Ar (androgen receptor) - Rat Genome Database

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Gene: Ar (androgen receptor) Rattus norvegicus
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Symbol: Ar
Name: androgen receptor
RGD ID: 2147
Description: Enables several functions, including androgen binding activity; nuclear androgen receptor binding activity; and nuclear receptor activity. Involved in several processes, including cellular response to hormone stimulus; positive regulation of penile erection; and regulation of DNA-templated transcription. Located in axon and dendrite. Used to study hypertension; osteoporosis; prostate adenocarcinoma; prostate cancer; and prostatic hypertrophy. Biomarker of acute kidney failure and androgen insensitivity syndrome. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; conduct disorder; disorder of sexual development (multiple); reproductive organ cancer (multiple); and spinal muscular atrophy (multiple). Orthologous to human AR (androgen receptor); PARTICIPATES IN altered androgen signaling pathway; androgen signaling pathway; forkhead class A signaling pathway; INTERACTS WITH (2,4,5-trichlorophenoxy)acetic acid; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Andr; Androgen receptor (Testicular feminization); Androgen receptor (Testicular feminization) same as Tfm; androgen receptor (Testicular feminization), same as Tfm; dihydrotestosterone receptor; nuclear receptor subfamily 3 group C member 4; Tfm
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X63,104,771 - 63,273,934 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX63,104,771 - 63,273,925 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX64,593,944 - 64,763,102 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X68,094,494 - 68,263,645 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X65,655,236 - 65,824,382 (+)NCBIRnor_WKY
Rnor_6.0X67,656,253 - 67,828,998 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX67,656,253 - 67,829,026 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X68,533,662 - 68,705,929 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X85,949,507 - 86,119,199 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X86,022,798 - 86,192,491 (+)NCBI
CeleraX63,512,152 - 63,679,533 (+)NCBICelera
Cytogenetic MapXq22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
46,XY sex reversal  (ISO)
acute kidney failure  (IEP)
alopecia  (ISO)
androgen insensitivity syndrome  (IEP,ISO)
Androgen Insensitivity Syndrome due to Coactivator Deficiency  (ISO)
aromatase excess syndrome  (ISO)
attention deficit hyperactivity disorder  (ISO)
autistic disorder  (ISO)
Breast Neoplasms  (ISO)
castration-resistant prostate carcinoma  (ISO)
conduct disorder  (ISO)
coronary artery disease  (ISO)
cryptorchidism  (ISO)
Denys-Drash syndrome  (ISO)
ductal carcinoma in situ  (ISO)
endometrial cancer  (ISO)
endometriosis  (ISO)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Mammary Neoplasms  (IEP)
Fabry disease  (ISO)
Familial Prostate Cancer  (ISO)
Female Infertility  (ISO)
genetic disease  (ISO)
gestational diabetes  (ISO)
hepatocellular carcinoma  (ISO)
hypertension  (IDA,IMP,ISO)
hypospadias  (ISO)
Hypospadias 1, X-Linked  (ISO)
Insulin Resistance  (ISO)
invasive ductal carcinoma  (ISO)
Kennedy's disease  (ISO)
Knee Osteoarthritis  (ISO)
leiomyoma  (ISO)
leukemia  (ISO)
Lubs Syndrome  (ISO)
Lung Neoplasms  (ISO)
Male Breast Neoplasms  (ISO)
male infertility  (ISO)
male reproductive system disease  (ISO)
malignant astrocytoma  (ISO)
Mayer-Rokitansky-Kuster-Hauser syndrome  (ISO)
multicentric Castleman disease  (ISO)
Neoplasm Recurrence, Local  (ISO)
obesity  (ISO,ISS)
oppositional defiant disorder  (ISO)
osteoporosis  (IDA,ISO)
Osteoporotic Fractures  (ISO)
ovarian cancer  (ISO)
partial androgen insensitivity syndrome  (ISO)
polycystic ovary syndrome  (ISO)
Postmenopausal Osteoporosis  (ISO)
prostate adenocarcinoma  (IDA)
prostate cancer  (IDA,ISO)
Prostate Cancer, Somatic  (ISO)
prostate carcinoma in situ  (ISO)
prostatic hypertrophy  (IMP)
Prostatic Neoplasms  (ISO)
Sarcopenia  (IDA,ISO)
spermatogenic failure 3  (ISO)
spinal muscular atrophy  (ISO)
syndromic X-linked intellectual disability Lubs type  (ISO)
type 2 diabetes mellitus  (ISS)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-Arctigenin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1E,4E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-one  (ISO)
(2,4,5-trichlorophenoxy)acetic acid  (EXP)
(20R)-17,20-dihydroxypregn-4-en-3-one  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(3-phenoxyphenyl)methanol  (ISO)
(Dimethoxymethyl)benzene  (ISO)
(E)-thiamethoxam  (ISO)
(R)-linalyl acetate  (ISO)
(S)-duloxetine hydrochloride  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2,3,6,7,8-Hexachlorodibenzodioxin  (ISO)
1,4-dithiothreitol  (EXP)
1-Hydroxypyrene  (ISO)
1-methylphenanthrene  (EXP)
1-naphthaldehyde  (EXP)
1-naphthol  (EXP)
1-naphthyl isothiocyanate  (ISO)
1-nitropyrene  (ISO)
10H-phenothiazine  (ISO)
11-deoxycorticosterone  (ISO)
11-deoxycortisol  (ISO)
11beta,21-Dihydroxypregn-4-ene-3,20-dione 21-acetate  (ISO)
15-acetyldeoxynivalenol  (ISO)
16-alpha,17-Epoxypregn-4-ene-3,20-dione  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17alpha-hydroxyprogesterone  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
2,2',3,3',6,6'-hexachlorobiphenyl  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',4,4'-tetrachlorobiphenyl  (EXP,ISO)
2,2',4,5'-Tetrabromodiphenyl ether  (ISO)
2,2',4,5-tetrachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,2'-Bisphenol F  (ISO)
2,2-(2-Chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene  (EXP,ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3',5-trichlorobiphenyl  (ISO)
2,3,3',4,4',5,5'-Heptachlorobiphenyl  (ISO)
2,3,3',4,4',5-Hexachlorobiphenyl  (ISO)
2,3,4,3',4'-Pentachlorobiphenyl  (ISO)
2,3,4,4'-tetrachlorobiphenyl  (ISO)
2,3,4,5-Tetrachloro-4'-biphenylol  (EXP)
2,3,4,7,8-Pentachlorodibenzofuran  (ISO)
2,3,5,6-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4'-dichlorobiphenyl  (EXP,ISO)
2,4,5-trichlorophenol  (ISO)
2,4-D  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2,4-dichlorophenol  (ISO)
2,4-Dihydroxybenzophenone  (EXP,ISO)
2,5-di-tert-butylbenzene-1,4-diol  (ISO)
2,6-Di-tert-butyl-4-hydroxymethylphenol  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2,6-dichlorobiphenyl  (ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
2-chlorobiphenyl  (ISO)
2-hydroxy-17beta-estradiol  (EXP)
2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester  (ISO)
2-hydroxypropanoic acid  (ISO)
2-naphthol  (EXP)
2-sec-butylphenol  (EXP)
2-tert-butylhydroquinone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,3'-Dichlorobenzidine  (ISO)
3,3'-diindolylmethane  (ISO)
3,3'-Dimethoxybenzidine  (ISO)
3,3'-Dimethylbenzidine  (ISO)
3,5,6-trichloro-2-pyridinol  (EXP,ISO)
3,5,6-trichloropyridine-2-one  (EXP,ISO)
3,5-di-tert-Butyl-4-hydroxybenzaldehyde  (ISO)
3,5-dichlorobiphenyl  (ISO)
3,6-diaminoacridine  (ISO)