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Gene: Mapk8 (mitogen-activated protein kinase 8) Rattus norvegicus
Symbol: Mapk8
Name: mitogen-activated protein kinase 8
RGD ID: 621506
Description: Exhibits JUN kinase activity and kinesin binding activity. Involved in several processes, including generation of neurons; regulation of apoptotic process; and regulation of microtubule cytoskeleton organization. Localizes to several cellular components, including dendrite cytoplasm; mitochondrion; and perikaryon. Used to study brain ischemia; hypertension; and type 2 diabetes mellitus. Biomarker of anti-basement membrane glomerulonephritis and non-alcoholic fatty liver disease. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm; colorectal adenoma; rectal benign neoplasm; and type 2 diabetes mellitus. Orthologous to human MAPK8 (mitogen-activated protein kinase 8); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; inflammatory response pathway; Rho/Rac/Cdc42 mediated signaling pathway; INTERACTS WITH (-)-anisomycin; (R)-lipoic acid; (R)-noradrenaline.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: c-Jun N-terminal kinase 1; c-jun NH2-terminal kinase; JNK; MAP kinase 8; MAPK 8; p54 gamma; SAPK gamma; stress-activated protein kinase JNK1
Homo sapiens (human) : MAPK8 (mitogen-activated protein kinase 8)  HGNC  Alliance
Mus musculus (house mouse) : Mapk8 (mitogen-activated protein kinase 8)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mapk8 (mitogen-activated protein kinase 8)
Pan paniscus (bonobo/pygmy chimpanzee) : MAPK8 (mitogen-activated protein kinase 8)
Canis lupus familiaris (dog) : MAPK8 (mitogen-activated protein kinase 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mapk8 (mitogen-activated protein kinase 8)
Sus scrofa (pig) : MAPK8 (mitogen-activated protein kinase 8)
Chlorocebus sabaeus (African green monkey) : MAPK8 (mitogen-activated protein kinase 8)
Heterocephalus glaber (naked mole-rat) : Mapk8 (mitogen-activated protein kinase 8)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0169,620,854 - 9,709,342 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl169,625,177 - 9,709,347 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01611,579,503 - 11,662,858 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4168,925,133 - 9,004,897 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1168,925,181 - 9,004,945 (-)NCBI
Celera166,485,592 - 6,568,388 (+)NCBICelera
Cytogenetic Map16p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)