HES1 (hes family bHLH transcription factor 1) - Rat Genome Database

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Gene: HES1 (hes family bHLH transcription factor 1) Sus scrofa
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Symbol: HES1
Name: hes family bHLH transcription factor 1
RGD ID: 13979071
Description: ENCODES a protein that exhibits chromatin binding (ortholog); DNA binding (ortholog); DNA-binding transcription repressor activity (ortholog); INVOLVED IN adenohypophysis development (ortholog); aorta morphogenesis (ortholog); artery morphogenesis (ortholog); PARTICIPATES IN Notch signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); amyotrophic lateral sclerosis (ortholog); Breast Neoplasms (ortholog); FOUND IN chromatin (ortholog); nuclear matrix (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: hairy and enhancer of split 1; transcription factor HES-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13131,135,724 - 131,138,236 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113131,135,970 - 131,137,865 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213140,633,207 - 140,635,734 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenohypophysis development  (IEA,ISO)
anterior/posterior pattern specification  (IBA)
aorta morphogenesis  (ISO)
artery morphogenesis  (ISO)
ascending aorta morphogenesis  (IEA)
cardiac neural crest cell development involved in outflow tract morphogenesis  (IEA,ISO)
cell adhesion  (IEA,ISO)
cell fate commitment  (ISO)
cell maturation  (IEA,ISO)
cell migration  (IEA,ISO)
cell morphogenesis involved in neuron differentiation  (IEA,ISO)
cellular response to fatty acid  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to nerve growth factor stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
cochlea development  (IEA,ISO)
comma-shaped body morphogenesis  (IEA,ISO)
common bile duct development  (IEA,ISO)
embryonic heart tube morphogenesis  (IEA)
establishment of epithelial cell polarity  (IEA,ISO)
forebrain radial glial cell differentiation  (ISO)
glomerulus vasculature development  (IEA,ISO)
hair cell differentiation  (ISO)
hindbrain morphogenesis  (IEA,ISO)
in utero embryonic development  (ISO)
inner ear receptor cell stereocilium organization  (IEA,ISO)
labyrinthine layer blood vessel development  (IEA)
lateral inhibition  (IEA,ISO)
liver development  (IEA,ISO)
lung development  (IEA,ISO)
metanephric nephron tubule morphogenesis  (IEA,ISO)
midbrain development  (IEA,ISO)
midbrain-hindbrain boundary morphogenesis  (IEA,ISO)
negative regulation of calcium ion import  (ISO)
negative regulation of cell differentiation  (ISO)
negative regulation of cell fate determination  (IEA,ISO)
negative regulation of DNA-binding transcription factor activity  (IEA)
negative regulation of forebrain neuron differentiation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of glial cell proliferation  (IEA)
negative regulation of inner ear auditory receptor cell differentiation  (IEA,ISO)
negative regulation of inner ear receptor cell differentiation  (ISO)
negative regulation of neurogenesis  (ISO)
negative regulation of neuron differentiation  (IBA,ISO)
negative regulation of neuron projection development  (ISO)
negative regulation of oligodendrocyte differentiation  (IEA,ISO)
negative regulation of pancreatic A cell differentiation  (IEA,ISO)
negative regulation of pro-B cell differentiation  (IEA)
negative regulation of stem cell differentiation  (IEA)
negative regulation of stomach neuroendocrine cell differentiation  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
negative regulation of transcription, DNA-templated  (ISO)
neural tube development  (ISO)
neuron differentiation  (ISO)
neuronal stem cell population maintenance  (IEA)
Notch signaling pathway  (IBA,ISO)
oculomotor nerve development  (IEA,ISO)
outflow tract morphogenesis  (ISO)
pancreas development  (IEA,ISO)
pattern specification process  (ISO)
pharyngeal arch artery morphogenesis  (IEA)
pituitary gland development  (ISO)
positive regulation of astrocyte differentiation  (IEA)
positive regulation of BMP signaling pathway  (IEA,ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of DNA binding  (IEA)
positive regulation of gene expression  (ISO)
positive regulation of glial cell differentiation  (ISO)
positive regulation of mitotic cell cycle, embryonic  (IEA)
positive regulation of Notch signaling pathway  (IEA)
positive regulation of receptor signaling pathway via JAK-STAT  (IEA)
positive regulation of T cell proliferation  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of transcription, DNA-templated  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (IEA)
protein-containing complex assembly  (IEA)
regulation of epithelial cell proliferation  (IEA,ISO)
regulation of fat cell differentiation  (IEA,ISO)
regulation of neurogenesis  (IBA,ISO)
regulation of protein-containing complex assembly  (ISO)
regulation of receptor signaling pathway via JAK-STAT  (ISO)
regulation of secondary heart field cardioblast proliferation  (IEA,ISO)
regulation of timing of cell differentiation  (ISO)
regulation of timing of neuron differentiation  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IBA,ISO)
renal interstitial fibroblast development  (IEA,ISO)
response to alkaloid  (ISO)
response to organic cyclic compound  (ISO)
response to thyroid hormone  (ISO)
S-shaped body morphogenesis  (IEA,ISO)
smoothened signaling pathway  (IEA,ISO)
somatic stem cell population maintenance  (IEA,ISO)
telencephalon development  (IEA,ISO)
thymus development  (IEA)
trochlear nerve development  (IEA,ISO)
ureteric bud morphogenesis  (IEA,ISO)
vascular associated smooth muscle cell development  (IEA)
ventricular septum development  (ISO)
ventricular septum morphogenesis  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:23611667  


Genomics

Comparative Map Data
HES1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13131,135,724 - 131,138,236 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113131,135,970 - 131,137,865 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213140,633,207 - 140,635,734 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HES1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3194,136,148 - 194,138,732 (+)EnsemblGRCh38hg38GRCh38
GRCh383194,136,148 - 194,138,732 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373193,853,937 - 193,856,521 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363195,336,628 - 195,339,090 (+)NCBINCBI36hg18NCBI36
Celera3192,270,388 - 192,272,854 (+)NCBI
Cytogenetic Map3q29NCBI
HuRef3191,241,261 - 191,243,734 (+)NCBIHuRef
CHM1_13193,816,827 - 193,819,297 (+)NCBICHM1_1
Hes1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391629,884,175 - 29,886,614 (+)NCBIGRCm39mm39
GRCm39 Ensembl1629,883,202 - 29,886,614 (+)Ensembl
GRCm381630,065,357 - 30,067,796 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1630,064,384 - 30,067,796 (+)EnsemblGRCm38mm10GRCm38
MGSCv371630,065,443 - 30,067,882 (+)NCBIGRCm37mm9NCBIm37
MGSCv361629,985,104 - 29,987,543 (+)NCBImm8
Celera1630,572,496 - 30,574,749 (+)NCBICelera
Cytogenetic Map16B2NCBI
cM Map1621.09NCBI
Hes1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21170,705,763 - 70,708,176 (-)NCBI
Rnor_6.0 Ensembl1174,312,806 - 74,315,248 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01174,312,837 - 74,315,249 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01177,360,109 - 77,362,521 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41172,603,482 - 72,605,673 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11172,661,439 - 72,663,801 (-)NCBI
Celera1169,677,011 - 69,679,422 (-)NCBICelera
Cytogenetic Map11q22NCBI
Hes1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542014,564,283 - 14,568,447 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542014,565,921 - 14,568,447 (-)NCBIChiLan1.0ChiLan1.0
HES1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13201,749,044 - 201,751,591 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3201,749,044 - 201,754,257 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03191,432,513 - 191,435,387 (+)NCBIMhudiblu_PPA_v0panPan3
HES1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha2352,257,121 - 52,259,752 (+)NCBI
ROS_Cfam_1.02353,157,666 - 53,160,303 (+)NCBI
UMICH_Zoey_3.12352,667,374 - 52,670,002 (+)NCBI
UNSW_CanFamBas_1.02352,721,885 - 52,724,518 (+)NCBI
UU_Cfam_GSD_1.02353,007,809 - 53,010,447 (+)NCBI
Hes1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602123,607,220 - 123,609,806 (+)NCBI
SpeTri2.0NW_004936711640,002 - 642,580 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HES1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11588,220,093 - 88,222,563 (+)NCBI
ChlSab1.1 Ensembl1588,220,083 - 88,223,243 (+)Ensembl
Vero_WHO_p1.0NW_02366604161,888,842 - 61,891,572 (+)NCBI
Hes1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473063,563,848 - 63,566,303 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1
Low 10 4 3 5 2 23 2 2 1
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000058748   ⟹   ENSSSCP00000047613
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl13131,135,724 - 131,138,236 (+)Ensembl
RefSeq Acc Id: NM_001195231   ⟹   NP_001182160
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113131,135,970 - 131,137,865 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001182160 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ADK26059 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001182160   ⟸   NM_001195231
- UniProtKB: E0A234 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000047613   ⟸   ENSSSCT00000058748
Protein Domains
bHLH   Orange


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000031356 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000047613 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000058748 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/TrEMBL
  Orange_dom UniProtKB/TrEMBL
KEGG Report ssc:100499567 UniProtKB/TrEMBL
NCBI Gene HES1 ENTREZGENE
Pfam Hairy_orange UniProtKB/TrEMBL
  HLH UniProtKB/TrEMBL
PROSITE BHLH UniProtKB/TrEMBL
  ORANGE UniProtKB/TrEMBL
SMART HLH UniProtKB/TrEMBL
  ORANGE UniProtKB/TrEMBL
Superfamily-SCOP SSF47459 UniProtKB/TrEMBL
UniProt A0A287AUT4_PIG UniProtKB/TrEMBL
  E0A234 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:88854 ENTREZGENE