S1pr5 (sphingosine-1-phosphate receptor 5) - Rat Genome Database

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Pathways
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Gene: S1pr5 (sphingosine-1-phosphate receptor 5) Rattus norvegicus
Analyze
Symbol: S1pr5
Name: sphingosine-1-phosphate receptor 5
RGD ID: 620566
Description: Enables G protein-coupled receptor activity. Involved in regulation of neuron differentiation. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human S1PR5 (sphingosine-1-phosphate receptor 5); PARTICIPATES IN sphingosine 1-phosphate signaling pathway; INTERACTS WITH 6-propyl-2-thiouracil; acetamide; aldehydo-D-glucose.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Edg-8; Edg8; endothelial differentiation G-protein-coupled receptor 8; endothelial differentiation, sphingolipid G-protein-coupled receptor, 8; nerve growth factor-regulated G-protein-coupled receptor 1; NRG-1; S1P receptor 5; S1P receptor Edg-8; S1P5; sphingosine 1-phosphate receptor; sphingosine 1-phosphate receptor 5; sphingosine 1-phosphate receptor Edg-8
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8828,062,841 - 28,068,013 (-)NCBIGRCr8
mRatBN7.2819,786,676 - 19,791,862 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl819,786,663 - 19,791,795 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx823,806,109 - 23,811,040 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0822,103,954 - 22,108,885 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0820,016,404 - 20,021,375 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0822,268,635 - 22,273,708 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl822,268,657 - 22,270,647 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0822,323,891 - 22,328,932 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4820,278,404 - 20,283,375 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1820,278,403 - 20,283,375 (-)NCBI
Celera821,180,228 - 21,185,199 (-)NCBICelera
Cytogenetic Map8q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The immune modulator FTY720 targets sphingosine 1-phosphate receptors. Brinkmann V, etal., J Biol Chem 2002 Jun 14;277(24):21453-7.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Molecular cloning, tissue-specific expression, and chromosomal localization of a novel nerve growth factor-regulated G-protein- coupled receptor, nrg-1. Glickman M, etal., Mol Cell Neurosci 1999 Aug;14(2):141-52.
4. Characterization of a novel sphingosine 1-phosphate receptor, Edg-8. Im DS, etal., J Biol Chem 2000 May 12;275(19):14281-6.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Comparative analysis of human and rat S1P(5) (edg8): differential expression profiles and sensitivities to antagonists. Niedernberg A, etal., Biochem Pharmacol 2002 Oct 15;64(8):1243-50.
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Edg-8 receptors are preferentially expressed in oligodendrocyte lineage cells of the rat CNS. Terai K, etal., Neuroscience 2003;116(4):1053-62.
Additional References at PubMed
PMID:11069896   PMID:15703400   PMID:15741218   PMID:18294150   PMID:22972346   PMID:24602016  


Genomics

Comparative Map Data
S1pr5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8828,062,841 - 28,068,013 (-)NCBIGRCr8
mRatBN7.2819,786,676 - 19,791,862 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl819,786,663 - 19,791,795 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx823,806,109 - 23,811,040 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0822,103,954 - 22,108,885 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0820,016,404 - 20,021,375 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0822,268,635 - 22,273,708 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl822,268,657 - 22,270,647 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0822,323,891 - 22,328,932 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4820,278,404 - 20,283,375 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1820,278,403 - 20,283,375 (-)NCBI
Celera821,180,228 - 21,185,199 (-)NCBICelera
Cytogenetic Map8q13NCBI
S1PR5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381910,512,742 - 10,517,965 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1910,512,742 - 10,517,931 (-)EnsemblGRCh38hg38GRCh38
GRCh371910,623,418 - 10,628,641 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361910,484,623 - 10,489,112 (-)NCBINCBI36Build 36hg18NCBI36
Build 341910,484,622 - 10,489,112NCBI
Celera1910,518,131 - 10,523,388 (-)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef1910,201,961 - 10,207,399 (-)NCBIHuRef
CHM1_11910,624,176 - 10,629,433 (-)NCBICHM1_1
T2T-CHM13v2.01910,639,179 - 10,644,407 (-)NCBIT2T-CHM13v2.0
S1pr5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39921,154,213 - 21,159,739 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl921,154,208 - 21,159,739 (-)EnsemblGRCm39 Ensembl
GRCm38921,242,917 - 21,248,443 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl921,242,912 - 21,248,443 (-)EnsemblGRCm38mm10GRCm38
MGSCv37921,047,361 - 21,052,887 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36920,993,319 - 20,996,611 (-)NCBIMGSCv36mm8
Celera918,512,032 - 18,517,558 (-)NCBICelera
Cytogenetic Map9A3NCBI
cM Map97.75NCBI
S1pr5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554951,717,549 - 1,722,257 (-)NCBIChiLan1.0ChiLan1.0
S1PR5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22015,430,929 - 15,436,593 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11914,429,534 - 14,435,210 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01910,064,332 - 10,069,999 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11910,726,661 - 10,731,230 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1910,727,527 - 10,728,728 (-)Ensemblpanpan1.1panPan2
S1PR5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12050,641,585 - 50,646,938 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2050,643,619 - 50,644,815 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2050,513,495 - 50,518,968 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02051,164,592 - 51,170,064 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2051,165,296 - 51,168,809 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12050,371,184 - 50,376,633 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02050,799,276 - 50,804,758 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02051,040,334 - 51,045,813 (+)NCBIUU_Cfam_GSD_1.0
S1pr5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118209,551,873 - 209,557,153 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936659798,707 - 799,903 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936659798,259 - 801,563 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
S1PR5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl269,293,546 - 69,298,377 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1269,293,537 - 69,299,408 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2269,646,773 - 69,649,084 (-)NCBISscrofa10.2Sscrofa10.2susScr3
S1PR5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.169,537,083 - 9,542,610 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl69,538,156 - 9,539,352 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607410,456,440 - 10,461,715 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
S1pr5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248282,592,475 - 2,601,943 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248282,590,664 - 2,602,136 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in S1pr5
33 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:85
Count of miRNA genes:71
Interacting mature miRNAs:79
Transcripts:ENSRNOT00000028380
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8124597739Rat
2317882Alcrsp24Alcohol response QTL 243.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)8125902202Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat

Markers in Region
Edg8  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2819,788,055 - 19,788,607 (+)MAPPERmRatBN7.2
Rnor_6.0822,269,993 - 22,270,544NCBIRnor6.0
Rnor_5.0822,325,249 - 22,325,800UniSTSRnor5.0
RGSC_v3.4820,279,740 - 20,280,291UniSTSRGSC3.4
Celera821,181,564 - 21,182,115UniSTS
Cytogenetic Map8q13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 22
Low 22 27 16 18 16 13 11 8 11
Below cutoff 3 21 28 23 23 7 9 37 24 33 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000028380   ⟹   ENSRNOP00000028380
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl819,786,663 - 19,791,795 (-)Ensembl
Rnor_6.0 Ensembl822,268,657 - 22,270,647 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000098087   ⟹   ENSRNOP00000090421
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl819,786,663 - 19,791,795 (-)Ensembl
RefSeq Acc Id: NM_021775   ⟹   NP_068543
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,062,898 - 28,067,869 (-)NCBI
mRatBN7.2819,786,720 - 19,791,692 (-)NCBI
Rnor_6.0822,268,657 - 22,273,628 (-)NCBI
Rnor_5.0822,323,891 - 22,328,932 (-)NCBI
RGSC_v3.4820,278,404 - 20,283,375 (-)RGD
Celera821,180,228 - 21,185,199 (-)RGD
Sequence:
RefSeq Acc Id: XM_006242663   ⟹   XP_006242725
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,062,841 - 28,068,013 (-)NCBI
mRatBN7.2819,786,698 - 19,791,862 (-)NCBI
Rnor_6.0822,268,635 - 22,273,708 (-)NCBI
Rnor_5.0822,323,891 - 22,328,932 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006242664   ⟹   XP_006242726
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,062,841 - 28,067,824 (-)NCBI
mRatBN7.2819,786,676 - 19,790,623 (-)NCBI
Rnor_6.0822,268,657 - 22,272,080 (-)NCBI
Rnor_5.0822,323,891 - 22,328,932 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006242665   ⟹   XP_006242727
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,062,841 - 28,067,824 (-)NCBI
mRatBN7.2819,786,676 - 19,790,623 (-)NCBI
Rnor_6.0822,268,657 - 22,272,080 (-)NCBI
Rnor_5.0822,323,891 - 22,328,932 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_068543   ⟸   NM_021775
- UniProtKB: Q9JKM5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006242725   ⟸   XM_006242663
- Peptide Label: isoform X1
- UniProtKB: Q9QY79 (UniProtKB/Swiss-Prot),   Q9JKM5 (UniProtKB/Swiss-Prot),   A6JNQ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242727   ⟸   XM_006242665
- Peptide Label: isoform X1
- UniProtKB: Q9QY79 (UniProtKB/Swiss-Prot),   Q9JKM5 (UniProtKB/Swiss-Prot),   A6JNQ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242726   ⟸   XM_006242664
- Peptide Label: isoform X1
- UniProtKB: Q9QY79 (UniProtKB/Swiss-Prot),   Q9JKM5 (UniProtKB/Swiss-Prot),   A6JNQ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000028380   ⟸   ENSRNOT00000028380
RefSeq Acc Id: ENSRNOP00000090421   ⟸   ENSRNOT00000098087
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JKM5-F1-model_v2 AlphaFold Q9JKM5 1-400 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620566 AgrOrtholog
BioCyc Gene G2FUF-31431 BioCyc
Ensembl Genes ENSRNOG00000020901 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055012564 UniProtKB/Swiss-Prot
  ENSRNOG00060021525 UniProtKB/Swiss-Prot
  ENSRNOG00065012198 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000028380.6 UniProtKB/Swiss-Prot
  ENSRNOT00000098087 ENTREZGENE
  ENSRNOT00000098087.1 UniProtKB/Swiss-Prot
  ENSRNOT00055021423 UniProtKB/Swiss-Prot
  ENSRNOT00055021429 UniProtKB/Swiss-Prot
  ENSRNOT00060037271 UniProtKB/Swiss-Prot
  ENSRNOT00060037288 UniProtKB/Swiss-Prot
  ENSRNOT00065019824 UniProtKB/Swiss-Prot
  ENSRNOT00065019825 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro EDG8_S1P_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S1P_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:60399 UniProtKB/Swiss-Prot
NCBI Gene 60399 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPHINGOSINE 1-PHOSPHATE RECEPTOR 5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen S1pr5 PhenoGen
PRINTS EDG8RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S1PRECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020901 RatGTEx
  ENSRNOG00055012564 RatGTEx
  ENSRNOG00060021525 RatGTEx
  ENSRNOG00065012198 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6JNQ5 ENTREZGENE, UniProtKB/TrEMBL
  Q9JKM5 ENTREZGENE
  Q9QY79 ENTREZGENE
  S1PR5_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q9QY79 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-05-20 S1pr5  sphingosine-1-phosphate receptor 5  Edg8  endothelial differentiation, sphingolipid G-protein-coupled receptor, 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Edg8  endothelial differentiation, sphingolipid G-protein-coupled receptor, 8    sphingosine 1-phosphate receptor  Name updated 1299863 APPROVED
2002-08-07 Edg8  sphingosine 1-phosphate receptor      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed only in the CNS, preferentially in oligodendrocyte lineage cells 632645
gene_expression expressed predominantly by oligodendrocytes and fibrous astrocytes 632648
gene_expression expressed in oligodendrocyte progenitor cells and immature/maturating oligodendrocytes 1299278
gene_pathway couples to G(i/o)alpha proteins 632648