HES1 (hes family bHLH transcription factor 1) - Rat Genome Database

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Gene: HES1 (hes family bHLH transcription factor 1) Homo sapiens
Analyze
Symbol: HES1
Name: hes family bHLH transcription factor 1
RGD ID: 1605434
HGNC Page HGNC
Description: Exhibits histone deacetylase binding activity and sequence-specific double-stranded DNA binding activity. Involved in several processes, including negative regulation of cell differentiation; negative regulation of transcription by RNA polymerase II; and neuronal stem cell population maintenance. Localizes to nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: bHLHb39; class B basic helix-loop-helix protein 39; FLJ20408; hairy homolog; hairy-like protein; HES-1; HHL; HRY; transcription factor HES-1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3194,136,148 - 194,138,732 (+)EnsemblGRCh38hg38GRCh38
GRCh383194,136,148 - 194,138,732 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373193,853,937 - 193,856,521 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363195,336,628 - 195,339,090 (+)NCBINCBI36hg18NCBI36
Celera3192,270,388 - 192,272,854 (+)NCBI
Cytogenetic Map3q29NCBI
HuRef3191,241,261 - 191,243,734 (+)NCBIHuRef
CHM1_13193,816,827 - 193,819,297 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (ISO)
2-hydroxypropanoic acid  (EXP)
2-tert-butylhydroquinone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-hydroperoxycyclophosphamide  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (EXP)
6-propyl-2-thiouracil  (ISO)
acetaldehyde  (EXP)
aconitine  (EXP,ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (EXP)
alpha-naphthoflavone  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (EXP)
Aroclor 1254  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (EXP)
arsenous acid  (EXP)
baicalein  (EXP)
baicalin  (EXP)
benzene-1,2,4-triol  (EXP)
benzo[a]pyrene  (EXP)
benzo[a]pyrene diol epoxide I  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (ISO)
buspirone  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (EXP)
calcium atom  (ISO)
calcium(0)  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (ISO)
chloropicrin  (EXP)
choline  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (EXP)
clofibrate  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
coumestrol  (EXP)
CU-O LINKAGE  (EXP)
curcumin  (ISO)
cyclosporin A  (EXP)
DAPT  (EXP,ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diallyl disulfide  (ISO)
diallyl trisulfide  (EXP)
diarsenic trioxide  (EXP)
dibutyl phthalate  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (EXP,ISO)
disulfiram  (EXP)
diuron  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
elemental selenium  (EXP)
Enterolactone  (EXP)
enzalutamide  (EXP)
ethyl methanesulfonate  (EXP)
fenofibrate  (ISO)
flavonoids  (ISO)
fluoranthene  (ISO)
fluoxetine  (ISO)
flusilazole  (ISO)
flutamide  (ISO)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (EXP)
genistein  (EXP)
glyphosate  (EXP)
hexaconazole  (ISO)
hydrogen peroxide  (EXP)
indometacin  (EXP)
irinotecan  (EXP)
isoprenaline  (ISO)
juglone  (EXP)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lead(0)  (EXP)
lead(2+)  (EXP)
leflunomide  (EXP)
mebendazole  (EXP)
menadione  (EXP)
methamphetamine  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (EXP)
methylisothiazolinone  (EXP)
methylmercury chloride  (EXP,ISO)
mifepristone  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
nickel sulfate  (EXP)
niclosamide  (EXP,ISO)
nitrofen  (ISO)
ochratoxin A  (ISO)
orphenadrine  (ISO)
oxaliplatin  (EXP,ISO)
oxidopamine  (EXP,ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (EXP)
Paeonol  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenobarbital  (ISO)
phenol  (EXP)
phenylmercury acetate  (EXP)
pirinixic acid  (ISO)
potassium chromate  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP)
propiconazole  (ISO)
quercetin  (EXP)
rac-lactic acid  (EXP)
resveratrol  (EXP)
retinyl acetate  (ISO)
rotenone  (ISO)
Salidroside  (ISO)
SB 431542  (EXP)
selenium atom  (EXP)
silicon dioxide  (EXP)
sirolimus  (EXP,ISO)
sodium arsenite  (EXP)
tert-butyl hydroperoxide  (EXP)
testosterone  (EXP)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
thimerosal  (EXP)
thyroxine  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
trans-caffeic acid  (ISO)
triadimefon  (ISO)
Tributyltin oxide  (ISO)
trichostatin A  (EXP)
Triptolide  (EXP,ISO)
triptonide  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
tyrphostin AG 1478  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vitamin E  (EXP,ISO)
XL147  (ISO)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenohypophysis development  (IEA,ISO)
anterior/posterior pattern specification  (IBA)
aorta morphogenesis  (ISO)
artery morphogenesis  (ISS)
ascending aorta morphogenesis  (ISS)
cardiac neural crest cell development involved in outflow tract morphogenesis  (IEA,ISO)
cell adhesion  (IEA,ISO)
cell fate commitment  (ISO)
cell maturation  (IEA,ISO)
cell migration  (IEA,ISO)
cell morphogenesis involved in neuron differentiation  (IEA,ISO)
cellular response to fatty acid  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to nerve growth factor stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
cochlea development  (IEA,ISO)
comma-shaped body morphogenesis  (IEA,ISO)
common bile duct development  (IEA,ISO)
embryonic heart tube morphogenesis  (ISS)
establishment of epithelial cell polarity  (IEA,ISO)
forebrain radial glial cell differentiation  (ISS)
glomerulus vasculature development  (IEA,ISO)
hair cell differentiation  (ISO)
hindbrain morphogenesis  (IEA,ISO)
in utero embryonic development  (ISO)
inner ear receptor cell stereocilium organization  (IEA,ISO)
labyrinthine layer blood vessel development  (IEA)
lateral inhibition  (IEA,ISO)
liver development  (IEA,ISO)
lung development  (IEA,ISO)
metanephric nephron tubule morphogenesis  (IEA,ISO)
midbrain development  (IEA,ISO)
midbrain-hindbrain boundary morphogenesis  (IEA,ISO)
negative regulation of calcium ion import  (ISO)
negative regulation of cell differentiation  (ISO)
negative regulation of cell fate determination  (IEA,ISO)
negative regulation of DNA-binding transcription factor activity  (ISS)
negative regulation of forebrain neuron differentiation  (ISS)
negative regulation of gene expression  (ISO)
negative regulation of glial cell proliferation  (ISS)
negative regulation of inner ear auditory receptor cell differentiation  (IEA,ISO)
negative regulation of inner ear receptor cell differentiation  (ISO)
negative regulation of neurogenesis  (ISO)
negative regulation of neuron differentiation  (IBA,ISO)
negative regulation of neuron projection development  (ISO)
negative regulation of oligodendrocyte differentiation  (ISO,ISS)
negative regulation of pancreatic A cell differentiation  (IEA,ISO)
negative regulation of pro-B cell differentiation  (IMP)
negative regulation of stem cell differentiation  (IMP)
negative regulation of stomach neuroendocrine cell differentiation  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IDA,ISO)
negative regulation of transcription, DNA-templated  (IDA,ISO)
nervous system development  (TAS)
neural tube development  (ISO)
neuron differentiation  (ISO)
neuronal stem cell population maintenance  (IEP)
Notch signaling pathway  (IBA,IDA,IMP,ISO)
oculomotor nerve development  (IEA,ISO)
outflow tract morphogenesis  (ISO,ISS)
pancreas development  (IEA,ISO)
pattern specification process  (ISO)
pharyngeal arch artery morphogenesis  (ISS)
pituitary gland development  (ISO)
positive regulation of astrocyte differentiation  (ISS)
positive regulation of BMP signaling pathway  (IEA,ISO)
positive regulation of cell population proliferation  (ISO,ISS)
positive regulation of DNA binding  (ISS)
positive regulation of gene expression  (ISO)
positive regulation of glial cell differentiation  (ISO)
positive regulation of mitotic cell cycle, embryonic  (ISS)
positive regulation of Notch signaling pathway  (IEA)
positive regulation of receptor signaling pathway via JAK-STAT  (ISS)
positive regulation of T cell proliferation  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (ISO,ISS)
positive regulation of tyrosine phosphorylation of STAT protein  (ISS)
protein-containing complex assembly  (ISS)
regulation of epithelial cell proliferation  (IEA,ISO)
regulation of fat cell differentiation  (IEA,ISO)
regulation of neurogenesis  (IBA,ISO)
regulation of protein-containing complex assembly  (ISO)
regulation of receptor signaling pathway via JAK-STAT  (ISS)
regulation of secondary heart field cardioblast proliferation  (IEA,ISO)
regulation of timing of cell differentiation  (ISO)
regulation of timing of neuron differentiation  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IBA,ISO)
renal interstitial fibroblast development  (IEA,ISO)
response to alkaloid  (ISO)
response to organic cyclic compound  (ISO)
response to thyroid hormone  (ISO)
S-shaped body morphogenesis  (IEA,ISO)
smoothened signaling pathway  (IEA,ISO)
somatic stem cell population maintenance  (IEA,ISO)
telencephalon development  (IEA,ISO)
thymus development  (ISS)
trochlear nerve development  (IEA,ISO)
ureteric bud morphogenesis  (IEA,ISO)
vascular associated smooth muscle cell development  (ISS)
ventricular septum development  (ISS)
ventricular septum morphogenesis  (ISS)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Schizophrenia  (IAGP)
References

Additional References at PubMed
PMID:7906273   PMID:8020957   PMID:8687460   PMID:9389649   PMID:9745030   PMID:9874198   PMID:10851137   PMID:11238932   PMID:11486045   PMID:11748221   PMID:11756408   PMID:12032823  
PMID:12065598   PMID:12406868   PMID:12477932   PMID:12535671   PMID:12972610   PMID:14702039   PMID:14722248   PMID:15156153   PMID:15467735   PMID:15492808   PMID:15536134   PMID:15546612  
PMID:15563463   PMID:16160079   PMID:16195230   PMID:16214363   PMID:16253247   PMID:16322473   PMID:16365048   PMID:16894395   PMID:17072841   PMID:17301032   PMID:17388915   PMID:17611704  
PMID:17681138   PMID:17822320   PMID:18274550   PMID:18491256   PMID:18524252   PMID:18550849   PMID:18599525   PMID:18611861   PMID:18719287   PMID:18821565   PMID:18976975   PMID:19039095  
PMID:19058789   PMID:19116245   PMID:19118200   PMID:19274049   PMID:19321451   PMID:19322201   PMID:19322650   PMID:19453261   PMID:19603167   PMID:19682396   PMID:19724860   PMID:19802006  
PMID:19808903   PMID:19880519   PMID:19891787   PMID:19935883   PMID:20022559   PMID:20091184   PMID:20515776   PMID:20668890   PMID:20816878   PMID:20832754   PMID:21103979   PMID:21106062  
PMID:21125297   PMID:21169257   PMID:21224467   PMID:21238798   PMID:21495212   PMID:21573214   PMID:21866461   PMID:21873635   PMID:21900206   PMID:21984123   PMID:21988832   PMID:22036964  
PMID:22333607   PMID:22411914   PMID:22705236   PMID:22846929   PMID:22871495   PMID:23037857   PMID:23235341   PMID:23379739   PMID:23423517   PMID:23860410   PMID:23900217   PMID:24270810  
PMID:24342613   PMID:24346283   PMID:24486648   PMID:24492635   PMID:24684754   PMID:24825862   PMID:24885297   PMID:24894488   PMID:25037575   PMID:25107895   PMID:25139105   PMID:25216517  
PMID:25234168   PMID:25605780   PMID:25636905   PMID:25672829   PMID:25733872   PMID:25781910   PMID:25784680   PMID:25817041   PMID:25849484   PMID:25906782   PMID:25920606   PMID:25987042  
PMID:26068074   PMID:26092281   PMID:26277624   PMID:26448192   PMID:26452025   PMID:26452029   PMID:26563369   PMID:26650241   PMID:26678889   PMID:26988248   PMID:27129302   PMID:27353377  
PMID:27476040   PMID:27567696   PMID:27609421   PMID:27612417   PMID:27639167   PMID:27677287   PMID:28013292   PMID:28079885   PMID:28122586   PMID:28245235   PMID:28420872   PMID:28423527  
PMID:28451898   PMID:28464285   PMID:28473536   PMID:28536281   PMID:28750047   PMID:28974640   PMID:29070679   PMID:29436668   PMID:29458175   PMID:29463306   PMID:29491143   PMID:29523683  
PMID:29665790   PMID:29845934   PMID:29981167   PMID:30107165   PMID:30419336   PMID:30548309   PMID:30615540   PMID:30653033   PMID:30895661   PMID:31109645   PMID:31232134   PMID:31919081  
PMID:32173531   PMID:32329442   PMID:32879444   PMID:32972441   PMID:33067264   PMID:33544929  


Genomics

Comparative Map Data
HES1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3194,136,148 - 194,138,732 (+)EnsemblGRCh38hg38GRCh38
GRCh383194,136,148 - 194,138,732 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373193,853,937 - 193,856,521 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363195,336,628 - 195,339,090 (+)NCBINCBI36hg18NCBI36
Celera3192,270,388 - 192,272,854 (+)NCBI
Cytogenetic Map3q29NCBI
HuRef3191,241,261 - 191,243,734 (+)NCBIHuRef
CHM1_13193,816,827 - 193,819,297 (+)NCBICHM1_1
Hes1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391629,884,175 - 29,886,614 (+)NCBIGRCm39mm39
GRCm39 Ensembl1629,883,202 - 29,886,614 (+)Ensembl
GRCm381630,065,357 - 30,067,796 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1630,064,384 - 30,067,796 (+)EnsemblGRCm38mm10GRCm38
MGSCv371630,065,443 - 30,067,882 (+)NCBIGRCm37mm9NCBIm37
MGSCv361629,985,104 - 29,987,543 (+)NCBImm8
Celera1630,572,496 - 30,574,749 (+)NCBICelera
Cytogenetic Map16B2NCBI
cM Map1621.09NCBI
Hes1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21170,705,763 - 70,708,176 (-)NCBI
Rnor_6.0 Ensembl1174,312,806 - 74,315,248 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01174,312,837 - 74,315,249 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01177,360,109 - 77,362,521 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41172,603,482 - 72,605,673 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11172,661,439 - 72,663,801 (-)NCBI
Celera1169,677,011 - 69,679,422 (-)NCBICelera
Cytogenetic Map11q22NCBI
Hes1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542014,564,283 - 14,568,447 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542014,565,921 - 14,568,447 (-)NCBIChiLan1.0ChiLan1.0
HES1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13201,749,044 - 201,751,591 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3201,749,044 - 201,754,257 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03191,432,513 - 191,435,387 (+)NCBIMhudiblu_PPA_v0panPan3
HES1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha2352,257,121 - 52,259,752 (+)NCBI
ROS_Cfam_1.02353,157,666 - 53,160,303 (+)NCBI
UMICH_Zoey_3.12352,667,374 - 52,670,002 (+)NCBI
UNSW_CanFamBas_1.02352,721,885 - 52,724,518 (+)NCBI
UU_Cfam_GSD_1.02353,007,809 - 53,010,447 (+)NCBI
Hes1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602123,607,220 - 123,609,806 (+)NCBI
SpeTri2.0NW_004936711640,002 - 642,580 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HES1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13131,135,724 - 131,138,236 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113131,135,970 - 131,137,865 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213140,633,207 - 140,635,734 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HES1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11588,220,093 - 88,222,563 (+)NCBI
ChlSab1.1 Ensembl1588,220,083 - 88,223,243 (+)Ensembl
Vero_WHO_p1.0NW_02366604161,888,842 - 61,891,572 (+)NCBI
Hes1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473063,563,848 - 63,566,303 (-)NCBI

Position Markers
RH93226  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373193,853,970 - 193,854,132UniSTSGRCh37
Build 363195,336,664 - 195,336,826RGDNCBI36
Celera3192,270,424 - 192,270,586RGD
Cytogenetic Map3q28-q29UniSTS
HuRef3191,241,300 - 191,241,462UniSTS
GeneMap99-GB4 RH Map3725.06UniSTS
STS-L19314  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373193,856,036 - 193,856,262UniSTSGRCh37
Build 363195,338,730 - 195,338,956RGDNCBI36
Celera3192,272,494 - 192,272,720RGD
Cytogenetic Map3q28-q29UniSTS
HuRef3191,243,369 - 191,243,595UniSTS
GeneMap99-GB4 RH Map3741.09UniSTS
UniSTS:265714  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373193,855,919 - 193,856,325UniSTSGRCh37
Build 363195,338,613 - 195,339,019RGDNCBI36
Celera3192,272,377 - 192,272,783RGD
HuRef3191,243,252 - 191,243,658UniSTS
HES1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373193,854,413 - 193,854,797UniSTSGRCh37
Celera3192,270,870 - 192,271,254UniSTS
HuRef3191,241,746 - 191,242,130UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR199Bhsa-miR-199b-5pMirtarbaseexternal_infoFlow//Immunohistochemistry//In situ hybridization/Functional MTI19308264
MIR199Bhsa-miR-199b-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23354452
MIR199Bhsa-miR-199b-5pOncomiRDBexternal_infoNANA19308264
MIR23Ahsa-miR-23a-3pMirtarbaseexternal_infoImmunofluorescence//Luciferase reporter assay//NorFunctional MTI12808467
MIR23Ahsa-miR-23a-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI15066185
MIR23Ahsa-miR-23a-3pMirecordsexternal_infoNANA15066185

Predicted Target Of
Summary Value
Count of predictions:460
Count of miRNA genes:373
Interacting mature miRNAs:404
Transcripts:ENST00000232424, ENST00000476918
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 1 2 1 25 5 3 6
Medium 2405 2084 1702 612 804 453 4303 2011 3016 399 1424 1558 175 1 1201 2765 6 2
Low 32 842 23 12 975 12 29 183 715 19 29 46 3 17
Below cutoff 1 61 135 3 1 2 6

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000232424   ⟹   ENSP00000232424
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl3194,136,148 - 194,138,732 (+)Ensembl
RefSeq Acc Id: ENST00000476918
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl3194,136,148 - 194,137,284 (+)Ensembl
RefSeq Acc Id: NM_005524   ⟹   NP_005515
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383194,136,148 - 194,138,732 (+)NCBI
GRCh373193,853,931 - 193,856,401 (+)ENTREZGENE
Build 363195,336,628 - 195,339,090 (+)NCBI Archive
HuRef3191,241,261 - 191,243,734 (+)ENTREZGENE
CHM1_13193,816,827 - 193,819,297 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_005515   ⟸   NM_005524
- UniProtKB: Q14469 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000232424   ⟸   ENST00000232424
Protein Domains
bHLH   Orange

Promoters
RGD ID:6866646
Promoter ID:EPDNEW_H6487
Type:initiation region
Name:HES1_1
Description:hes family bHLH transcription factor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh383194,136,148 - 194,136,208EPDNEW
RGD ID:6801118
Promoter ID:HG_KWN:47309
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000342632,   OTTHUMT00000342633
Position:
Human AssemblyChrPosition (strand)Source
Build 363195,335,636 - 195,336,677 (+)MPROMDB
RGD ID:6812306
Promoter ID:HG_ACW:57484
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:HES1.DAPR07-UNSPLICED
Position:
Human AssemblyChrPosition (strand)Source
Build 363195,337,671 - 195,338,362 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 3q27.2-29(chr3:185485849-198110178)x1 copy number loss See cases [RCV000051608] Chr3:185485849..198110178 [GRCh38]
Chr3:185203637..197837049 [GRCh37]
Chr3:186686331..199321446 [NCBI36]
Chr3:3q27.2-29
pathogenic
GRCh38/hg38 3q27.3-29(chr3:187446231-195029133)x1 copy number loss See cases [RCV000051610] Chr3:187446231..195029133 [GRCh38]
Chr3:187164019..194749862 [GRCh37]
Chr3:188646713..196231151 [NCBI36]
Chr3:3q27.3-29
pathogenic
GRCh38/hg38 3q24-29(chr3:147521892-198096565)x3 copy number gain See cases [RCV000051725] Chr3:147521892..198096565 [GRCh38]
Chr3:147239679..197823436 [GRCh37]
Chr3:148722369..199307833 [NCBI36]
Chr3:3q24-29
pathogenic
GRCh38/hg38 3q25.31-29(chr3:157293378-198134727)x3 copy number gain See cases [RCV000051726] Chr3:157293378..198134727 [GRCh38]
Chr3:157011167..197861598 [GRCh37]
Chr3:158493861..199345995 [NCBI36]
Chr3:3q25.31-29
pathogenic
GRCh38/hg38 3q26.32-29(chr3:178411707-198110319)x3 copy number gain See cases [RCV000051736] Chr3:178411707..198110319 [GRCh38]
Chr3:178129495..197837190 [GRCh37]
Chr3:179612189..199321587 [NCBI36]
Chr3:3q26.32-29
pathogenic
GRCh38/hg38 3q27.2-29(chr3:185920880-198110319)x3 copy number gain See cases [RCV000051738] Chr3:185920880..198110319 [GRCh38]
Chr3:185638668..197837190 [GRCh37]
Chr3:187121362..199321587 [NCBI36]
Chr3:3q27.2-29
pathogenic
GRCh38/hg38 3q28-29(chr3:189265371-198110178)x3 copy number gain See cases [RCV000051739] Chr3:189265371..198110178 [GRCh38]
Chr3:188983160..197837049 [GRCh37]
Chr3:190465854..199321446 [NCBI36]
Chr3:3q28-29
pathogenic
GRCh38/hg38 3q28-29(chr3:190667663-198110178)x3 copy number gain See cases [RCV000051740] Chr3:190667663..198110178 [GRCh38]
Chr3:190385452..197837049 [GRCh37]
Chr3:191868146..199321446 [NCBI36]
Chr3:3q28-29
pathogenic
GRCh38/hg38 3q29(chr3:193917490-198110319)x3 copy number gain See cases [RCV000051741] Chr3:193917490..198110319 [GRCh38]
Chr3:193635279..197837190 [GRCh37]
Chr3:195117973..199321587 [NCBI36]
Chr3:3q29
pathogenic
GRCh38/hg38 3q22.3-29(chr3:137126982-198110178)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051723]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051723]|See cases [RCV000051723] Chr3:137126982..198110178 [GRCh38]
Chr3:136845824..197837049 [GRCh37]
Chr3:138328514..199321446 [NCBI36]
Chr3:3q22.3-29
pathogenic
GRCh38/hg38 3q13.11-29(chr3:103426882-198110178)x3 copy number gain See cases [RCV000134948] Chr3:103426882..198110178 [GRCh38]
Chr3:103145726..197837049 [GRCh37]
Chr3:104628416..199321446 [NCBI36]
Chr3:3q13.11-29
pathogenic
GRCh38/hg38 3q26.2-29(chr3:168167568-198110178)x3 copy number gain See cases [RCV000137106] Chr3:168167568..198110178 [GRCh38]
Chr3:167885356..197837049 [GRCh37]
Chr3:169368050..199321446 [NCBI36]
Chr3:3q26.2-29
pathogenic
GRCh38/hg38 3q26.32-29(chr3:176439911-198118383)x3 copy number gain See cases [RCV000138009] Chr3:176439911..198118383 [GRCh38]
Chr3:176157699..197845254 [GRCh37]
Chr3:177640393..199329651 [NCBI36]
Chr3:3q26.32-29
pathogenic|likely benign
GRCh38/hg38 3q29(chr3:192752937-198118383)x3 copy number gain See cases [RCV000137827] Chr3:192752937..198118383 [GRCh38]
Chr3:192470726..197845254 [GRCh37]
Chr3:193953420..199329651 [NCBI36]
Chr3:3q29
pathogenic
GRCh38/hg38 3q27.3-29(chr3:186765148-194409416)x1 copy number loss See cases [RCV000137962] Chr3:186765148..194409416 [GRCh38]
Chr3:186482937..194130145 [GRCh37]
Chr3:187965631..195611434 [NCBI36]
Chr3:3q27.3-29
pathogenic|likely benign
GRCh38/hg38 3q26.32-29(chr3:176168525-198118383)x3 copy number gain See cases [RCV000138662] Chr3:176168525..198118383 [GRCh38]
Chr3:175886313..197845254 [GRCh37]
Chr3:177369007..199329651 [NCBI36]
Chr3:3q26.32-29
pathogenic
GRCh38/hg38 3q25.1-29(chr3:152100512-198118383)x3 copy number gain See cases [RCV000139435] Chr3:152100512..198118383 [GRCh38]
Chr3:151818301..197845254 [GRCh37]
Chr3:153300991..199329651 [NCBI36]
Chr3:3q25.1-29
pathogenic
GRCh38/hg38 3q25.31-29(chr3:156321878-198113452)x3 copy number gain See cases [RCV000140849] Chr3:156321878..198113452 [GRCh38]
Chr3:156039667..197840323 [GRCh37]
Chr3:157522361..199324720 [NCBI36]
Chr3:3q25.31-29
pathogenic
GRCh38/hg38 3q25.31-29(chr3:156118441-198125115)x3 copy number gain See cases [RCV000142310] Chr3:156118441..198125115 [GRCh38]
Chr3:155836230..197851986 [GRCh37]
Chr3:157318924..199336383 [NCBI36]
Chr3:3q25.31-29
pathogenic
GRCh38/hg38 3q26.1-29(chr3:166137209-198125115)x3 copy number gain See cases [RCV000143694] Chr3:166137209..198125115 [GRCh38]
Chr3:165854997..197851986 [GRCh37]
Chr3:167337691..199336383 [NCBI36]
Chr3:3q26.1-29
pathogenic
GRCh38/hg38 3q29(chr3:193704605-198125115)x3 copy number gain See cases [RCV000143501] Chr3:193704605..198125115 [GRCh38]
Chr3:193422394..197851986 [GRCh37]
Chr3:194905088..199336383 [NCBI36]
Chr3:3q29
pathogenic
GRCh37/hg19 3q29(chr3:193333511-194338436)x3 copy number gain Ductal breast carcinoma [RCV000207285] Chr3:193333511..194338436 [GRCh37]
Chr3:3q29
uncertain significance
GRCh37/hg19 3q25.32-29(chr3:158980631-197766890)x3 copy number gain See cases [RCV000447464] Chr3:158980631..197766890 [GRCh37]
Chr3:3q25.32-29
pathogenic
GRCh37/hg19 3q26.33-29(chr3:181911498-197851986)x4 copy number gain See cases [RCV000446732] Chr3:181911498..197851986 [GRCh37]
Chr3:3q26.33-29
pathogenic
GRCh37/hg19 3q25.2-29(chr3:152356847-197851986)x3 copy number gain See cases [RCV000448608] Chr3:152356847..197851986 [GRCh37]
Chr3:3q25.2-29
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986)x3 copy number gain See cases [RCV000511055] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986) copy number gain See cases [RCV000512358] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3q26.33-29(chr3:182539234-197851986)x3 copy number gain not provided [RCV000682336] Chr3:182539234..197851986 [GRCh37]
Chr3:3q26.33-29
pathogenic
GRCh37/hg19 3q27.1-29(chr3:184003967-197851986)x3 copy number gain not provided [RCV000682339] Chr3:184003967..197851986 [GRCh37]
Chr3:3q27.1-29
pathogenic
GRCh37/hg19 3q28-29(chr3:187913567-197851986)x3 copy number gain not provided [RCV000682344] Chr3:187913567..197851986 [GRCh37]
Chr3:3q28-29
pathogenic
GRCh37/hg19 3q28-29(chr3:191593619-197851986)x3 copy number gain not provided [RCV000682346] Chr3:191593619..197851986 [GRCh37]
Chr3:3q28-29
pathogenic
GRCh37/hg19 3q27.3-29(chr3:186374365-197851986)x3 copy number gain not provided [RCV000682341] Chr3:186374365..197851986 [GRCh37]
Chr3:3q27.3-29
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61495-197838262)x3 copy number gain not provided [RCV000742138] Chr3:61495..197838262 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:60174-197948027)x3 copy number gain not provided [RCV000742133] Chr3:60174..197948027 [GRCh37]
Chr3:3p26.3-q29
pathogenic
NC_000003.12:g.(?_187222939)_(194312782_?)del deletion Schizophrenia [RCV000754274] Chr3:187222939..194312782 [GRCh38]
Chr3:3q27.3-29
likely pathogenic
GRCh37/hg19 3q26.31-29(chr3:173281266-197838262)x3 copy number gain not provided [RCV000742968] Chr3:173281266..197838262 [GRCh37]
Chr3:3q26.31-29
pathogenic
GRCh37/hg19 3q27.3-29(chr3:186374671-197838262)x3 copy number gain not provided [RCV000743037] Chr3:186374671..197838262 [GRCh37]
Chr3:3q27.3-29
pathogenic
GRCh37/hg19 3q28-29(chr3:189101446-197838262)x1 copy number loss not provided [RCV000743049] Chr3:189101446..197838262 [GRCh37]
Chr3:3q28-29
pathogenic
NM_005524.4(HES1):c.777C>T (p.Asn259=) single nucleotide variant not provided [RCV000894087] Chr3:194138167 [GRCh38]
Chr3:193855956 [GRCh37]
Chr3:3q29
likely benign
NM_005524.4(HES1):c.293-5C>T single nucleotide variant not provided [RCV000963296] Chr3:194137678 [GRCh38]
Chr3:193855467 [GRCh37]
Chr3:3q29
benign
GRCh37/hg19 3q28-29(chr3:188386566-197838262)x3 copy number gain See cases [RCV000790566] Chr3:188386566..197838262 [GRCh37]
Chr3:3q28-29
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:5192 AgrOrtholog
COSMIC HES1 COSMIC
Ensembl Genes ENSG00000114315 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000232424 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000232424 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000114315 GTEx
HGNC ID HGNC:5192 ENTREZGENE
Human Proteome Map HES1 Human Proteome Map
InterPro bHLH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Orange_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:3280 UniProtKB/Swiss-Prot
NCBI Gene 3280 ENTREZGENE
OMIM 139605 OMIM
Pfam Hairy_orange UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA29465 PharmGKB
PROSITE BHLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ORANGE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ORANGE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47459 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt HES1_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q8IXV0_HUMAN UniProtKB/TrEMBL
UniProt Secondary Q6FHB2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-10-22 HES1  hes family bHLH transcription factor 1    hairy and enhancer of split 1, (Drosophila)  Symbol and/or name change 5135510 APPROVED
2011-08-16 HES1  hairy and enhancer of split 1, (Drosophila)  HES1  hairy and enhancer of split 1, (Drosophila)  Symbol and/or name change 5135510 APPROVED