Hes1 (hes family bHLH transcription factor 1) - Rat Genome Database

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Gene: Hes1 (hes family bHLH transcription factor 1) Heterocephalus glaber
Analyze
Symbol: Hes1
Name: hes family bHLH transcription factor 1
RGD ID: 18926608
Description: ENCODES a protein that exhibits chromatin binding (ortholog); DNA binding (ortholog); DNA-binding transcription factor activity, RNA polymerase II-specific (ortholog); INVOLVED IN adenohypophysis development (ortholog); amacrine cell differentiation (ortholog); aorta morphogenesis (ortholog); PARTICIPATES IN Notch signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); amyotrophic lateral sclerosis (ortholog); Breast Neoplasms (ortholog); FOUND IN chromatin (ortholog); cytoplasm (ortholog); nuclear matrix (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: hairy and enhancer of split 1; Transcription factor HES-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473063,563,754 - 63,566,781 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473063,563,848 - 63,566,303 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenohypophysis development  (ISO)
amacrine cell differentiation  (ISO)
aorta morphogenesis  (ISO)
artery morphogenesis  (ISO)
ascending aorta morphogenesis  (ISO)
BMP signaling pathway  (ISO)
Cajal-Retzius cell differentiation  (ISO)
cardiac neural crest cell development involved in outflow tract morphogenesis  (ISO)
cell adhesion  (ISO)
cell fate commitment  (ISO)
cell fate determination  (ISO)
cell maturation  (ISO)
cell migration  (ISO)
cell morphogenesis involved in neuron differentiation  (ISO)
cell population proliferation  (ISO)
cellular response to fatty acid  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to nerve growth factor stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
cochlea development  (ISO)
comma-shaped body morphogenesis  (ISO)
common bile duct development  (ISO)
embryonic heart tube morphogenesis  (ISO)
establishment of epithelial cell polarity  (ISO)
forebrain radial glial cell differentiation  (ISO)
glomerulus vasculature development  (ISO)
hair cell differentiation  (ISO)
hindbrain morphogenesis  (ISO)
in utero embryonic development  (ISO)
inhibition of neuroepithelial cell differentiation  (ISO)
inner ear auditory receptor cell differentiation  (ISO)
inner ear receptor cell stereocilium organization  (ISO)
labyrinthine layer blood vessel development  (ISO)
lateral inhibition  (ISO)
liver development  (ISO)
lung development  (ISO)
metanephric nephron tubule morphogenesis  (ISO)
midbrain development  (ISO)
midbrain-hindbrain boundary morphogenesis  (ISO)
negative regulation of amacrine cell differentiation  (ISO)
negative regulation of calcium ion import  (ISO)
negative regulation of cell differentiation  (ISO)
negative regulation of cell fate determination  (ISO)
negative regulation of DNA-binding transcription factor activity  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of forebrain neuron differentiation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of glial cell proliferation  (ISO)
negative regulation of inner ear auditory receptor cell differentiation  (ISO)
negative regulation of inner ear receptor cell differentiation  (ISO)
negative regulation of neurogenesis  (ISO)
negative regulation of neuron differentiation  (ISO)
negative regulation of neuron projection development  (ISO)
negative regulation of oligodendrocyte differentiation  (ISO)
negative regulation of pancreatic A cell differentiation  (ISO)
negative regulation of pro-B cell differentiation  (ISO)
negative regulation of stem cell differentiation  (ISO)
negative regulation of stomach neuroendocrine cell differentiation  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
neural tube development  (ISO)
neuroendocrine cell differentiation  (ISO)
neuron differentiation  (ISO)
neuronal stem cell population maintenance  (ISO)
Notch signaling pathway  (ISO)
oculomotor nerve development  (ISO)
outflow tract morphogenesis  (ISO)
pancreas development  (ISO)
pancreatic A cell differentiation  (ISO)
pattern specification process  (ISO)
pharyngeal arch artery morphogenesis  (ISO)
pituitary gland development  (ISO)
positive regulation of astrocyte differentiation  (ISO)
positive regulation of BMP signaling pathway  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of glial cell differentiation  (ISO)
positive regulation of mitotic cell cycle, embryonic  (ISO)
positive regulation of Notch signaling pathway  (ISO)
positive regulation of receptor signaling pathway via JAK-STAT  (ISO)
positive regulation of T cell proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
protein-containing complex assembly  (ISO)
regulation of DNA-templated transcription  (IEA)
regulation of epithelial cell proliferation  (ISO)
regulation of fat cell differentiation  (ISO)
regulation of neurogenesis  (ISO)
regulation of neuron differentiation  (ISO)
regulation of protein-containing complex assembly  (ISO)
regulation of receptor signaling pathway via JAK-STAT  (ISO)
regulation of secondary heart field cardioblast proliferation  (ISO)
regulation of timing of cell differentiation  (ISO)
regulation of timing of neuron differentiation  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
renal interstitial fibroblast development  (ISO)
response to alkaloid  (ISO)
response to Aroclor 1254  (ISO)
response to thyroid hormone  (ISO)
S-shaped body morphogenesis  (ISO)
smoothened signaling pathway  (ISO)
somatic stem cell population maintenance  (ISO)
stomach neuroendocrine cell differentiation  (ISO)
T cell proliferation  (ISO)
telencephalon development  (ISO)
thymus development  (ISO)
trochlear nerve development  (ISO)
ureteric bud morphogenesis  (ISO)
vascular associated smooth muscle cell development  (ISO)
ventricular septum development  (ISO)
ventricular septum morphogenesis  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Hes1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473063,563,754 - 63,566,781 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473063,563,848 - 63,566,303 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
HES1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383194,136,148 - 194,138,732 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3194,136,148 - 194,138,732 (+)EnsemblGRCh38hg38GRCh38
GRCh373193,853,937 - 193,856,521 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363195,336,628 - 195,339,090 (+)NCBINCBI36Build 36hg18NCBI36
Celera3192,270,388 - 192,272,854 (+)NCBICelera
Cytogenetic Map3q29NCBI
HuRef3191,241,261 - 191,243,734 (+)NCBIHuRef
CHM1_13193,816,827 - 193,819,297 (+)NCBICHM1_1
T2T-CHM13v2.03196,832,819 - 196,835,403 (+)NCBIT2T-CHM13v2.0
Hes1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391629,883,259 - 29,886,614 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1629,883,202 - 29,886,614 (+)EnsemblGRCm39 Ensembl
GRCm381630,065,357 - 30,067,796 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1630,064,384 - 30,067,796 (+)EnsemblGRCm38mm10GRCm38
MGSCv371630,065,443 - 30,067,882 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361629,985,104 - 29,987,543 (+)NCBIMGSCv36mm8
Celera1630,572,496 - 30,574,749 (+)NCBICelera
Cytogenetic Map16B2NCBI
cM Map1621.09NCBI
Hes1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81184,210,632 - 84,213,045 (-)NCBIGRCr8
mRatBN7.21170,705,763 - 70,708,176 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1170,705,764 - 70,708,192 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1179,549,796 - 79,552,209 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01172,184,221 - 72,186,634 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01171,238,898 - 71,241,311 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01174,312,837 - 74,315,249 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1174,312,806 - 74,315,248 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01177,360,109 - 77,362,521 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41172,603,482 - 72,605,673 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11172,661,439 - 72,663,801 (-)NCBI
Celera1169,677,011 - 69,679,422 (-)NCBICelera
Cytogenetic Map11q22NCBI
Hes1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542014,564,283 - 14,568,447 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542014,565,921 - 14,568,447 (-)NCBIChiLan1.0ChiLan1.0
HES1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22192,057,229 - 192,060,673 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13192,062,515 - 192,065,400 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03191,432,513 - 191,435,387 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13201,749,044 - 201,751,591 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3201,749,044 - 201,754,257 (+)Ensemblpanpan1.1panPan2
HES1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha2352,257,121 - 52,259,752 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02353,157,666 - 53,160,303 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2353,153,934 - 53,160,310 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12352,667,374 - 52,670,002 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02352,721,885 - 52,724,518 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02353,007,809 - 53,010,447 (+)NCBIUU_Cfam_GSD_1.0
Hes1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602123,607,220 - 123,609,806 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936711639,905 - 642,622 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936711640,002 - 642,580 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HES1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13131,135,725 - 131,138,237 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113131,135,970 - 131,137,865 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213140,633,207 - 140,635,734 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HES1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11588,220,093 - 88,222,563 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1588,220,083 - 88,223,243 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604161,888,842 - 61,891,572 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000024165   ⟹   ENSHGLP00000023947
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462473063,563,754 - 63,566,781 (-)Ensembl
RefSeq Acc Id: XM_004834759   ⟹   XP_004834816
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473063,563,848 - 63,566,303 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004834816 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHA97858 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000023947
RefSeq Acc Id: XP_004834816   ⟸   XM_004834759
- UniProtKB: G5ALE8 (UniProtKB/TrEMBL),   A0AAX6NQT4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000023947   ⟸   ENSHGLT00000024165


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000017070 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000024165 ENTREZGENE
Gene3D-CATH 6.10.250.980 UniProtKB/TrEMBL
  Helix-loop-helix DNA-binding domain UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/TrEMBL
  HES_HEY UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/TrEMBL
  Orange_dom UniProtKB/TrEMBL
NCBI Gene Hes1 ENTREZGENE
PANTHER BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED UniProtKB/TrEMBL
  TRANSCRIPTION FACTOR HES-1 UniProtKB/TrEMBL
Pfam Hairy_orange UniProtKB/TrEMBL
  HLH UniProtKB/TrEMBL
PROSITE BHLH UniProtKB/TrEMBL
  ORANGE UniProtKB/TrEMBL
SMART HLH UniProtKB/TrEMBL
  ORANGE UniProtKB/TrEMBL
Superfamily-SCOP HLH, helix-loop-helix DNA-binding domain UniProtKB/TrEMBL
  Orange domain-like UniProtKB/TrEMBL
UniProt A0AAX6NQT4 ENTREZGENE, UniProtKB/TrEMBL
  G5ALE8 ENTREZGENE, UniProtKB/TrEMBL