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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621227
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Daxx
Name: death-domain associated protein
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Daxxdecreases expressionISODAXX (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of DAXX proteinPMID:19690170
Daxxmultiple interactionsISODAXX (Homo sapiens)6480464CTDArsenic Trioxide affects the reaction [NR3C1 protein modified form binds to DAXX protein]; Arsenic Trioxide affects the reaction [PML protein modified form binds to DAXX protein]; Arsenic Trioxide inhibits the reaction [[DAXX protein binds to NR3C1 protein] which binds to TSC22D3 promoter]; Arsenic Trioxide inhibits the reaction [DAXX protein binds to CEBPB protein]PMID:17081986 PMID:19690170
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