Mapk8 (mitogen-activated protein kinase 8) - Rat Genome Database

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Gene: Mapk8 (mitogen-activated protein kinase 8) Ictidomys tridecemlineatus
Analyze
Symbol: Mapk8
Name: mitogen-activated protein kinase 8
RGD ID: 12660538
Description: ENCODES a protein that exhibits JUN kinase activity (ortholog); kinase activity (ortholog); kinesin binding (ortholog); INVOLVED IN apoptotic signaling pathway (ortholog); cellular response to amyloid-beta (ortholog); cellular response to hydrogen peroxide (ortholog); PARTICIPATES IN adenosine signaling pathway; c-Jun N-terminal kinases MAPK signaling pathway; ceramide signaling pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); Acute Liver Failure (ortholog); Acute Otitis Media (ortholog); FOUND IN axon (ortholog); basal dendrite (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721380,572,918 - 80,691,087 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367281,775,641 - 1,893,907 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367281,775,746 - 1,893,895 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Acute Liver Failure  (ISO)
Acute Otitis Media  (ISO)
alcohol use disorder  (ISO)
Alzheimer's disease  (ISO)
Animal Disease Models  (ISO)
anogenital venereal wart  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
Arenaviridae infectious disease  (ISO)
atopic dermatitis  (ISO)
bacterial pneumonia  (ISO)
brain ischemia  (ISO)
candidiasis  (ISO)
Cardiomegaly  (ISO)
chronic mucocutaneous candidiasis  (ISO)
chronic obstructive pulmonary disease  (ISO)
Cockayne syndrome B  (ISO)
Colonic Neoplasms  (ISO)
colorectal adenocarcinoma  (ISO)
colorectal adenoma  (ISO)
Contrast-Induced Nephropathy  (ISO)
dengue disease  (ISO)
endometriosis  (ISO)
Endotoxemia  (ISO)
extrahepatic cholestasis  (ISO)
Helicobacter Infections  (ISO)
hepatitis  (ISO)
hepatocellular carcinoma  (ISO)
Hyperalgesia  (ISO)
hypertension  (ISO)
Infectious Ectromelia  (ISO)
influenza A  (ISO)
Intestinal Neoplasms  (ISO)
Kuhnt-Junius degeneration  (ISO)
Liver Reperfusion Injury  (ISO)
megacolon  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplastic Cell Transformation  (ISO)
Oxygen-Induced Retinopathy  (ISO)
pancreatic adenocarcinoma  (ISO)
pancreatic ductal adenocarcinoma  (ISO)
Parkinsonism  (ISO)
pre-malignant neoplasm  (ISO)
Pseudomonas Infections  (ISO)
rectal benign neoplasm  (ISO)
Reperfusion Injury  (ISO)
schizophrenia  (ISO)
Sepsis  (ISO)
steatotic liver disease  (ISO)
Stomach Neoplasms  (ISO)
Stroke  (ISO)
trigeminal neuralgia  (ISO)
type 2 diabetes mellitus  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic signaling pathway  (ISO)
cellular response to amino acid starvation  (IEA)
cellular response to amyloid-beta  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to lipopolysaccharide  (IEA,ISO)
cellular response to mechanical stimulus  (IEA)
cellular response to nitric oxide  (ISO)
cellular response to oxidative stress  (IEA)
cellular response to oxygen-glucose deprivation  (ISO)
cellular response to reactive oxygen species  (IEA)
dendrite morphogenesis  (ISO)
energy homeostasis  (ISO)
glial cell apoptotic process  (ISO)
integrin-mediated signaling pathway  (ISO)
JNK cascade  (IEA)
JUN phosphorylation  (ISO)
MAPK cascade  (IEA)
modulation of chemical synaptic transmission  (ISO)
negative regulation of apoptotic process  (IEA,ISO)
neuron development  (ISO)
neuron migration  (ISO)
neuron projection development  (ISO)
neuronal stem cell population maintenance  (ISO)
ossification  (ISO)
peptidyl-serine phosphorylation  (ISO)
peptidyl-threonine phosphorylation  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of apoptotic signaling pathway  (ISO)
positive regulation of cardiac muscle cell apoptotic process  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cyclase activity  (ISO)
positive regulation of determination of dorsal identity  (ISO)
positive regulation of DNA replication  (ISO)
positive regulation of gene expression  (IEA)
positive regulation of glial cell apoptotic process  (ISO)
positive regulation of microtubule polymerization  (ISO)
positive regulation of neuroblast proliferation  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of neuron migration  (ISO)
positive regulation of NLRP3 inflammasome complex assembly  (IEA)
positive regulation of podosome assembly  (ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (ISO)
positive regulation of protein metabolic process  (IEA)
positive regulation of protein ubiquitination  (ISO)
programmed necrotic cell death  (ISO)
protein localization to tricellular tight junction  (ISO)
protein phosphorylation  (ISO)
regulation of centrosome cycle  (ISO)
regulation of circadian rhythm  (ISO)
regulation of dense core granule transport  (ISO)
regulation of DNA-templated transcription  (ISO)
regulation of gene expression  (ISO)
regulation of neuron differentiation  (ISO)
regulation of protein localization  (IEA)
response to cadmium ion  (ISO)
response to hydrogen peroxide  (ISO)
response to oxidative stress  (IEA)
response to steroid hormone  (ISO)
response to UV  (IEA,ISO)
rhythmic process  (IEA)
SMAD protein signal transduction  (ISO)
stress-activated MAPK cascade  (IEA)
type B pancreatic cell apoptotic process  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Mapk8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721380,572,918 - 80,691,087 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367281,775,641 - 1,893,907 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367281,775,746 - 1,893,895 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAPK8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381048,306,677 - 48,439,360 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1048,306,639 - 48,439,360 (+)EnsemblGRCh38hg38GRCh38
GRCh371049,514,720 - 49,647,403 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361049,279,693 - 49,313,189 (+)NCBINCBI36Build 36hg18NCBI36
Build 341049,279,692 - 49,313,189NCBI
Celera1043,195,579 - 43,229,096 (+)NCBICelera
Cytogenetic Map10q11.22NCBI
HuRef1043,779,561 - 43,912,232 (+)NCBIHuRef
CHM1_11049,796,560 - 49,929,236 (+)NCBICHM1_1
T2T-CHM13v2.01049,155,699 - 49,288,442 (+)NCBIT2T-CHM13v2.0
Mapk8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391433,099,855 - 33,169,213 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1433,099,855 - 33,169,115 (-)EnsemblGRCm39 Ensembl
GRCm381433,377,898 - 33,447,353 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1433,377,898 - 33,447,158 (-)EnsemblGRCm38mm10GRCm38
MGSCv371434,191,084 - 34,260,344 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361432,211,101 - 32,276,249 (-)NCBIMGSCv36mm8
Celera1429,636,611 - 29,705,910 (-)NCBICelera
Cytogenetic Map14BNCBI
cM Map1420.22NCBI
Mapk8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8168,645,171 - 8,728,225 (-)NCBIGRCr8
mRatBN7.2168,638,897 - 8,721,960 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl168,638,924 - 8,721,981 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx168,658,229 - 8,741,022 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0169,802,931 - 9,885,718 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0168,652,731 - 8,735,493 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0169,620,854 - 9,709,342 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl169,625,177 - 9,709,347 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01611,579,503 - 11,662,858 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4168,925,133 - 9,004,897 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1168,925,181 - 9,004,945 (-)NCBI
Celera166,485,592 - 6,568,388 (+)NCBICelera
Cytogenetic Map16p16NCBI
Mapk8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555561,593,494 - 1,665,784 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555561,593,552 - 1,705,543 (-)NCBIChiLan1.0ChiLan1.0
MAPK8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2860,574,189 - 60,702,156 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11060,579,543 - 60,707,592 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01045,806,748 - 45,936,362 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
MAPK8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.128323,361 - 410,367 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl28368,513 - 406,401 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha28552,432 - 639,965 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.028498,642 - 586,320 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl28498,626 - 586,317 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.128298,436 - 386,002 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.028339,385 - 427,241 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.028432,766 - 552,601 (+)NCBIUU_Cfam_GSD_1.0
MAPK8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1488,988,949 - 89,108,874 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11488,988,914 - 89,108,875 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21496,724,970 - 96,803,101 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAPK8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1943,356,603 - 43,489,066 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl943,356,308 - 43,393,425 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660483,124,408 - 3,258,374 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mapk8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249281,439,146 - 1,494,266 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249281,442,216 - 1,494,275 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000012618   ⟹   ENSSTOP00000011309
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049367281,780,065 - 1,814,967 (-)Ensembl
Ensembl Acc Id: ENSSTOT00000034592   ⟹   ENSSTOP00000028960
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049367281,780,199 - 1,814,967 (-)Ensembl
Ensembl Acc Id: ENSSTOT00000035557   ⟹   ENSSTOP00000031721
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049367281,775,641 - 1,893,907 (-)Ensembl
RefSeq Acc Id: XM_005339075   ⟹   XP_005339132
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440721380,572,918 - 80,691,087 (-)NCBI
SpeTri2.0NW_0049367281,775,746 - 1,893,895 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021735776   ⟹   XP_021591451
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440721380,572,918 - 80,691,086 (-)NCBI
SpeTri2.0NW_0049367281,775,746 - 1,847,190 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040273745   ⟹   XP_040129679
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440721380,572,918 - 80,691,086 (-)NCBI
RefSeq Acc Id: XM_040273746   ⟹   XP_040129680
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440721380,572,918 - 80,629,581 (-)NCBI
RefSeq Acc Id: XM_040273747   ⟹   XP_040129681
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440721380,572,918 - 80,691,085 (-)NCBI
RefSeq Acc Id: XM_040273748   ⟹   XP_040129682
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440721380,572,918 - 80,691,086 (-)NCBI
RefSeq Acc Id: XP_005339132   ⟸   XM_005339075
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_021591451   ⟸   XM_021735776
- Peptide Label: isoform X1
- UniProtKB: I3M116 (UniProtKB/TrEMBL),   I3MJI4 (UniProtKB/TrEMBL),   I3LZ97 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040129682   ⟸   XM_040273748
- Peptide Label: isoform X4
- UniProtKB: A0A287DDY1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040129679   ⟸   XM_040273745
- Peptide Label: isoform X1
- UniProtKB: I3M116 (UniProtKB/TrEMBL),   I3MJI4 (UniProtKB/TrEMBL),   I3LZ97 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040129681   ⟸   XM_040273747
- Peptide Label: isoform X3
RefSeq Acc Id: XP_040129680   ⟸   XM_040273746
- Peptide Label: isoform X1
- UniProtKB: I3M116 (UniProtKB/TrEMBL),   I3MJI4 (UniProtKB/TrEMBL),   I3LZ97 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSSTOP00000031721   ⟸   ENSSTOT00000035557
Ensembl Acc Id: ENSSTOP00000011309   ⟸   ENSSTOT00000012618
Ensembl Acc Id: ENSSTOP00000028960   ⟸   ENSSTOT00000034592
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000001819 UniProtKB/TrEMBL
  ENSSTOG00000012617 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000001817.3 UniProtKB/TrEMBL
  ENSSTOT00000012618.3 UniProtKB/TrEMBL
  ENSSTOT00000034592.1 UniProtKB/TrEMBL
  ENSSTOT00000035557.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  MAP_kinase UniProtKB/TrEMBL
  MAP_kinase_CS UniProtKB/TrEMBL
  MAPK_JNK UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene Mapk8 ENTREZGENE
PANTHER MITOGEN-ACTIVATED PROTEIN KINASE UniProtKB/TrEMBL
  MITOGEN-ACTIVATED PROTEIN KINASE 10 UniProtKB/TrEMBL
  MITOGEN-ACTIVATED PROTEIN KINASE 8 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PRINTS JNKMAPKINASE UniProtKB/TrEMBL
PROSITE MAPK UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A287D610_ICTTR UniProtKB/TrEMBL
  A0A287DDY1 ENTREZGENE, UniProtKB/TrEMBL
  I3LZ97 ENTREZGENE, UniProtKB/TrEMBL
  I3M116 ENTREZGENE
  I3MJI4 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary I3M116 UniProtKB/TrEMBL