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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2147
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ar
Name: androgen receptor
Acc ID: CHEBI:88522
Term: Monobutylphthalate
Definition: A phthalic acid monoester that has formula C12H14O4.
Chemical ID: MESH:C028577
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ardecreases expressionISOAR (Homo sapiens)6480464CTDmonobutyl phthalate results in decreased expression of AR proteinPMID:26922907
Arincreases activityISOAR (Homo sapiens)6480464CTDmonobutyl phthalate results in increased activity of AR proteinPMID:19643168
Armultiple interactionsISOAR (Homo sapiens)6480464CTDFlutamide inhibits the reaction [monobutyl phthalate results in increased activity of AR protein]; monobutyl phthalate inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]PMID:19643168
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