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Gene: Map3k5 (mitogen-activated protein kinase kinase kinase 5) Rattus norvegicus
Symbol: Map3k5
Name: mitogen-activated protein kinase kinase kinase 5
RGD ID: 1306565
Description: Exhibits MAP kinase kinase kinase activity. Involved in several processes, including endothelial cell apoptotic process; positive regulation of cardiac muscle cell apoptotic process; and positive regulation of stress-activated MAPK cascade. Localizes to cytosol and external side of plasma membrane. Used to study cerebral infarction and myocardial infarction. Biomarker of membranous glomerulonephritis; transient cerebral ischemia; and visual epilepsy. Human ortholog(s) of this gene implicated in Huntington's disease. Orthologous to human MAP3K5 (mitogen-activated protein kinase kinase kinase 5); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; p38 MAPK signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-Tetrachlorodibenzofuran; 4-vinylcyclohexene dioxide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: apoptosis signal regulating kinase 1; Ask1; LOC365057; RGD1306565; similar to apoptosis signal-regulating kinase 1
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0115,412,603 - 15,613,752 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl115,412,603 - 15,613,746 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0116,961,080 - 17,160,996 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4115,205,361 - 15,346,422 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1115,204,326 - 15,346,541 (+)NCBI
Celera113,127,308 - 13,336,631 (+)NCBICelera
Cytogenetic Map1p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Map3k5
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1306565
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.