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Gene: S1PR5 (sphingosine-1-phosphate receptor 5) Homo sapiens
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Symbol: S1PR5
Name: sphingosine-1-phosphate receptor 5
Description: The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; others (e.g., EDG2; MIM 602282) are LPA receptors.[supplied by OMIM, Mar 2008]
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Edg-8; EDG8; endothelial differentiation G-protein-coupled receptor 8; endothelial differentiation, sphingolipid G-protein-coupled receptor, 8; S1P receptor 5; S1P receptor Edg-8; S1P5; sphingosine 1-phosphate receptor 5; sphingosine 1-phosphate receptor Edg-8; sphingosine 1-phosphate receptor EDG8; SPPR-1; SPPR-2
Orthologs:
Mus musculus (house mouse) : S1pr5 (sphingosine-1-phosphate receptor 5)  MGI  Alliance
Rattus norvegicus (Norway rat) : S1pr5 (sphingosine-1-phosphate receptor 5)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : S1pr5 (sphingosine-1-phosphate receptor 5)
Pan paniscus (bonobo/pygmy chimpanzee) : S1PR5 (sphingosine-1-phosphate receptor 5)
Canis lupus familiaris (dog) : S1PR5 (sphingosine-1-phosphate receptor 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : S1pr5 (sphingosine-1-phosphate receptor 5)
Sus scrofa (pig) : S1PR5 (sphingosine-1-phosphate receptor 5)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381910,512,742 - 10,517,965 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371910,623,418 - 10,628,668 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361910,484,623 - 10,489,112 (-)NCBINCBI36hg18NCBI36
Build 341910,484,622 - 10,489,112NCBI
Celera1910,518,131 - 10,523,388 (-)NCBI
Cytogenetic Map19p13.2NCBI
HuRef1910,201,961 - 10,207,399 (-)NCBIHuRef
CHM1_11910,624,176 - 10,629,433 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on S1PR5
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733271
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.