Stmn2 (stathmin 2) - Rat Genome Database

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Pathways
Gene: Stmn2 (stathmin 2) Rattus norvegicus
Analyze
Symbol: Stmn2
Name: stathmin 2
RGD ID: 68947
Description: Predicted to enable calcium-dependent protein binding activity and tubulin binding activity. Predicted to be involved in several processes, including cellular response to nerve growth factor stimulus; regulation of microtubule polymerization or depolymerization; and regulation of neuron projection development. Located in growth cone and vesicle. Orthologous to human STMN2 (stathmin 2); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC105372; SCG10; Scgn10; stathmin-2; stathmin-like 2; superior cervical ganglion-10 protein; superiorcervical ganglia neural specific 10; superiorcervical ganglia, neural specific 10
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8295,112,017 - 95,159,642 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl295,112,019 - 95,159,335 (-)EnsemblGRCr8
mRatBN7.2293,204,690 - 93,252,011 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl293,204,692 - 93,252,011 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx299,728,967 - 99,776,344 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0297,849,998 - 97,897,381 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0292,906,867 - 92,954,252 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0295,424,251 - 95,471,900 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl295,424,251 - 95,472,115 (-)Ensemblrn6Rnor6.0
Rnor_5.02115,167,504 - 115,215,213 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4295,284,903 - 95,332,686 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera288,774,309 - 88,821,687 (-)NCBICelera
RGSC_v3.1295,229,866 - 95,277,648 (-)NCBI
Cytogenetic Map2q23NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,4-dihydroxybenzoic acid  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Brodifacoum  (EXP)
Butylparaben  (EXP)
C60 fullerene  (EXP)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
CHIR 99021  (ISO)
chlorpyrifos  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
cortisol  (ISO)
crocidolite asbestos  (ISO)
DDE  (EXP)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
dimethylarsinic acid  (EXP)
doramapimod  (EXP)
dorsomorphin  (ISO)
enzacamene  (EXP)
epoxiconazole  (EXP)
ethanol  (ISO)
etoposide  (ISO)
ferric oxide  (EXP)
furan  (EXP)
indometacin  (ISO)
ivermectin  (ISO)
ketoconazole  (EXP)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
linuron  (EXP)
methylazoxymethanol  (ISO)
methylmercury chloride  (ISO)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-N-nitrosourea  (ISO)
nickel atom  (ISO)
nitrofen  (EXP)
ozone  (ISO)
panobinostat  (ISO)
paraquat  (EXP)
pirinixic acid  (ISO)
prochloraz  (EXP)
procymidone  (EXP)
progesterone  (ISO)
rotenone  (ISO)
sarin  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
thalidomide  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
uranium atom  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
XAV939  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon  (IEA)
cell projection  (IEA)
cytoplasm  (IBA,IEA,ISO,ISS)
endosome  (IEA)
Golgi apparatus  (IEA)
growth cone  (IBA,IDA,IEA,ISO)
lamellipodium  (IEA,ISO,ISS)
membrane  (IEA)
neuron projection  (IBA,IEA,ISO,ISS)
neuronal cell body  (IEA,ISO,ISS)
perinuclear region of cytoplasm  (IEA,ISO)
vesicle  (IDA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. The stathmin phosphoprotein family: intracellular localization and effects on the microtubule network. Gavet O, etal., J Cell Sci 1998 Nov;111 ( Pt 22):3333-46.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. TRPC5 is a regulator of hippocampal neurite length and growth cone morphology. Greka A, etal., Nat Neurosci 2003 Aug;6(8):837-45.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. The interaction of RGSZ1 with SCG10 attenuates the ability of SCG10 to promote microtubule disassembly. Nixon AB, etal., J Biol Chem 2002 May 17;277(20):18127-33. Epub 2002 Mar 6.
8. Differential, regional, and cellular expression of the stathmin family transcripts in the adult rat brain. Ozon S, etal., J Neurosci Res 1999 Jun 1;56(5):553-64.
9. Identification of upregulated SCG10 mRNA expression associated with late-phase long-term potentiation in the rat hippocampal Schaffer-CA1 pathway in vivo. Peng H, etal., J Neurosci 2003 Jul 23;23(16):6617-26.
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. JNK1 phosphorylation of SCG10 determines microtubule dynamics and axodendritic length. Tararuk T, etal., J Cell Biol. 2006 Apr 24;173(2):265-77. Epub 2006 Apr 17.
14. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:3272176   PMID:12477932   PMID:14741408   PMID:15200951   PMID:15489334   PMID:15581637   PMID:16838365   PMID:18422486   PMID:18452648   PMID:18996843   PMID:19959466   PMID:20106964  
PMID:20621975   PMID:20802173   PMID:21215777   PMID:21471001  


Genomics

Comparative Map Data
Stmn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8295,112,017 - 95,159,642 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl295,112,019 - 95,159,335 (-)EnsemblGRCr8
mRatBN7.2293,204,690 - 93,252,011 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl293,204,692 - 93,252,011 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx299,728,967 - 99,776,344 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0297,849,998 - 97,897,381 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0292,906,867 - 92,954,252 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0295,424,251 - 95,471,900 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl295,424,251 - 95,472,115 (-)Ensemblrn6Rnor6.0
Rnor_5.02115,167,504 - 115,215,213 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4295,284,903 - 95,332,686 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera288,774,309 - 88,821,687 (-)NCBICelera
RGSC_v3.1295,229,866 - 95,277,648 (-)NCBI
Cytogenetic Map2q23NCBI
STMN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38879,611,117 - 79,666,158 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl879,611,117 - 79,666,158 (+)Ensemblhg38GRCh38
GRCh37880,523,352 - 80,578,393 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36880,685,935 - 80,739,792 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34880,685,934 - 80,739,779NCBI
Celera876,527,590 - 76,581,458 (+)NCBICelera
Cytogenetic Map8q21.13NCBI
HuRef876,012,743 - 76,068,118 (+)NCBIHuRef
CHM1_1880,575,276 - 80,630,679 (+)NCBICHM1_1
T2T-CHM13v2.0880,042,462 - 80,097,513 (+)NCBIT2T-CHM13v2.0
Stmn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3938,574,587 - 8,626,664 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl38,574,420 - 8,626,666 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3838,509,527 - 8,561,604 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl38,509,360 - 8,561,606 (+)Ensemblmm10GRCm38
MGSCv3738,509,527 - 8,561,604 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3638,492,600 - 8,544,677 (+)NCBIMGSCv36mm8
Celera38,514,599 - 8,566,747 (+)NCBICelera
Cytogenetic Map3A1NCBI
cM Map32.15NCBI
Stmn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554441,584,560 - 1,646,812 (-)Ensembl
ChiLan1.0NW_0049554441,585,042 - 1,646,812 (-)NCBIChiLan1.0ChiLan1.0
STMN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2795,350,636 - 95,406,105 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1870,980,769 - 71,036,051 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0876,137,827 - 76,193,112 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1877,768,471 - 77,823,909 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl877,765,243 - 77,827,611 (+)EnsemblpanPan2panpan1.1
STMN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12927,055,891 - 27,105,695 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2927,055,900 - 27,104,501 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2927,329,341 - 27,379,157 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02927,179,142 - 27,228,977 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2927,179,152 - 27,228,973 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12927,224,785 - 27,274,552 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02927,263,476 - 27,313,267 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02927,620,016 - 27,669,831 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Stmn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530351,992,013 - 52,044,650 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936871519,611 - 572,460 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936871519,611 - 572,429 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STMN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl456,952,978 - 57,006,462 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1456,952,968 - 57,006,744 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2462,173,165 - 62,226,945 (-)NCBISscrofa10.2Sscrofa10.2susScr3
STMN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1875,071,514 - 75,127,605 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl875,071,638 - 75,128,187 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603966,074,674 - 66,130,665 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Stmn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474411,572,745 - 11,630,819 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474411,573,707 - 11,630,570 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Stmn2
363 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:333
Count of miRNA genes:205
Interacting mature miRNAs:243
Transcripts:ENSRNOT00000015720
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578777Stresp15Stress response QTL 1520.05blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)261556902106556902Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)282947902127947902Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)284056790132859658Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)240306867124537199Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
61465Bp13Blood pressure QTL 133.3blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)278269809104744824Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
2317886Alcrsp23Alcohol response QTL 232.40.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)295142371140142371Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)241801363104744824Rat
2317058Aia13Adjuvant induced arthritis QTL 132.9joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)278269809123269809Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)244537979112567334Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
5684990Bmd82Bone mineral density QTL 822.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)261051541105724065Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)27605533104774005Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1359034Bp274Blood pressure QTL 274arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)25126685996266859Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)293602631145807373Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
631500Bp99Blood pressure QTL 992.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)261051883104684275Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)282214549127214549Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
5684996Bmd85Bone mineral density QTL 854.70.024tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)261051541105724065Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)260861391105861391Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
2306903Bp336Blood pressure QTL 3360.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)238426449111295694Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)261051541143746880Rat

Markers in Region
D8S1385E  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2293,204,790 - 93,204,900 (+)MAPPERmRatBN7.2
Rnor_6.0295,424,352 - 95,424,461NCBIRnor6.0
Rnor_5.02115,167,605 - 115,167,714UniSTSRnor5.0
RGSC_v3.4295,285,004 - 95,285,113UniSTSRGSC3.4
Celera288,774,410 - 88,774,519UniSTS
Cytogenetic Map2q23UniSTS
AI454126  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2293,204,851 - 93,205,039 (+)MAPPERmRatBN7.2
Rnor_6.0295,424,413 - 95,424,600NCBIRnor6.0
Rnor_5.02115,167,666 - 115,167,853UniSTSRnor5.0
RGSC_v3.4295,285,065 - 95,285,252UniSTSRGSC3.4
Celera288,774,471 - 88,774,658UniSTS
RH 3.4 Map2589.3UniSTS
Cytogenetic Map2q23UniSTS
D8S1388E  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8295,112,047 - 95,112,136 (+)Marker Load Pipeline
mRatBN7.2293,204,719 - 93,204,809 (+)MAPPERmRatBN7.2
Rnor_6.0295,424,281 - 95,424,370NCBIRnor6.0
Rnor_5.02115,167,534 - 115,167,623UniSTSRnor5.0
RGSC_v3.4295,284,933 - 95,285,022UniSTSRGSC3.4
Celera288,774,339 - 88,774,428UniSTS
Cytogenetic Map2q23UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
11 11 56 159 84 83 52 34 52 6 241 122 10 138 48 73 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000015720   ⟹   ENSRNOP00000015720
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl295,112,019 - 95,159,335 (-)Ensembl
mRatBN7.2 Ensembl293,204,692 - 93,252,011 (-)Ensembl
Rnor_6.0 Ensembl295,424,251 - 95,472,115 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095634   ⟹   ENSRNOP00000083052
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl295,112,019 - 95,131,167 (-)Ensembl
mRatBN7.2 Ensembl293,204,692 - 93,223,840 (-)Ensembl
RefSeq Acc Id: NM_053440   ⟹   NP_445892
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8295,112,017 - 95,159,335 (-)NCBI
mRatBN7.2293,204,690 - 93,252,011 (-)NCBI
Rnor_6.0295,424,251 - 95,471,900 (-)NCBI
Rnor_5.02115,167,504 - 115,215,213 (-)NCBI
RGSC_v3.4295,284,903 - 95,332,686 (-)RGD
Celera288,774,309 - 88,821,687 (-)RGD
Sequence:
RefSeq Acc Id: XM_063282645   ⟹   XP_063138715
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8295,112,017 - 95,159,642 (-)NCBI
Protein Sequences
Protein RefSeqs NP_445892 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138715 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG33230 (Get FASTA)   NCBI Sequence Viewer  
  AAH87660 (Get FASTA)   NCBI Sequence Viewer  
  EDM01022 (Get FASTA)   NCBI Sequence Viewer  
  EDM01023 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000015720
  ENSRNOP00000015720.5
GenBank Protein P21818 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_445892   ⟸   NM_053440
- UniProtKB: Q9ERH2 (UniProtKB/Swiss-Prot),   P21818 (UniProtKB/Swiss-Prot),   A6IH74 (UniProtKB/TrEMBL),   A6IH75 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015720   ⟸   ENSRNOT00000015720
Ensembl Acc Id: ENSRNOP00000083052   ⟸   ENSRNOT00000095634
RefSeq Acc Id: XP_063138715   ⟸   XM_063282645
- Peptide Label: isoform X1
Protein Domains
SLD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P21818-F1-model_v2 AlphaFold P21818 1-179 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691243
Promoter ID:EPDNEW_R1767
Type:multiple initiation site
Name:Stmn2_1
Description:stathmin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0295,471,943 - 95,472,003EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68947 AgrOrtholog
BioCyc Gene G2FUF-53712 BioCyc
Ensembl Genes ENSRNOG00000011705 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015720 ENTREZGENE
  ENSRNOT00000015720.7 UniProtKB/Swiss-Prot
Gene3D-CATH 6.10.280.30 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7313867 IMAGE-MGC_LOAD
InterPro Stathmin_CS UniProtKB/Swiss-Prot
  Stathmin_fam UniProtKB/Swiss-Prot
  Stathmin_sf UniProtKB/Swiss-Prot
KEGG Report rno:84510 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105372 IMAGE-MGC_LOAD
NCBI Gene 84510 ENTREZGENE
PANTHER PTHR10104 UniProtKB/Swiss-Prot
  PTHR10104:SF18 UniProtKB/Swiss-Prot
Pfam Stathmin UniProtKB/Swiss-Prot
PhenoGen Stmn2 PhenoGen
PIRSF Stathmin UniProtKB/Swiss-Prot
PRINTS STATHMIN UniProtKB/Swiss-Prot
PROSITE STATHMIN_1 UniProtKB/Swiss-Prot
  STATHMIN_2 UniProtKB/Swiss-Prot
  STATHMIN_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011705 RatGTEx
Superfamily-SCOP SSF101494 UniProtKB/Swiss-Prot
TIGR TC228640
UniProt A0A8I5ZV30_RAT UniProtKB/TrEMBL
  A6IH74 ENTREZGENE, UniProtKB/TrEMBL
  A6IH75 ENTREZGENE, UniProtKB/TrEMBL
  P21818 ENTREZGENE
  Q9ERH2 ENTREZGENE
  STMN2_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q9ERH2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-04-11 Stmn2  stathmin 2  Stmn2  stathmin-like 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Stmn2  stathmin-like 2   Scgn10  superiorcervical ganglia, neural specific 10  Symbol and Name updated 629477 APPROVED
2002-06-10 Scgn10  superiorcervical ganglia, neural specific 10      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization anchored to intracellular membranes, including the Golgi apparatus, by NH2-terminal domain through palmitoylation of two cysteines 61521
gene_cellular_localization anchored to intracellular membranes, including the Golgi apparatus, by NH2-terminal domain through palmitoylation of two cysteines 61528
gene_cellular_localization localizes to the Golgi apparatus 1299171
gene_expression present in glutamatergic neurons, such as pyramidal cells of the hippocampus and granular cells of the cerebellum 61521
gene_expression present in glutamatergic neurons, such as pyramidal cells of the hippocampus and granular cells of the cerebellum 61528
gene_physical_interaction interacts in vitro with tubulin in a phosphorylation-dependent manner 61528
gene_physical_interaction interacts with RGSZ1 1299171
gene_process involved in the neuronal-like differentiation of PC12 cells 61521
gene_process involved in the neuronal-like differentiation of PC12 cells 61528
gene_process sequesters free tubulin and promotes microtubule depolymerization 61528
gene_regulation expression controlled by a neuronal restricted silencer element (NRSE) 61521
gene_regulation expression controlled by a neuronal restricted silencer element (NRSE) 61528
gene_regulation interaction with RGSZ1 effectively blocked the ability to induce microtubule disassembly 1299171
gene_regulation transcription in vivo is regulated by long-lasting synaptic activity 1299172