MAPK8 (mitogen-activated protein kinase 8) - Rat Genome Database

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Gene: MAPK8 (mitogen-activated protein kinase 8) Sus scrofa
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Symbol: MAPK8
Name: mitogen-activated protein kinase 8
RGD ID: 14121138
Description: ENCODES a protein that exhibits enzyme binding (ortholog); JUN kinase activity (ortholog); kinase activity (ortholog); INVOLVED IN cellular response to amyloid-beta (ortholog); cellular response to hydrogen peroxide (ortholog); cellular response to interleukin-1 (ortholog); PARTICIPATES IN adenosine signaling pathway; c-Jun N-terminal kinases MAPK signaling pathway; ceramide signaling pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); Acute Liver Failure (ortholog); Acute Otitis Media (ortholog); FOUND IN axon (ortholog); basal dendrite (ortholog); cytoplasm (ortholog); INTERACTS WITH (S)-nicotine; anthra[1,9-cd]pyrazol-6(2H)-one; bifenthrin
Type: protein-coding
RefSeq Status: MODEL
Also known as: janus kinase 1; JNK; JNK1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1488,988,949 - 89,172,200 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11488,988,914 - 89,108,875 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21496,724,970 - 96,803,101 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to amino acid starvation  (IEA)
cellular response to amyloid-beta  (ISO)
cellular response to cadmium ion  (IEA)
cellular response to hydrogen peroxide  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to lipopolysaccharide  (IEA,ISO)
cellular response to mechanical stimulus  (IEA)
cellular response to nitric oxide  (ISO)
cellular response to reactive oxygen species  (IEA)
dendrite morphogenesis  (ISO)
glial cell apoptotic process  (ISO)
inflammatory response  (ISO)
intracellular signal transduction  (IBA)
JNK cascade  (IBA)
JUN phosphorylation  (IEA,ISO)
MAPK cascade  (IEA)
negative regulation of apoptotic process  (IEA,ISO)
negative regulation of protein binding  (IEA)
neuron development  (ISO)
neuron migration  (ISO)
neuron projection development  (ISO)
neuronal stem cell population maintenance  (ISO)
ossification  (ISO)
peptidyl-serine phosphorylation  (IEA,ISO)
peptidyl-threonine phosphorylation  (IEA,ISO)
positive regulation of apoptotic process  (IBA,ISO)
positive regulation of apoptotic signaling pathway  (ISO)
positive regulation of cardiac muscle cell apoptotic process  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cyclase activity  (IEA)
positive regulation of deacetylase activity  (IEA)
positive regulation of determination of dorsal identity  (ISO)
positive regulation of DNA replication  (ISO)
positive regulation of gene expression  (IEA)
positive regulation of glial cell apoptotic process  (ISO)
positive regulation of microtubule polymerization  (ISO)
positive regulation of neuroblast proliferation  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of neuron migration  (ISO)
positive regulation of podosome assembly  (ISO)
positive regulation of protein metabolic process  (IEA)
positive regulation of protein ubiquitination  (ISO)
positive regulation of transcription factor catabolic process  (ISO)
programmed necrotic cell death  (ISO)
protein localization to tricellular tight junction  (ISO)
protein phosphorylation  (IEA,ISO)
regulation of centrosome cycle  (ISO)
regulation of circadian rhythm  (ISO)
regulation of dense core granule transport  (ISO)
regulation of DNA replication origin binding  (IEA)
regulation of gene expression  (ISO)
regulation of histone deacetylation  (IEA)
regulation of neuron differentiation  (ISO)
regulation of protein localization  (IEA)
regulation of transcription, DNA-templated  (ISO)
response to cadmium ion  (ISO)
response to heat  (ISO)
response to hydrogen peroxide  (ISO)
response to mechanical stimulus  (IBA)
response to osmotic stress  (ISO)
response to oxidative stress  (ISO)
response to steroid hormone  (ISO)
response to UV  (IEA,ISO)
rhythmic process  (IEA)
signal transduction  (ISO)
stress-activated MAPK cascade  (ISO)
type B pancreatic cell apoptotic process  (ISO)

Cellular Component
axon  (ISO)
basal dendrite  (ISO)
cytoplasm  (IBA,ISO)
cytosol  (ISO)
dendrite cytoplasm  (ISO)
mitochondrion  (ISO)
nucleus  (IBA,IEA,ISO)
perikaryon  (ISO)
podosome  (ISO)
synapse  (ISO)
vesicle  (ISO)

References
Additional References at PubMed
PMID:18292600   PMID:18694803   PMID:19023183   PMID:20300568   PMID:22279582   PMID:22424736   PMID:28347884  


Genomics

Comparative Map Data
MAPK8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1488,988,949 - 89,172,200 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11488,988,914 - 89,108,875 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21496,724,970 - 96,803,101 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAPK8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1048,306,639 - 48,439,360 (+)EnsemblGRCh38hg38GRCh38
GRCh381048,306,673 - 48,439,360 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371049,514,720 - 49,647,403 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361049,279,693 - 49,313,189 (+)NCBINCBI36hg18NCBI36
Build 341049,279,692 - 49,313,189NCBI
Celera1043,195,579 - 43,229,096 (+)NCBI
Cytogenetic Map10q11.22NCBI
HuRef1043,779,561 - 43,912,232 (+)NCBIHuRef
CHM1_11049,796,560 - 49,929,236 (+)NCBICHM1_1
Mapk8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391433,099,855 - 33,169,215 (-)NCBIGRCm39mm39
GRCm39 Ensembl1433,099,855 - 33,169,115 (-)Ensembl
GRCm381433,377,898 - 33,447,353 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1433,377,898 - 33,447,158 (-)EnsemblGRCm38mm10GRCm38
MGSCv371434,191,084 - 34,260,344 (-)NCBIGRCm37mm9NCBIm37
MGSCv361432,211,101 - 32,276,249 (-)NCBImm8
Celera1429,636,611 - 29,705,910 (-)NCBICelera
Cytogenetic Map14BNCBI
Mapk8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2168,638,897 - 8,721,960 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl168,638,924 - 8,721,981 (-)Ensembl
Rnor_6.0169,620,854 - 9,709,342 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl169,625,177 - 9,709,347 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01611,579,503 - 11,662,858 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4168,925,133 - 9,004,897 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1168,925,181 - 9,004,945 (-)NCBI
Celera166,485,592 - 6,568,388 (+)NCBICelera
Cytogenetic Map16p16NCBI
Mapk8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555561,593,494 - 1,665,784 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555561,593,552 - 1,705,543 (-)NCBIChiLan1.0ChiLan1.0
MAPK8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Mhudiblu_PPA_v01045,806,748 - 45,936,362 (-)NCBIMhudiblu_PPA_v0panPan3
MAPK8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.128323,361 - 410,367 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl28368,513 - 406,401 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha28552,432 - 639,965 (+)NCBI
ROS_Cfam_1.028498,642 - 586,320 (+)NCBI
UMICH_Zoey_3.128298,436 - 386,002 (+)NCBI
UNSW_CanFamBas_1.028339,385 - 427,241 (+)NCBI
UU_Cfam_GSD_1.028432,766 - 552,601 (+)NCBI
Mapk8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721380,572,918 - 80,691,087 (-)NCBI
SpeTri2.0NW_0049367281,775,746 - 1,893,895 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAPK8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1943,356,603 - 43,489,066 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl943,356,308 - 43,393,425 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660483,124,408 - 3,258,374 (-)NCBIVero_WHO_p1.0
Mapk8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249281,442,216 - 1,494,275 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 2 3 1 1 19 2
Low 8 4 4 1 4 2 1 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000011362   ⟹   ENSSSCP00000011068
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1488,988,964 - 89,172,200 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000036610   ⟹   ENSSSCP00000030604
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1488,988,952 - 89,105,898 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000042018   ⟹   ENSSSCP00000054620
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1488,988,949 - 89,108,880 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000075747   ⟹   ENSSSCP00000061145
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1488,989,536 - 89,107,234 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000083678   ⟹   ENSSSCP00000063346
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1488,989,536 - 89,107,234 (+)Ensembl
RefSeq Acc Id: XM_001929166   ⟹   XP_001929201
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11488,988,914 - 89,108,875 (+)NCBI
Sequence:
RefSeq Acc Id: XM_003359272   ⟹   XP_003359320
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11488,988,914 - 89,108,875 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013983427   ⟹   XP_013838881
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11488,988,930 - 89,108,875 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013983428   ⟹   XP_013838882
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11488,988,914 - 89,108,875 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021073085   ⟹   XP_020928744
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11488,988,950 - 89,108,875 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021073086   ⟹   XP_020928745
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11488,988,914 - 89,108,875 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021073087   ⟹   XP_020928746
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11488,988,949 - 89,108,875 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_020928745   ⟸   XM_021073086
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_003359320   ⟸   XM_003359272
- Peptide Label: isoform X2
- UniProtKB: K7GRS5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013838882   ⟸   XM_013983428
- Peptide Label: isoform X3
- UniProtKB: A0A287BES1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_001929201   ⟸   XM_001929166
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013838881   ⟸   XM_013983427
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020928746   ⟸   XM_021073087
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_020928744   ⟸   XM_021073085
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSSSCP00000063346   ⟸   ENSSSCT00000083678
RefSeq Acc Id: ENSSSCP00000061145   ⟸   ENSSSCT00000075747
RefSeq Acc Id: ENSSSCP00000011068   ⟸   ENSSSCT00000011362
RefSeq Acc Id: ENSSSCP00000030604   ⟸   ENSSSCT00000036610
RefSeq Acc Id: ENSSSCP00000054620   ⟸   ENSSSCT00000042018
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000010380 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070024044 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000011068 UniProtKB/TrEMBL
  ENSSSCP00000030604 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000054620 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000061145 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000063346 UniProtKB/TrEMBL
  ENSSSCP00070040517 UniProtKB/TrEMBL
  ENSSSCP00070040522 UniProtKB/TrEMBL
  ENSSSCP00070040527 UniProtKB/TrEMBL
  ENSSSCP00070040534 UniProtKB/TrEMBL
  ENSSSCP00070040537 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000011362 UniProtKB/TrEMBL
  ENSSSCT00000036610 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000042018 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000075747 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000083678 UniProtKB/TrEMBL
  ENSSSCT00070048000 UniProtKB/TrEMBL
  ENSSSCT00070048005 UniProtKB/TrEMBL
  ENSSSCT00070048011 UniProtKB/TrEMBL
  ENSSSCT00070048018 UniProtKB/TrEMBL
  ENSSSCT00070048021 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  MAP_kinase_CS UniProtKB/TrEMBL
  MAPK_JNK UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report ssc:396610 UniProtKB/TrEMBL
NCBI Gene MAPK8 ENTREZGENE
Pfam Pkinase UniProtKB/TrEMBL
PRINTS JNKMAPKINASE UniProtKB/TrEMBL
PROSITE MAPK UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A287BES1 ENTREZGENE, UniProtKB/TrEMBL
  A0A480EHQ8_PIG UniProtKB/TrEMBL
  A0A4X1VFH8_PIG UniProtKB/TrEMBL
  A0A4X1VFI4_PIG UniProtKB/TrEMBL
  A0A4X1VFI9_PIG UniProtKB/TrEMBL
  A0A4X1VFJ9_PIG UniProtKB/TrEMBL
  A0A4X1VGK1_PIG UniProtKB/TrEMBL
  A0A5G2Q9X6_PIG UniProtKB/TrEMBL
  A0A5G2QHK3_PIG UniProtKB/TrEMBL
  F1SEL1_PIG UniProtKB/TrEMBL
  K7GRS5 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:90006 ENTREZGENE