Mapk8 (mitogen-activated protein kinase 8) - Rat Genome Database

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Gene: Mapk8 (mitogen-activated protein kinase 8) Rattus norvegicus
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Symbol: Mapk8
Name: mitogen-activated protein kinase 8
RGD ID: 621506
Description: Enables JUN kinase activity and kinesin binding activity. Involved in several processes, including SMAD protein signal transduction; regulation of apoptotic process; and regulation of nucleobase-containing compound metabolic process. Acts upstream of or within neuronal stem cell population maintenance. Located in several cellular components, including axon; dendrite cytoplasm; and perikaryon. Used to study Parkinsonism; alcohol use disorder; brain ischemia; hypertension; and type 2 diabetes mellitus. Biomarker of anti-basement membrane glomerulonephritis; metabolic dysfunction-associated steatotic liver disease; and myocardial infarction. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm; chronic mucocutaneous candidiasis; colorectal adenoma; rectal benign neoplasm; and type 2 diabetes mellitus. Orthologous to human MAPK8 (mitogen-activated protein kinase 8); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; inflammatory response pathway; Rho/Rac/Cdc42 mediated signaling pathway; INTERACTS WITH (+)-taxifolin; (-)-anisomycin; (R)-lipoic acid.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: c-Jun N-terminal kinase 1; c-jun NH2-terminal kinase; JNK; MAP kinase 8; MAPK 8; p54 gamma; SAPK gamma; stress-activated protein kinase JNK1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8168,645,171 - 8,728,225 (-)NCBIGRCr8
mRatBN7.2168,638,897 - 8,721,960 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl168,638,924 - 8,721,981 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx168,658,229 - 8,741,022 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0169,802,931 - 9,885,718 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0168,652,731 - 8,735,493 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0169,620,854 - 9,709,342 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl169,625,177 - 9,709,347 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01611,579,503 - 11,662,858 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4168,925,133 - 9,004,897 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1168,925,181 - 9,004,945 (-)NCBI
Celera166,485,592 - 6,568,388 (+)NCBICelera
Cytogenetic Map16p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Acute Liver Failure  (ISO)
Acute Otitis Media  (ISO)
alcohol use disorder  (IDA)
Alzheimer's disease  (ISO)
Animal Disease Models  (ISO)
anogenital venereal wart  (ISO)
anti-basement membrane glomerulonephritis  (IEP)
Arenaviridae infectious disease  (ISO)
atopic dermatitis  (ISO)
bacterial pneumonia  (ISO)
brain ischemia  (IDA)
candidiasis  (ISO)
Cardiomegaly  (ISO)
chronic mucocutaneous candidiasis  (ISO)
chronic obstructive pulmonary disease  (ISO)
Cockayne syndrome B  (ISO)
Colonic Neoplasms  (ISO)
colorectal adenocarcinoma  (ISO)
colorectal adenoma  (ISO)
Contrast-Induced Nephropathy  (IDA)
dengue disease  (ISO)
endometriosis  (ISO)
Endotoxemia  (IEP)
extrahepatic cholestasis  (ISO)
Helicobacter Infections  (ISO)
hepatitis  (ISO)
hepatocellular carcinoma  (ISO)
Hyperalgesia  (ISO)
hypertension  (IDA)
Infectious Ectromelia  (ISO)
influenza A  (ISO)
Intestinal Neoplasms  (ISO)
Kuhnt-Junius degeneration  (ISO)
Liver Reperfusion Injury  (IEP)
megacolon  (ISO)
metabolic dysfunction-associated steatotic liver disease  (IEP)
myocardial infarction  (IEP)
Myocardial Reperfusion Injury  (IDA,IEP)
Neoplastic Cell Transformation  (ISO)
Oxygen-Induced Retinopathy  (ISO)
pancreatic adenocarcinoma  (ISO)
pancreatic ductal adenocarcinoma  (ISO)
Parkinsonism  (IDA)
pre-malignant neoplasm  (ISO)
Pseudomonas Infections  (ISO)
rectal benign neoplasm  (ISO)
Reperfusion Injury  (IDA,ISO)
schizophrenia  (ISO)
Sepsis  (IDA)
steatotic liver disease  (ISO)
Stomach Neoplasms  (ISO)
Stroke  (IDA)
trigeminal neuralgia  (ISO)
type 2 diabetes mellitus  (IDA,ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(+)-taxifolin  (EXP,ISO)
(-)-anisomycin  (EXP,ISO)
(-)-Arctigenin  (ISO)
(-)-citrinin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-matairesinol  (ISO)
(1->4)-beta-D-glucan  (ISO)
(R)-lipoic acid  (EXP)
(R)-noradrenaline  (EXP)
(R)-salsolinol  (EXP)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-colchicine  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dichloropropan-2-ol  (EXP,ISO)
1,3-Dinitropyrene  (ISO)
1,4-dithiothreitol  (ISO)
1,4-phenylenediamine  (ISO)
1,8-cineole  (ISO)
1-chloro-2,4,6-trinitrobenzene  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-hydroxy-2-naphthoic acid  (ISO)
1-naphthyl isothiocyanate  (ISO)
1-nitropyrene  (ISO)
17beta-estradiol  (EXP,ISO)
2''-galloylhyperin  (ISO)
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (EXP)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-aminobiphenyl  (ISO)
2-butoxyethanol  (ISO)
2-methyl-6-(phenylethynyl)pyridine  (ISO)
2-trans,6-trans-farnesyl diphosphate  (ISO)
3',5'-cyclic GMP  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-acetyldeoxynivalenol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-Methoxynobiletin  (ISO)
3-methylcholanthrene  (ISO)
3-O-Caffeoyl-1-O-methylquinic acid  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nonylphenol  (ISO)
4-phenylbutyric acid  (EXP,ISO)
4-vinylcyclohexene dioxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
6-Methoxyflavone  (ISO)
7,12-dimethyltetraphene  (EXP)
acetaldehyde  (EXP,ISO)
acetic acid  (EXP)
acetylleucyl-leucyl-norleucinal  (ISO)
Aciculatin  (ISO)
acrolein  (EXP,ISO)
acrylamide  (EXP,ISO)
acrylonitrile  (ISO)
ADP  (ISO)
afimoxifene  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
Alisol B  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Chaconine  (ISO)
alpha-D-galactose  (EXP)
alpha-mangostin  (ISO)
aluminium sulfate (anhydrous)  (ISO)
alvocidib  (ISO)
amidotrizoic acid  (ISO)
amiloride  (ISO)
amino acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
amodiaquine  (ISO)
amphetamine  (EXP)
Anemoside B4  (ISO)
anethole  (ISO)
aniline  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimony trichloride  (ISO)
Antimony trioxide  (ISO)
ANTIMYCIN  (ISO)
Apicularen A  (ISO)
apigenin  (EXP)
apocynin  (ISO)
apremilast  (EXP)
arachidonic acid  (ISO)
Arctiin  (ISO)
arecoline  (EXP)
aristolochic acid A  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
asbestos  (ISO)
asiatic acid  (ISO)
astaxanthin  (ISO)
atrazine  (EXP,ISO)
atropine  (EXP)
auranofin  (ISO)
aureusidin  (EXP)
Azaspiracid  (ISO)
bafilomycin A1  (ISO)
baicalein  (ISO)
BAPTA  (ISO)
bathocuproine disulfonic acid  (EXP)
benomyl  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[a]pyrene-7,8-diol  (ISO)
benzyl isothiocyanate  (ISO)
berberine  (ISO)
beta-D-glucosamine  (ISO)
beta-hexachlorocyclohexane  (EXP)
beta-lapachone  (ISO)
betulin  (EXP)
bicuculline  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
bleomycin A2  (ISO)
bortezomib  (EXP,ISO)
bosutinib  (ISO)
bufalin  (ISO)
bupropion  (ISO)
butanal  (ISO)
butein  (ISO)
butylated hydroxyanisole  (EXP,ISO)
butyric acid  (ISO)
C.I. Natural Red 20  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium selenide  (ISO)
cadmium sulfate  (EXP,ISO)
Calcimycin  (ISO)
calcipotriol  (ISO)
calcitriol  (ISO)
camptothecin  (ISO)
candesartan  (ISO)
cannabidiol  (ISO)
cantharidic acid  (ISO)
capsaicin  (ISO)
capsazepine  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbendazim  (EXP)
carbon nanotube  (ISO)
carfilzomib  (EXP)
carnosic acid  (EXP,ISO)
carnosine  (ISO)
Carnosol  (ISO)
celastrol  (EXP)
celecoxib  (ISO)
ceruletide  (ISO)
chalcone  (ISO)
chenodeoxycholic acid  (ISO)
chlordecone  (ISO)
chlorogenic acid  (EXP)
chloroprene  (EXP)
chloroquine  (ISO)
chlorothalonil  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (EXP,ISO)
cholate  (ISO)
choline  (ISO)
chromium atom  (ISO)
chromium(6+)  (ISO)
chrysophanol  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (ISO)
coenzyme Q10  (EXP)
colistin  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP,ISO)
copper(II) sulfate  (ISO)
cordycepin  (EXP,ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cypermethrin  (EXP,ISO)
D-glucitol  (ISO)
D-glucose  (EXP,ISO)
D-mannitol  (ISO)
dapagliflozin  (EXP)
DDT  (ISO)
decabromodiphenyl ether  (ISO)
delphinidin  (ISO)
deoxynivalenol  (ISO)
Deoxyschizandrin  (ISO)
desferrioxamine B  (ISO)
desipramine  (ISO)
dexamethasone  (EXP,ISO)
Di-n-octyl phthalate  (ISO)
diallyl disulfide  (ISO)
Diallyl sulfide  (ISO)
diallyl trisulfide  (ISO)
Diallyltetrasulfane  (EXP)
diarsenic trioxide  (EXP,ISO)
diazepam  (EXP)
diazinon  (EXP)
dibenziodolium  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dicoumarol  (ISO)
dicrotophos  (ISO)
Dictamnine  (ISO)
diethyl maleate  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
diltiazem  (EXP)
dimethylarsinic acid  (EXP,ISO)
Dinitramine  (ISO)
dinophysistoxin 1  (ISO)
dioscin  (ISO)
diosmetin  (ISO)
dioxygen  (EXP,ISO)
diphenhydramine  (ISO)
dipyridamole  (ISO)
disodium selenite  (EXP,ISO)
disulfiram  (EXP,ISO)
donepezil hydrochloride  (EXP)
dopamine  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
edaravone  (ISO)
efavirenz  (ISO)
elemental selenium  (ISO)
ellagic acid  (ISO)
emetine  (ISO)
enilconazole  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
erastin  (ISO)
eriocitrin  (ISO)
eriodictyol  (ISO)
esculetin  (ISO)
estragole  (EXP)
etacrynic acid  (ISO)
ethanol  (EXP,ISO)
Ethyl pyruvate  (EXP)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP,ISO)
Evodiamine  (EXP,ISO)
fangchinoline  (ISO)
farnesyl diphosphate  (ISO)
febuxostat  (ISO)
fenvalerate  (ISO)
ferroheme b  (ISO)
ferrosoferric oxide  (ISO)
ferulic acid  (EXP,ISO)
flubendazole  (ISO)
flufenoxuron  (ISO)
fluorescein 5-isothiocyanate  (ISO)
fluoxetine  (EXP)
flutamide  (EXP,ISO)
folic acid  (ISO)
fomepizole  (ISO)
formononetin  (ISO)
formoterol fumarate  (EXP)
fraxetin  (ISO)
fructose  (EXP)
fucoxanthin  (ISO)
fulvestrant  (ISO)
Fulvic acid  (ISO)
furan  (ISO)
galactose  (EXP)
galangin  (EXP)
gallic acid  (ISO)
gamma-aminobutyric acid  (ISO)
gamma-hexachlorocyclohexane  (EXP)
Gastrodin  (EXP)
gefitinib  (ISO)
Geniposide pentaacetate  (EXP)
gentamycin  (EXP)
geraniol  (EXP)
ginkgolide B  (ISO)
ginsenoside Rg1  (ISO)
gliclazide  (EXP)
gliotoxin  (EXP)
glucose  (EXP,ISO)
glutathione  (EXP,ISO)
glycidyl methacrylate  (ISO)
glycochenodeoxycholic acid  (EXP)
glyphosate  (ISO)
Goe 6976  (ISO)
guggulsterone  (ISO)
GW 4064  (ISO)
haloperidol  (EXP)
heme b  (ISO)
hemin  (EXP)
hesperetin  (EXP,ISO)
hesperidin  (ISO)
hexachlorobenzene  (EXP)
hexadecanoic acid  (EXP,ISO)
hexaflumuron  (EXP)
hexamethylene diisocyanate  (ISO)
hispidulin  (ISO)
histamine  (EXP)
homocysteine  (ISO)
Honokiol  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
hydroxyurea  (EXP)
hymexazol  (EXP)
hypochlorous acid  (ISO)
ibuprofen  (ISO)
icatibant  (EXP)
ifosfamide  (EXP)
imidacloprid  (EXP)
indoxyl sulfate  (EXP,ISO)
insulin  (EXP)
iomeprol  (ISO)
ionomycin  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
Isoliensinine  (ISO)
isoprenaline  (EXP,ISO)
isorhamnetin  (EXP)
isorhapontigenin  (EXP)
ivermectin  (ISO)
kaempferol  (ISO)
kanamycin A  (EXP)
ketoconazole  (EXP,ISO)
KN-93  (EXP)
kojic acid  (ISO)
KT 5823  (ISO)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (ISO)
L-cysteine  (EXP)
L-gamma-glutamyl-L-cysteine  (EXP)
L-glutamic acid  (EXP)
L-methionine  (EXP,ISO)
lactacystin  (EXP,ISO)
lactulose  (EXP)
lead diacetate  (EXP)
lead(0)  (EXP)
lead(II) chloride  (ISO)
lenvatinib  (EXP)
leupeptin  (ISO)
Licochalcone A  (ISO)
Licochalcone B  (ISO)
linsidomine  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
lipoteichoic acid  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
Longikaurin A  (ISO)
loperamide  (ISO)
lovastatin  (EXP)
luteolin  (ISO)
LY294002  (EXP,ISO)
lycopene  (ISO)
Maduramicin  (EXP,ISO)
Magnolol  (ISO)
malonaldehyde  (EXP)
Malonoben  (ISO)
maneb  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
mangiferin  (ISO)
manumycin A  (ISO)
marimastat  (EXP)
masoprocol  (ISO)
mebendazole  (ISO)
Mecamylamine  (EXP)
mechlorethamine  (ISO)
melatonin  (ISO)
menadione  (EXP,ISO)
mercaptoethanol  (ISO)
mercury dichloride  (ISO)
Mesna  (ISO)
metam  (ISO)
metformin  (EXP,ISO)
methamphetamine  (ISO)
methidathion  (ISO)
methotrexate  (EXP,ISO)
methoxychlor  (ISO)
methylglyoxal  (ISO)
methylmercury chloride  (EXP,ISO)
methylphenidate  (ISO)
methylseleninic acid  (ISO)
miconazole  (EXP)
microcystin-LR  (ISO)
mifepristone  (ISO)
minocycline  (ISO)
mitomycin C  (ISO)
ML-7  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monodansylcadaverine  (ISO)
monosodium L-glutamate  (EXP)
montelukast  (ISO)
morin  (EXP)
muscimol  (ISO)
mycophenolic acid  (EXP,ISO)
myricitrin  (ISO)
N(6),N(6)-dimethyladenine  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N-[2-(diethylamino)ethyl]-2-methoxy-5-methylsulfonylbenzamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylsphingosine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (EXP,ISO)
N-Nitroso-N-methylurethane  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
Narciclasine  (ISO)
naringin  (ISO)
neocuproine  (EXP)
nerolidol  (ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotinamide  (EXP)
nicotine  (EXP,ISO)
nilotinib  (ISO)
nitroprusside  (EXP)
nocodazole  (ISO)
NORCANTHARIDIN  (ISO)
notoginsenoside R1  (EXP)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
oleanolic acid  (ISO)
oleic acid  (ISO)
olmesartan  (ISO)
oltipraz  (ISO)
osthole  (ISO)
oxidopamine  (EXP,ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parecoxib  (ISO)
paroxetine  (EXP)
parthenolide  (EXP,ISO)
patulin  (EXP)
PD 168393  (ISO)
pentanal  (ISO)
Pentoxifylline  (ISO)
peptidoglycan  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
perifosine  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
phloretin  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phorone  (ISO)
phosgene  (EXP)
phthalic anhydride  (ISO)
pifithrin-?  (ISO)
pipoxolan  (ISO)
pirfenidone  (ISO)
pirinixic acid  (EXP,ISO)
platycodin D  (ISO)
plitidepsin  (ISO)
potassium atom  (EXP)
potassium chromate  (ISO)
pramipexole  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
proanthocyanidin  (EXP)
procyanidin B3  (ISO)
procymidone  (ISO)
prodigiosin  (ISO)
progesterone  (EXP)
prostaglandin E2  (ISO)
prostaglandin F2alpha  (ISO)
protein kinase inhibitor  (EXP,ISO)
Pseudolaric acid B  (ISO)
psoralen  (ISO)
pterostilbene  (ISO)
puerarin  (ISO)
Pyridostigmine bromide  (ISO)
pyrrolidine dithiocarbamate  (EXP)
quercetin  (ISO)
quinoline  (ISO)
ramipril  (EXP)
razoxane  (ISO)
reactive oxygen species  (EXP,ISO)
resiniferatoxin  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rimonabant  (ISO)
Ro 31-8220  (EXP)
rosmarinic acid  (EXP)
rotenone  (EXP,ISO)
rottlerin  (ISO)
Ruscogenin  (ISO)
Rutecarpine  (ISO)
rutin  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
Salidroside  (ISO)
salubrinal  (EXP,ISO)
Salvianolic acid A  (ISO)
sanguinarine  (ISO)
sappanchalcone  (ISO)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
SCH772984  (EXP)
scopoletin  (EXP)
selenium atom  (ISO)
selenomethionine  (ISO)
serpentine asbestos  (ISO)
sertraline  (EXP)
Shikonin  (EXP)
silibinin  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
simvastatin  (EXP,ISO)
sinapic acid  (EXP)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sodium fluoride  (EXP,ISO)
Soman  (EXP)
sorafenib  (ISO)
spermine  (ISO)
SR 144528  (ISO)
stavudine  (ISO)
streptozocin  (EXP,ISO)
succimer  (ISO)
sucrose  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
sulindac sulfone  (ISO)
sunitinib  (ISO)
superoxide  (ISO)
surfactin  (ISO)
surfactin C  (ISO)
syringic acid  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (EXP)
tamoxifen  (ISO)
Tanshinone I  (ISO)
taurine  (EXP)
taurocholic acid  (ISO)
TEMPO  (ISO)
tenofovir disoproxil fumarate  (ISO)
tert-butyl hydroperoxide  (ISO)
tetracaine  (EXP)
Tetrachlorobisphenol A  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetramethylpyrazine  (ISO)
thapsigargin  (EXP,ISO)
Theaflavin 3,3'-digallate  (EXP,ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
Thrombin  (EXP)
titanium dioxide  (ISO)
tofacitinib  (ISO)
toluene 2,4-diisocyanate  (ISO)
trans-anethole  (ISO)
trans-chalcone  (ISO)
tributylstannane  (ISO)
tricetin  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trifluoperazine  (EXP,ISO)
trimellitic anhydride  (ISO)
trimethylarsine oxide  (EXP)
trimethyltin  (ISO)
troglitazone  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP)
trovafloxacin  (ISO)
tunicamycin  (EXP,ISO)
tyrphostin AG 1478  (EXP,ISO)
U-73122  (ISO)
umbelliferone  (EXP)
urethane  (ISO)
ursolic acid  (EXP)
valproic acid  (EXP,ISO)
vanillic acid  (ISO)
verapamil  (EXP)
Vernodalin  (ISO)
vincaleukoblastine  (ISO)
vinclozolin  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
WIN 55212-2  (ISO)
withaferin A  (ISO)
wogonin  (ISO)
wortmannin  (EXP,ISO)
xanthohumol  (ISO)
Yessotoxin  (ISO)
zearalenone  (ISO)
zidovudine  (ISO)
zinc acetate  (EXP)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)
zingerone  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic signaling pathway  (ISO)
cellular response to amino acid starvation  (IEA,ISO)
cellular response to amyloid-beta  (IEP)
cellular response to hydrogen peroxide  (ISO)
cellular response to interleukin-1  (IEP)
cellular response to lipopolysaccharide  (IEA,ISO)
cellular response to mechanical stimulus  (IEA,ISO)
cellular response to nitric oxide  (ISO)
cellular response to oxidative stress  (ISO)
cellular response to oxygen-glucose deprivation  (IEP,IMP)
cellular response to reactive oxygen species  (IEA,ISO)
dendrite morphogenesis  (ISO)
energy homeostasis  (ISO)
glial cell apoptotic process  (IEP)
integrin-mediated signaling pathway  (ISO)
JNK cascade  (IBA,IEA,ISO,ISS)
JUN phosphorylation  (ISO)
modulation of chemical synaptic transmission  (ISO)
negative regulation of apoptotic process  (IDA,IEA,ISO)
neuron development  (IEP)
neuron migration  (ISO)
neuron projection development  (IMP)
neuronal stem cell population maintenance  (IGI,IMP)
ossification  (ISO)
peptidyl-serine phosphorylation  (ISO,ISS)
peptidyl-threonine phosphorylation  (ISO)
positive regulation of apoptotic process  (IBA,IEP)
positive regulation of apoptotic signaling pathway  (ISO)
positive regulation of cardiac muscle cell apoptotic process  (IMP)
positive regulation of cell migration  (IDA)
positive regulation of cyclase activity  (ISO)
positive regulation of determination of dorsal identity  (ISO)
positive regulation of DNA replication  (IMP)
positive regulation of gene expression  (IEA,ISO)
positive regulation of glial cell apoptotic process  (IMP)
positive regulation of microtubule polymerization  (IMP)
positive regulation of neuroblast proliferation  (IMP)
positive regulation of neuron apoptotic process  (IMP)
positive regulation of neuron migration  (IMP)
positive regulation of NLRP3 inflammasome complex assembly  (IEA,ISO,ISS)
positive regulation of podosome assembly  (ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (ISO)
positive regulation of protein metabolic process  (IEA,ISO)
positive regulation of protein ubiquitination  (ISO)
programmed necrotic cell death  (ISO)
protein localization to tricellular tight junction  (ISO)
protein phosphorylation  (ISO)
regulation of centrosome cycle  (IMP)
regulation of circadian rhythm  (ISO,ISS)
regulation of dense core granule transport  (IDA)
regulation of DNA-templated transcription  (IDA)
regulation of gene expression  (ISO)
regulation of neuron differentiation  (IMP)
regulation of protein localization  (IEA,ISO)
response to cadmium ion  (ISO)
response to hydrogen peroxide  (IDA)
response to mechanical stimulus  (IBA)
response to oxidative stress  (ISO)
response to steroid hormone  (IEP)
response to UV  (IEA,ISO)
rhythmic process  (IEA)
SMAD protein signal transduction  (IMP)
stress-activated MAPK cascade  (IEA,ISO)
type B pancreatic cell apoptotic process  (IMP)

Cellular Component
axon  (IDA,ISO)
basal dendrite  (ISO)
cytoplasm  (IBA,IEA,ISO)
cytosol  (ISO,TAS)
dendrite cytoplasm  (IDA)
mitochondrion  (ISO)
neuron projection  (ISO)
nucleoplasm  (TAS)
nucleus  (IBA,IEA,ISO)
perikaryon  (IDA)
podosome  (ISO)
Schaffer collateral - CA1 synapse  (ISO)
synapse  (IDA)
vesicle  (IDA)

Molecular Pathway Annotations     Click to see Annotation Detail View
adenosine signaling pathway   (ISO)
c-Jun N-terminal kinases MAPK signaling pathway  (IDA,ISO)
ceramide signaling pathway  (IEA,ISO)
Chagas disease pathway   (IEA)
colorectal cancer pathway  (IEA)
Endoplasmic Reticulum-associated degradation pathway  (IEA)
endothelin signaling pathway  (ISO)
ephrin - ephrin receptor bidirectional signaling axis   (ISO)
epidermal growth factor/neuregulin signaling pathway  (IEA)
erythropoietin signaling pathway   (ISO)
FasL mediated signaling pathway  (ISO)
Fc epsilon receptor mediated signaling pathway  (IEA,ISO)
glypican signaling pathway  (ISO)
gonadotropin-releasing hormone signaling pathway  (IEA)
hepatitis C pathway  (IEA)
inflammatory response pathway  (IDA)
influenza A pathway   (IEA)
insulin signaling pathway   (IEA)
interleukin-1 signaling pathway  (ISO)
interleukin-2 signaling pathway   (ISO)
mitogen activated protein kinase signaling pathway  (IEA)
N-cadherin signaling pathway  (ISO)
neurotrophic factor signaling pathway  (IEA)
NOD-like receptor signaling pathway   (IEA)
p53 signaling pathway   (ISO)
pancreatic cancer pathway  (IEA)
platelet-derived growth factor signaling pathway   (ISO)
Reelin signaling pathway  (ISO)
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathway  (IEA)
Rho/Rac/Cdc42 mediated signaling pathway  (IMP)
sphingosine 1-phosphate signaling pathway  (ISO)
syndecan signaling pathway   (ISO)
Toll-like receptor signaling pathway  (IEA)
toxoplasmosis pathway   (IEA)
Trail mediated signaling pathway  (ISO)
tuberculosis pathway   (IEA)
type 2 diabetes mellitus pathway  (IEA)
Wnt signaling pathway  (IEA)
Wnt signaling, non-canonical pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
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2. The Ras/Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists stimulate DNA synthesis in primary cultures of rat hepatocytes. Auer KL, etal., Mol Biol Cell. 1998 Mar;9(3):561-73.
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24. Inhibition of c-Jun N-terminal kinase 1, but not c-Jun N-terminal kinase 2, suppresses apoptosis induced by ischemia/reoxygenation in rat cardiac myocytes. Hreniuk D, etal., Mol Pharmacol. 2001 Apr;59(4):867-74.
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28. Hypoosmotic stress activates p38, ERK 1 and 2, and SAPK/JNK in rat hepatocytes. Kim RD, etal., J Surg Res. 2000 May 1;90(1):58-66.
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49. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
50. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
51. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
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55. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
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59. Rapamycin attenuates load-induced cardiac hypertrophy in mice. Shioi T, etal., Circulation. 2003 Apr 1;107(12):1664-70. Epub 2003 Mar 17.
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72. c-Jun NH2-terminal kinase 1 plays a critical role in intestinal homeostasis and tumor suppression. Tong C, etal., Am J Pathol. 2007 Jul;171(1):297-303.
73. Mitogen-activated protein kinase kinase 7 is activated during low potassium-induced apoptosis in rat cerebellar granule neurons. Trotter L, etal., Neurosci Lett. 2002 Mar 1;320(1-2):29-32.
74. Pseudomonas aeruginosa colonization enhances ventilator-associated pneumonia-induced lung injury. Tsay TB, etal., Respir Res. 2016 Aug 9;17(1):101. doi: 10.1186/s12931-016-0417-5.
75. Activation of c-Jun N-terminal kinase 1 and caspase 3 in the tamoxifen-induced apoptosis of rat glioma cells. Tseng SH, etal., J Cancer Res Clin Oncol. 2004 May;130(5):285-93. Epub 2004 Mar 2.
76. Differential requirement for c-Jun N-terminal kinase 1 in lung inflammation and host defense. Van der Velden J, etal., PLoS One. 2012;7(4):e34638. doi: 10.1371/journal.pone.0034638. Epub 2012 Apr 13.
77. Inhibition of MLK3-MKK4/7-JNK1/2 pathway by Akt1 in exogenous estrogen-induced neuroprotection against transient global cerebral ischemia by a non-genomic mechanism in male rats. Wang R, etal., J Neurochem. 2006 Dec;99(6):1543-54. Epub 2006 Oct 25.
78. Protective effects of octacosanol on 6-hydroxydopamine-induced Parkinsonism in rats via regulation of ProNGF and NGF signaling. Wang T, etal., Acta Pharmacol Sin. 2010 Jul;31(7):765-74. doi: 10.1038/aps.2010.69. Epub 2010 Jun 28.
79. Regulation of c-Jun N-terminal kinase activation in hydrogen peroxide induced neurotoxicity. Wang W, etal., J Neurocytol. 2003 Feb;32(2):143-51.
80. Defective antiviral CD8 T-cell response and viral clearance in the absence of c-Jun N-terminal kinases. Wang YQ, etal., Immunology. 2014 Aug;142(4):603-13. doi: 10.1111/imm.12270.
81. [Expression and significance of JNK1, Raf-1 and Livin in the carcinogenesis of sporadic colorectal tubular adenoma]. Wu WX, etal., Zhonghua Zhong Liu Za Zhi. 2010 Sep;32(9):671-5.
82. Microcephaly-associated protein WDR62 regulates neurogenesis through JNK1 in the developing neocortex. Xu D, etal., Cell Rep. 2014 Jan 16;6(1):104-16. doi: 10.1016/j.celrep.2013.12.016. Epub 2014 Jan 2.
83. Activin A/Smads signaling pathway negatively regulates Oxygen Glucose Deprivation-induced autophagy via suppression of JNK and p38 MAPK pathways in neuronal PC12 cells. Xue LX, etal., Biochem Biophys Res Commun. 2016 Nov 18;480(3):355-361. doi: 10.1016/j.bbrc.2016.10.050. Epub 2016 Oct 18.
84. Inhibition of JNK suppresses autophagy and attenuates insulin resistance in a rat model of nonalcoholic fatty liver disease. Yan H, etal., Mol Med Rep. 2017 Jan;15(1):180-186. doi: 10.3892/mmr.2016.5966. Epub 2016 Nov 24.
85. Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase. Yoshimura K, etal., Nat Med. 2005 Dec;11(12):1330-8. Epub 2005 Nov 27.
86. TNFalpha induces apoptosis through JNK/Bax-dependent pathway in differentiated, but not naive PC12 cells. Zhang L, etal., Cell Cycle. 2007 Jun 15;6(12):1479-86. Epub 2007 Apr 18.
87. Crosstalk between PSD-95 and JIP1-mediated signaling modules: the mechanism of MLK3 activation in cerebral ischemia. Zhang QX, etal., Biochemistry. 2007 Apr 3;46(13):4006-16. Epub 2007 Mar 10.
88. JNK1 negatively controls antifungal innate immunity by suppressing CD23 expression. Zhao X, etal., Nat Med. 2017 Mar;23(3):337-346. doi: 10.1038/nm.4260. Epub 2017 Jan 23.
89. Activation and redistribution of c-jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease. Zhu X, etal., J Neurochem. 2001 Jan;76(2):435-41.
90. Peroxisome proliferator activator receptor-gamma ligands, 15-deoxy-Delta(12,14)-prostaglandin J2 and ciglitazone, reduce systemic inflammation in polymicrobial sepsis by modulation of signal transduction pathways. Zingarelli B, etal., J Immunol. 2003 Dec 15;171(12):6827-37. doi: 10.4049/jimmunol.171.12.6827.
Additional References at PubMed
PMID:8654373   PMID:8889548   PMID:9516415   PMID:9710592   PMID:10811224   PMID:11096076   PMID:11146548   PMID:11884367   PMID:12376548   PMID:12445686   PMID:12606754   PMID:12700162  
PMID:12808090   PMID:12865320   PMID:12869386   PMID:12869527   PMID:12933347   PMID:12971962   PMID:14615289   PMID:14633134   PMID:14643766   PMID:14769808   PMID:14967141   PMID:14983993  
PMID:15030387   PMID:15093613   PMID:15145937   PMID:15254243   PMID:15316358   PMID:15326485   PMID:15356200   PMID:15483136   PMID:15579909   PMID:15591151   PMID:15689551   PMID:15739188  
PMID:15767678   PMID:15820682   PMID:15850461   PMID:15911351   PMID:16000625   PMID:16005241   PMID:16055088   PMID:16092944   PMID:16157589   PMID:16246848   PMID:16260609   PMID:16336220  
PMID:16396984   PMID:16458303   PMID:16491099   PMID:16491125   PMID:16771680   PMID:16902157   PMID:16942465   PMID:16971530   PMID:17003331   PMID:17015265   PMID:17041759   PMID:17251057  
PMID:17287517   PMID:17325051   PMID:17333127   PMID:17410600   PMID:17519787   PMID:17521827   PMID:17542038   PMID:17546627   PMID:17555943   PMID:17583725   PMID:17668873   PMID:17698050  
PMID:17723265   PMID:17923323   PMID:17923327   PMID:17932215   PMID:17959308   PMID:18007661   PMID:18023197   PMID:18056745   PMID:18060575   PMID:18096574   PMID:18206660   PMID:18222916  
PMID:18316368   PMID:18330891   PMID:18351465   PMID:18355160   PMID:18371080   PMID:18455449   PMID:18547751   PMID:18566605   PMID:18625195   PMID:18650245   PMID:18666320   PMID:18782186  
PMID:18800014   PMID:18806094   PMID:18822271   PMID:18926830   PMID:18957384   PMID:19011585   PMID:19061880   PMID:19080378   PMID:19099816   PMID:19109696   PMID:19272379   PMID:19289495  
PMID:19332546   PMID:19362079   PMID:19368836   PMID:19430970   PMID:19460707   PMID:19593445   PMID:19648647   PMID:19723053   PMID:19723098   PMID:19776350   PMID:19819946   PMID:19840222  
PMID:19885391   PMID:19923798   PMID:19937805   PMID:19996110   PMID:20014487   PMID:20027304   PMID:20051532   PMID:20081110   PMID:20110876   PMID:20111901   PMID:20196785   PMID:20421303  
PMID:20450637   PMID:20497490   PMID:20501438   PMID:20808772   PMID:20808927   PMID:20945380   PMID:21042752   PMID:21095239   PMID:21132399   PMID:21134288   PMID:21181362   PMID:21184129  
PMID:21186629   PMID:21255465   PMID:21263381   PMID:21297631   PMID:21300140   PMID:21336655   PMID:21478152   PMID:21488184   PMID:21518436   PMID:21542012   PMID:21554942   PMID:21726169  
PMID:21764057   PMID:21779001   PMID:21856198   PMID:21856377   PMID:21996423   PMID:22027397   PMID:22065586   PMID:22088537   PMID:22143198   PMID:22227208   PMID:22229265   PMID:22363806  
PMID:22384127   PMID:22441692   PMID:22467874   PMID:22513717   PMID:22681856   PMID:22683681   PMID:22699892   PMID:22775755   PMID:23000971   PMID:23139803   PMID:23157661   PMID:23209658  
PMID:23262141   PMID:23640896   PMID:23667638   PMID:23776175   PMID:23815272   PMID:23969109   PMID:24040124   PMID:24126863   PMID:24127566   PMID:24134609   PMID:24225419   PMID:24330599  
PMID:24421392   PMID:24434514   PMID:24801387   PMID:24859228   PMID:24889144   PMID:24936061   PMID:24942612   PMID:25098198   PMID:25178280   PMID:25234391   PMID:25268311   PMID:25285524  
PMID:25326457   PMID:25479410   PMID:25744836   PMID:25752945   PMID:26002468   PMID:26165348   PMID:26370512   PMID:26427475   PMID:26491907   PMID:26514923   PMID:26549199   PMID:26565704  
PMID:26610752   PMID:26751999   PMID:26962537   PMID:27220977   PMID:27322569   PMID:27430327   PMID:27769859   PMID:27884327   PMID:27916420   PMID:28118532   PMID:28533328   PMID:29115603  
PMID:29153991   PMID:29207022   PMID:29896988   PMID:29901107   PMID:30942391   PMID:30988348   PMID:31060780   PMID:31111559   PMID:31630301   PMID:32414595   PMID:32657446   PMID:33044948  
PMID:33607044   PMID:35033142   PMID:37325630   PMID:38302075  


Genomics

Comparative Map Data
Mapk8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8168,645,171 - 8,728,225 (-)NCBIGRCr8
mRatBN7.2168,638,897 - 8,721,960 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl168,638,924 - 8,721,981 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx168,658,229 - 8,741,022 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0169,802,931 - 9,885,718 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0168,652,731 - 8,735,493 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0169,620,854 - 9,709,342 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl169,625,177 - 9,709,347 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01611,579,503 - 11,662,858 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4168,925,133 - 9,004,897 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1168,925,181 - 9,004,945 (-)NCBI
Celera166,485,592 - 6,568,388 (+)NCBICelera
Cytogenetic Map16p16NCBI
MAPK8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381048,306,677 - 48,439,360 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1048,306,639 - 48,439,360 (+)EnsemblGRCh38hg38GRCh38
GRCh371049,514,720 - 49,647,403 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361049,279,693 - 49,313,189 (+)NCBINCBI36Build 36hg18NCBI36
Build 341049,279,692 - 49,313,189NCBI
Celera1043,195,579 - 43,229,096 (+)NCBICelera
Cytogenetic Map10q11.22NCBI
HuRef1043,779,561 - 43,912,232 (+)NCBIHuRef
CHM1_11049,796,560 - 49,929,236 (+)NCBICHM1_1
T2T-CHM13v2.01049,155,699 - 49,288,442 (+)NCBIT2T-CHM13v2.0
Mapk8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391433,099,855 - 33,169,213 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1433,099,855 - 33,169,115 (-)EnsemblGRCm39 Ensembl
GRCm381433,377,898 - 33,447,353 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1433,377,898 - 33,447,158 (-)EnsemblGRCm38mm10GRCm38
MGSCv371434,191,084 - 34,260,344 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361432,211,101 - 32,276,249 (-)NCBIMGSCv36mm8
Celera1429,636,611 - 29,705,910 (-)NCBICelera
Cytogenetic Map14BNCBI
cM Map1420.22NCBI
Mapk8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555561,593,494 - 1,665,784 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555561,593,552 - 1,705,543 (-)NCBIChiLan1.0ChiLan1.0
MAPK8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2860,574,189 - 60,702,156 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11060,579,543 - 60,707,592 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01045,806,748 - 45,936,362 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
MAPK8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.128323,361 - 410,367 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl28368,513 - 406,401 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha28552,432 - 639,965 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.028498,642 - 586,320 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl28498,626 - 586,317 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.128298,436 - 386,002 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.028339,385 - 427,241 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.028432,766 - 552,601 (+)NCBIUU_Cfam_GSD_1.0
Mapk8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721380,572,918 - 80,691,087 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367281,775,641 - 1,893,907 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367281,775,746 - 1,893,895 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAPK8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1488,988,949 - 89,108,874 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11488,988,914 - 89,108,875 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21496,724,970 - 96,803,101 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAPK8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1943,356,603 - 43,489,066 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl943,356,308 - 43,393,425 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660483,124,408 - 3,258,374 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mapk8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249281,439,146 - 1,494,266 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249281,442,216 - 1,494,275 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mapk8
607 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:132
Count of miRNA genes:118
Interacting mature miRNAs:120
Transcripts:ENSRNOT00000065216
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1619639137Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
737825Alc13Alcohol consumption QTL 134.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760916039848Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
61372Bp40Blood pressure QTL 402.2blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)16422773017696785Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)16285170915884239Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat

Markers in Region
STS-L26318  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2168,643,214 - 8,643,351 (+)MAPPERmRatBN7.2
Rnor_6.0169,625,172 - 9,625,308NCBIRnor6.0
Rnor_5.01611,583,821 - 11,583,957UniSTSRnor5.0
RGSC_v3.4168,925,128 - 8,925,264UniSTSRGSC3.4
Celera166,563,984 - 6,564,120UniSTS
Cytogenetic Map16p16UniSTS
RH129367  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2168,639,061 - 8,639,268 (+)MAPPERmRatBN7.2
Rnor_6.0169,621,019 - 9,621,225NCBIRnor6.0
Rnor_5.01611,579,668 - 11,579,874UniSTSRnor5.0
RGSC_v3.4168,920,975 - 8,921,181UniSTSRGSC3.4
Celera166,568,017 - 6,568,223UniSTS
RH 3.4 Map1686.3UniSTS
Cytogenetic Map16p16UniSTS
AI849689  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2168,638,957 - 8,639,041 (+)MAPPERmRatBN7.2
Rnor_6.0169,620,915 - 9,620,998NCBIRnor6.0
Rnor_5.01611,579,564 - 11,579,647UniSTSRnor5.0
RGSC_v3.4168,920,871 - 8,920,954UniSTSRGSC3.4
Celera166,568,244 - 6,568,327UniSTS
Cytogenetic Map16p16UniSTS
RH143559  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2168,721,332 - 8,721,441 (+)MAPPERmRatBN7.2
Rnor_6.0169,708,715 - 9,708,823NCBIRnor6.0
Rnor_5.01611,662,231 - 11,662,339UniSTSRnor5.0
RGSC_v3.4169,004,320 - 9,004,428UniSTSRGSC3.4
Celera166,486,111 - 6,486,219UniSTS
RH 3.4 Map1685.6UniSTS
Cytogenetic Map16p16UniSTS
RH139074  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2168,638,992 - 8,639,125 (+)MAPPERmRatBN7.2
Rnor_6.0169,620,950 - 9,621,082NCBIRnor6.0
Rnor_5.01611,579,599 - 11,579,731UniSTSRnor5.0
RGSC_v3.4168,920,906 - 8,921,038UniSTSRGSC3.4
Celera166,568,160 - 6,568,292UniSTS
RH 3.4 Map1686.3UniSTS
Cytogenetic Map16p16UniSTS
RH140683  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2168,709,744 - 8,709,941 (+)MAPPERmRatBN7.2
Rnor_6.0169,697,129 - 9,697,325NCBIRnor6.0
Rnor_5.01611,650,645 - 11,650,841UniSTSRnor5.0
RGSC_v3.4168,992,733 - 8,992,929UniSTSRGSC3.4
Celera166,497,603 - 6,497,799UniSTS
RH 3.4 Map1687.9UniSTS
Cytogenetic Map16p16UniSTS
UniSTS:237161  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2168,639,728 - 8,640,023 (+)MAPPERmRatBN7.2
Rnor_6.0169,621,686 - 9,621,980NCBIRnor6.0
Rnor_5.01611,580,335 - 11,580,629UniSTSRnor5.0
RGSC_v3.4168,921,642 - 8,921,936UniSTSRGSC3.4
Celera166,567,262 - 6,567,556UniSTS
Cytogenetic Map16p16UniSTS
MARC_13424-13425:1002294866:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2168,647,690 - 8,648,300 (+)MAPPERmRatBN7.2
Rnor_6.0169,629,648 - 9,630,257NCBIRnor6.0
Rnor_5.01611,588,297 - 11,588,906UniSTSRnor5.0
RGSC_v3.4168,929,604 - 8,930,213UniSTSRGSC3.4
Celera166,559,083 - 6,559,692UniSTS
Cytogenetic Map16p16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000065216   ⟹   ENSRNOP00000062048
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl168,643,220 - 8,721,960 (-)Ensembl
Rnor_6.0 Ensembl169,625,177 - 9,658,484 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000083933   ⟹   ENSRNOP00000075277
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl168,642,937 - 8,721,981 (-)Ensembl
Rnor_6.0 Ensembl169,640,480 - 9,709,347 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099742   ⟹   ENSRNOP00000082511
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl168,638,924 - 8,721,960 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101766   ⟹   ENSRNOP00000096591
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl168,638,924 - 8,721,960 (-)Ensembl
RefSeq Acc Id: NM_053829   ⟹   NP_446281
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8168,645,171 - 8,728,225 (-)NCBI
mRatBN7.2168,638,897 - 8,721,960 (-)NCBI
Rnor_6.0169,620,854 - 9,709,342 (-)NCBI
Rnor_5.01611,579,503 - 11,662,858 (-)NCBI
Celera166,485,592 - 6,568,388 (+)NCBI
Sequence:
RefSeq Acc Id: NP_446281   ⟸   NM_053829
- UniProtKB: P49185 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000062048   ⟸   ENSRNOT00000065216
Ensembl Acc Id: ENSRNOP00000075277   ⟸   ENSRNOT00000083933
Ensembl Acc Id: ENSRNOP00000082511   ⟸   ENSRNOT00000099742
Ensembl Acc Id: ENSRNOP00000096591   ⟸   ENSRNOT00000101766
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P49185-F1-model_v2 AlphaFold P49185 1-411 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699958
Promoter ID:EPDNEW_R10474
Type:multiple initiation site
Name:Mapk8_1
Description:mitogen-activated protein kinase 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0169,709,355 - 9,709,415EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621506 AgrOrtholog
BioCyc Gene G2FUF-12092 BioCyc
Ensembl Genes ENSRNOG00000020155 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000065216.4 UniProtKB/TrEMBL
  ENSRNOT00000083933.2 UniProtKB/TrEMBL
  ENSRNOT00000099742.1 UniProtKB/TrEMBL
  ENSRNOT00000101766.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAP_kinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAP_kinase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAPK_JNK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:116554 UniProtKB/Swiss-Prot
NCBI Gene 116554 ENTREZGENE
PANTHER MITOGEN-ACTIVATED PROTEIN KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MITOGEN-ACTIVATED PROTEIN KINASE 8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB MAPK8 RGD
PhenoGen Mapk8 PhenoGen
PRINTS JNKMAPKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MAPK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020155 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2KA63_RAT UniProtKB/TrEMBL
  A0A8I5ZXC7_RAT UniProtKB/TrEMBL
  A0A8I6B4F5_RAT UniProtKB/TrEMBL
  A6KFU2_RAT UniProtKB/TrEMBL
  A6KFU3_RAT UniProtKB/TrEMBL
  A6KFU4_RAT UniProtKB/TrEMBL
  A6KFU5_RAT UniProtKB/TrEMBL
  F1LP66_RAT UniProtKB/TrEMBL
  MK08_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Mapk8  mitogen-activated protein kinase 8      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Mapk8  mitogen-activated protein kinase 8      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation activated by cellular stress, sphingomyelinase and tumour necrosis factor (TNF)-alpha 729029