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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621506
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk8
Name: mitogen-activated protein kinase 8
Acc ID: CHEBI:47807
Term: sulforaphane
Definition: An isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen.
Chemical ID: MESH:C016766
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk8increases activityISOMAPK8 (Homo sapiens)6480464CTDsulforaphane results in increased activity of MAPK8 proteinPMID:16201852
Mapk8multiple interactionsISOMAPK8 (Homo sapiens)6480464CTDsulforaphane inhibits the reaction [Pyruvaldehyde results in increased phosphorylation of MAPK8 protein]; sulforaphane metabolite promotes the reaction [[Tobacco Smoke Pollution co-treated with Particulate Matter] results in increased phosphorylation of MAPK8 protein]; sulforaphane promotes the reaction [[Tobacco Smoke Pollution co-treated with Particulate Matter] results in increased phosphorylation of MAPK8 protein]PMID:25933243 PMID:32387680
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