Gene: Daxx (death-domain associated protein) Rattus norvegicus
Analyze
Symbol:
Daxx
Name:
death-domain associated protein
Description:
Exhibits JUN kinase binding activity; androgen receptor binding activity; and kinesin binding activity. Involved in several processes, including PML body organization; cellular response to anoxia; and positive regulation of histone phosphorylation. Localizes to several cellular components, including PML body; XY body; and microtubule. Used to study transient cerebral ischemia. Human ortholog(s) of this gene implicated in ovary epithelial cancer. Orthologous to human DAXX (death domain associated protein); PARTICIPATES IN aldosterone signaling pathway; histone modification pathway; p53 signaling pathway; INTERACTS WITH 2,4-dinitrotoluene; acetamide; ammonium chloride.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
death domain-associated protein 6; Fas death domain-associated protein; MGC156601
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
DAXX (death domain associated protein) HGNC
Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):
Daxx (Fas death domain-associated protein) HGNC
Treefam, OrthoMCL, NCBI, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Daxx (death domain associated protein) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
DAXX (death domain associated protein) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
DAXX (death domain associated protein) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Daxx (death domain associated protein) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
DAXX (death domain associated protein) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
DAXX (death domain associated protein) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Daxx (death domain associated protein) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Mus musculus (house mouse):
Daxx (Fas death domain-associated protein)
Alliance
DIOPT (PANTHER|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid|TreeFam)
Homo sapiens (human):
DAXX (death domain associated protein)
Alliance
DIOPT (PANTHER|HGNC|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid|TreeFam)
Danio rerio (zebrafish):
daxx (death-domain associated protein)
Alliance
DIOPT (PANTHER|OrthoFinder|InParanoid|OrthoInspector|Hieranoid)
Drosophila melanogaster (fruit fly):
Daxx
Alliance
DIOPT (TreeFam|OrthoInspector|OrthoFinder|PANTHER)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 20 5,480,103 - 5,485,962 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 20 5,480,103 - 5,485,926 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 20 7,538,715 - 7,544,538 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 20 5,121,854 - 5,127,601 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 20 5,122,244 - 5,126,875 (-) NCBI Celera 20 6,554,093 - 6,559,840 (-) NCBI Celera Cytogenetic Map 20 p12 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
Imported Annotations - ClinVar
autosomal dominant non-syndromic intellectual disability 5 ISO RGD:1345950 8554872 ClinVar Annotator: match by term: Mental retardation, autosomal dominant 5 ClinVar PMID:28492532
Imported Annotations - CTD
adrenocortical carcinoma ISO RGD:1345950 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:24747642 neuroendocrine tumor ISO RGD:1345950 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21252315 pancreatic cancer ISO RGD:1345950 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21252315
(+)-dexrazoxane multiple interactions ISO RGD:732822 6480464 [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of DAXX mRNA CTD PMID:26873546 1-naphthyl isothiocyanate multiple interactions ISO RGD:732822 6480464 O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1, 2-diolate inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of DAXX mRNA] CTD PMID:15913567 1-naphthyl isothiocyanate increases expression ISO RGD:732822 6480464 1-Naphthylisothiocyanate results in increased expression of DAXX mRNA CTD PMID:15913567 17alpha-ethynylestradiol multiple interactions ISO RGD:732822 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DAXX mRNA CTD PMID:17942748 17alpha-ethynylestradiol increases expression ISO RGD:732822 6480464 Ethinyl Estradiol results in increased expression of DAXX mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:732822 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DAXX mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:732822 6480464 Tetrachlorodibenzodioxin affects the expression of DAXX mRNA CTD PMID:24680724 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:732822 6480464 Tetrachlorodibenzodioxin results in increased expression of DAXX mRNA CTD PMID:12167310 2,4-dinitrotoluene affects expression EXP 6480464 2, 4-dinitrotoluene affects the expression of DAXX mRNA CTD PMID:21346803 4,4'-diaminodiphenylmethane decreases expression ISO RGD:732822 6480464 4, 4'-diaminodiphenylmethane results in decreased expression of DAXX mRNA CTD PMID:18648102 acetamide increases expression EXP 6480464 acetamide results in increased expression of DAXX mRNA CTD PMID:31881176 aldehydo-D-glucose multiple interactions ISO RGD:1345950 6480464 Glucose deficiency promotes the reaction [DAXX protein binds to MAP3K5 protein] CTD PMID:14505347 aldehydo-D-glucose affects localization ISO RGD:1345950 6480464 Glucose deficiency affects the localization of DAXX protein CTD PMID:14505347 all-trans-retinoic acid multiple interactions ISO RGD:1345950 6480464 Tretinoin inhibits the reaction [DAXX protein binds to CEBPB protein] CTD PMID:19690170 aluminium atom increases expression ISO RGD:1345950 6480464 Aluminum results in increased expression of DAXX mRNA CTD PMID:16308480 aluminium sulfate (anhydrous) increases expression ISO RGD:1345950 6480464 aluminum sulfate results in increased expression of DAXX mRNA CTD PMID:15961160 aluminium(0) increases expression ISO RGD:1345950 6480464 Aluminum results in increased expression of DAXX mRNA CTD PMID:16308480 ammonium chloride increases expression EXP 6480464 Ammonium Chloride results in increased expression of DAXX protein CTD PMID:16483693 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of DAXX mRNA CTD PMID:16483693 arsane affects methylation ISO RGD:1345950 6480464 Arsenic affects the methylation of DAXX gene CTD PMID:25304211 arsenic atom affects methylation ISO RGD:1345950 6480464 Arsenic affects the methylation of DAXX gene CTD PMID:25304211 arsenous acid multiple interactions ISO RGD:1345950 6480464 Arsenic Trioxide affects the reaction [NR3C1 protein modified form binds to DAXX protein] more ... CTD PMID:17081986 , PMID:19690170 arsenous acid decreases expression ISO RGD:1345950 6480464 Arsenic Trioxide results in decreased expression of DAXX protein CTD PMID:19690170 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of DAXX mRNA CTD PMID:25181051 cadmium dichloride multiple interactions ISO RGD:732822 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride affects the localization of DAXX protein], SB 203580 inhibits the reaction [Cadmium Chloride affects the localization of DAXX protein] CTD PMID:12508112 cadmium dichloride affects localization ISO RGD:732822 6480464 Cadmium Chloride affects the localization of DAXX protein CTD PMID:12508112 carbon nanotube increases expression ISO RGD:732822 6480464 Nanotubes, Carbon analog results in increased expression of DAXX mRNA, Nanotubes, Carbon results in increased expression of DAXX mRNA CTD PMID:25554681 chromium atom increases expression EXP 6480464 Chromium results in increased expression of DAXX mRNA CTD PMID:17692352 cisplatin increases expression ISO RGD:732822 6480464 Cisplatin results in increased expression of DAXX mRNA CTD PMID:21151649 cladribine multiple interactions ISO RGD:1345950 6480464 Cladribine promotes the reaction [Bendamustine Hydrochloride results in decreased expression of DAXX protein] CTD PMID:12948851 crocidolite asbestos affects expression ISO RGD:1345950 6480464 Asbestos, Crocidolite affects the expression of DAXX mRNA CTD PMID:17331233 curcumin increases expression ISO RGD:1345950 6480464 Curcumin results in increased expression of DAXX mRNA CTD PMID:16101141 cyclosporin A decreases expression ISO RGD:1345950 6480464 Cyclosporine results in decreased expression of DAXX mRNA CTD PMID:22147139 , PMID:27989131 D-glucose affects localization ISO RGD:1345950 6480464 Glucose deficiency affects the localization of DAXX protein CTD PMID:14505347 D-glucose multiple interactions ISO RGD:1345950 6480464 Glucose deficiency promotes the reaction [DAXX protein binds to MAP3K5 protein] CTD PMID:14505347 diarsenic trioxide decreases expression ISO RGD:1345950 6480464 Arsenic Trioxide results in decreased expression of DAXX protein CTD PMID:19690170 diarsenic trioxide multiple interactions ISO RGD:1345950 6480464 Arsenic Trioxide affects the reaction [NR3C1 protein modified form binds to DAXX protein] more ... CTD PMID:17081986 , PMID:19690170 diazinon increases methylation ISO RGD:1345950 6480464 Diazinon results in increased methylation of DAXX gene CTD PMID:22964155 dicrotophos increases expression ISO RGD:1345950 6480464 dicrotophos results in increased expression of DAXX mRNA CTD PMID:28302478 dieldrin affects expression EXP 6480464 Dieldrin affects the expression of DAXX mRNA CTD PMID:22546817 disodium selenite decreases expression ISO RGD:1345950 6480464 Sodium Selenite results in decreased expression of DAXX mRNA CTD PMID:16705456 doxorubicin increases expression ISO RGD:732822 6480464 Doxorubicin results in increased expression of DAXX mRNA CTD PMID:26873546 doxorubicin decreases expression ISO RGD:1345950 6480464 Doxorubicin results in decreased expression of DAXX mRNA CTD PMID:29803840 doxorubicin multiple interactions ISO RGD:732822 6480464 [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of DAXX mRNA CTD PMID:26873546 edaravone decreases expression EXP 6480464 Edaravone results in decreased expression of DAXX mRNA, Edaravone results in decreased expression of DAXX protein CTD PMID:17967739 ellagic acid decreases expression ISO RGD:1345950 6480464 Ellagic Acid results in decreased expression of DAXX mRNA CTD PMID:12002526 enzyme inhibitor multiple interactions ISO RGD:1345950 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of DAXX protein CTD PMID:23301498 ethanol affects splicing ISO RGD:732822 6480464 Ethanol affects the splicing of DAXX mRNA CTD PMID:30319688 glucose affects localization ISO RGD:1345950 6480464 Glucose deficiency affects the localization of DAXX protein CTD PMID:14505347 glucose multiple interactions ISO RGD:1345950 6480464 Glucose deficiency promotes the reaction [DAXX protein binds to MAP3K5 protein] CTD PMID:14505347 iron atom increases expression ISO RGD:1345950 6480464 Iron results in increased expression of DAXX mRNA CTD PMID:16308480 iron(0) increases expression ISO RGD:1345950 6480464 Iron results in increased expression of DAXX mRNA CTD PMID:16308480 leflunomide decreases expression ISO RGD:1345950 6480464 leflunomide results in decreased expression of DAXX mRNA CTD PMID:28988120 N-methyl-4-phenylpyridinium increases expression ISO RGD:1345950 6480464 1-Methyl-4-phenylpyridinium results in increased expression of DAXX mRNA CTD PMID:25234470 nickel dichloride affects expression EXP 6480464 nickel chloride affects the expression of DAXX mRNA CTD PMID:22546817 olmesartan decreases expression ISO RGD:732822 6480464 olmesartan results in decreased expression of DAXX protein CTD PMID:17208988 oxybenzone increases expression EXP 6480464 oxybenzone results in increased expression of DAXX mRNA CTD PMID:30316929 p-menthan-3-ol decreases expression ISO RGD:1345950 6480464 Menthol results in decreased expression of DAXX mRNA CTD PMID:26760959 paracetamol affects expression ISO RGD:732822 6480464 Acetaminophen affects the expression of DAXX mRNA CTD PMID:17562736 paracetamol decreases expression ISO RGD:1345950 6480464 Acetaminophen results in decreased expression of DAXX mRNA CTD PMID:21420995 pentachlorophenol increases expression ISO RGD:732822 6480464 Pentachlorophenol results in increased expression of DAXX mRNA CTD PMID:23892564 pirinixic acid multiple interactions ISO RGD:1345950 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of DAXX mRNA CTD PMID:19710929 raloxifene affects expression ISO RGD:1345950 6480464 Raloxifene Hydrochloride affects the expression of DAXX mRNA CTD PMID:14699072 resveratrol multiple interactions ISO RGD:1345950 6480464 BCL2 protein inhibits the reaction [resveratrol promotes the reaction [PML protein binds to DAXX protein]], resveratrol promotes the reaction [PML protein binds to DAXX protein] CTD PMID:19631782 resveratrol decreases expression ISO RGD:1345950 6480464 resveratrol results in decreased expression of DAXX mRNA CTD PMID:12002526 SB 203580 multiple interactions ISO RGD:732822 6480464 SB 203580 inhibits the reaction [Cadmium Chloride affects the localization of DAXX protein] CTD PMID:12508112 silver atom decreases expression ISO RGD:732822 6480464 Silver results in decreased expression of DAXX mRNA CTD PMID:27131904 silver(0) decreases expression ISO RGD:732822 6480464 Silver results in decreased expression of DAXX mRNA CTD PMID:27131904 sodium arsenite decreases expression ISO RGD:1345950 6480464 sodium arsenite results in decreased expression of DAXX mRNA CTD PMID:12760830 tamoxifen affects expression ISO RGD:1345950 6480464 Tamoxifen affects the expression of DAXX mRNA CTD PMID:14699072 tetrachloromethane increases expression ISO RGD:732822 6480464 Carbon Tetrachloride results in increased expression of DAXX mRNA CTD PMID:15056808 trichostatin A affects expression ISO RGD:1345950 6480464 trichostatin A affects the expression of DAXX mRNA CTD PMID:28542535 valproic acid increases methylation ISO RGD:1345950 6480464 Valproic Acid results in increased methylation of DAXX gene CTD PMID:29154799 valproic acid increases expression ISO RGD:1345950 6480464 Valproic Acid results in increased expression of DAXX mRNA CTD PMID:23179753 valproic acid decreases expression ISO RGD:1345950 6480464 Valproic Acid results in decreased expression of DAXX mRNA CTD PMID:29154799 vorinostat multiple interactions ISO RGD:1345950 6480464 vorinostat promotes the reaction [PML protein binds to DAXX protein] CTD PMID:19631782
Biological Process activation of protein kinase activity IEA GO:0030295 1600115 GO_REF:0000108 GOC GO_REF:0000108 androgen receptor signaling pathway ISO RGD:1345950 1624291 (PMID:15572661) RGD PMID:15572661 androgen receptor signaling pathway IEA UniProtKB:Q9UER7 , ensembl:ENSP000002660001600115 GO_REF:0000107 Ensembl GO_REF:0000107 apoptotic signaling pathway ISO RGD:732822 1624291 MGI:MGI:1203520 more ... RGD MGI:MGI:3687891 , PMID:12917339 cellular response to anoxia IEP 9587773 RGD cellular response to cadmium ion ISO RGD:1345950 1624291 (PMID:15016915) RGD PMID:15016915 cellular response to cadmium ion ISS UniProtKB:Q9UER7 1600115 GO_REF:0000024 UniProt GO_REF:0000024 cellular response to cadmium ion IEA UniProtKB:Q9UER7 , ensembl:ENSP000002660001600115 GO_REF:0000107 Ensembl GO_REF:0000107 cellular response to copper ion ISO RGD:1345950 1624291 (PMID:15016915) RGD PMID:15016915 cellular response to copper ion ISS UniProtKB:Q9UER7 1600115 GO_REF:0000024 UniProt GO_REF:0000024 cellular response to copper ion IEA UniProtKB:Q9UER7 , ensembl:ENSP000002660001600115 GO_REF:0000107 Ensembl GO_REF:0000107 cellular response to diamide ISO RGD:1345950 1624291 (PMID:15016915) RGD PMID:15016915 cellular response to diamide ISS UniProtKB:Q9UER7 1600115 GO_REF:0000024 UniProt GO_REF:0000024 cellular response to diamide IEA UniProtKB:Q9UER7 , ensembl:ENSP000002660001600115 GO_REF:0000107 Ensembl GO_REF:0000107 cellular response to heat ISO RGD:1345950 1624291 (PMID:15016915) RGD PMID:15016915 cellular response to heat ISS UniProtKB:Q9UER7 1600115 GO_REF:0000024 UniProt GO_REF:0000024 cellular response to heat IEA UniProtKB:Q9UER7 , ensembl:ENSP000002660001600115 GO_REF:0000107 Ensembl GO_REF:0000107 cellular response to sodium arsenite ISO RGD:1345950 1624291 (PMID:15016915) RGD PMID:15016915 cellular response to sodium arsenite ISS UniProtKB:Q9UER7 1600115 GO_REF:0000024 UniProt GO_REF:0000024 cellular response to sodium arsenite IEA UniProtKB:Q9UER7 , ensembl:ENSP000002660001600115 GO_REF:0000107 Ensembl GO_REF:0000107 cellular response to tumor necrosis factor IEP 9587767 RGD cellular response to unfolded protein ISO RGD:1345950 1624291 (PMID:15016915) RGD PMID:15016915 cellular response to unfolded protein ISS UniProtKB:Q9UER7 1600115 GO_REF:0000024 UniProt GO_REF:0000024 cellular response to unfolded protein IEA UniProtKB:Q9UER7 , ensembl:ENSP000002660001600115 GO_REF:0000107 Ensembl GO_REF:0000107 chromatin remodeling ISO RGD:1345950 1624291 (PMID:20651253) RGD PMID:20651253 chromatin remodeling IEA UniProtKB:Q9UER7 , ensembl:ENSP000002660001600115 GO_REF:0000107 Ensembl GO_REF:0000107 mitotic cytokinesis ISO RGD:732822 1624291 MGI:MGI:3051780 (MGI:MGI:3051070 , PMID:15252119) RGD MGI:MGI:3051070 , PMID:15252119 negative regulation of apoptotic process ISO RGD:732822 1624291 MGI:MGI:2179457 (MGI:MGI:1342427 , PMID:10444590) RGD MGI:MGI:1342427 , PMID:10444590 negative regulation of myotube differentiation IDA 9587764 RGD negative regulation of transcription by RNA polymerase II IDA 9587764 RGD negative regulation of transcription, DNA-templated ISO RGD:732822 1624291 (MGI:MGI:2449749, PMID:12529400) RGD MGI:MGI:2449749 , PMID:12529400 negative regulation of transcription, DNA-templated IBA FB:FBgn0024250 more ... 13792537 PMID:21873635 GO_Central negative regulation of transcription, DNA-templated ISS UniProtKB:Q9UER7-1 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of transcription, DNA-templated IEA UniProtKB:Q9UER7 , ensembl:ENSP000002660001600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of transcription, DNA-templated ISO RGD:1345950 1624291 (PMID:10698492), (PMID:12140263), (PMID:15572661) RGD PMID:10698492 more ... nucleosome assembly IEA UniProtKB:Q9UER7 , ensembl:ENSP000002660001600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleosome assembly IBA MGI:MGI:1197015 more ... 13792537 PMID:21873635 GO_Central nucleosome assembly ISO RGD:732822 1624291 (MGI:MGI:5567907, PMID:20651253) RGD MGI:MGI:5567907 , PMID:20651253 nucleosome assembly ISO RGD:1345950 1624291 (PMID:20504901), (PMID:20651253) RGD PMID:20504901 , PMID:20651253 PML body organization IMP 9587773 RGD positive regulation of apoptotic process IMP 9587767 RGD positive regulation of apoptotic signaling pathway ISO RGD:732822 1624291 MGI:MGI:104662 (MGI:MGI:4942266 , PMID:10684855) RGD MGI:MGI:4942266 , PMID:10684855 positive regulation of histone phosphorylation IMP 9587767 RGD positive regulation of neuron death ISO RGD:1345950 1624291 UniProtKB:Q99683 (PMID:15983381) RGD PMID:15983381 positive regulation of neuron death IEA UniProtKB:Q9UER7 , ensembl:ENSP000002660001600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of nucleic acid-templated transcription IEA GO:0003713 1600115 GO_REF:0000108 GOC GO_REF:0000108 positive regulation of protein kinase activity ISO RGD:1345950 1624291 UniProtKB:Q99683 (PMID:15983381) RGD PMID:15983381 positive regulation of protein phosphorylation ISO RGD:1345950 1624291 UniProtKB:Q99683 (PMID:15983381) RGD PMID:15983381 positive regulation of transcription by RNA polymerase II ISO RGD:732822 1624291 (MGI:MGI:5440404, PMID:22500635) RGD MGI:MGI:5440404 , PMID:22500635 protein localization to chromatin ISO RGD:732822 1624291 UniProtKB:Q60953 (MGI:MGI:5882889 , PMID:17081986) RGD MGI:MGI:5882889 , PMID:17081986 regulation of apoptotic process IBA FB:FBgn0031820 more ... 13792537 PMID:21873635 GO_Central regulation of multicellular organism growth ISO RGD:732822 1624291 MGI:MGI:2179457 (MGI:MGI:1342427 , PMID:10444590) RGD MGI:MGI:1342427 , PMID:10444590 regulation of protein ubiquitination ISO RGD:1345950 1624291 (PMID:18566590) RGD PMID:18566590 regulation of protein ubiquitination ISS UniProtKB:Q9UER7 1600115 GO_REF:0000024 UniProt GO_REF:0000024 regulation of protein ubiquitination IEA UniProtKB:Q9UER7 , ensembl:ENSP000002660001600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of transcription, DNA-templated ISO RGD:1345950 1624291 (PMID:15878163) RGD PMID:15878163 response to metal ion IEP 9587799 RGD Cellular Component cell body IDA 4142863 large pyramidal neurons RGD cell cortex IDA 2298728 RGD chromosome, centromeric region IEA UniProtKB:Q9UER7 , ensembl:ENSP000002660001600115 GO_REF:0000107 Ensembl GO_REF:0000107 chromosome, centromeric region ISO RGD:1345950 1624291 (PMID:10504293) RGD PMID:10504293 cytoplasm IDA 2298728 RGD cytoplasm IDA 4142863 large pyramidal neurons RGD cytosol ISO RGD:732822 1624291 (MGI:MGI:4942266, PMID:10684855) RGD MGI:MGI:4942266 , PMID:10684855 cytosol ISS UniProtKB:O35613 1600115 GO_REF:0000024 UniProt GO_REF:0000024 heterochromatin ISO RGD:732822 1624291 (MGI:MGI:3051070, PMID:15252119) RGD MGI:MGI:3051070 , PMID:15252119 heterochromatin colocalizes_with ISO RGD:732822 1624291 (MGI:MGI:5882889, PMID:17081986) RGD MGI:MGI:5882889 , PMID:17081986 microtubule IDA 9587790 RGD neuron projection IDA 4142863 large pyramidal neurons RGD nuclear body ISO RGD:1345950 1624291 RGD GO_REF:0000052 nucleolus IEA UniProtKB-SubCell:SL-0188 1600115 GO_REF:0000044 UniProt GO_REF:0000044 nucleoplasm ISO RGD:1345950 1624291 RGD GO_REF:0000052 nucleus IDA 4142863 large pyramidal neurons RGD nucleus ISO RGD:1345950 1624291 (PMID:10698492), (PMID:15572661), (PMID:15878163), (PMID:15983381), (PMID:17081986) RGD PMID:10698492 more ... nucleus ISS UniProtKB:Q9UER7-1 1600115 GO_REF:0000024 UniProt GO_REF:0000024 nucleus ISO RGD:732822 1624291 (MGI:MGI:1342427 more ... RGD MGI:MGI:1342427 more ... PML body IDA 9587773 RGD PML body IBA MGI:MGI:1197015 more ... 13792537 PMID:21873635 GO_Central PML body ISS UniProtKB:Q9UER7 1600115 GO_REF:0000024 UniProt GO_REF:0000024 PML body ISS UniProtKB:O35613 1600115 GO_REF:0000024 UniProt GO_REF:0000024 PML body IEA UniProtKB:Q9UER7 , ensembl:ENSP000002660001600115 GO_REF:0000107 Ensembl GO_REF:0000107 PML body ISO RGD:732822 1624291 (MGI:MGI:2178905 more ... RGD MGI:MGI:2178905 more ... PML body ISO RGD:1345950 1624291 (PMID:10669754), (PMID:18566590) RGD PMID:10669754 , PMID:18566590 XY body IDA 9587797 RGD Molecular Function androgen receptor binding IPI RGD:2147 1358129 RGD androgen receptor binding IEA UniProtKB:Q9UER7 , ensembl:ENSP000002660001600115 GO_REF:0000107 Ensembl GO_REF:0000107 androgen receptor binding ISO RGD:1345950 1624291 UniProtKB:P10275 (PMID:15572661) RGD PMID:15572661 DNA-binding transcription factor inhibitor activity ISO RGD:1345950 1624291 (PMID:15572661) RGD PMID:15572661 enzyme binding ISO RGD:1345950 1624291 UniProtKB:Q93009 (PMID:16845383) RGD PMID:16845383 histone binding ISO RGD:1345950 1624291 (PMID:12140263), (PMID:20211137), (PMID:20504901) RGD PMID:12140263 more ... histone binding IBA MGI:MGI:1197015 more ... 13792537 PMID:21873635 GO_Central histone binding IEA UniProtKB:Q9UER7 , ensembl:ENSP000002660001600115 GO_REF:0000107 Ensembl GO_REF:0000107 histone binding ISO RGD:732822 1624291 (MGI:MGI:4457804 more ... RGD MGI:MGI:4457804 more ... JUN kinase binding IPI RGD:621506 9587790 RGD kinesin binding IPI RGD:621559 9587790 RGD p53 binding ISO RGD:1345950 1624291 UniProtKB:P04637 (PMID:16845383) RGD PMID:16845383 p53 binding IEA UniProtKB:Q9UER7 , ensembl:ENSP000002660001600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein binding IPI RGD:1310457 2298728 following seizure RGD protein binding ISO RGD:1345950 1624291 UniProtKB:A6NEM1 more ... RGD PMID:10669754 more ... protein binding ISO RGD:732822 1624291 MGI:MGI:104662 more ... RGD MGI:MGI:2449749 more ... protein binding IPI UniProtKB:P03244 9587788 RGD protein binding IPI RGD:1306565 9587791 RGD protein binding IPI RGD:619831 9587791 RGD protein homodimerization activity ISO RGD:1345950 1624291 (PMID:10698492) RGD PMID:10698492 protein homodimerization activity ISS UniProtKB:Q9UER7-1 1600115 GO_REF:0000024 UniProt GO_REF:0000024 protein kinase activator activity ISO RGD:1345950 1624291 UniProtKB:Q99683 (PMID:15983381) RGD PMID:15983381 protein kinase activator activity IEA UniProtKB:Q9UER7 , ensembl:ENSP000002660001600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein kinase binding IPI RGD:3780 9587767 RGD protein kinase binding IEA UniProtKB:Q9UER7 , ensembl:ENSP000002660001600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein kinase binding ISO RGD:1345950 1624291 UniProtKB:Q99683 (PMID:15983381) RGD PMID:15983381 protein N-terminus binding IEA UniProtKB:Q9UER7 , ensembl:ENSP000002660001600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein N-terminus binding ISO RGD:1345950 1624291 UniProtKB:Q9NS23 (PMID:18566590) RGD PMID:18566590 sumo-dependent protein binding ISO RGD:1345950 1624291 UniProtKB:P29590 (PMID:17081986) RGD PMID:17081986 sumo-dependent protein binding IEA UniProtKB:Q9UER7 , ensembl:ENSP000002660001600115 GO_REF:0000107 Ensembl GO_REF:0000107 transcription coactivator activity ISO RGD:1345950 1624291 (PMID:15016915) RGD PMID:15016915 transcription coactivator activity ISS UniProtKB:Q9UER7 1600115 GO_REF:0000024 UniProt GO_REF:0000024 transcription coactivator activity ISO RGD:732822 1624291 (MGI:MGI:3688031, PMID:11799127) RGD MGI:MGI:3688031 , PMID:11799127 transcription coactivator activity IEA UniProtKB:Q9UER7 , ensembl:ENSP000002660001600115 GO_REF:0000107 Ensembl GO_REF:0000107 transcription corepressor activity IEA UniProtKB:Q9UER7 , ensembl:ENSP000002660001600115 GO_REF:0000107 Ensembl GO_REF:0000107 transcription corepressor activity IBA PANTHER:PTN000298848 more ... 13792537 PMID:21873635 GO_Central transcription corepressor activity ISO RGD:1345950 1624291 (PMID:12140263), (PMID:17081986) RGD PMID:12140263 , PMID:17081986 transcription factor binding IPI RGD:1351290 9587764 RGD transcription factor binding IBA PANTHER:PTN000298848 more ... 13792537 PMID:21873635 GO_Central transcription factor binding ISS UniProtKB:Q9UER7-1 1600115 GO_REF:0000024 UniProt GO_REF:0000024 transcription factor binding ISO RGD:1345950 1624291 (PMID:10698492) RGD PMID:10698492 ubiquitin protein ligase binding ISO RGD:1345950 1624291 UniProtKB:Q00987 (PMID:16845383) RGD PMID:16845383 ubiquitin protein ligase binding IEA UniProtKB:Q9UER7 , ensembl:ENSP000002660001600115 GO_REF:0000107 Ensembl GO_REF:0000107
Gene-Chemical Interaction Annotations
