activity  (IEA,ISS)
positive regulation of penile erection  (ISO)
positive regulation of phosphorylation  (IEA,ISS)
positive regulation of transcription by RNA polymerase II  (IEA,ISO,ISS)
positive regulation of transcription by RNA polymerase III  (IEA)
positive regulation of transcription, DNA-templated  (ISO)
prostate gland epithelium morphogenesis  (IEA,ISO)
prostate gland growth  (IEA,ISO)
regulation of developmental growth  (IEA,ISO)
regulation of gene expression  (ISO)
regulation of prostatic bud formation  (ISO)
regulation of protein localization to plasma membrane  (IEA,ISS)
regulation of systemic arterial blood pressure  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IBA,ISO)
regulation of transcription, DNA-templated  (IEA,ISO)
reproductive behavior  (ISO)
reproductive structure development  (ISO)
reproductive system development  (ISO)
response to estradiol  (ISO)
response to insulin  (ISO)
response to testosterone  (ISO)
seminiferous tubule development  (IEA,ISO)
single fertilization  (IEA,ISO)
skeletal muscle hypertrophy  (ISO)
spermatogenesis  (IEA,ISO)
tertiary branching involved in mammary gland duct morphogenesis  (IEA,ISO)

Cellular Component
axon  (ISO)
chromatin  (IEA,ISS)
cytoplasm  (IEA,ISO,ISS)
cytosol  (IEA)
dendrite  (ISO)
nuclear speck  (IEA)
nucleus  (IEA,ISO,ISS)
plasma membrane  (IEA,ISO)
protein-containing complex  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:11086548   PMID:15157735   PMID:17482664   PMID:17553131   PMID:22522230   PMID:24151599  


Genomics

Comparative Map Data
AR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX53,609,176 - 53,805,578 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X53,609,113 - 53,806,778 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X60,313,281 - 60,504,529 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig CytomapXq11-q13NCBI
AR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX67,544,021 - 67,730,619 (+)EnsemblGRCh38hg38GRCh38
GRCh38X67,544,021 - 67,730,619 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X66,763,863 - 66,950,461 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh37X66,763,874 - 66,950,461 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X66,680,599 - 66,860,844 (+)NCBINCBI36hg18NCBI36
Build 34X66,571,703 - 66,727,140NCBI
CeleraX67,112,960 - 67,293,967 (+)NCBI
Cytogenetic MapXq12NCBI
HuRefX60,592,006 - 60,778,929 (+)NCBIHuRef
CHM1_1X66,656,369 - 66,842,989 (+)NCBICHM1_1
Ar
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X97,192,363 - 97,366,824 (+)NCBIGRCm39mm39
GRCm38X98,148,757 - 98,323,218 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX98,148,769 - 98,323,215 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X95,345,089 - 95,512,486 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X94,352,469 - 94,519,866 (+)NCBImm8
CeleraX85,096,584 - 85,263,216 (+)NCBICelera
Cytogenetic MapXC3NCBI
cM MapX42.82NCBI
Ar
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X63,104,771 - 63,273,934 (+)NCBI
Rnor_6.0 EnsemblX67,656,253 - 67,829,026 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0X67,656,253 - 67,828,998 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X68,533,662 - 68,705,929 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X85,949,507 - 86,119,199 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X86,022,798 - 86,192,491 (+)NCBI
CeleraX63,512,152 - 63,679,533 (+)NCBICelera
Cytogenetic MapXq22NCBI
Ar
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554757,013,960 - 7,186,069 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554757,013,960 - 7,192,473 (+)NCBIChiLan1.0ChiLan1.0
AR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X66,790,419 - 66,975,921 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX66,791,081 - 66,969,357 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X56,722,828 - 56,909,004 (+)NCBIMhudiblu_PPA_v0panPan3
AR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 EnsemblX51,969,785 - 52,151,912 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12434,713,390 - 34,731,461 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1X51,969,785 - 52,167,450 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ar
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936635485,903 - 647,820 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AR
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X57,380,587 - 57,553,613 (+)NCBI
ChlSab1.1 EnsemblX57,380,611 - 57,546,776 (+)Ensembl
Ar
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248913,135,824 - 3,330,487 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 2 3
Low 4 2 3 3 2 16 1
Below cutoff 4 2 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000013528   ⟹   ENSSSCP00000013166
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 EnsemblX53,609,285 - 53,802,018 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000061391   ⟹   ENSSSCP00000056596
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 EnsemblX53,609,176 - 53,767,226 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000064060   ⟹   ENSSSCP00000043455
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 EnsemblX53,633,615 - 53,805,578 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000073087   ⟹   ENSSSCP00000067369
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 EnsemblX53,609,176 - 53,800,145 (+)Ensembl
RefSeq Acc Id: NM_214314   ⟹   NP_999479
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1X53,610,362 - 53,800,369 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013986227   ⟹   XP_013841681
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1X53,609,115 - 53,806,778 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021079513   ⟹   XP_020935172
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1X53,609,113 - 53,806,778 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_020935172   ⟸   XM_021079513
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_013841681   ⟸   XM_013986227
- Peptide Label: isoform X1
- UniProtKB: F1RTM6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_999479   ⟸   NM_214314
- UniProtKB: Q9GKL7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSSSCP00000043455   ⟸   ENSSSCT00000064060
RefSeq Acc Id: ENSSSCP00000056596   ⟸   ENSSSCT00000061391
RefSeq Acc Id: ENSSSCP00000013166   ⟸   ENSSSCT00000013528
RefSeq Acc Id: ENSSSCP00000067369   ⟸   ENSSSCT00000073087
Protein Domains
NR LBD   Nuclear receptor


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000012371 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070026766 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000013166 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000043455 UniProtKB/TrEMBL
  ENSSSCP00000056596 UniProtKB/TrEMBL
  ENSSSCP00000067369 UniProtKB/TrEMBL
  ENSSSCP00070045612 UniProtKB/TrEMBL
  ENSSSCP00070045649 UniProtKB/TrEMBL
  ENSSSCP00070045656 UniProtKB/TrEMBL
  ENSSSCP00070045673 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000013528 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000061391 UniProtKB/TrEMBL
  ENSSSCT00000064060 UniProtKB/TrEMBL
  ENSSSCT00000073087 UniProtKB/TrEMBL
  ENSSSCT00070053803 UniProtKB/TrEMBL
  ENSSSCT00070053845 UniProtKB/TrEMBL
  ENSSSCT00070053852 UniProtKB/TrEMBL
  ENSSSCT00070053868 UniProtKB/TrEMBL
Gene3D-CATH 1.10.565.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.50.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Andrgn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NHR-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucl_hrmn_rcpt_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuclear_hrmn_rcpt UniProtKB/TrEMBL
  Znf_hrmn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:397582 UniProtKB/Swiss-Prot
NCBI Gene AR ENTREZGENE
Pfam Androgen_recep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hormone_recep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS ANDROGENR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STRDHORMONER UniProtKB/TrEMBL
  STROIDFINGER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NR_LBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HOLI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnF_C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48508 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1B2TT49_PIG UniProtKB/TrEMBL
  A0A287AHV0_PIG UniProtKB/TrEMBL
  A0A287BJP3_PIG UniProtKB/TrEMBL
  A0A4X1VQ12_PIG UniProtKB/TrEMBL
  A0A4X1VUS1_PIG UniProtKB/TrEMBL
  A0A4X1VUX3_PIG UniProtKB/TrEMBL
  A0A4X1VWJ2_PIG UniProtKB/TrEMBL
  A0A5G2QRH9_PIG UniProtKB/TrEMBL
  ANDR_PIG UniProtKB/Swiss-Prot
  F1RTM6 ENTREZGENE, UniProtKB/TrEMBL
  Q9BE98_PIG UniProtKB/TrEMBL
  Q9GKL7 ENTREZGENE
  Q9XS80_PIG UniProtKB/TrEMBL
UniProt Secondary Q9GKN9 UniProtKB/Swiss-Prot
VGNC ID VGNC:103903 ENTREZGENE