Mapk8 (mitogen-activated protein kinase 8) - Rat Genome Database

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Gene: Mapk8 (mitogen-activated protein kinase 8) Rattus norvegicus
Symbol: Mapk8
Name: mitogen-activated protein kinase 8
RGD ID: 621506
Description: Enables JUN kinase activity and kinesin binding activity. Involved in several processes, including cellular response to amyloid-beta; regulation of apoptotic process; and regulation of nucleobase-containing compound metabolic process. Acts upstream of or within neuronal stem cell population maintenance. Located in several cellular components, including axon; dendrite cytoplasm; and perikaryon. Used to study brain ischemia; hypertension; and type 2 diabetes mellitus. Biomarker of anti-basement membrane glomerulonephritis and non-alcoholic fatty liver disease. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm; chronic mucocutaneous candidiasis; colorectal adenoma; rectal benign neoplasm; and type 2 diabetes mellitus. Orthologous to human MAPK8 (mitogen-activated protein kinase 8); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; inflammatory response pathway; Rho/Rac/Cdc42 mediated signaling pathway; INTERACTS WITH (-)-anisomycin; (R)-lipoic acid; (R)-noradrenaline.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: c-Jun N-terminal kinase 1; c-jun NH2-terminal kinase; JNK; MAP kinase 8; MAPK 8; p54 gamma; SAPK gamma; stress-activated protein kinase JNK1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2168,638,897 - 8,721,960 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl168,638,924 - 8,721,981 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx168,658,229 - 8,741,022 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0169,802,931 - 9,885,718 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0168,652,731 - 8,735,493 (-)NCBIRnor_WKY
Rnor_6.0169,620,854 - 9,709,342 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl169,625,177 - 9,709,347 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01611,579,503 - 11,662,858 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4168,925,133 - 9,004,897 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1168,925,181 - 9,004,945 (-)NCBI
Celera166,485,592 - 6,568,388 (+)NCBICelera
Cytogenetic Map16p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(+)-taxifolin  (ISO)
(-)-anisomycin  (EXP,ISO)
(-)-Arctigenin  (ISO)
(-)-citrinin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-matairesinol  (ISO)
(1->4)-beta-D-glucan  (ISO)
(R)-lipoic acid  (EXP)
(R)-noradrenaline  (EXP)
(R)-salsolinol  (EXP)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-colchicine  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dichloropropan-2-ol  (EXP,ISO)
1,3-Dinitropyrene  (ISO)
1,4-dithiothreitol  (ISO)
1,4-phenylenediamine  (ISO)
1,8-cineole  (ISO)
1-chloro-2,4,6-trinitrobenzene  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-hydroxy-2-naphthoic acid  (ISO)
1-naphthyl isothiocyanate  (ISO)
1-nitropyrene  (ISO)
17beta-estradiol  (EXP,ISO)
2''-galloylhyperin  (ISO)
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (EXP)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butoxyethanol  (ISO)
2-methyl-6-(phenylethynyl)pyridine  (ISO)
2-trans,6-trans-farnesyl diphosphate  (ISO)
3',5'-cyclic GMP  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-acetyldeoxynivalenol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3-O-Caffeoyl-1-O-methylquinic acid  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nonylphenol  (ISO)
4-phenylbutyric acid  (EXP,ISO)
4-vinylcyclohexene dioxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
7,12-dimethyltetraphene  (EXP)
acetaldehyde  (EXP,ISO)
acetic acid  (EXP)
acetylleucyl-leucyl-norleucinal  (ISO)
Aciculatin  (ISO)
acrolein  (EXP,ISO)
acrylamide  (EXP,ISO)
acrylonitrile  (ISO)
afimoxifene  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-Chaconine  (ISO)
alpha-D-galactose  (EXP)
alpha-mangostin  (ISO)
alvocidib  (ISO)
amidotrizoic acid  (ISO)
amiloride  (ISO)
amino acid  (ISO)
ammonium chloride  (EXP)
amodiaquine  (ISO)
amphetamine  (EXP)
anethole  (ISO)
aniline  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
Antimony trioxide  (ISO)
apigenin  (EXP)
apocynin  (ISO)
arachidonic acid  (ISO)
Arctiin  (ISO)
arecoline  (EXP)
aristolochic acid A  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
asbestos  (ISO)
asiatic acid  (ISO)
astaxanthin  (ISO)
atrazine  (EXP,ISO)
atropine  (EXP)
aureusidin  (EXP)
Azaspiracid  (ISO)
bafilomycin A1  (ISO)
baicalein  (ISO)
bathocuproine disulfonic acid  (EXP)
benomyl  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[a]pyrene-7,8-diol  (ISO)
benzyl isothiocyanate  (ISO)
berberine  (ISO)
beta-D-glucosamine  (ISO)
beta-hexachlorocyclohexane  (EXP)
betulin  (EXP)
bicuculline  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
bleomycin A2  (ISO)
bortezomib  (ISO)
bosutinib  (ISO)
bufalin  (ISO)
bupropion  (ISO)
butanal  (ISO)
butein  (ISO)
butylated hydroxyanisole  (EXP,ISO)
butyric acid  (ISO)
C.I. Natural Red 20  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium selenide  (ISO)
cadmium sulfate  (EXP,ISO)
Calcimycin  (ISO)
calcipotriol  (ISO)
calcitriol  (ISO)
camptothecin  (ISO)
candesartan  (ISO)
cannabidiol  (ISO)
cantharidic acid  (ISO)
capsaicin  (ISO)
capsazepine  (ISO)
carbamazepine  (ISO)
carbendazim  (EXP)
carbon nanotube  (ISO)
carnosic acid  (EXP,ISO)
carnosine  (ISO)
Carnosol  (ISO)
celecoxib  (ISO)
chalcone  (ISO)
chenodeoxycholic acid  (ISO)
chlordecone  (ISO)
chlorogenic acid  (EXP)
chloroprene  (EXP)
chloroquine  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (EXP,ISO)
cholate  (ISO)
choline  (ISO)
chromium atom  (ISO)
chromium(6+)  (ISO)
chrysophanol  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP,ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cypermethrin  (ISO)
D-glucitol  (ISO)
D-glucose  (EXP,ISO)
D-mannitol  (ISO)
decabromodiphenyl ether  (ISO)
delphinidin  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
desipramine  (ISO)
dexamethasone  (EXP,ISO)
diallyl disulfide  (ISO)
Diallyl sulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
diazepam  (EXP)
diazinon  (EXP)
dibenziodolium  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dicoumarol  (ISO)
dicrotophos  (ISO)
Dictamnine  (ISO)
diethyl maleate  (ISO)
diethylstilbestrol  (ISO)
diltiazem  (EXP)
dimethylarsinic acid  (EXP,ISO)
Dinitramine  (ISO)
dinophysistoxin 1  (ISO)
dioscin  (ISO)
diosmetin  (ISO)
dioxygen  (EXP,ISO)
diphenhydramine  (ISO)
dipyridamole  (ISO)
disodium selenite  (ISO)
disulfiram  (EXP,ISO)
donepezil hydrochloride  (EXP)
dopamine  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
edaravone  (ISO)
efavirenz  (ISO)
elemental selenium  (ISO)
ellagic acid  (ISO)
emetine  (ISO)
enilconazole  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
erastin  (ISO)
eriocitrin  (ISO)
eriodictyol  (ISO)
esculetin  (ISO)
Estragole  (EXP)
etacrynic acid  (ISO)
ethanol  (EXP,ISO)
Ethyl pyruvate  (EXP)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP,ISO)
Evodiamine  (ISO)
farnesyl diphosphate  (ISO)
febuxostat  (ISO)
fenvalerate  (ISO)
ferroheme b  (ISO)
ferrosoferric oxide  (ISO)
ferulic acid  (EXP,ISO)
flubendazole  (ISO)
flufenoxuron  (ISO)
fluorescein 5-isothiocyanate  (ISO)
fluoxetine  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fomepizole  (ISO)
formononetin  (ISO)
formoterol fumarate  (EXP)
fructose  (EXP)
furan  (ISO)
galactose  (EXP)
gallic acid  (ISO)
gamma-aminobutyric acid  (ISO)
gamma-hexachlorocyclohexane  (EXP)
Gastrodin  (EXP)
gefitinib  (ISO)
Geniposide pentaacetate  (EXP)
gentamycin  (EXP)
geraniol  (EXP)
ginkgolide B  (ISO)
ginsenoside Rg1  (ISO)
gliclazide  (EXP)
gliotoxin  (EXP)
glucose  (EXP,ISO)
glutathione  (EXP,ISO)
glycochenodeoxycholic acid  (EXP)
glyphosate  (ISO)
Goe 6976  (ISO)
guggulsterone  (ISO)
GW 4064  (ISO)
haloperidol  (EXP)
heme b  (ISO)
hemin  (EXP)
hesperetin  (EXP,ISO)
hesperidin  (ISO)
hexachlorobenzene  (EXP)
hexadecanoic acid  (EXP,ISO)
hexamethylene diisocyanate  (ISO)
histamine  (EXP)
homocysteine  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
hydroxyurea  (EXP)
hypochlorous acid  (ISO)
icatibant  (EXP)
ifosfamide  (EXP)
indoxyl sulfate  (EXP,ISO)
insulin  (EXP)
iomeprol  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
isoprenaline  (EXP,ISO)
isorhamnetin  (EXP)
Isorhapontigenin  (EXP)
ivermectin  (ISO)
kaempferol  (ISO)
kanamycin A  (EXP)
ketoconazole  (EXP,ISO)
KN-93  (EXP)
kojic acid  (ISO)
KT 5823  (ISO)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (ISO)
L-cysteine  (EXP)
L-gamma-glutamyl-L-cysteine  (EXP)
L-glutamic acid  (EXP)
L-methionine  (EXP,ISO)
lactacystin  (EXP,ISO)
lead diacetate  (EXP)
lead(0)  (EXP)
lead(2+)  (EXP)
lead(II) chloride  (ISO)
lenvatinib  (EXP)
leupeptin  (ISO)
Licochalcone A  (ISO)
Licochalcone B  (ISO)
linsidomine  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
lipoteichoic acid  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
Longikaurin A  (ISO)
loperamide  (ISO)
lovastatin  (EXP)
luteolin  (ISO)
LY294002  (EXP,ISO)
lycopene  (ISO)
Maduramicin  (EXP,ISO)
Magnolol  (ISO)
malonaldehyde  (EXP)
Malonoben  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
mangiferin  (ISO)
manumycin A  (ISO)
marimastat  (EXP)
masoprocol  (ISO)
mebendazole  (ISO)
Mecamylamine  (EXP)
mechlorethamine  (ISO)
melatonin  (ISO)
menadione  (EXP,ISO)
mercaptoethanol  (ISO)
mercury dichloride  (ISO)
Mesna  (ISO)
metam  (ISO)
metformin  (EXP)
methamphetamine  (ISO)
methidathion  (ISO)
methotrexate  (EXP,ISO)
methoxychlor  (ISO)
methylglyoxal  (ISO)
methylmercury chloride  (ISO)
methylphenidate  (ISO)
methylseleninic acid  (ISO)
miconazole  (EXP)
microcystin-LR  (ISO)
mifepristone  (ISO)
minocycline  (ISO)
mitomycin C  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monodansylcadaverine  (ISO)
monosodium L-glutamate  (EXP)
morin  (EXP)
muscimol  (ISO)
mycophenolic acid  (EXP,ISO)
myricitrin  (ISO)
N(6),N(6)-dimethyladenine  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N-[2-(diethylamino)ethyl]-2-methoxy-5-methylsulfonylbenzamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (EXP,ISO)
N-Nitroso-N-methylurethane  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
Narciclasine  (ISO)
naringin  (ISO)
neocuproine  (EXP)
nerolidol  (ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotinamide  (EXP)
nicotine  (EXP,ISO)
nitroprusside  (EXP)
nocodazole  (ISO)
notoginsenoside R1  (EXP)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
oleanolic acid  (ISO)
olmesartan  (ISO)
osthole  (ISO)
oxidopamine  (EXP,ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
paroxetine  (EXP)
parthenolide  (EXP,ISO)
patulin  (EXP)
PD 168393  (ISO)
pentanal  (ISO)
Pentoxifylline  (ISO)
peptidoglycan  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perifosine  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phorone  (ISO)
phosgene  (EXP)
phthalic anhydride  (ISO)
pipoxolan  (ISO)
pirfenidone  (ISO)
pirinixic acid  (EXP,ISO)
platycodin D  (ISO)
plitidepsin  (ISO)
potassium atom  (EXP)
potassium chromate  (ISO)
pramipexole  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
proanthocyanidin  (EXP)
procyanidin B3  (ISO)
prodigiosin  (ISO)
progesterone  (EXP)
prostaglandin E2  (ISO)
prostaglandin F2alpha  (ISO)
protein kinase inhibitor  (EXP,ISO)
pterostilbene  (ISO)
puerarin  (ISO)
Pyridostigmine bromide  (ISO)
pyrrolidine dithiocarbamate  (EXP)
quercetin  (ISO)
quinoline  (ISO)
ramipril  (EXP)
razoxane  (ISO)
reactive oxygen species  (EXP,ISO)
resiniferatoxin  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rimonabant  (ISO)
Ro 31-8220  (EXP)
rosmarinic acid  (EXP)
rotenone  (EXP,ISO)
rottlerin  (ISO)
rutin  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
Salidroside  (ISO)
salubrinal  (EXP,ISO)
Salvianolic acid A  (ISO)
sanguinarine  (ISO)
sappanchalcone  (ISO)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
SCH772984  (EXP)
scopoletin  (EXP)
selenium atom  (ISO)
selenomethionine  (ISO)
serpentine asbestos  (ISO)
sertraline  (EXP)
Shikonin  (EXP)
silibinin  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sodium fluoride  (EXP,ISO)
Soman  (EXP)
sorafenib  (ISO)
spermine  (ISO)
SR 144528  (ISO)
stavudine  (ISO)
streptozocin  (EXP,ISO)
succimer  (ISO)
sucrose  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
sulindac sulfone  (ISO)
sunitinib  (ISO)
superoxide  (ISO)
surfactin  (ISO)
surfactin C  (ISO)
syringic acid  (ISO)
tacrolimus hydrate  (EXP)
tamoxifen  (ISO)
Tanshinone I  (ISO)
taurine  (EXP)
taurocholic acid  (ISO)
tenofovir disoproxil fumarate  (ISO)
tert-butyl hydroperoxide  (ISO)
tetracaine  (EXP)
Tetrachlorobisphenol A  (ISO)
tetrachloromethane  (EXP,ISO)
tetramethylpyrazine  (ISO)
thapsigargin  (EXP,ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tofacitinib  (ISO)
toluene 2,4-diisocyanate  (ISO)
trans-anethole  (ISO)
trans-chalcone  (ISO)
tributylstannane  (ISO)
tricetin  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trifluoperazine  (EXP,ISO)
trimellitic anhydride  (ISO)
trimethylarsine oxide  (EXP)
trimethyltin  (ISO)
troglitazone  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP)
trovafloxacin  (ISO)
tunicamycin  (EXP,ISO)
tyrphostin AG 1478  (EXP,ISO)
U-73122  (ISO)
umbelliferone  (EXP)
urethane  (ISO)
ursolic acid  (EXP)
valproic acid  (EXP,ISO)
verapamil  (EXP)
Vernodalin  (ISO)
vincaleukoblastine  (ISO)
vinclozolin  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
WIN 55212-2  (ISO)
withaferin A  (ISO)
wogonin  (ISO)
wortmannin  (EXP,ISO)
xanthohumol  (ISO)
Yessotoxin  (ISO)
zearalenone  (ISO)
zidovudine  (ISO)
zinc acetate  (EXP)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic signaling pathway  (ISO)
cellular response to amino acid starvation  (IEA,ISO)
cellular response to amyloid-beta  (IEP)
cellular response to cadmium ion  (IEA,ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to interleukin-1  (IEP)
cellular response to lipopolysaccharide  (IEA,ISO)
cellular response to mechanical stimulus  (IEA,ISO)
cellular response to nitric oxide  (ISO)
cellular response to oxidative stress  (ISO)
cellular response to reactive oxygen species  (IEA,ISO)
dendrite morphogenesis  (ISO)
glial cell apoptotic process  (IEP)
JNK cascade  (IBA,ISO,ISS)
JUN phosphorylation  (IEA,ISO)
MAPK cascade  (IEA)
modulation of chemical synaptic transmission  (ISO)
negative regulation of apoptotic process  (IDA,IEA,ISO)
negative regulation of protein binding  (IEA,ISO)
neuron development  (IEP)
neuron migration  (ISO)
neuron projection development  (IMP)
neuronal stem cell population maintenance  (IGI,IMP)
ossification  (ISO)
peptidyl-serine phosphorylation  (IEA,ISO,ISS)
peptidyl-threonine phosphorylation  (IEA,ISO)
positive regulation of apoptotic process  (IBA,IEP)
positive regulation of apoptotic signaling pathway  (ISO)
positive regulation of cardiac muscle cell apoptotic process  (IMP)
positive regulation of cell migration  (IDA)
positive regulation of cyclase activity  (IEA,ISO)
positive regulation of deacetylase activity  (IEA,ISO)
positive regulation of determination of dorsal identity  (ISO)
positive regulation of DNA replication  (IMP)
positive regulation of gene expression  (IEA,ISO)
positive regulation of glial cell apoptotic process  (IMP)
positive regulation of microtubule polymerization  (IMP)
positive regulation of neuroblast proliferation  (IMP)
positive regulation of neuron apoptotic process  (IMP)
positive regulation of neuron migration  (IMP)
positive regulation of NLRP3 inflammasome complex assembly  (IEA,ISO,ISS)
positive regulation of podosome assembly  (ISO)
positive regulation of protein metabolic process  (IEA,ISO)
positive regulation of protein ubiquitination  (ISO)
positive regulation of transcription factor catabolic process  (ISO)
programmed necrotic cell death  (ISO)
protein localization to tricellular tight junction  (ISO)
protein phosphorylation  (IEA,ISO)
regulation of centrosome cycle  (IMP)
regulation of circadian rhythm  (ISO,ISS)
regulation of dense core granule transport  (IDA)
regulation of DNA replication origin binding  (IEA,ISO)
regulation of DNA-templated transcription  (IDA)
regulation of gene expression  (ISO)
regulation of neuron differentiation  (IMP)
regulation of protein localization  (IEA,ISO)
response to cadmium ion  (ISO)
response to hydrogen peroxide  (IDA)
response to mechanical stimulus  (IBA)
response to oxidative stress  (ISO)
response to steroid hormone  (IEP)
response to UV  (IEA,ISO)
rhythmic process  (IEA)
stress-activated MAPK cascade  (ISO)
type B pancreatic cell apoptotic process  (IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
adenosine signaling pathway  (ISO)
c-Jun N-terminal kinases MAPK signaling pathway  (IDA,ISO)
ceramide signaling pathway  (IEA,ISO)
Chagas disease pathway  (IEA)
colorectal cancer pathway  (IEA)
Endoplasmic Reticulum-associated degradation pathway  (IEA)
endothelin signaling pathway  (ISO)
ephrin - ephrin receptor bidirectional signaling axis  (ISO)
epidermal growth factor/neuregulin signaling pathway  (IEA)
erythropoietin signaling pathway  (ISO)
FasL mediated signaling pathway  (ISO)
Fc epsilon receptor mediated signaling pathway  (IEA,ISO)
glypican signaling pathway  (ISO)
gonadotropin-releasing hormone signaling pathway  (IEA)
hepatitis C pathway  (IEA)
inflammatory response pathway  (IDA)
influenza A pathway  (IEA)
insulin signaling pathway  (IEA)
interleukin-1 signaling pathway  (ISO)
interleukin-2 signaling pathway  (ISO)
mitogen activated protein kinase signaling pathway  (IEA)
N-cadherin signaling pathway  (ISO)
neurotrophic factor signaling pathway  (IEA)
NOD-like receptor signaling pathway  (IEA)
p53 signaling pathway  (ISO)
pancreatic cancer pathway  (IEA)
platelet-derived growth factor signaling pathway  (ISO)
Reelin signaling pathway  (ISO)
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathway  (IEA)
Rho/Rac/Cdc42 mediated signaling pathway  (IMP)
sphingosine 1-phosphate signaling pathway  (ISO)
syndecan signaling pathway  (ISO)
Toll-like receptor signaling pathway  (IEA)
toxoplasmosis pathway  (IEA)
Trail mediated signaling pathway  (ISO)
tuberculosis pathway  (IEA)
type 2 diabetes mellitus pathway  (IEA)
Wnt signaling pathway  (IEA)
Wnt signaling, non-canonical pathway  (ISO)


References - curated
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Additional References at PubMed
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