Stmn2 (stathmin 2) - Rat Genome Database

Name: Stmn2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Stmn2 (stathmin 2) Rattus norvegicus

Analyze

Symbol:

Stmn2

Name:

stathmin 2

RGD ID:

68947

Description:

Predicted to have calcium-dependent protein binding activity and tubulin binding activity. Predicted to be involved in several processes, including cellular response to nerve growth factor stimulus; regulation of microtubule polymerization or depolymerization; and regulation of neuron projection development. Localizes to Golgi apparatus; growth cone; and vesicle. Orthologous to human STMN2 (stathmin 2); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

MGC105372; SCG10; Scgn10; stathmin-2; stathmin-like 2; superior cervical ganglion-10 protein; superiorcervical ganglia neural specific 10; superiorcervical ganglia, neural specific 10

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	STMN2 (stathmin 2)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Stmn2 (stathmin-like 2)	HGNC	NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Stmn2 (stathmin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	STMN2 (stathmin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	STMN2 (stathmin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Stmn2 (stathmin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	STMN2 (stathmin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	STMN2 (stathmin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Stmn2 (stathmin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	STMN3 (stathmin 3)	HGNC	OrthoDB
Alliance orthologs ³
Homo sapiens (human):	STMN2 (stathmin 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Mus musculus (house mouse):	Stmn2 (stathmin-like 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Danio rerio (zebrafish):	stmn2b (stathmin 2b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Danio rerio (zebrafish):	stmn2a (stathmin 2a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Drosophila melanogaster (fruit fly):	stai	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER)

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	2	93,204,690 - 93,252,011 (-)	NCBI
Rnor_6.0 Ensembl	2	95,424,251 - 95,472,115 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	2	95,424,251 - 95,471,900 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	2	115,167,504 - 115,215,213 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	95,284,903 - 95,332,686 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	2	95,229,866 - 95,277,648 (-)	NCBI
Celera	2	88,774,309 - 88,821,687 (-)	NCBI		Celera
Cytogenetic Map	2	q23	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (ISO)

17beta-estradiol 3-benzoate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

3,4-methylenedioxymethamphetamine (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

5-aza-2'-deoxycytidine (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

ammonium chloride (EXP)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

belinostat (ISO)

benzo[a]pyrene (EXP,ISO)

benzo[b]fluoranthene (ISO)

bis(2-ethylhexyl) phthalate (EXP,ISO)

bisphenol A (EXP)

Brodifacoum (EXP)

Butylparaben (EXP)

C60 fullerene (EXP)

cadmium dichloride (EXP)

carbon nanotube (ISO)

ciguatoxin CTX1B (ISO)

cisplatin (ISO)

cobalt dichloride (EXP)

copper atom (EXP)

copper(0) (EXP)

crocidolite asbestos (ISO)

DDE (EXP)

dexamethasone (ISO)

dibutyl phthalate (EXP)

doramapimod (EXP)

dorsomorphin (ISO)

enzacamene (EXP)

epoxiconazole (EXP)

ethanol (ISO)

etoposide (ISO)

furan (EXP)

indometacin (ISO)

linuron (EXP)

methylazoxymethanol (ISO)

methylmercury chloride (ISO)

mifepristone (ISO)

N-methyl-N-nitrosourea (ISO)

nickel atom (ISO)

panobinostat (ISO)

pirinixic acid (ISO)

prochloraz (EXP)

procymidone (EXP)

progesterone (ISO)

sarin (ISO)

SB 431542 (ISO)

thalidomide (ISO)

titanium dioxide (ISO)

trichostatin A (ISO)

triclosan (ISO)

uranium atom (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to nerve growth factor stimulus (ISO,ISS)

microtubule depolymerization (IBA)

negative regulation of microtubule depolymerization (ISO)

negative regulation of microtubule polymerization (ISO,ISS)

negative regulation of neuron projection development (ISO)

neuron projection development (IBA)

positive regulation of microtubule depolymerization (ISO)

positive regulation of neuron projection development (ISO,ISS)

regulation of microtubule polymerization or depolymerization (IBA)

Cellular Component

cytoplasm (IBA,ISO,ISS)

endosome (IEA)

Golgi apparatus (IDA)

growth cone (IBA,IDA,ISO)

lamellipodium (ISO,ISS)

membrane (IEA)

neuron projection (IBA,ISO,ISS)

neuronal cell body (ISO,ISS)

perinuclear region of cytoplasm (ISO)

vesicle (IDA)

Molecular Function

calcium-dependent protein binding (ISO)

protein binding (IPI,ISO)

tubulin binding (IBA)

References

References - curated


1.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Gavet O, etal., J Cell Sci 1998 Nov;111 ( Pt 22):3333-46.
3.	GOA data from the GO Consortium
4.	Greka A, etal., Nat Neurosci 2003 Aug;6(8):837-45.
5.	MGD data from the GO Consortium
6.	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	Nixon AB, etal., J Biol Chem 2002 May 17;277(20):18127-33. Epub 2002 Mar 6.
8.	Ozon S, etal., J Neurosci Res 1999 Jun 1;56(5):553-64.
9.	Peng H, etal., J Neurosci 2003 Jul 23;23(16):6617-26.
10.	RGD automated data pipeline
11.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12.	RGD automated import pipeline for gene-chemical interactions
13.	Tararuk T, etal., J Cell Biol. 2006 Apr 24;173(2):265-77. Epub 2006 Apr 17.
14.	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data

Additional References at PubMed

PMID:3272176	PMID:12477932	PMID:14741408	PMID:15200951	PMID:15489334	PMID:15581637	PMID:16838365	PMID:18422486	PMID:18452648	PMID:18996843	PMID:19959466	PMID:20106964
PMID:20621975	PMID:20802173	PMID:21215777	PMID:21471001

Genomics

Comparative Map Data

Stmn2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	2	93,204,690 - 93,252,011 (-)	NCBI
Rnor_6.0 Ensembl	2	95,424,251 - 95,472,115 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	2	95,424,251 - 95,471,900 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	2	115,167,504 - 115,215,213 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	95,284,903 - 95,332,686 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	2	95,229,866 - 95,277,648 (-)	NCBI
Celera	2	88,774,309 - 88,821,687 (-)	NCBI		Celera
Cytogenetic Map	2	q23	NCBI

STMN2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	8	79,611,117 - 79,666,158 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38.p13 Ensembl	8	79,610,814 - 79,666,175 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	8	79,611,117 - 79,666,162 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	8	80,523,352 - 80,578,393 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	80,685,935 - 80,739,792 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	8	80,685,934 - 80,739,779	NCBI
Celera	8	76,527,590 - 76,581,458 (+)	NCBI
Cytogenetic Map	8	q21.13	NCBI
HuRef	8	76,012,743 - 76,068,118 (+)	NCBI		HuRef
CHM1_1	8	80,575,276 - 80,630,679 (+)	NCBI		CHM1_1

Stmn2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	8,574,587 - 8,626,664 (+)	NCBI	GRCm39		mm39
GRCm39 Ensembl	3	8,574,420 - 8,626,666 (+)	Ensembl
GRCm38	3	8,509,527 - 8,561,604 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	8,509,360 - 8,561,606 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	8,509,527 - 8,561,604 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	3	8,492,600 - 8,544,677 (+)	NCBI			mm8
Celera	3	8,514,599 - 8,566,747 (+)	NCBI		Celera
Cytogenetic Map	3	A1	NCBI
cM Map	3	2.15	NCBI

Stmn2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955444	1,585,042 - 1,646,812 (-)	NCBI	ChiLan1.0	ChiLan1.0

STMN2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	8	77,768,471 - 77,823,909 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	77,765,243 - 77,827,611 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	8	76,137,827 - 76,193,112 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

STMN2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	29	27,055,891 - 27,105,695 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	29	27,055,900 - 27,104,501 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	29	27,329,341 - 27,379,157 (+)	NCBI
ROS_Cfam_1.0	29	27,179,142 - 27,228,977 (+)	NCBI
UMICH_Zoey_3.1	29	27,224,785 - 27,274,552 (+)	NCBI
UNSW_CanFamBas_1.0	29	27,263,476 - 27,313,267 (+)	NCBI
UU_Cfam_GSD_1.0	29	27,620,016 - 27,669,831 (+)	NCBI

Stmn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	51,992,013 - 52,044,650 (-)	NCBI
SpeTri2.0	NW_004936871	519,611 - 572,429 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

STMN2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	56,952,973 - 57,006,463 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	56,952,968 - 57,006,744 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	62,173,165 - 62,226,945 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

STMN2
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	75,071,514 - 75,127,605 (+)	NCBI
ChlSab1.1 Ensembl	8	75,071,638 - 75,128,187 (+)	Ensembl

Stmn2
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624744	11,573,707 - 11,630,570 (-)	NCBI

Position Markers

D8S1385E

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	93,204,790 - 93,204,900 (+)	MAPPER
Rnor_6.0	2	95,424,352 - 95,424,461	NCBI	Rnor6.0
Rnor_5.0	2	115,167,605 - 115,167,714	UniSTS	Rnor5.0
RGSC_v3.4	2	95,285,004 - 95,285,113	UniSTS	RGSC3.4
Celera	2	88,774,410 - 88,774,519	UniSTS
Cytogenetic Map	2	q23	UniSTS

AI454126

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	93,204,851 - 93,205,039 (+)	MAPPER
Rnor_6.0	2	95,424,413 - 95,424,600	NCBI	Rnor6.0
Rnor_5.0	2	115,167,666 - 115,167,853	UniSTS	Rnor5.0
RGSC_v3.4	2	95,285,065 - 95,285,252	UniSTS	RGSC3.4
Celera	2	88,774,471 - 88,774,658	UniSTS
RH 3.4 Map	2	589.3	UniSTS
Cytogenetic Map	2	q23	UniSTS

D8S1388E

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	93,204,719 - 93,204,809 (+)	MAPPER
Rnor_6.0	2	95,424,281 - 95,424,370	NCBI	Rnor6.0
Rnor_5.0	2	115,167,534 - 115,167,623	UniSTS	Rnor5.0
RGSC_v3.4	2	95,284,933 - 95,285,022	UniSTS	RGSC3.4
Celera	2	88,774,339 - 88,774,428	UniSTS
Cytogenetic Map	2	q23	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61355	Bp36	Blood pressure QTL 36	2.9		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	2	3127638	105149020	Rat
10755499	Bp389	Blood pressure QTL 389	2.61		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	16679272	245624402	Rat
1302794	Stl27	Serum triglyceride level QTL 27	4.4	0.0001	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	2	23837491	149614623	Rat
1358894	Kidm24	Kidney mass QTL 24	4.03		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	23837491	169852800	Rat
1358899	Kidm23	Kidney mass QTL 23	3.88		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	23837491	169852800	Rat
1358901	Cm38	Cardiac mass QTL 38	2		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	23837491	169852800	Rat
1358904	Cm39	Cardiac mass QTL 39	2.26		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	23837491	169852800	Rat
1358910	Kidm27	Kidney mass QTL 27	5.77		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	23837491	169852800	Rat
1358911	Kidm28	Kidney mass QTL 28	5.42		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	23837491	169852800	Rat
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	23837491	218957222	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	23837491	218957222	Rat
1358887	Bw50	Body weight QTL 50	2.39		body mass (VT:0001259)	body weight (CMO:0000012)	2	23837719	169852670	Rat
1358908	Bw49	Body weight QTL 49	3.36		body mass (VT:0001259)	body weight (CMO:0000012)	2	23837719	169852670	Rat
1354603	Bp243	Blood pressure QTL 243	3.9		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	26186097	135654963	Rat
2290453	Scl55	Serum cholesterol level QTL 55	2.83		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	26186097	142053534	Rat
12879841	Cm87	Cardiac mass QTL 87		0.026	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	2	27161361	148295267	Rat
12879842	Cm88	Cardiac mass QTL 88		0.042	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	27161361	148295267	Rat
12879843	Am3	Aortic mass QTL 3		0.016	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	2	27161361	148295267	Rat
12879844	Kidm62	Kidney mass QTL 62		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27161361	148295267	Rat
2306903	Bp336	Blood pressure QTL 336		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	36245223	112175725	Rat
70174	BpQTLCluster2	Blood pressure QTL cluster 2	4.24		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	40171834	105089682	Rat
70174	BpQTLCluster2	Blood pressure QTL cluster 2	4.24		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	40171834	105089682	Rat
70174	BpQTLCluster2	Blood pressure QTL cluster 2	4.24		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	40171834	105089682	Rat
70174	BpQTLCluster2	Blood pressure QTL cluster 2	4.24		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	2	40171834	105089682	Rat
70174	BpQTLCluster2	Blood pressure QTL cluster 2	4.24		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	2	40171834	105089682	Rat
2293835	Kiddil5	Kidney dilation QTL 5	3.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	42776916	169852800	Rat
2293843	Kiddil6	Kidney dilation QTL 6	3.1		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	42776916	195645082	Rat
1298085	Bp165	Blood pressure QTL 165		0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	42776916	217498710	Rat
1298074	Bp164	Blood pressure QTL 164		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	42776916	217498710	Rat
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	43133606	217498545	Rat
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	43133606	217498545	Rat
2293676	Bmd19	Bone mineral density QTL 19	10.7	0.0001	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	2	43141290	114164944	Rat
2293682	Bmd24	Bone mineral density QTL 24	8.9	0.0001	femur mineral mass (VT:0010011)	cortical volumetric bone mineral density (CMO:0001730)	2	43141290	114164944	Rat
2293671	Bss44	Bone structure and strength QTL 44	10.97	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	2	43141290	154583160	Rat
1354601	Slep1	Serum leptin concentration QTL 1	5.39		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	2	43149788	198704485	Rat
631266	Bp132	Blood pressure QTL 132		0.0005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	46537589	217498710	Rat
1331760	Bp206	Blood pressure QTL 206	3.62454		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	56244671	217498710	Rat
1558648	Smcn1	Smooth muscle cell number QTL 1		0.039	blood vessel smooth muscle cell quantity (VT:0010525)	aorta smooth muscle cell count per unit vessel length (CMO:0001646)	2	60131410	135646395	Rat
5684990	Bmd82	Bone mineral density QTL 82	2.8		tibia mineral mass (VT:1000283)	bone mineral content (CMO:0001554)	2	60325352	106432915	Rat
5684996	Bmd85	Bone mineral density QTL 85	4.7	0.024	tibia mineral mass (VT:1000283)	bone mineral density (CMO:0001226)	2	60325352	106432915	Rat
61438	Cia7	Collagen induced arthritis QTL 7	4.6	0.0001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	2	60325352	147522851	Rat
631500	Bp99	Blood pressure QTL 99	2.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	60325686	105059293	Rat
1578777	Stresp15	Stress response QTL 15	2	0.05	blood aldosterone amount (VT:0005346)	plasma aldosterone level (CMO:0000551)	2	61924251	106924251	Rat
1298080	Bp163	Blood pressure QTL 163		0.02	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66828049	217498710	Rat
1354648	Bp239	Blood pressure QTL 239		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66828236	243550655	Rat
1358900	Bw48	Body weight QTL 48	4.88		body mass (VT:0001259)	body weight (CMO:0000012)	2	68865414	169852800	Rat
1581578	Cm49	Cardiac mass QTL 49	4.9	0.01	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	68866454	149614466	Rat
7411551	Bw131	Body weight QTL 131	29.6	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	2	70132175	115132175	Rat
2317041	Aia14	Adjuvant induced arthritis QTL 14	3.29		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	2	71495404	116495404	Rat
1359034	Bp274	Blood pressure QTL 274			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	75687495	96556760	Rat
1359034	Bp274	Blood pressure QTL 274			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	75687495	96556760	Rat
1354605	Rf48	Renal function QTL 48	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	2	75687495	221880419	Rat
61465	Bp13	Blood pressure QTL 13	3.3		blood pressure trait (VT:0000183)	diastolic blood pressure (CMO:0000005)	2	78321410	105089682	Rat
61465	Bp13	Blood pressure QTL 13	3.3		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	2	78321410	105089682	Rat
631198	Cm22	Cardiac mass QTL 22	4.3	0.0008	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	78321410	158159410	Rat
61374	Edpm2	Estrogen-dependent pituitary mass QTL 2	4.42	0.86	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	2	78321410	217498710	Rat
2299162	Iddm32	Insulin dependent diabetes mellitus QTL 32	2.36		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	2	80631950	149614623	Rat
61392	Bp6	Blood pressure QTL 6	7		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	2	82574487	127574487	Rat
1598865	Bp296	Blood pressure QTL 296	2.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	83656855	128656855	Rat
8662832	Vetf7	Vascular elastic tissue fragility QTL 7	3.5		aorta elastin amount (VT:0003905)	aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)	2	83754907	237610852	Rat
1354622	Kidm16	Kidney mass QTL 16	3		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	2	83819608	239166203	Rat
1354649	Kidm17	Kidney mass QTL 17	2.9		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	2	83819608	243901375	Rat
1578772	Stresp14	Stress response QTL 14	5	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	2	84424139	132130578	Rat
2300165	Bmd49	Bone mineral density QTL 49	4.8	0.0001	lumbar vertebra mineral mass (VT:0010511)	bone mineral density (CMO:0001226)	2	91664872	136664872	Rat
2300170	Bmd45	Bone mineral density QTL 45	12.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	2	91664872	136664872	Rat
2300185	Bmd46	Bone mineral density QTL 46	8.4	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	2	91664872	136664872	Rat
7207808	Bmd89	Bone mineral density QTL 89	4.1		femur strength trait (VT:0010010)	femoral neck ultimate force (CMO:0001703)	2	91664872	136664872	Rat
1558653	Prcr1	Prostate cancer resistance QTL 1	5		prostate integrity trait (VT:0010571)	area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)	2	93995316	169852800	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	333
Count of miRNA genes:	205
Interacting mature miRNAs:	243
Transcripts:	ENSRNOT00000015720
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High									37
Medium	1	12	14	14	2	14			37		12
Low	2	16	20	7	14	7	7	10		17	22	11	7
Below cutoff		14	18	15	3	15	1	1		18	6		1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053440	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF306458	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC087660	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473961	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000067	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000015720 ⟹ ENSRNOP00000015720

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	2	95,424,251 - 95,472,115 (-)	Ensembl

RefSeq Acc Id:

NM_053440 ⟹ NP_445892

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	93,204,690 - 93,252,011 (-)	NCBI
Rnor_6.0	2	95,424,251 - 95,471,900 (-)	NCBI
Rnor_5.0	2	115,167,504 - 115,215,213 (-)	NCBI
RGSC_v3.4	2	95,284,903 - 95,332,686 (-)	RGD
Celera	2	88,774,309 - 88,821,687 (-)	RGD

Sequence:

show sequence

CCGCTCCGAGCGTGCACATCCCTACAATGGCTAAAACAGCAATGGCCTACAAGGAAAAAATGAA
GGAGCTGTCTATGCTGTCACTGATCTGCTCCTGCTTCTACCCGGAGCCTCGCAACATCAACATC
TACACCTACGATGACATGGAGGTGAAGCAGATCAACAAGCGTGCTTCCGGCCAGGCTTTCGAGC
TGATCTTAAAGCCCCCGTCTCCCATCTCGGAAGCTCCACGAACTCTAGCTTCTCCAAAGAAGAA
AGACCTGTCTCTGGAGGAGATCCAGAAAAAGCTGGAGGCTGCAGAGGGGCGAAGGAAGTCTCAG
GAGGCCCAGGTGCTGAAGCAGTTGGCAGAGAAGAGGGAGCACGAGCGAGAAGTCCTCCAGAAGG
CTTTGGAGGAGAATAACAACTTCAGCAAGATGGCGGAGGAGAAGCTGATCCTGAAAATGGAACA
AATTAAGGAAAACCGTGAGGCTAATCTAGCTGCTATCATTGAACGTCTGCAGGAAAAGGAGAGG
CATGCTGCCGAGGTGCGCAGGAACAAGGAACTGCAGGTTGAACTGTCTGGCTGAAGCAATGGCG
GGTATGGCACGCCCCTCCCATAGTAAATCCCCCTGCCTATATTATAATGGATCATGCGATATCA
GTATGGGAAAATGTATGACATGGTTTAAAAAGAACTCATTATGAAAAAAAAACAGAATCAAAAA
TAAAATAAATCAATGCGGTCTCTTTGCAGAATGTTTTGCTTGATGTTTAAAAAAGTACCTTGGA
TCTTATTTTGTAAATATTTACATTTTTGTTAAAAAATACAAGTATTGCATTATGCAAGTTATTT
CATAATCTTACATGTCCTGTAACAGGCATTCGATGTTGTGTCTTCCCACTCAAATGAATTTGCT
AGCTCTATTCTTTTGGAAGCTCCCCCATGTTGAACTCAGTCCCTGCCCTTTTCATTCCACCCAA
AAATGAGGTCAGTAGACAGTCTATGGTGCTAGAAACCCACCATTGCCTAGTGACCTAGATGACT
CCATACTCTCCGAGCTTGGCCAAGACCACACCTAGATCGTGGGGACCGTGTGCCCATGTGAACC
TCCACATTTCTCTGCTCATAATCTGCTTCCTGCCTAGAAACCACAAAGCCAGGCTAAGGAAATC
CACCAGTCCTAGCACTGACCTCTGCTTCTCGTGGAGTGTGTGCTTCACTCGTGTTTGGGTTTTA
GAAAGAGATGAATGGGAAGACAGAGCTGTGCTCAATGAGGGTAGAAGGGCGAGGCTGAACCTTC
TAATGGGCCGAACACAAACACAAAGCTAGAGGGTTCGAGCGGCCATGACGTTGTTCTTCATGAA
GTGGGCTTTCTTCTCTTGTTTCGGTTATTTTGATGGAATGACTTAATCAACATGTCGATGGCTT
ATCTGTGGGTGCCATGGGTGACGATGTTCGTTTTAAGCTTTTGCCTGTAGTACAAGCACATGAT
GCTACTAAATATTTTTCCACTTGGAGACTGTGAGCTGGTTGTTGCATTAAACACACAAACGAAA
TCACAAACACTGTGGACTTTTACTCAAGCTGGTCTTTCATTCCCAGTGTAGGGCAATCCTGCCT
ATAAACAAGACCAAATCACTCCATCTGTGACGCTGCCGCAGTTAAGGGGGCTAGGCAGGGCATT
TGTGCCACTGTAAGAATCAGCAGAGACCCAGCATACGTACCTTTTGCAGTTTTGAAGTTGTCTT
TCCCCAACTCCCAACTCCTGAAGGTTGCTGCCTGCATACTTACTTCTCGTCAGTGCTATCTTCT
TGTATGTCATTGTGAGCAAACTGTGATGAATAAAGAATTGGAGTTCTGTGAACTAAAAAAAAAA
AAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_445892	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAG33230	(Get FASTA)	NCBI Sequence Viewer
	AAH87660	(Get FASTA)	NCBI Sequence Viewer
	EDM01022	(Get FASTA)	NCBI Sequence Viewer
	EDM01023	(Get FASTA)	NCBI Sequence Viewer
	P21818	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_445892 ⟸ NM_053440
- UniProtKB:	P21818 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MAKTAMAYKEKMKELSMLSLICSCFYPEPRNINIYTYDDMEVKQINKRASGQAFELILKPPSPI SEAPRTLASPKKKDLSLEEIQKKLEAAEGRRKSQEAQVLKQLAEKREHEREVLQKALEENNNFS KMAEEKLILKMEQIKENREANLAAIIERLQEKERHAAEVRRNKELQVELSG hide sequence

RefSeq Acc Id:

ENSRNOP00000015720 ⟸ ENSRNOT00000015720

Protein Domains

SLD

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691243

Promoter ID:

EPDNEW_R1767

Type:

multiple initiation site

Name:

Stmn2_1

Description:

stathmin 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	95,471,943 - 95,472,003	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:68947	AgrOrtholog
Ensembl Genes	ENSRNOG00000011705	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSRNOP00000015720	ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000015720	ENTREZGENE, UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7313867	IMAGE-MGC_LOAD
InterPro	Stathmin-2	UniProtKB/Swiss-Prot
	Stathmin_CS	UniProtKB/Swiss-Prot
	Stathmin_fam	UniProtKB/Swiss-Prot
	Stathmin_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:84510	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:105372	IMAGE-MGC_LOAD
NCBI Gene	84510	ENTREZGENE
PANTHER	PTHR10104	UniProtKB/Swiss-Prot
	PTHR10104:SF18	UniProtKB/Swiss-Prot
Pfam	Stathmin	UniProtKB/Swiss-Prot
PhenoGen	Stmn2	PhenoGen
PIRSF	Stathmin	UniProtKB/Swiss-Prot
PRINTS	STATHMIN	UniProtKB/Swiss-Prot
PROSITE	STATHMIN_1	UniProtKB/Swiss-Prot
	STATHMIN_2	UniProtKB/Swiss-Prot
	STATHMIN_3	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF101494	UniProtKB/Swiss-Prot
TIGR	TC228640
UniProt	P21818	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	Q9ERH2	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2014-04-11	Stmn2	stathmin 2	Stmn2	stathmin-like 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2003-04-09	Stmn2	stathmin-like 2	Scgn10	superiorcervical ganglia, neural specific 10	Symbol and Name updated	629477	APPROVED
2002-06-10	Scgn10	superiorcervical ganglia, neural specific 10			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_cellular_localization	anchored to intracellular membranes, including the Golgi apparatus, by NH2-terminal domain through palmitoylation of two cysteines	61521
gene_cellular_localization	anchored to intracellular membranes, including the Golgi apparatus, by NH2-terminal domain through palmitoylation of two cysteines	61528
gene_cellular_localization	localizes to the Golgi apparatus	1299171
gene_expression	present in glutamatergic neurons, such as pyramidal cells of the hippocampus and granular cells of the cerebellum	61521
gene_expression	present in glutamatergic neurons, such as pyramidal cells of the hippocampus and granular cells of the cerebellum	61528
gene_physical_interaction	interacts in vitro with tubulin in a phosphorylation-dependent manner	61528
gene_physical_interaction	interacts with RGSZ1	1299171
gene_process	involved in the neuronal-like differentiation of PC12 cells	61521
gene_process	involved in the neuronal-like differentiation of PC12 cells	61528
gene_process	sequesters free tubulin and promotes microtubule depolymerization	61528
gene_regulation	expression controlled by a neuronal restricted silencer element (NRSE)	61521
gene_regulation	expression controlled by a neuronal restricted silencer element (NRSE)	61528
gene_regulation	interaction with RGSZ1 effectively blocked the ability to induce microtubule disassembly	1299171
gene_regulation	transcription in vivo is regulated by long-lasting synaptic activity	1299172

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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