AR (androgen receptor) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: AR (androgen receptor) Canis lupus familiaris
Analyze
Symbol: AR
Name: androgen receptor
RGD ID: 12330959
Description: ENCODES a protein that exhibits androgen binding (ortholog); beta-catenin binding (ortholog); chromatin binding (ortholog); INVOLVED IN activation of prostate induction by androgen receptor signaling pathway (ortholog); androgen receptor signaling pathway (ortholog); animal organ formation (ortholog); PARTICIPATES IN altered androgen signaling pathway; androgen signaling pathway; forkhead class A signaling pathway; ASSOCIATED WITH 46,XY sex reversal (ortholog); acute kidney failure (ortholog); alopecia (ortholog); FOUND IN axon (ortholog); chromatin (ortholog); cytoplasm (ortholog); INTERACTS WITH eplerenone
Type: protein-coding
RefSeq Status: MODEL
Previously known as: androgen receptor (dihydrotestosterone receptor, testicular feminization, spinal and bulbar muscular atrophy, Kennedy disease); canine androgen receptor; dihydrotestosterone receptor; nuclear receptor subfamily 3 group C member 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X51,969,785 - 52,167,450 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.12434,713,390 - 34,731,461 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX51,969,785 - 52,151,912 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX42,802,440 - 42,991,502 (+)NCBI
ROS_Cfam_1.0X52,938,974 - 53,121,719 (+)NCBI
ROS_Cfam_1.0 EnsemblX52,939,453 - 53,121,588 (+)Ensembl
UMICH_Zoey_3.1X50,910,919 - 51,093,566 (+)NCBI
UNSW_CanFamBas_1.0X52,242,285 - 52,424,949 (+)NCBI
UU_Cfam_GSD_1.0X52,163,183 - 52,345,868 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
46,XY sex reversal  (ISO)
acute kidney failure  (ISO)
alopecia  (ISO)
androgen insensitivity syndrome  (ISO)
aromatase excess syndrome  (ISO)
attention deficit hyperactivity disorder  (ISO)
autistic disorder  (ISO)
Breast Neoplasms  (ISO)
castration-resistant prostate carcinoma  (ISO)
conduct disorder  (ISO)
cryptorchidism  (ISO)
Denys-Drash syndrome  (ISO)
ductal carcinoma in situ  (ISO)
endometrial cancer  (ISO)
endometriosis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Fabry disease  (ISO)
Familial Prostate Cancer  (ISO)
Female Infertility  (ISO)
genetic disease  (ISO)
gestational diabetes  (ISO)
hepatocellular carcinoma  (ISO)
hypertension  (ISO)
hypospadias  (ISO)
Hypospadias 1, X-Linked  (ISO)
Insulin Resistance  (ISO)
invasive ductal carcinoma  (ISO)
Kennedy's disease  (ISO)
Knee Osteoarthritis  (ISO)
leiomyoma  (ISO)
leukemia  (ISO)
Lubs Syndrome  (ISO)
Lung Neoplasms  (ISO)
Male Breast Neoplasms  (ISO)
male infertility  (ISO)
male reproductive system disease  (ISO)
malignant astrocytoma  (ISO)
Mammary Neoplasms, Experimental  (ISO)
Mayer-Rokitansky-Kuster-Hauser syndrome  (ISO)
multicentric Castleman disease  (ISO)
Neoplasm Recurrence, Local  (ISO)
obesity  (ISO)
oppositional defiant disorder  (ISO)
osteoporosis  (ISO)
Osteoporotic Fractures  (ISO)
partial androgen insensitivity syndrome  (ISO)
polycystic ovary syndrome  (ISO)
Postmenopausal Osteoporosis  (ISO)
prostate adenocarcinoma  (ISO)
prostate cancer  (ISO)
Prostate Cancer, Somatic  (ISO)
prostate carcinoma in situ  (ISO)
prostatic hypertrophy  (ISO)
Prostatic Neoplasms  (ISO)
Sarcopenia  (ISO)
spermatogenic failure 3  (ISO)
spinal muscular atrophy  (ISO)
syndromic X-linked intellectual disability Lubs type  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
eplerenone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of prostate induction by androgen receptor signaling pathway  (ISO)
androgen receptor signaling pathway  (IEA,ISO,ISS)
animal organ formation  (ISO)
cellular response to estrogen stimulus  (IEA)
cellular response to follicle-stimulating hormone stimulus  (ISO)
cellular response to steroid hormone stimulus  (ISO)
cellular response to testosterone stimulus  (IEA)
copulation  (ISO)
DNA-templated transcription  (ISO)
epithelial cell differentiation involved in prostate gland development  (ISO)
epithelial cell morphogenesis  (ISO)
epithelial cell proliferation  (ISO)
fertilization  (ISO)
in utero embryonic development  (ISO)
insulin-like growth factor receptor signaling pathway  (ISO)
intracellular estrogen receptor signaling pathway  (IEA,ISO)
intracellular receptor signaling pathway  (ISS)
intracellular steroid hormone receptor signaling pathway  (IBA)
lateral sprouting involved in mammary gland duct morphogenesis  (ISO)
Leydig cell differentiation  (ISO)
male courtship behavior  (ISO)
male genitalia morphogenesis  (ISO)
male gonad development  (IBA,ISO)
male sex differentiation  (ISO)
male somatic sex determination  (ISO)
mammary gland alveolus development  (ISO)
MAPK cascade  (ISO)
morphogenesis of an epithelial fold  (ISO)
multicellular organism growth  (ISO)
negative regulation of cell population proliferation  (IEA)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of extrinsic apoptotic signaling pathway  (IEA,ISS)
negative regulation of integrin biosynthetic process  (IEA,ISS)
negative regulation of transcription by RNA polymerase II  (IEA)
positive regulation of cell differentiation  (IEA)
positive regulation of cell population proliferation  (IEA,ISS)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of epithelial cell proliferation involved in prostate gland development  (ISO)
positive regulation of gene expression  (IEA,ISS)
positive regulation of insulin-like growth factor receptor signaling pathway  (ISO)
positive regulation of integrin biosynthetic process  (IEA)
positive regulation of intracellular estrogen receptor signaling pathway  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of NF-kappaB transcription factor activity  (IEA,ISS)
positive regulation of penile erection  (ISO)
positive regulation of phosphorylation  (IEA,ISS)
positive regulation of transcription by RNA polymerase II  (IEA,ISO,ISS)
positive regulation of transcription by RNA polymerase III  (IEA)
prostate gland epithelium morphogenesis  (ISO)
prostate gland growth  (ISO)
regulation of developmental growth  (ISO)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of gene expression  (ISO)
regulation of prostatic bud formation  (ISO)
regulation of protein localization to plasma membrane  (IEA,ISS)
regulation of systemic arterial blood pressure  (ISO)
regulation of transcription by RNA polymerase II  (IBA,ISO)
reproductive behavior  (ISO)
reproductive structure development  (ISO)
reproductive system development  (ISO)
response to estradiol  (ISO)
response to insulin  (ISO)
response to testosterone  (ISO)
seminiferous tubule development  (ISO)
single fertilization  (ISO)
skeletal muscle hypertrophy  (ISO)
spermatogenesis  (ISO)
tertiary branching involved in mammary gland duct morphogenesis  (ISO)
transcription by RNA polymerase II  (ISO)

Cellular Component
axon  (ISO)
chromatin  (IEA,ISS)
cytoplasm  (IEA,ISO,ISS)
cytosol  (IEA)
dendrite  (ISO)
nuclear speck  (IEA)
nucleus  (IEA,ISO,ISS)
plasma membrane  (ISO)
protein-containing complex  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:8291737   PMID:11768233   PMID:18198998   PMID:18583166   PMID:19136389   PMID:19482445   PMID:26767421   PMID:28599655   PMID:30925701   PMID:31055572  


Genomics

Comparative Map Data
AR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X51,969,785 - 52,167,450 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.12434,713,390 - 34,731,461 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX51,969,785 - 52,151,912 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX42,802,440 - 42,991,502 (+)NCBI
ROS_Cfam_1.0X52,938,974 - 53,121,719 (+)NCBI
ROS_Cfam_1.0 EnsemblX52,939,453 - 53,121,588 (+)Ensembl
UMICH_Zoey_3.1X50,910,919 - 51,093,566 (+)NCBI
UNSW_CanFamBas_1.0X52,242,285 - 52,424,949 (+)NCBI
UU_Cfam_GSD_1.0X52,163,183 - 52,345,868 (+)NCBI
AR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X67,544,021 - 67,730,619 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 EnsemblX67,544,021 - 67,730,619 (+)EnsemblGRCh38hg38GRCh38
GRCh37X66,763,863 - 66,950,461 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X66,680,599 - 66,860,844 (+)NCBINCBI36hg18NCBI36
Build 34X66,571,703 - 66,727,140NCBI
CeleraX67,112,960 - 67,293,967 (+)NCBI
Cytogenetic MapXq12NCBI
HuRefX60,592,006 - 60,778,929 (+)NCBIHuRef
CHM1_1X66,656,369 - 66,842,989 (+)NCBICHM1_1
T2T-CHM13v2.0X65,973,852 - 66,160,479 (+)NCBI
Ar
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X97,192,363 - 97,366,824 (+)NCBIGRCm39mm39
GRCm39 EnsemblX97,192,375 - 97,366,821 (+)Ensembl
GRCm38X98,148,757 - 98,323,218 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX98,148,769 - 98,323,215 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X95,345,089 - 95,512,486 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X94,352,469 - 94,519,866 (+)NCBImm8
CeleraX85,096,584 - 85,263,216 (+)NCBICelera
Cytogenetic MapXC3NCBI
cM MapX42.82NCBI
Ar
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X63,104,771 - 63,273,934 (+)NCBImRatBN7.2
mRatBN7.2 EnsemblX63,104,771 - 63,273,925 (+)Ensembl
Rnor_6.0X67,656,253 - 67,828,998 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX67,656,253 - 67,829,026 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X68,533,662 - 68,705,929 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X85,949,507 - 86,119,199 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X86,022,798 - 86,192,491 (+)NCBI
CeleraX63,512,152 - 63,679,533 (+)NCBICelera
Cytogenetic MapXq22NCBI
Ar
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554757,013,960 - 7,186,069 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554757,013,960 - 7,192,473 (+)NCBIChiLan1.0ChiLan1.0
AR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X66,790,419 - 66,975,921 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX66,791,081 - 66,969,357 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X56,722,828 - 56,909,004 (+)NCBIMhudiblu_PPA_v0panPan3
Ar
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X49,717,252 - 49,882,487 (-)NCBI
SpeTri2.0NW_004936635485,903 - 647,820 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX53,609,176 - 53,800,677 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X53,609,113 - 53,806,778 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X60,313,281 - 60,504,529 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig CytomapXq11-q13NCBI
AR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X57,380,587 - 57,553,613 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 EnsemblX57,380,611 - 57,546,776 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660834,772,253 - 4,943,244 (+)NCBIVero_WHO_p1.0
Ar
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248913,138,848 - 3,329,459 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046248913,135,824 - 3,330,487 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 9 1 1 4
Below cutoff 5 5 13 5 6 5 6 6 8 8 10 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000026381   ⟹   ENSCAFP00000024499
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 EnsemblX51,969,785 - 52,151,912 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000090246   ⟹   ENSCAFP00000057697
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 EnsemblX51,992,318 - 52,151,912 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845049586   ⟹   ENSCAFP00845038896
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 EnsemblX52,939,453 - 53,121,588 (+)Ensembl
RefSeq Acc Id: XM_038450180   ⟹   XP_038306108
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0X52,938,974 - 53,121,719 (+)NCBI
RefSeq Acc Id: XM_038464610   ⟹   XP_038320538
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_TashaX42,802,440 - 42,991,502 (+)NCBI
RefSeq Acc Id: XM_038523625   ⟹   XP_038379553
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1X50,910,919 - 51,093,566 (+)NCBI
RefSeq Acc Id: XM_038587597   ⟹   XP_038443525
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0X52,163,183 - 52,345,868 (+)NCBI
RefSeq Acc Id: XM_038652120   ⟹   XP_038508048
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0X52,242,285 - 52,424,949 (+)NCBI
Reference Sequences
RefSeq Acc Id: ENSCAFP00000057697   ⟸   ENSCAFT00000090246
RefSeq Acc Id: ENSCAFP00000024499   ⟸   ENSCAFT00000026381
RefSeq Acc Id: XP_038379553   ⟸   XM_038523625
RefSeq Acc Id: XP_038508048   ⟸   XM_038652120
RefSeq Acc Id: XP_038306108   ⟸   XM_038450180
RefSeq Acc Id: XP_038320538   ⟸   XM_038464610
RefSeq Acc Id: XP_038443525   ⟸   XM_038587597
RefSeq Acc Id: ENSCAFP00845038896   ⟸   ENSCAFT00845049586
Protein Domains
NR LBD


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000016656 Ensembl
  ENSCAFG00845028051 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00845038896 ENTREZGENE
  ENSCAFP00845038896.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00845049586 ENTREZGENE
  ENSCAFT00845049586.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.565.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.50.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Andrgn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NHR-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucl_hrmn_rcpt_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_hrmn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene AR ENTREZGENE
Pfam Androgen_recep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hormone_recep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS ANDROGENR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STROIDFINGER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NR_LBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HOLI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnF_C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48508 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I3PZ26_CANLF UniProtKB/TrEMBL
  ANDR_CANLF UniProtKB/Swiss-Prot
  H8XW66_CANLF UniProtKB/TrEMBL
  Q9TT90 ENTREZGENE
UniProt Secondary Q6WSP7 UniProtKB/Swiss-Prot
VGNC ID VGNC:38023 ENTREZGENE