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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621506
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk8
Name: mitogen-activated protein kinase 8
Acc ID: CHEBI:52289
Term: wortmannin
Definition: A delta-lactone that has formula C23H24O8.
Chemical ID: MESH:C009687
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk8multiple interactionsEXP 6480464CTDWortmannin inhibits the reaction [dinitrophenyl-human serum albumin conjugate results in increased phosphorylation of MAPK8 protein]PMID:10611455
Mapk8decreases phosphorylationISOMapk8 (Mus musculus)6480464CTDwortmannin results in decreased phosphorylation of MAPK8 proteinPMID:18950629
Mapk8multiple interactionsISOMAPK8 (Homo sapiens)6480464CTDWortmannin inhibits the reaction [tetrachlorodian results in increased expression of MAPK8 mRNA]PMID:36190352
Mapk8multiple interactionsISOMapk8 (Mus musculus)6480464CTDwortmannin inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased phosphorylation of MAPK8 protein]; wortmannin inhibits the reaction [HU 211 results in increased phosphorylation of MAPK8 protein]PMID:18950629
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