GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mapk8 | increases expression | EXP | | 6480464 | CTD | Acetaminophen results in increased expression of MAPK8 mRNA | PMID:33387578 | Mapk8 | increases response to substance | EXP | | 6480464 | CTD | MAPK8 results in increased susceptibility to Acetaminophen | PMID:11562448 | Mapk8 | multiple interactions | EXP | | 6480464 | CTD | Acetaminophen results in increased phosphorylation of and results in increased activity of MAPK8 protein; MAP2K4 mutant form inhibits the reaction [Acetaminophen results in increased activity of MAPK8 protein] | PMID:11562448 | Mapk8 | decreases expression | ISO | MAPK8 (Homo sapiens) | 6480464 | CTD | Acetaminophen results in decreased expression of MAPK8 mRNA | PMID:27761495 | Mapk8 | increases expression | ISO | MAPK8 (Homo sapiens) | 6480464 | CTD | Acetaminophen results in increased expression of MAPK8 mRNA | PMID:20732408 PMID:27761495 | Mapk8 | increases phosphorylation | ISO | MAPK8 (Homo sapiens) | 6480464 | CTD | Acetaminophen results in increased phosphorylation of MAPK8 protein | PMID:33959992 | Mapk8 | increases phosphorylation | ISO | Mapk8 (Mus musculus) | 6480464 | CTD | Acetaminophen results in increased phosphorylation of MAPK8 protein | PMID:19931551 PMID:20363829 PMID:20423716 PMID:22107450 PMID:25956474 PMID:30375433 PMID:31444509 PMID:33290831 PMID:33458793 PMID:34890640 PMID:35292334 PMID:36928416 PMID:37179516 | Mapk8 | increases response to substance | ISO | Mapk8 (Mus musculus) | 6480464 | CTD | MAPK8 protein results in increased susceptibility to Acetaminophen | PMID:18700144 | Mapk8 | multiple interactions | ISO | MAPK8 (Homo sapiens) | 6480464 | CTD | Acetaminophen results in increased phosphorylation of and affects the activity of MAPK8 protein; N-acetylsphingosine promotes the reaction [Acetaminophen results in increased phosphorylation of MAPK8 protein]; oltipraz inhibits the reaction [Acetaminophen results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Acetaminophen results in increased phosphorylation of MAPK8 protein] | PMID:17185352 PMID:33959992 | Mapk8 | multiple interactions | ISO | Mapk8 (Mus musculus) | 6480464 | CTD | [Acetaminophen co-treated with Carbon Tetrachloride] results in increased phosphorylation of MAPK8 protein; [RIPK1 protein affects the susceptibility to Acetaminophen] which affects the phosphorylation of and affects the localization of MAPK8 protein; [TNFAIP3 protein affects the susceptibility to Acetaminophen] which affects the phosphorylation of and affects the localization of MAPK8 protein; Acetaminophen results in increased activity of and affects the localization of MAPK8 protein; Acetaminophen results in increased activity of and results in increased phosphorylation of MAPK8 protein; Acetaminophen results in increased phosphorylation of and affects the activity of MAPK8 protein; Acetaminophen results in increased phosphorylation of and affects the localization of MAPK8 protein; Acetaminophen results in increased phosphorylation of and results in increased activity of MAPK8 protein; Fomepizole inhibits the reaction [Acetaminophen results in increased phosphorylation of and affects the localization of MAPK8 protein]; Glutathione inhibits the reaction [Acetaminophen results in increased phosphorylation of MAPK8 protein]; IL4 gene mutant form promotes the reaction [Acetaminophen results in increased phosphorylation of MAPK8 protein]; leupeptin promotes the reaction [Acetaminophen results in increased phosphorylation of MAPK8 protein]; manumycin inhibits the reaction [Acetaminophen results in increased phosphorylation of and results in increased activity of MAPK8 protein]; MAP3K5 protein promotes the reaction [Acetaminophen results in increased phosphorylation of and results in increased activity of MAPK8 protein]; MitoTEMPO inhibits the reaction [Acetaminophen results in increased phosphorylation of MAPK8 protein]; OGT gene mutant form inhibits the reaction [Acetaminophen results in increased phosphorylation of and results in increased activity of MAPK8 protein]; pirfenidone inhibits the reaction [Acetaminophen results in increased phosphorylation of MAPK8 protein]; PRKN gene mutant form affects the reaction [Acetaminophen results in increased phosphorylation of and affects the localization of MAPK8 protein]; PRKN mutant form affects the reaction [Acetaminophen results in increased phosphorylation of MAPK8 protein]; PTGES2 protein affects the reaction [Acetaminophen results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone affects the reaction [TALDO1 gene mutant form promotes the reaction [Acetaminophen results in increased activity of and results in increased phosphorylation of MAPK8 protein]]; pyrazolanthrone inhibits the reaction [Acetaminophen results in increased activity of and results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Acetaminophen results in increased phosphorylation of and affects the activity of MAPK8 protein]; Resveratrol inhibits the reaction [Acetaminophen results in increased phosphorylation of MAPK8 protein]; SHP gene mutant form inhibits the reaction [Acetaminophen results in increased phosphorylation of and affects the localization of MAPK8 protein]; TALDO1 gene mutant form promotes the reaction [Acetaminophen results in increased activity of and results in increased phosphorylation of MAPK8 protein]; TEMPO inhibits the reaction [Acetaminophen results in increased phosphorylation of MAPK8 protein]; thiamet G promotes the reaction [Acetaminophen results in increased phosphorylation of and results in increased activity of MAPK8 protein]; zinc chloride inhibits the reaction [Acetaminophen results in increased phosphorylation of MAPK8 protein] | PMID:17185352 PMID:18700144 PMID:19436114 PMID:19739265 PMID:20423716 PMID:22107450 PMID:22980195 PMID:25752611 PMID:25956474 PMID:27002509 PMID:29325178 PMID:29739258 PMID:29873576 PMID:30903181 PMID:31444509 PMID:33290831 PMID:33458793 PMID:33460648 PMID:34546377 PMID:34890640 PMID:37792503 | | ||||||||||||||||||||||
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