Mapk8 (mitogen-activated protein kinase 8) - Rat Genome Database

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Gene: Mapk8 (mitogen-activated protein kinase 8) Rattus norvegicus
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Symbol: Mapk8
Name: mitogen-activated protein kinase 8
RGD ID: 621506
Description: Enables JUN kinase activity and kinesin binding activity. Involved in several processes, including generation of neurons; regulation of apoptotic process; and regulation of cellular macromolecule biosynthetic process. Acts upstream of or within neuronal stem cell population maintenance. Located in several cellular components, including dendrite cytoplasm; mitochondrion; and perikaryon. Used to study brain ischemia; hypertension; and type 2 diabetes mellitus. Biomarker of anti-basement membrane glomerulonephritis and non-alcoholic fatty liver disease. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm; colorectal adenoma; rectal benign neoplasm; and type 2 diabetes mellitus. Orthologous to human MAPK8 (mitogen-activated protein kinase 8); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; inflammatory response pathway; Rho/Rac/Cdc42 mediated signaling pathway; INTERACTS WITH (-)-anisomycin; (R)-lipoic acid; (R)-noradrenaline.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: c-Jun N-terminal kinase 1; c-jun NH2-terminal kinase; JNK; MAP kinase 8; MAPK 8; p54 gamma; SAPK gamma; stress-activated protein kinase JNK1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2168,638,897 - 8,721,960 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl168,638,924 - 8,721,981 (-)Ensembl
Rnor_6.0169,620,854 - 9,709,342 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl169,625,177 - 9,709,347 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01611,579,503 - 11,662,858 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4168,925,133 - 9,004,897 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1168,925,181 - 9,004,945 (-)NCBI
Celera166,485,592 - 6,568,388 (+)NCBICelera
Cytogenetic Map16p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(+)-taxifolin  (ISO)
(-)-anisomycin  (EXP,ISO)
(-)-citrinin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-lipoic acid  (EXP)
(R)-noradrenaline  (EXP)
(R)-Salsolinol  (EXP)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-colchicine  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dichloropropan-2-ol  (EXP,ISO)
1,3-Dinitropyrene  (ISO)
1,4-dithiothreitol  (ISO)
1,4-phenylenediamine  (ISO)
1,8-cineole  (ISO)
1-chloro-2,4,6-trinitrobenzene  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-hydroxy-2-naphthoic acid  (ISO)
1-nitropyrene  (ISO)
17beta-estradiol  (EXP,ISO)
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (EXP)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butoxyethanol  (ISO)
2-methyl-6-(phenylethynyl)pyridine  (ISO)
2-trans,6-trans-farnesyl diphosphate  (ISO)
3',5'-cyclic GMP  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3-O-Caffeoyl-1-O-methylquinic acid  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nonylphenol  (ISO)
4-phenylbutyric acid  (EXP)
4-vinylcyclohexene dioxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
acetaldehyde  (EXP,ISO)
acetic acid  (EXP)
acetylleucyl-leucyl-norleucinal  (ISO)
acrolein  (EXP,ISO)
acrylamide  (EXP,ISO)
ADP  (ISO)
afimoxifene  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-Chaconine  (ISO)
alpha-mangostin  (ISO)
alvocidib  (ISO)
amidotrizoic acid  (ISO)
amiloride  (ISO)
amino acid  (ISO)
ammonium chloride  (EXP)
amodiaquine  (ISO)
amphetamine  (EXP)
anethole  (ISO)
aniline  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
Antimony trioxide  (ISO)
ANTIMYCIN  (ISO)
apigenin  (EXP)
apocynin  (ISO)
arachidonic acid  (ISO)
aristolochic acid  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
asbestos  (ISO)
asiatic acid  (ISO)
atrazine  (EXP,ISO)
atropine  (EXP)
aureusidin  (EXP)
Azaspiracid  (ISO)
bafilomycin A1  (ISO)
baicalein  (ISO)
BAPTA  (ISO)
bathocuproine disulfonic acid  (EXP)
benomyl  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[a]pyrene-7,8-diol  (ISO)
benzyl isothiocyanate  (ISO)
beta-D-glucosamine  (ISO)
beta-hexachlorocyclohexane  (EXP)
bicuculline  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
bortezomib  (ISO)
bufalin  (ISO)
bupropion  (ISO)
butanal  (ISO)
butylated hydroxyanisole  (EXP,ISO)
butyric acid  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium selenide  (ISO)
cadmium sulfate  (EXP,ISO)
Calcimycin  (ISO)
calcipotriol  (ISO)
calcitriol  (ISO)
camptothecin  (ISO)
candesartan  (ISO)
cantharidic acid  (ISO)
capsaicin  (ISO)
capsazepine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carnosic acid  (EXP,ISO)
carnosine  (ISO)
celecoxib  (ISO)
chalcone  (ISO)
chenodeoxycholic acid  (ISO)
chlordecone  (ISO)
chloroprene  (EXP)
chloroquine  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (EXP)
cholate  (ISO)
choline  (ISO)
chromium atom  (ISO)
chromium(6+)  (ISO)
chrysophanol  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP,ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cypermethrin  (ISO)
D-glucose  (EXP,ISO)
D-mannitol  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (ISO)
delphinidin  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
desipramine  (ISO)
dexamethasone  (EXP,ISO)
diallyl disulfide  (ISO)
Diallyl sulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
diazepam  (EXP)
diazinon  (EXP)
dibenziodolium  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dicoumarol  (ISO)
dicrotophos  (ISO)
Dictamnine  (ISO)
diethylstilbestrol  (ISO)
diltiazem  (EXP)
dimethylarsinic acid  (EXP,ISO)
Dinitramine  (ISO)
dinophysistoxin 1  (ISO)
dioscin  (ISO)
dioxygen  (EXP,ISO)
diphenhydramine  (ISO)
dipyridamole  (ISO)
disodium selenite  (ISO)
disulfiram  (EXP,ISO)
donepezil hydrochloride  (EXP)
dopamine  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
edaravone  (ISO)
efavirenz  (ISO)
elemental selenium  (ISO)
ellagic acid  (ISO)
emetine  (ISO)
enilconazole  (ISO)
entinostat  (ISO)
erastin  (ISO)
eriodictyol  (ISO)
esculetin  (ISO)
Estragole  (EXP)
etacrynic acid  (ISO)
ethanol  (EXP,ISO)
Ethyl pyruvate  (EXP)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP,ISO)
Evodiamine  (ISO)
farnesyl diphosphate  (ISO)
fenvalerate  (ISO)
ferrosoferric oxide  (ISO)
ferulic acid  (EXP,ISO)
flubendazole  (ISO)
flufenoxuron  (ISO)
fluorescein 5-isothiocyanate  (ISO)
fluoxetine  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fomepizole  (ISO)
formoterol fumarate  (EXP)
fructose  (EXP)
gallic acid  (ISO)
gamma-aminobutyric acid  (ISO)
gamma-hexachlorocyclohexane  (EXP)
Gastrodin  (EXP)
gefitinib  (ISO)
Geniposide pentaacetate  (EXP)
gentamycin  (EXP)
ginkgolide B  (ISO)
ginsenoside Rg1  (ISO)
gliclazide  (EXP)
gliotoxin  (EXP)
glucose  (EXP,ISO)
glutathione  (EXP,ISO)
glyphosate  (ISO)
Goe 6976  (ISO)
guggulsterone  (ISO)
GW 4064  (ISO)
haloperidol  (EXP)
hemin  (EXP)
hesperetin  (EXP,ISO)
hesperidin  (ISO)
hexachlorobenzene  (EXP)
hexadecanoic acid  (EXP,ISO)
hexamethylene diisocyanate  (ISO)
histamine  (EXP)
homocysteine  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
hydroxyurea  (EXP)
hypochlorous acid  (ISO)
icatibant  (EXP)
ifosfamide  (EXP)
indoxyl sulfate  (EXP,ISO)
iomeprol  (ISO)
isoprenaline  (EXP,ISO)
isorhamnetin  (EXP)
Isorhapontigenin  (EXP)
ivermectin  (ISO)
kaempferol  (ISO)
kanamycin A  (EXP)
ketoconazole  (EXP,ISO)
KN-93  (EXP)
kojic acid  (ISO)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (ISO)
L-cysteine  (EXP)
L-methionine  (EXP,ISO)
lactacystin  (EXP,ISO)
lead diacetate  (EXP)
lead(II) chloride  (ISO)
Licochalcone A  (ISO)
Licochalcone B  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
lipoteichoic acid  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
Longikaurin A  (ISO)
lovastatin  (EXP)
luteolin  (ISO)
LY294002  (EXP,ISO)
lycopene  (ISO)
Magnolol  (ISO)
malonaldehyde  (EXP)
Malonoben  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
mangiferin  (ISO)
Manumycin A  (ISO)
marimastat  (EXP)
masoprocol  (ISO)
mebendazole  (ISO)
Mecamylamine  (EXP)
mechlorethamine  (ISO)
melatonin  (ISO)
menadione  (EXP,ISO)
mercaptoethanol  (ISO)
mercury dichloride  (ISO)
Mesna  (ISO)
metam  (ISO)
methamphetamine  (ISO)
methotrexate  (EXP,ISO)
methoxychlor  (ISO)
methylglyoxal  (ISO)
methylmercury chloride  (ISO)
methylphenidate  (ISO)
methylseleninic acid  (ISO)
miconazole  (EXP)
microcystin-LR  (ISO)
mifepristone  (ISO)
minocycline  (ISO)
mitomycin C  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monodansylcadaverine  (ISO)
monosodium L-glutamate  (EXP)
morin  (EXP)
muscimol  (ISO)
mycophenolic acid  (EXP,ISO)
myricitrin  (ISO)
N(6),N(6)-dimethyladenine  (EXP)
N-[2-(diethylamino)ethyl]-2-methoxy-5-methylsulfonylbenzamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (EXP,ISO)
N-Nitroso-N-methylurethane  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
Narciclasine  (ISO)
naringin  (ISO)
neocuproine  (EXP)
nickel dichloride  (EXP,ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotinamide  (EXP)
nicotine  (EXP,ISO)
nitroprusside  (EXP)
nocodazole  (ISO)
notoginsenoside R1  (EXP)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
oleanolic acid  (ISO)
olmesartan  (ISO)
osthole  (ISO)
oxidopamine  (EXP,ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
paroxetine  (EXP)
parthenolide  (EXP,ISO)
PD 168393  (ISO)
pentanal  (ISO)
Pentoxifylline  (ISO)
peptidoglycan  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perifosine  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phorone  (ISO)
phosgene  (EXP)
phthalic anhydride  (ISO)
pipoxolan  (ISO)
pirinixic acid  (EXP,ISO)
platycodin D  (ISO)
plitidepsin  (ISO)
potassium atom  (EXP)
potassium chromate  (ISO)
pramipexole  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
proanthocyanidin  (EXP)
procyanidin B3  (ISO)
prodigiosin  (ISO)
progesterone  (EXP)
prostaglandin E2  (ISO)
prostaglandin F2alpha  (ISO)
protein kinase inhibitor  (EXP,ISO)
pterostilbene  (ISO)
puerarin  (ISO)
pyrrolidine dithiocarbamate  (EXP)
quercetin  (ISO)
quinoline  (ISO)
ramipril  (EXP)
razoxane  (ISO)
reactive oxygen species  (EXP,ISO)
resiniferatoxin  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rimonabant  (ISO)
Ro 31-8220  (EXP)
rosmarinic acid  (EXP)
rotenone  (EXP,ISO)
rottlerin  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
salubrinal  (EXP,ISO)
Salvianolic acid A  (ISO)
sanguinarine  (ISO)
sappanchalcone  (ISO)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
SCH772984  (EXP)
selenium atom  (ISO)
selenomethionine  (ISO)
serpentine asbestos  (ISO)
sertraline  (EXP)
silibinin  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sodium fluoride  (EXP,ISO)
Soman  (EXP)
sorafenib  (ISO)
spermine  (ISO)
SR 144528  (ISO)
stavudine  (ISO)
streptozocin  (EXP,ISO)
succimer  (ISO)
sucrose  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
sulindac sulfone  (ISO)
sunitinib  (ISO)
superoxide  (ISO)
syringic acid  (ISO)
tacrolimus hydrate  (EXP)
tamoxifen  (ISO)
Tanshinone I  (ISO)
taurine  (EXP)
taurocholic acid  (ISO)
TEMPO  (ISO)
tenofovir disoproxil fumarate  (ISO)
tert-butyl hydroperoxide  (ISO)
tetracaine  (EXP)
tetrachloromethane  (EXP,ISO)
tetramethylpyrazine  (ISO)
thapsigargin  (EXP,ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tofacitinib  (ISO)
toluene 2,4-diisocyanate  (ISO)
trans-anethole  (ISO)
trans-chalcone  (ISO)
tributylstannane  (ISO)
tricetin  (ISO)
trichostatin A  (ISO)
trifluoperazine  (EXP,ISO)
trimellitic anhydride  (ISO)
trimethylarsine oxide  (EXP)
trimethyltin  (ISO)
troglitazone  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP)
trovafloxacin  (ISO)
tunicamycin  (EXP,ISO)
tyrphostin AG 1478  (EXP,ISO)
U-73122  (ISO)
urethane  (ISO)
ursolic acid  (EXP)
valproic acid  (EXP,ISO)
verapamil  (EXP)
vincaleukoblastine  (ISO)
vinclozolin  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
WIN 55212-2  (ISO)
withaferin A  (ISO)
wogonin  (ISO)
wortmannin  (EXP,ISO)
Yessotoxin  (ISO)
zearalenone  (ISO)
zidovudine  (ISO)
zinc acetate  (EXP)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to amino acid starvation  (IEA,ISO)
cellular response to amyloid-beta  (IEP)
cellular response to cadmium ion  (IEA,ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to interleukin-1  (IEP)
cellular response to lipopolysaccharide  (IEA,ISO)
cellular response to mechanical stimulus  (IEA,ISO)
cellular response to nitric oxide  (ISO)
cellular response to reactive oxygen species  (IEA,ISO)
dendrite morphogenesis  (ISO)
glial cell apoptotic process  (IEP)
inflammatory response  (IDA)
intracellular signal transduction  (IBA)
JNK cascade  (IBA,ISO,ISS)
JUN phosphorylation  (IEA,ISO)
MAPK cascade  (IEA)
negative regulation of apoptotic process  (IDA,IEA,ISO)
negative regulation of protein binding  (IEA,ISO)
neuron development  (IEP)
neuron migration  (ISO)
neuron projection development  (IMP)
neuronal stem cell population maintenance  (IGI,IMP)
ossification  (ISO)
peptidyl-serine phosphorylation  (IEA,ISO,ISS)
peptidyl-threonine phosphorylation  (IEA,ISO)
positive regulation of apoptotic process  (IBA,IEP)
positive regulation of apoptotic signaling pathway  (ISO)
positive regulation of cardiac muscle cell apoptotic process  (IMP)
positive regulation of cell migration  (IDA)
positive regulation of cyclase activity  (IEA,ISO)
positive regulation of deacetylase activity  (IEA,ISO)
positive regulation of determination of dorsal identity  (ISO)
positive regulation of DNA replication  (IMP)
positive regulation of gene expression  (IEA,ISO)
positive regulation of glial cell apoptotic process  (IMP)
positive regulation of microtubule polymerization  (IMP)
positive regulation of neuroblast proliferation  (IMP)
positive regulation of neuron apoptotic process  (IMP)
positive regulation of neuron migration  (IMP)
positive regulation of podosome assembly  (ISO)
positive regulation of protein metabolic process  (IEA,ISO)
positive regulation of protein ubiquitination  (ISO)
positive regulation of transcription factor catabolic process  (ISO)
programmed necrotic cell death  (ISO)
protein localization to tricellular tight junction  (ISO)
protein phosphorylation  (IEA,ISO)
regulation of centrosome cycle  (IMP)
regulation of circadian rhythm  (ISO,ISS)
regulation of dense core granule transport  (IDA)
regulation of DNA replication origin binding  (IEA,ISO)
regulation of gene expression  (ISO)
regulation of histone deacetylation  (IEA)
regulation of neuron differentiation  (IMP)
regulation of protein localization  (IEA,ISO)
regulation of transcription, DNA-templated  (IDA)
response to cadmium ion  (ISO)
response to heat  (IDA)
response to hydrogen peroxide  (IDA)
response to mechanical stimulus  (IBA)
response to osmotic stress  (IDA)
response to oxidative stress  (ISO)
response to steroid hormone  (IEP)
response to UV  (IEA,ISO)
rhythmic process  (IEA)
signal transduction  (IDA)
stress-activated MAPK cascade  (ISO)
type B pancreatic cell apoptotic process  (IMP)

Cellular Component
axon  (IDA,ISO)
basal dendrite  (ISO)
cytoplasm  (IBA,IDA,ISO)
cytosol  (ISO,TAS)
dendrite cytoplasm  (IDA)
mitochondrion  (IDA,ISO)
nucleoplasm  (TAS)
nucleus  (IBA,IDA,IEA,ISO)
perikaryon  (IDA)
podosome  (ISO)
synapse  (IDA)
vesicle  (IDA)

Molecular Pathway Annotations     Click to see Annotation Detail View
adenosine signaling pathway  (ISO)
c-Jun N-terminal kinases MAPK signaling pathway  (IDA,ISO)
ceramide signaling pathway  (IEA,ISO)
Chagas disease pathway  (IEA)
colorectal cancer pathway  (IEA)
Endoplasmic Reticulum-associated degradation pathway  (IEA)
endothelin signaling pathway  (ISO)
ephrin - ephrin receptor bidirectional signaling axis  (ISO)
epidermal growth factor/neuregulin signaling pathway  (IEA)
erythropoietin signaling pathway  (ISO)
FasL mediated signaling pathway  (ISO)
Fc epsilon receptor mediated signaling pathway  (IEA,ISO)
glypican signaling pathway  (ISO)
gonadotropin-releasing hormone signaling pathway  (IEA)
hepatitis C pathway  (IEA)
inflammatory response pathway  (IDA)
influenza A pathway  (IEA)
insulin signaling pathway  (IEA)
interleukin-1 signaling pathway  (ISO)
interleukin-2 signaling pathway  (ISO)
mitogen activated protein kinase signaling pathway  (IEA)
N-cadherin signaling pathway  (ISO)
neurotrophic factor signaling pathway  (IEA)
NOD-like receptor signaling pathway  (IEA)
p53 signaling pathway  (ISO)
pancreatic cancer pathway  (IEA)
platelet-derived growth factor signaling pathway  (ISO)
Reelin signaling pathway  (ISO)
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathway  (IEA)
Rho/Rac/Cdc42 mediated signaling pathway  (IMP)
sphingosine 1-phosphate signaling pathway  (ISO)
syndecan signaling pathway  (ISO)
Toll-like receptor signaling pathway  (IEA)
toxoplasmosis pathway  (IEA)
Trail mediated signaling pathway  (ISO)
tuberculosis pathway  (IEA)
type 2 diabetes mellitus pathway  (IEA)
Wnt signaling pathway  (IEA)
Wnt signaling, non-canonical pathway  (ISO)

References

References - curated
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Additional References at PubMed
PMID:8654373   PMID:8889548   PMID:9516415   PMID:9710592   PMID:10811224   PMID:11096076   PMID:11146548   PMID:11884367   PMID:12376548   PMID:12445686   PMID:12606754   PMID:12700162  
PMID:12808090   PMID:12865320   PMID:12869386   PMID:12869527   PMID:12933347   PMID:12971962   PMID:14615289   PMID:14633134   PMID:14643766   PMID:14769808   PMID:14967141   PMID:14983993  
PMID:15030387   PMID:15093613   PMID:15145937   PMID:15254243   PMID:15316358   PMID:15326485   PMID:15356200   PMID:15483136   PMID:15579909   PMID:15591151   PMID:15689551   PMID:15739188  
PMID:15767678   PMID:15820682   PMID:15850461   PMID:15911351   PMID:16000625   PMID:16005241   PMID:16055088   PMID:16092944   PMID:16157589   PMID:16246848   PMID:16260609   PMID:16336220  
PMID:16396984   PMID:16458303   PMID:16491099   PMID:16491125   PMID:16771680   PMID:16902157   PMID:16942465   PMID:16971530   PMID:17003331   PMID:17015265   PMID:17041759   PMID:17251057  
PMID:17287517   PMID:17325051   PMID:17333127   PMID:17410600   PMID:17519787   PMID:17521827   PMID:17542038   PMID:17546627   PMID:17555943   PMID:17583725   PMID:17668873   PMID:17698050  
PMID:17723265   PMID:17923323   PMID:17923327   PMID:17932215   PMID:17959308   PMID:18007661   PMID:18023197   PMID:18056745   PMID:18060575   PMID:18096574   PMID:18206660   PMID:18222916  
PMID:18316368   PMID:18330891   PMID:18351465   PMID:18355160   PMID:18371080   PMID:18455449   PMID:18547751   PMID:18566605   PMID:18625195   PMID:18650245   PMID:18666320   PMID:18782186  
PMID:18800014   PMID:18806094   PMID:18822271   PMID:18926830   PMID:18957384   PMID:19011585   PMID:19061880   PMID:19080378   PMID:19099816   PMID:19109696   PMID:19272379   PMID:19289495  
PMID:19332546   PMID:19362079   PMID:19368836   PMID:19430970   PMID:19460707   PMID:19593445   PMID:19648647   PMID:19723053   PMID:19723098   PMID:19776350   PMID:19819946   PMID:19840222  
PMID:19885391   PMID:19923798   PMID:19937805   PMID:19996110   PMID:20014487   PMID:20027304   PMID:20051532   PMID:20081110   PMID:20110876   PMID:20111901   PMID:20196785   PMID:20421303  
PMID:20450637   PMID:20497490   PMID:20501438   PMID:20808772   PMID:20808927   PMID:20945380   PMID:21042752   PMID:21095239   PMID:21132399   PMID:21134288   PMID:21181362   PMID:21184129  
PMID:21186629   PMID:21255465   PMID:21263381   PMID:21297631   PMID:21300140   PMID:21336655   PMID:21478152   PMID:21488184   PMID:21518436   PMID:21542012   PMID:21554942   PMID:21726169  
PMID:21764057   PMID:21779001   PMID:21856198   PMID:21856377   PMID:21996423   PMID:22027397   PMID:22065586   PMID:22088537   PMID:22143198   PMID:22227208   PMID:22229265   PMID:22363806  
PMID:22384127   PMID:22441692   PMID:22467874   PMID:22513717   PMID:22681856   PMID:22683681   PMID:22699892   PMID:22775755   PMID:23000971   PMID:23139803   PMID:23157661   PMID:23209658  
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PMID:25326457   PMID:25479410   PMID:25744836   PMID:25752945   PMID:26002468   PMID:26165348   PMID:26370512   PMID:26427475   PMID:26491907   PMID:26514923   PMID:26549199   PMID:26565704  
PMID:26610752   PMID:26751999   PMID:26962537   PMID:27220977   PMID:27322569   PMID:27430327   PMID:27769859   PMID:27884327   PMID:27916420   PMID:28118532   PMID:28533328   PMID:29115603  
PMID:29153991   PMID:29207022   PMID:29896988   PMID:29901107   PMID:30942391   PMID:30988348   PMID:31060780   PMID:31111559   PMID:31630301   PMID:32414595   PMID:32657446   PMID:33044948  
PMID:33607044  


Genomics

Comparative Map Data
Mapk8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2168,638,897 - 8,721,960 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl168,638,924 - 8,721,981 (-)Ensembl
Rnor_6.0169,620,854 - 9,709,342 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl169,625,177 - 9,709,347 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01611,579,503 - 11,662,858 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4168,925,133 - 9,004,897 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1168,925,181 - 9,004,945 (-)NCBI
Celera166,485,592 - 6,568,388 (+)NCBICelera
Cytogenetic Map16p16NCBI
MAPK8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1048,306,639 - 48,439,360 (+)EnsemblGRCh38hg38GRCh38
GRCh381048,306,673 - 48,439,360 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371049,514,720 - 49,647,403 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361049,279,693 - 49,313,189 (+)NCBINCBI36hg18NCBI36
Build 341049,279,692 - 49,313,189NCBI
Celera1043,195,579 - 43,229,096 (+)NCBI
Cytogenetic Map10q11.22NCBI
HuRef1043,779,561 - 43,912,232 (+)NCBIHuRef
CHM1_11049,796,560 - 49,929,236 (+)NCBICHM1_1
Mapk8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391433,099,855 - 33,169,215 (-)NCBIGRCm39mm39
GRCm39 Ensembl1433,099,855 - 33,169,115 (-)Ensembl
GRCm381433,377,898 - 33,447,353 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1433,377,898 - 33,447,158 (-)EnsemblGRCm38mm10GRCm38
MGSCv371434,191,084 - 34,260,344 (-)NCBIGRCm37mm9NCBIm37
MGSCv361432,211,101 - 32,276,249 (-)NCBImm8
Celera1429,636,611 - 29,705,910 (-)NCBICelera
Cytogenetic Map14BNCBI
Mapk8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555561,593,494 - 1,665,784 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555561,593,552 - 1,705,543 (-)NCBIChiLan1.0ChiLan1.0
MAPK8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Mhudiblu_PPA_v01045,806,748 - 45,936,362 (-)NCBIMhudiblu_PPA_v0panPan3
MAPK8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.128323,361 - 410,367 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl28368,513 - 406,401 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha28552,432 - 639,965 (+)NCBI
ROS_Cfam_1.028498,642 - 586,320 (+)NCBI
UMICH_Zoey_3.128298,436 - 386,002 (+)NCBI
UNSW_CanFamBas_1.028339,385 - 427,241 (+)NCBI
UU_Cfam_GSD_1.028432,766 - 552,601 (+)NCBI
Mapk8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721380,572,918 - 80,691,087 (-)NCBI
SpeTri2.0NW_0049367281,775,746 - 1,893,895 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAPK8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1488,988,949 - 89,172,200 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11488,988,914 - 89,108,875 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21496,724,970 - 96,803,101 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAPK8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1943,356,603 - 43,489,066 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl943,356,308 - 43,393,425 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660483,124,408 - 3,258,374 (-)NCBIVero_WHO_p1.0
Mapk8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249281,442,216 - 1,494,275 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
STS-L26318  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2168,643,214 - 8,643,351 (+)MAPPERmRatBN7.2
Rnor_6.0169,625,172 - 9,625,308NCBIRnor6.0
Rnor_5.01611,583,821 - 11,583,957UniSTSRnor5.0
RGSC_v3.4168,925,128 - 8,925,264UniSTSRGSC3.4
Celera166,563,984 - 6,564,120UniSTS
Cytogenetic Map16p16UniSTS
RH129367  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2168,639,061 - 8,639,268 (+)MAPPERmRatBN7.2
Rnor_6.0169,621,019 - 9,621,225NCBIRnor6.0
Rnor_5.01611,579,668 - 11,579,874UniSTSRnor5.0
RGSC_v3.4168,920,975 - 8,921,181UniSTSRGSC3.4
Celera166,568,017 - 6,568,223UniSTS
RH 3.4 Map1686.3UniSTS
Cytogenetic Map16p16UniSTS
AI849689  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2168,638,957 - 8,639,041 (+)MAPPERmRatBN7.2
Rnor_6.0169,620,915 - 9,620,998NCBIRnor6.0
Rnor_5.01611,579,564 - 11,579,647UniSTSRnor5.0
RGSC_v3.4168,920,871 - 8,920,954UniSTSRGSC3.4
Celera166,568,244 - 6,568,327UniSTS
Cytogenetic Map16p16UniSTS
RH143559  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2168,721,332 - 8,721,441 (+)MAPPERmRatBN7.2
Rnor_6.0169,708,715 - 9,708,823NCBIRnor6.0
Rnor_5.01611,662,231 - 11,662,339UniSTSRnor5.0
RGSC_v3.4169,004,320 - 9,004,428UniSTSRGSC3.4
Celera166,486,111 - 6,486,219UniSTS
RH 3.4 Map1685.6UniSTS
Cytogenetic Map16p16UniSTS
RH139074  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2168,638,992 - 8,639,125 (+)MAPPERmRatBN7.2
Rnor_6.0169,620,950 - 9,621,082NCBIRnor6.0
Rnor_5.01611,579,599 - 11,579,731UniSTSRnor5.0
RGSC_v3.4168,920,906 - 8,921,038UniSTSRGSC3.4
Celera166,568,160 - 6,568,292UniSTS
RH 3.4 Map1686.3UniSTS
Cytogenetic Map16p16UniSTS
RH140683  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2168,709,744 - 8,709,941 (+)MAPPERmRatBN7.2
Rnor_6.0169,697,129 - 9,697,325NCBIRnor6.0
Rnor_5.01611,650,645 - 11,650,841UniSTSRnor5.0
RGSC_v3.4168,992,733 - 8,992,929UniSTSRGSC3.4
Celera166,497,603 - 6,497,799UniSTS
RH 3.4 Map1687.9UniSTS
Cytogenetic Map16p16UniSTS
UniSTS:237161  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2168,639,728 - 8,640,023 (+)MAPPERmRatBN7.2
Rnor_6.0169,621,686 - 9,621,980NCBIRnor6.0
Rnor_5.01611,580,335 - 11,580,629UniSTSRnor5.0
RGSC_v3.4168,921,642 - 8,921,936UniSTSRGSC3.4
Celera166,567,262 - 6,567,556UniSTS
Cytogenetic Map16p16UniSTS
MARC_13424-13425:1002294866:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2168,647,690 - 8,648,300 (+)MAPPERmRatBN7.2
Rnor_6.0169,629,648 - 9,630,257NCBIRnor6.0
Rnor_5.01611,588,297 - 11,588,906UniSTSRnor5.0
RGSC_v3.4168,929,604 - 8,930,213UniSTSRGSC3.4
Celera166,559,083 - 6,559,692UniSTS
Cytogenetic Map16p16UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1619639137Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
631561Hcuc2Hepatic copper content QTL 22.8hepatic copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)16285170915884239Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
737825Alc13Alcohol consumption QTL 134.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760916039848Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
61372Bp40Blood pressure QTL 402.2blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)16422773017696785Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:132
Count of miRNA genes:118
Interacting mature miRNAs:120
Transcripts:ENSRNOT00000065216
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 36 40 24 19 24 8 10