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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hes1
Name: hes family bHLH transcription factor 1
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hes1affects expressionISOHES1 (Homo sapiens)6480464CTDHydrogen Peroxide affects the expression of HES1 mRNAPMID:20044591
Hes1increases expressionISOHES1 (Homo sapiens)6480464CTDHydrogen Peroxide results in increased expression of HES1 proteinPMID:25005833 PMID:25108166
Hes1multiple interactionsISOHES1 (Homo sapiens)6480464CTDEUK-134 inhibits the reaction [Hydrogen Peroxide results in increased expression of HES1 protein]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Hydrogen Peroxide results in increased expression of HES1 protein]; Quercetin inhibits the reaction [Hydrogen Peroxide results in increased expression of HES1 protein]PMID:25005833 PMID:25108166
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