MAPK8 (mitogen-activated protein kinase 8) - Rat Genome Database

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Gene: MAPK8 (mitogen-activated protein kinase 8) Homo sapiens
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Symbol: MAPK8
Name: mitogen-activated protein kinase 8
RGD ID: 732271
HGNC Page HGNC
Description: Enables JUN kinase activity; histone deacetylase binding activity; and histone deacetylase regulator activity. Involved in several processes, including cellular response to mechanical stimulus; positive regulation of macromolecule metabolic process; and protein phosphorylation. Acts upstream of or within several processes, including JUN phosphorylation; cellular response to lipopolysaccharide; and response to UV. Located in nucleus. Implicated in abdominal aortic aneurysm; chronic mucocutaneous candidiasis; colorectal adenoma; rectal benign neoplasm; and type 2 diabetes mellitus. Biomarker of Alzheimer's disease; carcinoma (multiple); chronic obstructive pulmonary disease; and colorectal adenoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: c-Jun N-terminal kinase 1; JNK; JNK-46; JNK1; JNK1 alpha protein kinase; JNK1 beta protein kinase; JNK1A2; JNK21B1/2; JUN N-terminal kinase; MAP kinase 8; MAPK 8; mitogen-activated protein kinase 8 isoform JNK1 alpha1; mitogen-activated protein kinase 8 isoform JNK1 beta2; PRKM8; protein kinase JNK1; SAPK1; SAPK1c; stress-activated protein kinase 1; stress-activated protein kinase 1c; stress-activated protein kinase JNK1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1048,306,639 - 48,439,360 (+)EnsemblGRCh38hg38GRCh38
GRCh381048,306,673 - 48,439,360 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371049,514,720 - 49,647,403 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361049,279,693 - 49,313,189 (+)NCBINCBI36hg18NCBI36
Build 341049,279,692 - 49,313,189NCBI
Celera1043,195,579 - 43,229,096 (+)NCBI
Cytogenetic Map10q11.22NCBI
HuRef1043,779,561 - 43,912,232 (+)NCBIHuRef
CHM1_11049,796,560 - 49,929,236 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(+)-taxifolin  (EXP)
(-)-anisomycin  (EXP,ISO)
(-)-citrinin  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
(R)-lipoic acid  (ISO)
(R)-noradrenaline  (ISO)
(R)-Salsolinol  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-colchicine  (EXP)
(S)-naringenin  (EXP)
(S)-nicotine  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dichloropropan-2-ol  (ISO)
1,3-Dinitropyrene  (ISO)
1,4-dithiothreitol  (EXP)
1,4-phenylenediamine  (EXP)
1,8-cineole  (EXP)
1-chloro-2,4,6-trinitrobenzene  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
1-fluoro-2,4-dinitrobenzene  (EXP)
1-hydroxy-2-naphthoic acid  (ISO)
1-nitropyrene  (ISO)
17beta-estradiol  (EXP,ISO)
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (ISO)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-butoxyethanol  (ISO)
2-methyl-6-(phenylethynyl)pyridine  (ISO)
2-trans,6-trans-farnesyl diphosphate  (ISO)
3',5'-cyclic GMP  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (EXP)
3-O-Caffeoyl-1-O-methylquinic acid  (EXP)
3-phenylprop-2-enal  (EXP,ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (ISO)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP)
4-nonylphenol  (ISO)
4-phenylbutyric acid  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (EXP)
acetaldehyde  (EXP,ISO)
acetic acid  (ISO)
acetylleucyl-leucyl-norleucinal  (ISO)
Aciculatin  (ISO)
acrolein  (EXP,ISO)
acrylamide  (ISO)
ADP  (EXP)
afimoxifene  (EXP)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-Chaconine  (ISO)
alpha-mangostin  (EXP)
alvocidib  (EXP)
amidotrizoic acid  (EXP)
amiloride  (ISO)
amino acid  (ISO)
ammonium chloride  (ISO)
amodiaquine  (EXP)
amphetamine  (ISO)
anethole  (EXP)
aniline  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
Antimony trioxide  (EXP,ISO)
ANTIMYCIN  (ISO)
apigenin  (ISO)
apocynin  (EXP,ISO)
arachidonic acid  (EXP)
aristolochic acid  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenic trichloride  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
asbestos  (ISO)
asiatic acid  (ISO)
atrazine  (EXP,ISO)
atropine  (ISO)
aureusidin  (ISO)
Azaspiracid  (ISO)
bafilomycin A1  (ISO)
baicalein  (EXP)
BAPTA  (EXP)
bathocuproine disulfonic acid  (ISO)
benomyl  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP,ISO)
Benzo[a]pyrene-7,8-diol  (EXP)
benzyl isothiocyanate  (EXP)
beta-D-glucosamine  (EXP)
beta-hexachlorocyclohexane  (ISO)
bicuculline  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bortezomib  (EXP)
bufalin  (EXP)
bupropion  (EXP)
butanal  (EXP)
butylated hydroxyanisole  (EXP,ISO)
butyric acid  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium selenide  (EXP)
cadmium sulfate  (ISO)
Calcimycin  (EXP)
calcipotriol  (ISO)
calcitriol  (EXP)
camptothecin  (EXP)
candesartan  (ISO)
cantharidic acid  (EXP)
capsaicin  (EXP)
capsazepine  (EXP)
carbamazepine  (EXP)
carbon nanotube  (EXP)
carnosic acid  (ISO)
carnosine  (ISO)
celecoxib  (EXP,ISO)
chalcone  (ISO)
chenodeoxycholic acid  (ISO)
chlordecone  (ISO)
chloroprene  (ISO)
chloroquine  (EXP,ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
cholate  (ISO)
choline  (ISO)
chromium atom  (ISO)
chromium(6+)  (EXP,ISO)
chrysophanol  (EXP)
cisplatin  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (EXP,ISO)
Cuprizon  (ISO)
curcumin  (EXP,ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cypermethrin  (EXP,ISO)
D-glucose  (EXP,ISO)
D-mannitol  (EXP)
DDT  (EXP)
decabromodiphenyl ether  (EXP)
delphinidin  (EXP)
deoxynivalenol  (EXP,ISO)
desferrioxamine B  (EXP)
desipramine  (EXP)
dexamethasone  (EXP,ISO)
diallyl disulfide  (EXP)
Diallyl sulfide  (EXP)
diarsenic trioxide  (EXP,ISO)
diazepam  (ISO)
diazinon  (ISO)
dibenziodolium  (EXP)
dibutyl phthalate  (ISO)
diclofenac  (EXP)
dicoumarol  (EXP)
dicrotophos  (EXP)
Dictamnine  (EXP)
diethylstilbestrol  (ISO)
diltiazem  (ISO)
dimethylarsinic acid  (ISO)
Dinitramine  (ISO)
dinophysistoxin 1  (EXP)
dioscin  (EXP)
dioxygen  (EXP,ISO)
diphenhydramine  (EXP)
dipyridamole  (EXP)
disodium selenite  (EXP,ISO)
disulfiram  (EXP,ISO)
donepezil hydrochloride  (ISO)
dopamine  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
edaravone  (EXP,ISO)
efavirenz  (EXP)
elemental selenium  (EXP,ISO)
ellagic acid  (EXP)
emetine  (ISO)
enilconazole  (EXP)
entinostat  (EXP)
erastin  (ISO)
eriodictyol  (ISO)
esculetin  (EXP)
Estragole  (ISO)
etacrynic acid  (EXP)
ethanol  (EXP,ISO)
Ethyl pyruvate  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP,ISO)
Evodiamine  (EXP)
farnesyl diphosphate  (ISO)
fenvalerate  (EXP)
ferrosoferric oxide  (EXP)
ferulic acid  (ISO)
flubendazole  (EXP)
flufenoxuron  (ISO)
fluorescein 5-isothiocyanate  (EXP)
fluoxetine  (ISO)
flutamide  (ISO)
folic acid  (ISO)
fomepizole  (ISO)
formononetin  (EXP)
formoterol fumarate  (ISO)
fructose  (ISO)
gallic acid  (EXP)
gamma-aminobutyric acid  (ISO)
gamma-hexachlorocyclohexane  (ISO)
Gastrodin  (ISO)
gefitinib  (EXP)
Geniposide pentaacetate  (ISO)
gentamycin  (ISO)
ginkgolide B  (EXP)
ginsenoside Rg1  (EXP)
gliclazide  (ISO)
gliotoxin  (ISO)
glucose  (EXP,ISO)
glutathione  (EXP,ISO)
glyphosate  (EXP)
Goe 6976  (EXP)
guggulsterone  (EXP)
GW 4064  (EXP,ISO)
haloperidol  (ISO)
hemin  (ISO)
hesperetin  (EXP,ISO)
hesperidin  (EXP)
hexachlorobenzene  (ISO)
hexadecanoic acid  (EXP,ISO)
hexamethylene diisocyanate  (EXP)
histamine  (ISO)
homocysteine  (EXP)
hydrogen peroxide  (EXP,ISO)
hydroquinone O-beta-D-glucopyranoside  (EXP)
hydroxyurea  (ISO)
hypochlorous acid  (EXP)
icatibant  (ISO)
ifosfamide  (ISO)
indoxyl sulfate  (ISO)
iomeprol  (EXP)
isoprenaline  (ISO)
isorhamnetin  (ISO)
Isorhapontigenin  (ISO)
ivermectin  (EXP,ISO)
kaempferol  (EXP)
kanamycin A  (ISO)
ketoconazole  (EXP,ISO)
KN-93  (ISO)
kojic acid  (EXP)
L-1,4-dithiothreitol  (EXP)
L-ascorbic acid  (EXP)
L-cysteine  (ISO)
L-methionine  (EXP,ISO)
lactacystin  (ISO)
lead diacetate  (ISO)
lead(II) chloride  (EXP)
Licochalcone A  (EXP)
Licochalcone B  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lipoteichoic acid  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
Longikaurin A  (EXP)
lovastatin  (ISO)
luteolin  (EXP)
LY294002  (EXP,ISO)
lycopene  (EXP)
Magnolol  (ISO)
malonaldehyde  (ISO)
Malonoben  (EXP)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
mangiferin  (ISO)
manumycin A  (ISO)
marimastat  (ISO)
masoprocol  (EXP)
mebendazole  (EXP)
Mecamylamine  (ISO)
mechlorethamine  (ISO)
melatonin  (EXP)
menadione  (EXP,ISO)
mercaptoethanol  (EXP)
mercury dichloride  (ISO)
Mesna  (ISO)
metam  (ISO)
methamphetamine  (ISO)
methotrexate  (EXP,ISO)
methoxychlor  (ISO)
methylglyoxal  (EXP,ISO)
methylmercury chloride  (ISO)
methylphenidate  (ISO)
methylseleninic acid  (EXP)
miconazole  (ISO)
microcystin-LR  (EXP)
mifepristone  (EXP)
minocycline  (EXP)
mitomycin C  (EXP)
mono(2-ethylhexyl) phthalate  (EXP)
monodansylcadaverine  (ISO)
monosodium L-glutamate  (ISO)
morin  (ISO)
muscimol  (ISO)
mycophenolic acid  (EXP,ISO)
myricitrin  (EXP)
N(6),N(6)-dimethyladenine  (ISO)
N-[2-(diethylamino)ethyl]-2-methoxy-5-methylsulfonylbenzamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-methyl-N-nitrosourea  (ISO)
N-Nitroso-N-methylurethane  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
Narciclasine  (ISO)
naringin  (ISO)
neocuproine  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (EXP,ISO)
niclosamide  (ISO)
nicotinamide  (ISO)
nicotine  (EXP,ISO)
nitroprusside  (ISO)
nocodazole  (EXP)
notoginsenoside R1  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (EXP)
oleanolic acid  (EXP)
olmesartan  (ISO)
osthole  (EXP)
oxidopamine  (EXP,ISO)
ozone  (EXP)
p-menthan-3-ol  (EXP)
paclitaxel  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
paroxetine  (ISO)
parthenolide  (EXP,ISO)
PD 168393  (EXP)
pentanal  (EXP)
Pentoxifylline  (EXP)
peptidoglycan  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perifosine  (EXP)
phenobarbital  (EXP)
phenylephrine  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phorone  (ISO)
phosgene  (ISO)
phthalic anhydride  (EXP)
pipoxolan  (ISO)
pirinixic acid  (ISO)
platycodin D  (EXP)
plitidepsin  (EXP)
potassium atom  (ISO)
potassium chromate  (EXP)
pramipexole  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
proanthocyanidin  (ISO)
procyanidin B3  (ISO)
prodigiosin  (EXP)
progesterone  (ISO)
prostaglandin E2  (ISO)
prostaglandin F2alpha  (ISO)
protein kinase inhibitor  (EXP,ISO)
pterostilbene  (EXP)
puerarin  (EXP)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP)
quinoline  (EXP)
ramipril  (ISO)
razoxane  (EXP)
reactive oxygen species  (EXP,ISO)
resiniferatoxin  (EXP)
resveratrol  (EXP,ISO)
rifampicin  (EXP)
rimonabant  (ISO)
Ro 31-8220  (ISO)
rosmarinic acid  (ISO)
rotenone  (EXP,ISO)
rottlerin  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
salubrinal  (EXP,ISO)
Salvianolic acid A  (ISO)
sanguinarine  (EXP)
sappanchalcone  (EXP)
SB 203580  (EXP,ISO)
SB 431542  (EXP)
SCH772984  (ISO)
selenium atom  (EXP,ISO)
selenomethionine  (EXP)
serpentine asbestos  (EXP)
sertraline  (ISO)
silibinin  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
simvastatin  (ISO)
sirolimus  (EXP)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
Soman  (ISO)
sorafenib  (EXP)
spermine  (EXP)
SR 144528  (ISO)
stavudine  (EXP)
streptozocin  (EXP,ISO)
succimer  (ISO)
sucrose  (EXP)
sulforaphane  (EXP)
sulindac  (EXP,ISO)
sulindac sulfide  (EXP)
sulindac sulfone  (EXP)
sunitinib  (EXP)
superoxide  (ISO)
syringic acid  (EXP)
tacrolimus hydrate  (ISO)
tamoxifen  (EXP,ISO)
Tanshinone I  (ISO)
taurine  (ISO)
taurocholic acid  (ISO)
TEMPO  (ISO)
tenofovir disoproxil fumarate  (EXP)
tert-butyl hydroperoxide  (EXP,ISO)
tetracaine  (ISO)
tetrachloromethane  (ISO)
tetramethylpyrazine  (EXP)
thapsigargin  (ISO)
thimerosal  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP,ISO)
tofacitinib  (EXP)
toluene 2,4-diisocyanate  (EXP,ISO)
trans-anethole  (EXP)
trans-chalcone  (ISO)
tributylstannane  (EXP)
tricetin  (EXP)
trichostatin A  (EXP)
trifluoperazine  (EXP,ISO)
trimellitic anhydride  (EXP)
trimethylarsine oxide  (ISO)
trimethyltin  (ISO)
troglitazone  (EXP,ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
trovafloxacin  (EXP)
tunicamycin  (ISO)
tyrphostin AG 1478  (EXP,ISO)
U-73122  (EXP)
urethane  (EXP)
ursolic acid  (ISO)
valproic acid  (EXP,ISO)
verapamil  (ISO)
Vernodalin  (EXP)
vincaleukoblastine  (EXP)
vinclozolin  (ISO)
vitamin E  (EXP)
vorinostat  (EXP)
WIN 55212-2  (EXP)
withaferin A  (EXP)
wogonin  (ISO)
wortmannin  (ISO)
Yessotoxin  (ISO)
zearalenone  (ISO)
zidovudine  (EXP)
zinc acetate  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc sulfate  (EXP)
zinc(0)  (EXP,ISO)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to amino acid starvation  (IDA)
cellular response to amyloid-beta  (ISO)
cellular response to cadmium ion  (IMP)
cellular response to hydrogen peroxide  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to lipopolysaccharide  (IDA)
cellular response to mechanical stimulus  (IEP)
cellular response to nitric oxide  (ISO)
cellular response to reactive oxygen species  (IMP)
cellular senescence  (TAS)
dendrite morphogenesis  (ISO)
Fc-epsilon receptor signaling pathway  (TAS)
glial cell apoptotic process  (ISO)
inflammatory response  (ISO)
intracellular signal transduction  (IBA)
JNK cascade  (IBA,IDA)
JUN phosphorylation  (IDA)
MAPK cascade  (IEA)
negative regulation of apoptotic process  (IDA,ISO)
negative regulation of protein binding  (IDA)
neuron development  (ISO)
neuron migration  (ISO)
neuron projection development  (ISO)
neuronal stem cell population maintenance  (ISO)
ossification  (ISO)
peptidyl-serine phosphorylation  (IDA,ISO)
peptidyl-threonine phosphorylation  (IDA,IMP,ISO)
positive regulation of apoptotic process  (IBA,ISO,TAS)
positive regulation of apoptotic signaling pathway  (ISO)
positive regulation of cardiac muscle cell apoptotic process  (ISO)
positive regulation of cell killing  (TAS)
positive regulation of cell migration  (ISO)
positive regulation of cyclase activity  (IMP)
positive regulation of deacetylase activity  (IMP)
positive regulation of determination of dorsal identity  (ISO)
positive regulation of DNA replication  (ISO)
positive regulation of gene expression  (IMP)
positive regulation of glial cell apoptotic process  (ISO)
positive regulation of microtubule polymerization  (ISO)
positive regulation of neuroblast proliferation  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of neuron migration  (ISO)
positive regulation of podosome assembly  (ISO)
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway  (TAS)
positive regulation of protein metabolic process  (IMP)
positive regulation of protein ubiquitination  (ISO)
positive regulation of transcription factor catabolic process  (ISO)
programmed necrotic cell death  (ISO)
protein localization to tricellular tight junction  (ISO)
protein phosphorylation  (IDA,IEA,IMP,ISO)
regulation of centrosome cycle  (ISO)
regulation of circadian rhythm  (ISS)
regulation of dense core granule transport  (ISO)
regulation of DNA replication origin binding  (IMP)
regulation of DNA-binding transcription factor activity  (TAS)
regulation of gene expression  (ISO)
regulation of histone deacetylation  (IEA)
regulation of macroautophagy  (TAS)
regulation of neuron differentiation  (ISO)
regulation of protein localization  (IDA)
regulation of transcription, DNA-templated  (ISO)
response to cadmium ion  (ISO)
response to heat  (ISO)
response to hydrogen peroxide  (ISO)
response to mechanical stimulus  (IBA)
response to osmotic stress  (ISO)
response to oxidative stress  (IDA)
response to steroid hormone  (ISO)
response to UV  (IDA)
rhythmic process  (IEA)
signal transduction  (ISO)
stress-activated MAPK cascade  (IDA)
type B pancreatic cell apoptotic process  (ISO)

Cellular Component
axon  (ISO,ISS)
basal dendrite  (ISS)
cytoplasm  (IBA,IEA,ISO)
cytosol  (TAS)
dendrite cytoplasm  (ISO)
mitochondrion  (IEA,ISO)
nucleoplasm  (TAS)
nucleus  (IBA,IDA,ISO)
perikaryon  (ISO)
podosome  (ISO)
synapse  (ISS)
vesicle  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
adenosine signaling pathway  (EXP)
c-Jun N-terminal kinases MAPK signaling pathway  (IDA,ISO,TAS)
ceramide signaling pathway  (EXP,IEA)
Chagas disease pathway  (IEA)
colorectal cancer pathway  (IEA)
Endoplasmic Reticulum-associated degradation pathway  (IEA)
endothelin signaling pathway  (EXP)
ephrin - ephrin receptor bidirectional signaling axis  (EXP)
epidermal growth factor/neuregulin signaling pathway  (IEA)
erythropoietin signaling pathway  (EXP)
FasL mediated signaling pathway  (EXP)
Fc epsilon receptor mediated signaling pathway  (EXP)
glypican signaling pathway  (EXP)
gonadotropin-releasing hormone signaling pathway  (IEA)
hepatitis C pathway  (IEA)
inflammatory response pathway  (ISO)
insulin signaling pathway  (IEA)
interleukin-1 signaling pathway  (EXP)
interleukin-2 signaling pathway  (EXP)
mitogen activated protein kinase signaling pathway  (IEA)
N-cadherin signaling pathway  (EXP)
neurotrophic factor signaling pathway  (IEA)
NOD-like receptor signaling pathway  (IEA)
p53 signaling pathway  (EXP)
pancreatic cancer pathway  (IEA)
platelet-derived growth factor signaling pathway  (EXP)
Reelin signaling pathway  (EXP)
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathway  (IEA)
Rho/Rac/Cdc42 mediated signaling pathway  (ISO)
Shigella infection pathway  (IEA)
sphingosine 1-phosphate signaling pathway  (EXP)
syndecan signaling pathway  (EXP)
Toll-like receptor signaling pathway  (IEA)
toxoplasmosis pathway  (IEA)
Trail mediated signaling pathway  (EXP)
tuberculosis pathway  (IEA)
type 2 diabetes mellitus pathway  (IEA)
Wnt signaling pathway  (IEA)
Wnt signaling, non-canonical pathway  (EXP)

References

References - curated
1. Arbour N, etal., J Exp Med. 2002 Apr 1;195(7):801-10. doi: 10.1084/jem.20011481.
2. Bi X, etal., J Hematol Oncol. 2013 Jan 17;6:8. doi: 10.1186/1756-8722-6-8.
3. Butterfield L, etal., Biochem J. 1999 Mar 15;338 ( Pt 3):681-6.
4. Chen S, etal., Oncogene. 2021 May;40(19):3378-3393. doi: 10.1038/s41388-021-01780-y. Epub 2021 Apr 19.
5. Chuang CY, etal., Immunobiology. 2011 Jun;216(6):707-14. doi: 10.1016/j.imbio.2010.10.009. Epub 2010 Nov 4.
6. Crenesse D, etal., Hepatology. 2001 Nov;34(5):972-8.
7. Doan HQ, etal., Viral Immunol. 2015 May;28(4):236-40. doi: 10.1089/vim.2014.0144. Epub 2015 Mar 16.
8. Du H, etal., Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2377-82. doi: 10.1073/pnas.1221729110. Epub 2013 Jan 22.
9. Engelbrecht AM, etal., Basic Res Cardiol. 2004 Sep;99(5):338-50. Epub 2004 Jun 14.
10. Gao Z, etal., J Biol Chem. 2011 Jun 24;286(25):22227-34. doi: 10.1074/jbc.M111.228874. Epub 2011 May 3.
11. GOA_HUMAN data from the GO Consortium
12. Guma M, etal., Proc Natl Acad Sci U S A. 2009 May 26;106(21):8760-5. doi: 10.1073/pnas.0902659106. Epub 2009 May 11.
13. Han Z, etal., J Clin Invest. 2001 Jul;108(1):73-81.
14. Hayashi T, etal., Neurosci Lett. 2000 Apr 28;284(3):195-9.
15. Hofman VJ, etal., Mod Pathol. 2007 Sep;20(9):974-89. doi: 10.1038/modpathol.3800930. Epub 2007 Jul 20.
16. Hosono K, etal., World J Gastroenterol. 2012 Oct 14;18(38):5360-8. doi: 10.3748/wjg.v18.i38.5360.
17. Johnson GL and Nakamura K, Biochim Biophys Acta. 2007 Aug;1773(8):1341-8. Epub 2007 Jan 4.
18. Lei P, etal., Carcinogenesis. 2008 Jun;29(6):1139-47. doi: 10.1093/carcin/bgn103. Epub 2008 May 5.
19. Li J, etal., Sci Immunol. 2019 Nov 29;4(41). pii: 4/41/eaax7965. doi: 10.1126/sciimmunol.aax7965.
20. Liang T, etal., Int J Mol Sci. 2014 Sep 5;15(9):15754-65. doi: 10.3390/ijms150915754.
21. Lu W, etal., Int J Clin Oncol. 2014 Dec;19(6):1011-9. doi: 10.1007/s10147-013-0648-0. Epub 2013 Dec 25.
22. MacArthur CJ, etal., Otol Neurotol. 2011 Apr;32(3):508-15. doi: 10.1097/MAO.0b013e31820e6de4.
23. Miao B, etal., J Biol Chem. 2005 Jun 10;280(23):21693-9. Epub 2005 Mar 29.
24. Murayama T, etal., Transplantation. 2006 May 15;81(9):1325-30.
25. Nolan Y, etal., Neuroimmunomodulation. 2002;10(1):40-6. doi: 10.1159/000064413.
26. Pipeline to import KEGG annotations from KEGG into RGD
27. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
28. Pipeline to import SMPDB annotations from SMPDB into RGD
29. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
30. RGD automated import pipeline for gene-chemical interactions
31. Rosso SB, etal., Nat Neurosci. 2005 Jan;8(1):34-42. Epub 2004 Dec 19.
32. Ryan J, etal., Lab Invest. 2011 Dec;91(12):1727-38. doi: 10.1038/labinvest.2011.137. Epub 2011 Sep 5.
33. Sato T, etal., Cancer Sci. 2017 Nov;108(11):2156-2165. doi: 10.1111/cas.13382. Epub 2017 Sep 18.
34. Shioi T, etal., Circulation. 2003 Apr 1;107(12):1664-70. Epub 2003 Mar 17.
35. Slattery ML, etal., Carcinogenesis. 2012 Dec;33(12):2398-408. doi: 10.1093/carcin/bgs305. Epub 2012 Oct 1.
36. Slattery ML, etal., Int J Mol Epidemiol Genet. 2011;2(4):328-38. Epub 2011 Oct 20.
37. Sreekanth GP, etal., Antiviral Res. 2017 May;141:7-18. doi: 10.1016/j.antiviral.2017.02.003. Epub 2017 Feb 7.
38. Sugita M, etal., Hypertension. 2004 Oct;44(4):484-9. Epub 2004 Aug 9.
39. Sun Y, etal., Curr Vasc Pharmacol. 2017;15(2):174-183. doi: 10.2174/1570161114666161025100656.
40. Syed I, etal., Diabetes. 2011 Nov;60(11):2843-52. doi: 10.2337/db11-0809. Epub 2011 Sep 12.
41. Takahashi R, etal., Cancer Sci. 2013 Mar;104(3):337-44. doi: 10.1111/cas.12080. Epub 2013 Jan 24.
42. Tian F, etal., PLoS One. 2014 Jan 3;9(1):e83819. doi: 10.1371/journal.pone.0083819. eCollection 2014.
43. Tkacova R, etal., Respiration. 2011;81(5):386-93. Epub 2010 Aug 12.
44. Tong C, etal., Am J Pathol. 2007 Jul;171(1):297-303.
45. Tsay TB, etal., Respir Res. 2016 Aug 9;17(1):101. doi: 10.1186/s12931-016-0417-5.
46. Van der Velden J, etal., PLoS One. 2012;7(4):e34638. doi: 10.1371/journal.pone.0034638. Epub 2012 Apr 13.
47. Wang R, etal., J Neurochem. 2006 Dec;99(6):1543-54. Epub 2006 Oct 25.
48. Wang YQ, etal., Immunology. 2014 Aug;142(4):603-13. doi: 10.1111/imm.12270.
49. Wu WX, etal., Zhonghua Zhong Liu Za Zhi. 2010 Sep;32(9):671-5.
50. Yan H, etal., Mol Med Rep. 2017 Jan;15(1):180-186. doi: 10.3892/mmr.2016.5966. Epub 2016 Nov 24.
51. Yoshimura K, etal., Nat Med. 2005 Dec;11(12):1330-8. Epub 2005 Nov 27.
52. Young VJ, etal., PLoS One. 2014 Sep 10;9(9):e106773. doi: 10.1371/journal.pone.0106773. eCollection 2014.
53. Zhao X, etal., Nat Med. 2017 Mar;23(3):337-346. doi: 10.1038/nm.4260. Epub 2017 Jan 23.
54. Zhu X, etal., J Neurochem. 2001 Jan;76(2):435-41.
55. Zingarelli B, etal., J Immunol. 2003 Dec 15;171(12):6827-37. doi: 10.4049/jimmunol.171.12.6827.
Additional References at PubMed
PMID:1748630   PMID:7527398   PMID:7535770   PMID:7642542   PMID:7737129   PMID:7737130   PMID:7839144   PMID:8001819   PMID:8137421   PMID:8177321   PMID:8224842   PMID:8586671  
PMID:8621542   PMID:8632909   PMID:8654373   PMID:8846788   PMID:8917518   PMID:8943324   PMID:9020136   PMID:9030579   PMID:9032244   PMID:9045910   PMID:9129988   PMID:9162092  
PMID:9195981   PMID:9199329   PMID:9199504   PMID:9207092   PMID:9211903   PMID:9223324   PMID:9235954   PMID:9343414   PMID:9374537   PMID:9393873   PMID:9396779   PMID:9399639  
PMID:9403476   PMID:9405400   PMID:9405416   PMID:9520479   PMID:9575168   PMID:9621077   PMID:9661668   PMID:9670954   PMID:9692890   PMID:9724739   PMID:9732264   PMID:9733513  
PMID:9774977   PMID:9788880   PMID:9808624   PMID:9851932   PMID:9872331   PMID:9889198   PMID:9990010   PMID:10101227   PMID:10187783   PMID:10346818   PMID:10357815   PMID:10383391  
PMID:10391943   PMID:10393177   PMID:10394361   PMID:10398438   PMID:10419510   PMID:10446219   PMID:10464310   PMID:10471813   PMID:10490659   PMID:10509564   PMID:10521505   PMID:10523642  
PMID:10551811   PMID:10567572   PMID:10585392   PMID:10597297   PMID:10601313   PMID:10629060   PMID:10713157   PMID:10722755   PMID:10747973   PMID:10756100   PMID:10797012   PMID:10799874  
PMID:10856240   PMID:10878576   PMID:10908726   PMID:10912793   PMID:10913135   PMID:10962563   PMID:10978313   PMID:10987838   PMID:11042694   PMID:11057897   PMID:11062067   PMID:11096076  
PMID:11108663   PMID:11153078   PMID:11238452   PMID:11260070   PMID:11278389   PMID:11278395   PMID:11278789   PMID:11278799   PMID:11279118   PMID:11279197   PMID:11279232   PMID:11283254  
PMID:11323415   PMID:11350938   PMID:11387337   PMID:11408587   PMID:11432831   PMID:11448159   PMID:11468147   PMID:11479302   PMID:11489891   PMID:11504923   PMID:11517249   PMID:11525649  
PMID:11532856   PMID:11551945   PMID:11566021   PMID:11602244   PMID:11606564   PMID:11698270   PMID:11700324   PMID:11707464   PMID:11749722   PMID:11781324   PMID:11788583   PMID:11865055  
PMID:11907583   PMID:11912216   PMID:11931768   PMID:11944898   PMID:11948398   PMID:11971973   PMID:11983683   PMID:11988087   PMID:12023963   PMID:12039864   PMID:12052834   PMID:12058026  
PMID:12058028   PMID:12079429   PMID:12089333   PMID:12095152   PMID:12097334   PMID:12121974   PMID:12135322   PMID:12138158   PMID:12140754   PMID:12143039   PMID:12148599   PMID:12149229  
PMID:12167088   PMID:12171600   PMID:12185592   PMID:12189133   PMID:12206715   PMID:12225289   PMID:12228228   PMID:12239168   PMID:12242293   PMID:12296995   PMID:12351658   PMID:12351702  
PMID:12354774   PMID:12359245   PMID:12376548   PMID:12391307   PMID:12407442   PMID:12413764   PMID:12417588   PMID:12421945   PMID:12477932   PMID:12478662   PMID:12514174   PMID:12538493  
PMID:12576423   PMID:12591950   PMID:12592382   PMID:12646240   PMID:12646564   PMID:12659851   PMID:12689591   PMID:12707267   PMID:12714584   PMID:12734330   PMID:12756254   PMID:12763138  
PMID:12775419   PMID:12787561   PMID:12788955   PMID:12804775   PMID:12810082   PMID:12818176   PMID:12821118   PMID:12832416   PMID:12847227   PMID:12853963   PMID:12857973   PMID:12859962  
PMID:12874243   PMID:12878610   PMID:12902351   PMID:12917434   PMID:12958075   PMID:12960231   PMID:12963725   PMID:13130464   PMID:14500675   PMID:14500727   PMID:14504284   PMID:14514687  
PMID:14517282   PMID:14532003   PMID:14551213   PMID:14557262   PMID:14557276   PMID:14561739   PMID:14572659   PMID:14597672   PMID:14612408   PMID:14615289   PMID:14633987   PMID:14637155  
PMID:14688370   PMID:14699155   PMID:14701702   PMID:14701799   PMID:14702039   PMID:14724588   PMID:14729602   PMID:14764673   PMID:14766760   PMID:14967141   PMID:14981905   PMID:15013949  
PMID:15143066   PMID:15184502   PMID:15225643   PMID:15228592   PMID:15238629   PMID:15246824   PMID:15276183   PMID:15289320   PMID:15299005   PMID:15302935   PMID:15326485   PMID:15334056  
PMID:15345747   PMID:15383283   PMID:15456887   PMID:15474087   PMID:15483136   PMID:15516492   PMID:15527495   PMID:15528994   PMID:15538975   PMID:15542843   PMID:15569856   PMID:15590691  
PMID:15603708   PMID:15629131   PMID:15637062   PMID:15655348   PMID:15657352   PMID:15659383   PMID:15665513   PMID:15677475   PMID:15688026   PMID:15693750   PMID:15696159   PMID:15721744  
PMID:15722200   PMID:15733859   PMID:15749833   PMID:15755722   PMID:15769735   PMID:15778365   PMID:15778501   PMID:15827086   PMID:15850461   PMID:15857981   PMID:15860507   PMID:15890690  
PMID:15894542   PMID:15958389   PMID:15979846   PMID:15981086   PMID:15998799   PMID:16007099   PMID:16038800   PMID:16086581   PMID:16105650   PMID:16141199   PMID:16142216   PMID:16153436  
PMID:16157600   PMID:16166642   PMID:16176806   PMID:16243842   PMID:16260419   PMID:16260609   PMID:16264271   PMID:16282329   PMID:16283431   PMID:16291755   PMID:16307741   PMID:16321971  
PMID:16328781   PMID:16339571   PMID:16343492   PMID:16344560   PMID:16381010   PMID:16395283   PMID:16407310   PMID:16412424   PMID:16434970   PMID:16446428   PMID:16465391   PMID:16481105  
PMID:16533805   PMID:16539678   PMID:16549498   PMID:16569638   PMID:16581800   PMID:16611996   PMID:16636664   PMID:16648634   PMID:16687404   PMID:16699726   PMID:16740711   PMID:16760468  
PMID:16794185   PMID:16802349   PMID:16810318   PMID:16814421   PMID:16815888   PMID:16824735   PMID:16840345   PMID:16895791   PMID:16912864   PMID:16927023   PMID:16972261   PMID:16982329  
PMID:16983342   PMID:17008315   PMID:17023523   PMID:17054907   PMID:17074809   PMID:17079291   PMID:17145805   PMID:17158878   PMID:17178870   PMID:17189706   PMID:17192257   PMID:17255354  
PMID:17296730   PMID:17303384   PMID:17317777   PMID:17363973   PMID:17453826   PMID:17478078   PMID:17481915   PMID:17496921   PMID:17541429   PMID:17545598   PMID:17567906   PMID:17568996  
PMID:17584736   PMID:17603935   PMID:17620321   PMID:17626013   PMID:17640761   PMID:17652454   PMID:17690186   PMID:17693927   PMID:17699782   PMID:17702750   PMID:17703233   PMID:17704768  
PMID:17719653   PMID:17785464   PMID:17875713   PMID:17883418   PMID:17891170   PMID:17904874   PMID:17908987   PMID:17913539   PMID:17933493   PMID:17942603   PMID:17967471   PMID:17982228  
PMID:18003900   PMID:18025271   PMID:18036196   PMID:18055217   PMID:18082745   PMID:18086557   PMID:18087676   PMID:18094581   PMID:18160848   PMID:18164704   PMID:18181766   PMID:18199680  
PMID:18212053   PMID:18218857   PMID:18219313   PMID:18249102   PMID:18253836   PMID:18256527   PMID:18276794   PMID:18286207   PMID:18288129   PMID:18292600   PMID:18293403   PMID:18297686  
PMID:18316600   PMID:18316603   PMID:18325654   PMID:18337589   PMID:18344085   PMID:18348163   PMID:18356158   PMID:18371080   PMID:18373696   PMID:18387958   PMID:18401423   PMID:18405916  
PMID:18429822   PMID:18439101   PMID:18457359   PMID:18495129   PMID:18506470   PMID:18524773   PMID:18540881   PMID:18541008   PMID:18547751   PMID:18570871   PMID:18573678   PMID:18586681  
PMID:18594007   PMID:18603327   PMID:18620777   PMID:18636174   PMID:18651223   PMID:18663379   PMID:18667537   PMID:18681908   PMID:18682391   PMID:18703151   PMID:18713649   PMID:18713996  
PMID:18718914   PMID:18723442   PMID:18757369   PMID:18769111   PMID:18782768   PMID:18813780   PMID:18815275   PMID:18818208   PMID:18845538   PMID:18922473   PMID:18936517   PMID:18950845  
PMID:18957422   PMID:18978303   PMID:18979912   PMID:18982452   PMID:18989785   PMID:18996088   PMID:19033664   PMID:19036714   PMID:19037093   PMID:19041150   PMID:19052872   PMID:19056926  
PMID:19060920   PMID:19069644   PMID:19071215   PMID:19074436   PMID:19097143   PMID:19153595   PMID:19154785   PMID:19159663   PMID:19166930   PMID:19168796   PMID:19194824   PMID:19204086  
PMID:19206162   PMID:19234442   PMID:19245816   PMID:19248119   PMID:19270716   PMID:19275580   PMID:19286999   PMID:19287189   PMID:19319745   PMID:19339050   PMID:19351724   PMID:19352384  
PMID:19418584   PMID:19424800   PMID:19454725   PMID:19468799   PMID:19478459   PMID:19479051   PMID:19523467   PMID:19527717   PMID:19567513   PMID:19570911   PMID:19574423   PMID:19589256  
PMID:19593445   PMID:19596001   PMID:19604147   PMID:19616043   PMID:19620725   PMID:19638579   PMID:19651615   PMID:19664626   PMID:19667122   PMID:19676104   PMID:19686584   PMID:19690982  
PMID:19693773   PMID:19695707   PMID:19723092   PMID:19723627   PMID:19748889   PMID:19778898   PMID:19782079   PMID:19801633   PMID:19802005   PMID:19803394   PMID:19806201   PMID:19815509  
PMID:19822148   PMID:19822666   PMID:19843478   PMID:19859790   PMID:19862774   PMID:19864026   PMID:19877043   PMID:19893453   PMID:19900593   PMID:19901160   PMID:19910452   PMID:19910486  
PMID:19913121   PMID:19923798   PMID:19937141   PMID:19940360   PMID:19966288   PMID:19995557   PMID:19996270   PMID:20018857   PMID:20027304   PMID:20051532   PMID:20056178   PMID:20056910  
PMID:20060003