MAPK8 (mitogen-activated protein kinase 8) - Rat Genome Database

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Gene: MAPK8 (mitogen-activated protein kinase 8) Homo sapiens
Symbol: MAPK8
Name: mitogen-activated protein kinase 8
RGD ID: 732271
Description: Enables JUN kinase activity; histone deacetylase binding activity; and histone deacetylase regulator activity. Involved in several processes, including cellular response to mechanical stimulus; positive regulation of macromolecule metabolic process; and protein phosphorylation. Acts upstream of or within several processes, including JUN phosphorylation; cellular response to lipopolysaccharide; and response to UV. Located in nucleus. Implicated in abdominal aortic aneurysm; chronic mucocutaneous candidiasis; colorectal adenoma; rectal benign neoplasm; and type 2 diabetes mellitus. Biomarker of Alzheimer's disease; carcinoma (multiple); chronic obstructive pulmonary disease; and colorectal adenoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: c-Jun N-terminal kinase 1; JNK; JNK-46; JNK1; JNK1 alpha protein kinase; JNK1 beta protein kinase; JNK1A2; JNK21B1/2; JUN N-terminal kinase; MAP kinase 8; MAPK 8; mitogen-activated protein kinase 8 isoform JNK1 alpha1; mitogen-activated protein kinase 8 isoform JNK1 beta2; PRKM8; protein kinase JNK1; SAPK1; SAPK1c; stress-activated protein kinase 1; stress-activated protein kinase 1c; stress-activated protein kinase JNK1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1048,306,639 - 48,439,360 (+)EnsemblGRCh38hg38GRCh38
GRCh381048,306,673 - 48,439,360 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371049,514,720 - 49,647,403 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361049,279,693 - 49,313,189 (+)NCBINCBI36hg18NCBI36
Build 341049,279,692 - 49,313,189NCBI
Celera1043,195,579 - 43,229,096 (+)NCBI
Cytogenetic Map10q11.22NCBI
HuRef1043,779,561 - 43,912,232 (+)NCBIHuRef
CHM1_11049,796,560 - 49,929,236 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(+)-taxifolin  (EXP)
(-)-anisomycin  (EXP,ISO)
(-)-citrinin  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
(R)-lipoic acid  (ISO)
(R)-noradrenaline  (ISO)
(R)-Salsolinol  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-colchicine  (EXP)
(S)-naringenin  (EXP)
(S)-nicotine  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dichloropropan-2-ol  (ISO)
1,3-Dinitropyrene  (ISO)
1,4-dithiothreitol  (EXP)
1,4-phenylenediamine  (EXP)
1,8-cineole  (EXP)
1-chloro-2,4,6-trinitrobenzene  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
1-fluoro-2,4-dinitrobenzene  (EXP)
1-hydroxy-2-naphthoic acid  (ISO)
1-nitropyrene  (ISO)
17beta-estradiol  (EXP,ISO)
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (ISO)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-butoxyethanol  (ISO)
2-methyl-6-(phenylethynyl)pyridine  (ISO)
2-trans,6-trans-farnesyl diphosphate  (ISO)
3',5'-cyclic GMP  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (EXP)
3-O-Caffeoyl-1-O-methylquinic acid  (EXP)
3-phenylprop-2-enal  (EXP,ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (ISO)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP)
4-nonylphenol  (ISO)
4-phenylbutyric acid  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (EXP)
acetaldehyde  (EXP,ISO)
acetic acid  (ISO)
acetylleucyl-leucyl-norleucinal  (ISO)
Aciculatin  (ISO)
acrolein  (EXP,ISO)
acrylamide  (ISO)
afimoxifene  (EXP)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-Chaconine  (ISO)
alpha-mangostin  (EXP)
alvocidib  (EXP)
amidotrizoic acid  (EXP)
amiloride  (ISO)
amino acid  (ISO)
ammonium chloride  (ISO)
amodiaquine  (EXP)
amphetamine  (ISO)
anethole  (EXP)
aniline  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
Antimony trioxide  (EXP,ISO)
apigenin  (ISO)
apocynin  (EXP,ISO)
arachidonic acid  (EXP)
aristolochic acid  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenic trichloride  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
asbestos  (ISO)
asiatic acid  (ISO)
atrazine  (EXP,ISO)
atropine  (ISO)
aureusidin  (ISO)
Azaspiracid  (ISO)
bafilomycin A1  (ISO)
baicalein  (EXP)
bathocuproine disulfonic acid  (ISO)
benomyl  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP,ISO)
Benzo[a]pyrene-7,8-diol  (EXP)
benzyl isothiocyanate  (EXP)
beta-D-glucosamine  (EXP)
beta-hexachlorocyclohexane  (ISO)
bicuculline  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bortezomib  (EXP)
bufalin  (EXP)
bupropion  (EXP)
butanal  (EXP)
butylated hydroxyanisole  (EXP,ISO)
butyric acid  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium selenide  (EXP)
cadmium sulfate  (ISO)
Calcimycin  (EXP)
calcipotriol  (ISO)
calcitriol  (EXP)
camptothecin  (EXP)
candesartan  (ISO)
cantharidic acid  (EXP)
capsaicin  (EXP)
capsazepine  (EXP)
carbamazepine  (EXP)
carbon nanotube  (EXP)
carnosic acid  (ISO)
carnosine  (ISO)
celecoxib  (EXP,ISO)
chalcone  (ISO)
chenodeoxycholic acid  (ISO)
chlordecone  (ISO)
chloroprene  (ISO)
chloroquine  (EXP,ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
cholate  (ISO)
choline  (ISO)
chromium atom  (ISO)
chromium(6+)  (EXP,ISO)
chrysophanol  (EXP)
cisplatin  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (EXP,ISO)
Cuprizon  (ISO)
curcumin  (EXP,ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cypermethrin  (EXP,ISO)
D-glucose  (EXP,ISO)
D-mannitol  (EXP)
decabromodiphenyl ether  (EXP)
delphinidin  (EXP)
deoxynivalenol  (EXP,ISO)
desferrioxamine B  (EXP)
desipramine  (EXP)
dexamethasone  (EXP,ISO)
diallyl disulfide  (EXP)
Diallyl sulfide  (EXP)
diarsenic trioxide  (EXP,ISO)
diazepam  (ISO)
diazinon  (ISO)
dibenziodolium  (EXP)
dibutyl phthalate  (ISO)
diclofenac  (EXP)
dicoumarol  (EXP)
dicrotophos  (EXP)
Dictamnine  (EXP)
diethylstilbestrol  (ISO)
diltiazem  (ISO)
dimethylarsinic acid  (ISO)
Dinitramine  (ISO)
dinophysistoxin 1  (EXP)
dioscin  (EXP)
dioxygen  (EXP,ISO)
diphenhydramine  (EXP)
dipyridamole  (EXP)
disodium selenite  (EXP,ISO)
disulfiram  (EXP,ISO)
donepezil hydrochloride  (ISO)
dopamine  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
edaravone  (EXP,ISO)
efavirenz  (EXP)
elemental selenium  (EXP,ISO)
ellagic acid  (EXP)
emetine  (ISO)
enilconazole  (EXP)
entinostat  (EXP)
erastin  (ISO)
eriodictyol  (ISO)
esculetin  (EXP)
Estragole  (ISO)
etacrynic acid  (EXP)
ethanol  (EXP,ISO)
Ethyl pyruvate  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP,ISO)
Evodiamine  (EXP)
farnesyl diphosphate  (ISO)
fenvalerate  (EXP)
ferrosoferric oxide  (EXP)
ferulic acid  (ISO)
flubendazole  (EXP)
flufenoxuron  (ISO)
fluorescein 5-isothiocyanate  (EXP)
fluoxetine  (ISO)
flutamide  (ISO)
folic acid  (ISO)
fomepizole  (ISO)
formononetin  (EXP)
formoterol fumarate  (ISO)
fructose  (ISO)
gallic acid  (EXP)
gamma-aminobutyric acid  (ISO)
gamma-hexachlorocyclohexane  (ISO)
Gastrodin  (ISO)
gefitinib  (EXP)
Geniposide pentaacetate  (ISO)
gentamycin  (ISO)
ginkgolide B  (EXP)
ginsenoside Rg1  (EXP)
gliclazide  (ISO)
gliotoxin  (ISO)
glucose  (EXP,ISO)
glutathione  (EXP,ISO)
glyphosate  (EXP)
Goe 6976  (EXP)
guggulsterone  (EXP)
GW 4064  (EXP,ISO)
haloperidol  (ISO)
hemin  (ISO)
hesperetin  (EXP,ISO)
hesperidin  (EXP)
hexachlorobenzene  (ISO)
hexadecanoic acid  (EXP,ISO)
hexamethylene diisocyanate  (EXP)
histamine  (ISO)
homocysteine  (EXP)
hydrogen peroxide  (EXP,ISO)
hydroquinone O-beta-D-glucopyranoside  (EXP)
hydroxyurea  (ISO)
hypochlorous acid  (EXP)
icatibant  (ISO)
ifosfamide  (ISO)
indoxyl sulfate  (ISO)
iomeprol  (EXP)
isoprenaline  (ISO)
isorhamnetin  (ISO)
Isorhapontigenin  (ISO)
ivermectin  (EXP,ISO)
kaempferol  (EXP)
kanamycin A  (ISO)
ketoconazole  (EXP,ISO)
KN-93  (ISO)
kojic acid  (EXP)
L-1,4-dithiothreitol  (EXP)
L-ascorbic acid  (EXP)
L-cysteine  (ISO)
L-methionine  (EXP,ISO)
lactacystin  (ISO)
lead diacetate  (ISO)
lead(II) chloride  (EXP)
Licochalcone A  (EXP)
Licochalcone B  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lipoteichoic acid  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
Longikaurin A  (EXP)
lovastatin  (ISO)
luteolin  (EXP)
LY294002  (EXP,ISO)
lycopene  (EXP)
Magnolol  (ISO)
malonaldehyde  (ISO)
Malonoben  (EXP)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
mangiferin  (ISO)
manumycin A  (ISO)
marimastat  (ISO)
masoprocol  (EXP)
mebendazole  (EXP)
Mecamylamine  (ISO)
mechlorethamine  (ISO)
melatonin  (EXP)
menadione  (EXP,ISO)
mercaptoethanol  (EXP)
mercury dichloride  (ISO)
Mesna  (ISO)
metam  (ISO)
methamphetamine  (ISO)
methotrexate  (EXP,ISO)
methoxychlor  (ISO)
methylglyoxal  (EXP,ISO)
methylmercury chloride  (ISO)
methylphenidate  (ISO)
methylseleninic acid  (EXP)
miconazole  (ISO)
microcystin-LR  (EXP)
mifepristone  (EXP)
minocycline  (EXP)
mitomycin C  (EXP)
mono(2-ethylhexyl) phthalate  (EXP)
monodansylcadaverine  (ISO)
monosodium L-glutamate  (ISO)
morin  (ISO)
muscimol  (ISO)
mycophenolic acid  (EXP,ISO)
myricitrin  (EXP)
N(6),N(6)-dimethyladenine  (ISO)
N-[2-(diethylamino)ethyl]-2-methoxy-5-methylsulfonylbenzamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-methyl-N-nitrosourea  (ISO)
N-Nitroso-N-methylurethane  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
Narciclasine  (ISO)
naringin  (ISO)
neocuproine  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (EXP,ISO)
niclosamide  (ISO)
nicotinamide  (ISO)
nicotine  (EXP,ISO)
nitroprusside  (ISO)
nocodazole  (EXP)
notoginsenoside R1  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (EXP)
oleanolic acid  (EXP)
olmesartan  (ISO)
osthole  (EXP)
oxidopamine  (EXP,ISO)
ozone  (EXP)
p-menthan-3-ol  (EXP)
paclitaxel  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
paroxetine  (ISO)
parthenolide  (EXP,ISO)
PD 168393  (EXP)
pentanal  (EXP)
Pentoxifylline  (EXP)
peptidoglycan  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perifosine  (EXP)
phenobarbital  (EXP)
phenylephrine  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phorone  (ISO)
phosgene  (ISO)
phthalic anhydride  (EXP)
pipoxolan  (ISO)
pirinixic acid  (ISO)
platycodin D  (EXP)
plitidepsin  (EXP)
potassium atom  (ISO)
potassium chromate  (EXP)
pramipexole  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
proanthocyanidin  (ISO)
procyanidin B3  (ISO)
prodigiosin  (EXP)
progesterone  (ISO)
prostaglandin E2  (ISO)
prostaglandin F2alpha  (ISO)
protein kinase inhibitor  (EXP,ISO)
pterostilbene  (EXP)
puerarin  (EXP)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP)
quinoline  (EXP)
ramipril  (ISO)
razoxane  (EXP)
reactive oxygen species  (EXP,ISO)
resiniferatoxin  (EXP)
resveratrol  (EXP,ISO)
rifampicin  (EXP)
rimonabant  (ISO)
Ro 31-8220  (ISO)
rosmarinic acid  (ISO)
rotenone  (EXP,ISO)
rottlerin  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
salubrinal  (EXP,ISO)
Salvianolic acid A  (ISO)
sanguinarine  (EXP)
sappanchalcone  (EXP)
SB 203580  (EXP,ISO)
SB 431542  (EXP)
SCH772984  (ISO)
selenium atom  (EXP,ISO)
selenomethionine  (EXP)
serpentine asbestos  (EXP)
sertraline  (ISO)
silibinin  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
simvastatin  (ISO)
sirolimus  (EXP)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
Soman  (ISO)
sorafenib  (EXP)
spermine  (EXP)
SR 144528  (ISO)
stavudine  (EXP)
streptozocin  (EXP,ISO)
succimer  (ISO)
sucrose  (EXP)
sulforaphane  (EXP)
sulindac  (EXP,ISO)
sulindac sulfide  (EXP)
sulindac sulfone  (EXP)
sunitinib  (EXP)
superoxide  (ISO)
syringic acid  (EXP)
tacrolimus hydrate  (ISO)
tamoxifen  (EXP,ISO)
Tanshinone I  (ISO)
taurine  (ISO)
taurocholic acid  (ISO)
tenofovir disoproxil fumarate  (EXP)
tert-butyl hydroperoxide  (EXP,ISO)
tetracaine  (ISO)
tetrachloromethane  (ISO)
tetramethylpyrazine  (EXP)
thapsigargin  (ISO)
thimerosal  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP,ISO)
tofacitinib  (EXP)
toluene 2,4-diisocyanate  (EXP,ISO)
trans-anethole  (EXP)
trans-chalcone  (ISO)
tributylstannane  (EXP)
tricetin  (EXP)
trichostatin A  (EXP)
trifluoperazine  (EXP,ISO)
trimellitic anhydride  (EXP)
trimethylarsine oxide  (ISO)
trimethyltin  (ISO)
troglitazone  (EXP,ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
trovafloxacin  (EXP)
tunicamycin  (ISO)
tyrphostin AG 1478  (EXP,ISO)
U-73122  (EXP)
urethane  (EXP)
ursolic acid  (ISO)
valproic acid  (EXP,ISO)
verapamil  (ISO)
Vernodalin  (EXP)
vincaleukoblastine  (EXP)
vinclozolin  (ISO)
vitamin E  (EXP)
vorinostat  (EXP)
WIN 55212-2  (EXP)
withaferin A  (EXP)
wogonin  (ISO)
wortmannin  (ISO)
Yessotoxin  (ISO)
zearalenone  (ISO)
zidovudine  (EXP)
zinc acetate  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc sulfate  (EXP)
zinc(0)  (EXP,ISO)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to amino acid starvation  (IDA)
cellular response to amyloid-beta  (ISO)
cellular response to cadmium ion  (IMP)
cellular response to hydrogen peroxide  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to lipopolysaccharide  (IDA)
cellular response to mechanical stimulus  (IEP)
cellular response to nitric oxide  (ISO)
cellular response to reactive oxygen species  (IMP)
cellular senescence  (TAS)
dendrite morphogenesis  (ISO)
Fc-epsilon receptor signaling pathway  (TAS)
glial cell apoptotic process  (ISO)
inflammatory response  (ISO)
intracellular signal transduction  (IBA)
JNK cascade  (IBA,IDA)
JUN phosphorylation  (IDA)
MAPK cascade  (IEA)
negative regulation of apoptotic process  (IDA,ISO)
negative regulation of protein binding  (IDA)
neuron development  (ISO)
neuron migration  (ISO)
neuron projection development  (ISO)
neuronal stem cell population maintenance  (ISO)
ossification  (ISO)
peptidyl-serine phosphorylation  (IDA,ISO)
peptidyl-threonine phosphorylation  (IDA,IMP,ISO)
positive regulation of apoptotic process  (IBA,ISO,TAS)
positive regulation of apoptotic signaling pathway  (ISO)
positive regulation of cardiac muscle cell apoptotic process  (ISO)
positive regulation of cell killing  (TAS)
positive regulation of cell migration  (ISO)
positive regulation of cyclase activity  (IMP)
positive regulation of deacetylase activity  (IMP)
positive regulation of determination of dorsal identity  (ISO)
positive regulation of DNA replication  (ISO)
positive regulation of gene expression  (IMP)
positive regulation of glial cell apoptotic process  (ISO)
positive regulation of microtubule polymerization  (ISO)
positive regulation of neuroblast proliferation  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of neuron migration  (ISO)
positive regulation of podosome assembly  (ISO)
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway  (TAS)
positive regulation of protein metabolic process  (IMP)
positive regulation of protein ubiquitination  (ISO)
positive regulation of transcription factor catabolic process  (ISO)
programmed necrotic cell death  (ISO)
protein localization to tricellular tight junction  (ISO)
protein phosphorylation  (IDA,IEA,IMP,ISO)
regulation of centrosome cycle  (ISO)
regulation of circadian rhythm  (ISS)
regulation of dense core granule transport  (ISO)
regulation of DNA replication origin binding  (IMP)
regulation of DNA-binding transcription factor activity  (TAS)
regulation of gene expression  (ISO)
regulation of histone deacetylation  (IEA)
regulation of macroautophagy  (TAS)
regulation of neuron differentiation  (ISO)
regulation of protein localization  (IDA)
regulation of transcription, DNA-templated  (ISO)
response to cadmium ion  (ISO)
response to heat  (ISO)
response to hydrogen peroxide  (ISO)
response to mechanical stimulus  (IBA)
response to osmotic stress  (ISO)
response to oxidative stress  (IDA)
response to steroid hormone  (ISO)
response to UV  (IDA)
rhythmic process  (IEA)
signal transduction  (ISO)
stress-activated MAPK cascade  (IDA)
type B pancreatic cell apoptotic process  (ISO)

Cellular Component
axon  (ISO,ISS)
basal dendrite  (ISS)
cytoplasm  (IBA,IEA,ISO)
cytosol  (TAS)
dendrite cytoplasm  (ISO)
mitochondrion  (IEA,ISO)
nucleoplasm  (TAS)
nucleus  (IBA,IDA,ISO)
perikaryon  (ISO)
podosome  (ISO)
synapse  (ISS)
vesicle  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
adenosine signaling pathway  (EXP)
c-Jun N-terminal kinases MAPK signaling pathway  (IDA,ISO,TAS)
ceramide signaling pathway  (EXP,IEA)
Chagas disease pathway  (IEA)
colorectal cancer pathway  (IEA)
Endoplasmic Reticulum-associated degradation pathway  (IEA)
endothelin signaling pathway  (EXP)
ephrin - ephrin receptor bidirectional signaling axis  (EXP)
epidermal growth factor/neuregulin signaling pathway  (IEA)
erythropoietin signaling pathway  (EXP)
FasL mediated signaling pathway  (EXP)
Fc epsilon receptor mediated signaling pathway  (EXP)
glypican signaling pathway  (EXP)
gonadotropin-releasing hormone signaling pathway  (IEA)
hepatitis C pathway  (IEA)
inflammatory response pathway  (ISO)
insulin signaling pathway  (IEA)
interleukin-1 signaling pathway  (EXP)
interleukin-2 signaling pathway  (EXP)
mitogen activated protein kinase signaling pathway  (IEA)
N-cadherin signaling pathway  (EXP)
neurotrophic factor signaling pathway  (IEA)
NOD-like receptor signaling pathway  (IEA)
p53 signaling pathway  (EXP)
pancreatic cancer pathway  (IEA)
platelet-derived growth factor signaling pathway  (EXP)
Reelin signaling pathway  (EXP)
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathway  (IEA)
Rho/Rac/Cdc42 mediated signaling pathway  (ISO)
Shigella infection pathway  (IEA)
sphingosine 1-phosphate signaling pathway  (EXP)
syndecan signaling pathway  (EXP)
Toll-like receptor signaling pathway  (IEA)
toxoplasmosis pathway  (IEA)
Trail mediated signaling pathway  (EXP)
tuberculosis pathway  (IEA)
type 2 diabetes mellitus pathway  (IEA)
Wnt signaling pathway  (IEA)
Wnt signaling, non-canonical pathway  (EXP)


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