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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621506
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk8
Name: mitogen-activated protein kinase 8
Acc ID: CHEBI:81520
Term: 2,3',4,4',5-Pentachlorobiphenyl
Definition: A pentachlorobiphenyl that has formula C12H5Cl5.
Chemical ID: MESH:C070055
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk8increases phosphorylationEXP 6480464CTD2,3',4,4',5-pentachlorobiphenyl results in increased phosphorylation of MAPK8 proteinPMID:36450500
Mapk8multiple interactionsEXP 6480464CTDMAPK8 affects the reaction [2,3',4,4',5-pentachlorobiphenyl results in increased expression of ICAM1 mRNA]; MAPK8 affects the reaction [2,3',4,4',5-pentachlorobiphenyl results in increased expression of IL6 mRNA]PMID:26519956
Mapk8increases expressionISOMapk8 (Mus musculus)6480464CTD2,3',4,4',5-pentachlorobiphenyl results in increased expression of MAPK8 mRNAPMID:31388691
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