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Gene: S1PR5 (sphingosine-1-phosphate receptor 5) Homo sapiens
Symbol: S1PR5
Name: sphingosine-1-phosphate receptor 5
Description: The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; others (e.g., EDG2; MIM 602282) are LPA receptors.[supplied by OMIM, Mar 2008]
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Edg-8; EDG8; endothelial differentiation G-protein-coupled receptor 8; endothelial differentiation, sphingolipid G-protein-coupled receptor, 8; S1P receptor 5; S1P receptor Edg-8; S1P5; sphingosine 1-phosphate receptor 5; sphingosine 1-phosphate receptor Edg-8; sphingosine 1-phosphate receptor EDG8; SPPR-1; SPPR-2
Mus musculus (house mouse) : S1pr5 (sphingosine-1-phosphate receptor 5)  MGI  Alliance
Rattus norvegicus (Norway rat) : S1pr5 (sphingosine-1-phosphate receptor 5)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : S1pr5 (sphingosine-1-phosphate receptor 5)
Pan paniscus (bonobo/pygmy chimpanzee) : S1PR5 (sphingosine-1-phosphate receptor 5)
Canis lupus familiaris (dog) : S1PR5 (sphingosine-1-phosphate receptor 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : S1pr5 (sphingosine-1-phosphate receptor 5)
Sus scrofa (pig) : S1PR5 (sphingosine-1-phosphate receptor 5)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381910,512,742 - 10,517,965 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371910,623,418 - 10,628,668 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361910,484,623 - 10,489,112 (-)NCBINCBI36hg18NCBI36
Build 341910,484,622 - 10,489,112NCBI
Celera1910,518,131 - 10,523,388 (-)NCBI
Cytogenetic Map19p13.2NCBI
HuRef1910,201,961 - 10,207,399 (-)NCBIHuRef
CHM1_11910,624,176 - 10,629,433 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on S1PR5
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733271
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.