Hes1 (hes family bHLH transcription factor 1)

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Gene: Hes1 (hes family bHLH transcription factor 1) Ictidomys tridecemlineatus

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Symbol:

Hes1

Name:

hes family bHLH transcription factor 1

RGD ID:

12592358

Description:

ENCODES a protein that exhibits chromatin binding (ortholog); DNA binding (ortholog); E-box binding (ortholog); INVOLVED IN adenohypophysis development (ortholog); amacrine cell differentiation (ortholog); BMP signaling pathway (ortholog); PARTICIPATES IN Notch signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); amyotrophic lateral sclerosis (ortholog); Breast Neoplasms (ortholog); FOUND IN chromatin (ortholog); nuclear matrix (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

hairy and enhancer of split 1; transcription factor HES-1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	123,607,220 - 123,609,806 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936711	639,905 - 642,622 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936711	640,002 - 642,580 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute kidney failure (ISO)

amyotrophic lateral sclerosis (ISO)

Breast Neoplasms (ISO)

Cardiomegaly (ISO)

chronic myeloid leukemia (ISO)

Colonic Neoplasms (ISO)

diabetes mellitus (ISO)

diabetic retinopathy (ISO)

epilepsy (ISO)

glioblastoma (ISO)

hemangiopericytoma (ISO)

Lung Neoplasms (ISO)

lung non-small cell carcinoma (ISO)

lymphangioleiomyomatosis (ISO)

meningioma (ISO)

oligodendroglioma (ISO)

oral squamous cell carcinoma (ISO)

pancreatic ductal carcinoma (ISO)

Primitive Neuroectodermal Tumors (ISO)

schizophrenia (ISO)

ureteral obstruction (ISO)

Uterine Cervical Neoplasms (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenohypophysis development (IEA,ISO)

amacrine cell differentiation (IEA,ISO)

anterior/posterior pattern specification (IEA)

aorta morphogenesis (IEA)

artery morphogenesis (IEA)

ascending aorta morphogenesis (IEA)

BMP signaling pathway (IEA,ISO)

Cajal-Retzius cell differentiation (IEA,ISO)

cardiac neural crest cell development involved in outflow tract morphogenesis (IEA,ISO)

cell adhesion (IEA,ISO)

cell fate commitment (IEA,ISO)

cell fate determination (IEA,ISO)

cell maturation (IEA,ISO)

cell migration (IEA,ISO)

cell morphogenesis involved in neuron differentiation (IEA,ISO)

cell population proliferation (IEA,ISO)

cellular response to fatty acid (ISO)

cellular response to interleukin-1 (ISO)

cellular response to nerve growth factor stimulus (ISO)

cellular response to tumor necrosis factor (ISO)

cochlea development (IEA,ISO)

comma-shaped body morphogenesis (IEA)

common bile duct development (IEA,ISO)

embryonic heart tube morphogenesis (IEA)

establishment of epithelial cell polarity (IEA,ISO)

forebrain radial glial cell differentiation (ISO)

glomerulus vasculature development (IEA)

hair cell differentiation (ISO)

hindbrain morphogenesis (IEA,ISO)

in utero embryonic development (IEA,ISO)

inhibition of neuroepithelial cell differentiation (IEA,ISO)

inner ear auditory receptor cell differentiation (IEA,ISO)

inner ear receptor cell stereocilium organization (IEA,ISO)

labyrinthine layer blood vessel development (IEA)

lateral inhibition (IEA,ISO)

liver development (IEA,ISO)

lung development (IEA,ISO)

metanephric nephron tubule morphogenesis (IEA)

midbrain development (IEA,ISO)

midbrain-hindbrain boundary morphogenesis (IEA,ISO)

negative regulation of amacrine cell differentiation (IEA,ISO)

negative regulation of calcium ion import (ISO)

negative regulation of cell differentiation (IEA,ISO)

negative regulation of cell fate determination (IEA,ISO)

negative regulation of DNA-binding transcription factor activity (IEA)

negative regulation of DNA-templated transcription (IEA,ISO)

negative regulation of forebrain neuron differentiation (ISO)

negative regulation of gene expression (ISO)

negative regulation of glial cell proliferation (IEA)

negative regulation of inner ear auditory receptor cell differentiation (IEA,ISO)

negative regulation of inner ear receptor cell differentiation (IEA)

negative regulation of neurogenesis (ISO)

negative regulation of neuron differentiation (IEA,ISO)

negative regulation of neuron projection development (ISO)

negative regulation of oligodendrocyte differentiation (IEA,ISO)

negative regulation of pancreatic A cell differentiation (IEA,ISO)

negative regulation of pro-B cell differentiation (IEA)

negative regulation of stem cell differentiation (IEA)

negative regulation of stomach neuroendocrine cell differentiation (IEA,ISO)

negative regulation of transcription by RNA polymerase II (IEA,ISO)

neural tube development (IEA,ISO)

neuroendocrine cell differentiation (IEA,ISO)

neuron differentiation (IEA,ISO)

neuronal stem cell population maintenance (IEA)

Notch signaling pathway (IEA,ISO)

oculomotor nerve development (IEA,ISO)

outflow tract morphogenesis (IEA,ISO)

pancreas development (IEA,ISO)

pancreatic A cell differentiation (IEA,ISO)

pattern specification process (IEA,ISO)

pharyngeal arch artery morphogenesis (IEA)

pituitary gland development (IEA,ISO)

positive regulation of astrocyte differentiation (IEA)

positive regulation of BMP signaling pathway (IEA,ISO)

positive regulation of cell population proliferation (IEA,ISO)

positive regulation of DNA-templated transcription (IEA)

positive regulation of gene expression (ISO)

positive regulation of glial cell differentiation (ISO)

positive regulation of mitotic cell cycle, embryonic (IEA)

positive regulation of Notch signaling pathway (IEA)

positive regulation of receptor signaling pathway via JAK-STAT (IEA)

positive regulation of T cell proliferation (IEA,ISO)

positive regulation of transcription by RNA polymerase II (IEA,ISO)

positive regulation of tyrosine phosphorylation of STAT protein (IEA)

protein-containing complex assembly (IEA)

regulation of DNA-templated transcription (IEA)

regulation of epithelial cell proliferation (IEA,ISO)

regulation of fat cell differentiation (IEA,ISO)

regulation of neurogenesis (IEA,ISO)

regulation of neuron differentiation (IEA,ISO)

regulation of protein-containing complex assembly (ISO)

regulation of receptor signaling pathway via JAK-STAT (IEA)

regulation of secondary heart field cardioblast proliferation (IEA,ISO)

regulation of timing of cell differentiation (IEA,ISO)

regulation of timing of neuron differentiation (IEA,ISO)

regulation of transcription by RNA polymerase II (IEA,ISO)

renal interstitial fibroblast development (IEA)

response to alkaloid (ISO)

response to organic cyclic compound (ISO)

response to thyroid hormone (ISO)

S-shaped body morphogenesis (IEA)

smoothened signaling pathway (IEA,ISO)

somatic stem cell population maintenance (IEA,ISO)

stomach neuroendocrine cell differentiation (IEA,ISO)

T cell proliferation (IEA,ISO)

telencephalon development (IEA,ISO)

thymus development (IEA)

trochlear nerve development (IEA,ISO)

ureteric bud morphogenesis (IEA)

vascular associated smooth muscle cell development (IEA)

ventricular septum development (IEA)

ventricular septum morphogenesis (IEA)

Cellular Component

chromatin (ISO)

cytoplasm (IEA)

nuclear matrix (ISO)

nucleoplasm (IEA)

nucleus (IEA)

protein-containing complex (IEA)

Molecular Function

chromatin binding (ISO)

DNA binding (IEA,ISO)

DNA-binding transcription factor activity, RNA polymerase II-specific (IEA)

DNA-binding transcription repressor activity (IEA)

DNA-binding transcription repressor activity, RNA polymerase II-specific (IEA)

E-box binding (IEA,ISO)

histone deacetylase binding (IEA)

HLH domain binding (IEA)

identical protein binding (ISO)

JUN kinase binding (ISO)

N-box binding (IEA,ISO)

protein binding (ISO)

protein dimerization activity (IEA)

protein homodimerization activity (IEA)

protein-containing complex binding (ISO)

protein-folding chaperone binding (IEA)

RNA polymerase II-specific DNA-binding transcription factor binding (IEA)

sequence-specific DNA binding (ISO)

sequence-specific double-stranded DNA binding (IEA)

transcription corepressor binding (ISO)

transcription factor binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

Notch signaling pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Hes1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	123,607,220 - 123,609,806 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936711	639,905 - 642,622 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936711	640,002 - 642,580 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HES1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	194,136,148 - 194,138,732 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	194,136,148 - 194,138,732 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	193,853,937 - 193,856,521 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	195,336,628 - 195,339,090 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	3	192,270,388 - 192,272,854 (+)	NCBI		Celera
Cytogenetic Map	3	q29	NCBI
HuRef	3	191,241,261 - 191,243,734 (+)	NCBI		HuRef
CHM1_1	3	193,816,827 - 193,819,297 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	3	196,832,819 - 196,835,403 (+)	NCBI		T2T-CHM13v2.0

Hes1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	29,883,259 - 29,886,614 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	29,883,202 - 29,886,614 (+)	Ensembl		GRCm39 Ensembl
GRCm38	16	30,065,357 - 30,067,796 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	30,064,384 - 30,067,796 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	30,065,443 - 30,067,882 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	29,985,104 - 29,987,543 (+)	NCBI		MGSCv36	mm8
Celera	16	30,572,496 - 30,574,749 (+)	NCBI		Celera
Cytogenetic Map	16	B2	NCBI
cM Map	16	21.09	NCBI

Hes1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	84,210,632 - 84,213,045 (-)	NCBI		GRCr8
mRatBN7.2	11	70,705,763 - 70,708,176 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	70,705,764 - 70,708,192 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	79,549,796 - 79,552,209 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	72,184,221 - 72,186,634 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	71,238,898 - 71,241,311 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	74,312,837 - 74,315,249 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	74,312,806 - 74,315,248 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	77,360,109 - 77,362,521 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	72,603,482 - 72,605,673 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	72,661,439 - 72,663,801 (-)	NCBI
Celera	11	69,677,011 - 69,679,422 (-)	NCBI		Celera
Cytogenetic Map	11	q22	NCBI

Hes1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955420	14,564,283 - 14,568,447 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955420	14,565,921 - 14,568,447 (-)	NCBI	ChiLan1.0	ChiLan1.0

HES1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	192,057,229 - 192,060,673 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	192,062,515 - 192,065,400 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	191,432,513 - 191,435,387 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	201,749,044 - 201,751,591 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	201,749,044 - 201,754,257 (+)	Ensembl	panpan1.1		panPan2

HES1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Dog10K_Boxer_Tasha	23	52,257,121 - 52,259,752 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	23	53,157,666 - 53,160,303 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	23	53,153,934 - 53,160,310 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	23	52,667,374 - 52,670,002 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	23	52,721,885 - 52,724,518 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	23	53,007,809 - 53,010,447 (+)	NCBI		UU_Cfam_GSD_1.0

HES1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	131,135,725 - 131,138,237 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	131,135,970 - 131,137,865 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	140,633,207 - 140,635,734 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

HES1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	88,220,093 - 88,222,563 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	15	88,220,083 - 88,223,243 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	61,888,842 - 61,891,572 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Hes1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	63,563,754 - 63,566,781 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624730	63,563,848 - 63,566,303 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005338416	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000662	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000023475 ⟹ ENSSTOP00000020051

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936711	639,905 - 642,622 (-)	Ensembl

RefSeq Acc Id:

XM_005338416 ⟹ XP_005338473

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405602	123,607,220 - 123,609,806 (+)	NCBI
SpeTri2.0	NW_004936711	640,002 - 642,580 (-)	NCBI

Sequence:

show sequence

GGGATCACACTGGATCCGGAGCTGGTGCTGATAACAGCGGAATCCCCCGTCTACCTCTCTCCTT
GGTCCTGGAATAGCGCTACCGATCACCAAGTAGCCATAAAATAATAAATTCTCAGCACTCGCTC
AGTAGTTTTGTGAATGTCTCAAGTAAAAGAGACATAAGCAAAAAAAAAAAATTTTTTTTTTGCA
TGAAGTATTCCAAAAATAAAATTCTCTAGGGATTAAAAAAAAAGGAATAGAAAAAAAATGCCAG
CCGATATAATGGAGAAAAATTCCTCGTCCCCGGTGGCTGCTACCCCAGCCAGTGTCAACACGAC
ACCGGATAAACCAAAGACAGCATCTGAGCACAGAAAGTCATCCAAACCTATCATGGAGAAAAGA
CGAAGAGCAAGAATAAATGAAAGTCTGAGCCAACTGAAAACGCTGATTTTGGATGCCCTTAAAA
AAGATAGCTCCCGGCATTCCAAGCTGGAGAAGGCGGACATTCTGGAAATGACAGTGAAGCACCT
CCGGAACCTGCAGCGGGCGCAGATGACTGCTGCGCTGAGCACAGACCCGAGCGTGCTGGGGAAG
TACCGCGCCGGCTTCAGCGAGTGCATGAACGAGGTGACCCGCTTCCTGTCCACGTGCGAGGGCG
TTAACACCGAGGTACGCACTCGGCTGCTCGGCCACCTGGCCAACTGCATGACCCAGATCAACGC
CATGACCTACCCTGGGCAGCCGCATCCCGCCTTGCAGGCGCCGCCACCGCCCCCGCCAGGACCC
GGCGGCCCCCAGCACGCGCCGTTCGCGCCGCCGCCGCCACTTGTGCCCATCCCCGGAGGTGCGG
CGCCCCCTCCCGGCGGCGCACCCTGCAAGCTGGGCAGCCAGGCTGGAGAGGCGGCCAAGGTGTT
TGGTGGCTTCCAGGTGGTGCCAGCTCCTGACGGCCAATTTGCCTTCCTCATCCCCAATGGGGCC
TTCGCGCACAGCGGCCCAGTCATCCCGGTCTACACCAGCAACAGTGGGACCTCAGTGGGTCCCA
ACGCAGTGTCTCCTTCCAGCGGCTCCTCGCTCACGGCGGACTCCATGTGGAGGCCGTGGCGGAA
CTGAGGGGCTCAGACCACCCTTCCCCTAAATTCCCCAGCCCACCTCTCTCCCCTCCGGACACTA
AACAGGAACTTGCTGTTAGGAAAGAAGACTTTTGTGATTAAGTGGTTACTTCGGATTTTTTGTT
TTTAATTTCTAAAAAGTTACTTTTTTTGTAGAGAGCTGTATTAAGTGACTGACCATGCACTATA
TTTGTATATATTTTATATGTTCATATTGGATTGCGCCTTTGTATTATAAAACTTGAGATGACAT
TTCGTTTTTTACACGAGATTTCTTTTTTATGTGATGCCAAAGATGTTTGAAAATGCTCTTAAAG
TATCTTCCTTTGGGGAAGTTTGAGAAAATAAAAGAAAAAAGTGAAGGCTTTTA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005338473	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000020051.1
GenBank Protein	KAG3271227	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005338473 ⟸ XM_005338416

- UniProtKB:

I3N6Q5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPADIMEKNSSSPVAATPASVNTTPDKPKTASEHRKSSKPIMEKRRRARINESLSQLKTLILDA
LKKDSSRHSKLEKADILEMTVKHLRNLQRAQMTAALSTDPSVLGKYRAGFSECMNEVTRFLSTC
EGVNTEVRTRLLGHLANCMTQINAMTYPGQPHPALQAPPPPPPGPGGPQHAPFAPPPPLVPIPG
GAAPPPGGAPCKLGSQAGEAAKVFGGFQVVPAPDGQFAFLIPNGAFAHSGPVIPVYTSNSGTSV
GPNAVSPSSGSSLTADSMWRPWRN

hide sequence

Ensembl Acc Id:

ENSSTOP00000020051 ⟸ ENSSTOT00000023475

Protein Domains

bHLH Orange

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000026531	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000023475.2	UniProtKB/TrEMBL
Gene3D-CATH	4.10.280.10	UniProtKB/TrEMBL
	6.10.250.980	UniProtKB/TrEMBL
InterPro	bHLH_dom	UniProtKB/TrEMBL
	HES_HEY	UniProtKB/TrEMBL
	HLH_DNA-bd_sf	UniProtKB/TrEMBL
	Orange_dom	UniProtKB/TrEMBL
NCBI Gene	Hes1	ENTREZGENE
PANTHER	BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED	UniProtKB/TrEMBL
	TRANSCRIPTION FACTOR HES-1	UniProtKB/TrEMBL
Pfam	Hairy_orange	UniProtKB/TrEMBL
	HLH	UniProtKB/TrEMBL
PROSITE	BHLH	UniProtKB/TrEMBL
	ORANGE	UniProtKB/TrEMBL
SMART	HLH	UniProtKB/TrEMBL
	ORANGE	UniProtKB/TrEMBL
Superfamily-SCOP	Orange domain-like	UniProtKB/TrEMBL
	SSF47459	UniProtKB/TrEMBL
UniProt	I3N6Q5	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations