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Gene: Hes1 (hes family bHLH transcription factor 1) Rattus norvegicus
Symbol: Hes1
Name: hes family bHLH transcription factor 1
RGD ID: 62081
Description: Exhibits several functions, including JUN kinase binding activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in several processes, including cellular response to cytokine stimulus; generation of neurons; and regulation of gene expression. Localizes to chromatin and nuclear matrix. Used to study chronic myeloid leukemia and epilepsy. Biomarker of acute kidney failure. Orthologous to human HES1 (hes family bHLH transcription factor 1); PARTICIPATES IN Notch signaling pathway; maturity-onset diabetes of the young pathway; Notch signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 2-tert-butylhydroquinone.
Type: protein-coding
Also known as: hairy and enhancer of split 1; hairy and enhancer of split 1 (Drosophila); hairy and enhancer of split 1, (Drosophila) ; hairy-like protein; RHL; transcription factor HES-1
Homo sapiens (human) : HES1 (hes family bHLH transcription factor 1)  HGNC  Alliance
Mus musculus (house mouse) : Hes1 (hes family bHLH transcription factor 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hes1 (hes family bHLH transcription factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : HES1 (hes family bHLH transcription factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hes1 (hes family bHLH transcription factor 1)
Sus scrofa (pig) : HES1 (hes family bHLH transcription factor 1)
Chlorocebus sabaeus (African green monkey) : HES1 (hes family bHLH transcription factor 1)
Heterocephalus glaber (naked mole-rat) : Hes1 (hes family bHLH transcription factor 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01174,312,837 - 74,315,249 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1174,312,806 - 74,315,248 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01177,360,109 - 77,362,521 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41172,603,482 - 72,605,673 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11172,661,439 - 72,663,801 (-)NCBI
Celera1169,677,011 - 69,679,422 (-)NCBICelera
Cytogenetic Map11q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Hes1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 62081
Created: 2001-04-11
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.