RGD Reference Report - Effects of matrine on oval cellmediated liver regeneration and expression of RBPJkappa and HES1. - Rat Genome Database

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Effects of matrine on oval cellmediated liver regeneration and expression of RBPJkappa and HES1.

Authors: Yang, ZY  Wang, L  Hou, YX  Wang, XB 
Citation: Yang ZY, etal., Mol Med Rep. 2013 May;7(5):1533-8. doi: 10.3892/mmr.2013.1398. Epub 2013 Mar 27.
RGD ID: 9685361
Pubmed: PMID:23545940   (View Abstract at PubMed)
DOI: DOI:10.3892/mmr.2013.1398   (Journal Full-text)

In the present study a rat model of oval cellmediated liver regeneration was constructed to examine the molecular mechanisms of matrine in oval cellmediated liver regeneration and the effects of matrine on hepatic function and the expression of OV6 protein and recombination signal sequencebinding protein Jkappa (RBPJkappa) and HES1 mRNA. A total of 48 Sprague Dawley rats were equally and randomly assigned to two groups. The model group underwent oval cellmediated liver regeneration, whereas the matrine group underwent oval cellmediated liver regeneration and received oral gavage of matrine. Expression of OV6 protein was tested by immunohistochemistry and RBPJkappa and HES1 mRNA expression was determined by reversetranscription polymerase chain reaction. Recovery of hepatic function was faster in the matrine group compared with the model (P<0.05). OV6 protein, RBPJkappa and HES1 mRNA expression levels were lower in the matrine than the model group (P<0.05). Matrine promotes oval cellmediated liver regeneration through downregulation of the RBPJkappaHES1 signaling pathway.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to alkaloid  IEP 9685361matrineRGD 

Objects Annotated

Genes (Rattus norvegicus)
Hes1  (hes family bHLH transcription factor 1)


Additional Information