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Gene: Hes1 (hes family bHLH transcription factor 1) Mus musculus
Symbol: Hes1
Name: hes family bHLH transcription factor 1
Description: Exhibits several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; HLH domain binding activity; and N-box binding activity. Involved in several processes, including animal organ development; nervous system development; and vasculature development. Localizes to cytoplasm; nucleus; and protein-containing complex. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; foot bone; and sensory organ. Orthologous to human HES1 (hes family bHLH transcription factor 1); PARTICIPATES IN maturity-onset diabetes of the young pathway; Notch signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
Also known as: bHLHb3; bHLHb39; hairy and enhancer of split 1; hairy and enhancer of split 1 (Drosophila); Hr; Hry; transcription factor HES-1
Homo sapiens (human) : HES1 (hes family bHLH transcription factor 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Hes1 (hes family bHLH transcription factor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hes1 (hes family bHLH transcription factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : HES1 (hes family bHLH transcription factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hes1 (hes family bHLH transcription factor 1)
Sus scrofa (pig) : HES1 (hes family bHLH transcription factor 1)
Chlorocebus sabaeus (African green monkey) : HES1 (hes family bHLH transcription factor 1)
Heterocephalus glaber (naked mole-rat) : Hes1 (hes family bHLH transcription factor 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1630,064,384 - 30,067,796 (+)EnsemblGRCm38mm10GRCm38
GRCm381630,065,357 - 30,067,796 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371630,065,443 - 30,067,882 (+)NCBIGRCm37mm9NCBIm37
MGSCv361629,985,104 - 29,987,543 (+)NCBImm8
Celera1630,572,496 - 30,574,749 (+)NCBICelera
Cytogenetic Map16B2NCBI
cM Map1621.09NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Hes1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 62373
Created: 2001-04-11
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.