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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621506
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk8
Name: mitogen-activated protein kinase 8
Acc ID: CHEBI:10022
Term: deoxynivalenol
Definition: A trichothecene mycotoxin produced by Fusarium to which wheat, barley, maize (corn) and their products are susceptible to contamination.
Chemical ID: MESH:C007262
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk8decreases activityISOMAPK8 (Homo sapiens)6480464CTDdeoxynivalenol results in decreased activity of MAPK8 proteinPMID:20708668
Mapk8increases phosphorylationISOMapk8 (Mus musculus)6480464CTDdeoxynivalenol results in increased phosphorylation of MAPK8 proteinPMID:12377986 PMID:12604842 PMID:14644621 PMID:14690764 PMID:15570035 PMID:15772366 PMID:16424113 PMID:18502741 PMID:23352502 PMID:32416088
Mapk8multiple interactionsISOMAPK8 (Homo sapiens)6480464CTD[deoxynivalenol results in increased expression of DUSP1 protein] which results in decreased activity of MAPK8 protein; deoxynivalenol results in increased phosphorylation of and results in increased activity of MAPK8 proteinPMID:18485432 PMID:19360757 PMID:20708668
Mapk8multiple interactionsISOMapk8 (Mus musculus)6480464CTD4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [deoxynivalenol results in increased phosphorylation of MAPK8 protein]; AG 1879 inhibits the reaction [deoxynivalenol results in increased phosphorylation of MAPK8 protein]; Celecoxib inhibits the reaction [deoxynivalenol results in increased phosphorylation of MAPK8 protein]; deoxynivalenol promotes the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]; Docosahexaenoic Acids inhibits the reaction [deoxynivalenol results in increased phosphorylation of MAPK8 protein]; Eicosapentaenoic Acid inhibits the reaction [deoxynivalenol results in increased phosphorylation of MAPK8 protein]; Fish Oils inhibits the reaction [deoxynivalenol results in increased phosphorylation of MAPK8 protein]PMID:14644621 PMID:14690764 PMID:15570035 PMID:15772366 PMID:16424113 PMID:32416088
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