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Gene: MAPK8 (mitogen-activated protein kinase 8) Homo sapiens
Symbol: MAPK8
Name: mitogen-activated protein kinase 8
Description: Exhibits JUN kinase activity; histone deacetylase binding activity; and histone deacetylase regulator activity. Involved in several processes, including cellular response to mechanical stimulus; positive regulation of macromolecule metabolic process; and protein phosphorylation. Localizes to the nucleus. Implicated in abdominal aortic aneurysm; colorectal adenoma; rectal neoplasm; and type 2 diabetes mellitus. Biomarker of Alzheimer's disease; chronic obstructive pulmonary disease; colorectal adenocarcinoma; and colorectal adenoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: c-Jun N-terminal kinase 1; JNK; JNK-46; JNK1; JNK1 alpha protein kinase; JNK1 beta protein kinase; JNK1A2; JNK21B1/2; JUN N-terminal kinase; MAP kinase 8; MAPK 8; mitogen-activated protein kinase 8 isoform JNK1 alpha1; mitogen-activated protein kinase 8 isoform JNK1 beta2; PRKM8; protein kinase JNK1; SAPK1; SAPK1c; stress-activated protein kinase 1; stress-activated protein kinase 1c; stress-activated protein kinase JNK1
Mus musculus (house mouse) : Mapk8 (mitogen-activated protein kinase 8)  MGI  Alliance
Rattus norvegicus (Norway rat) : Mapk8 (mitogen-activated protein kinase 8)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mapk8 (mitogen-activated protein kinase 8)
Pan paniscus (bonobo/pygmy chimpanzee) : MAPK8 (mitogen-activated protein kinase 8)
Canis lupus familiaris (dog) : MAPK8 (mitogen-activated protein kinase 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mapk8 (mitogen-activated protein kinase 8)
Sus scrofa (pig) : MAPK8 (mitogen-activated protein kinase 8)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381048,306,639 - 48,439,360 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371049,514,682 - 49,647,403 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361049,279,693 - 49,313,189 (+)NCBINCBI36hg18NCBI36
Build 341049,279,692 - 49,313,189NCBI
Celera1043,195,579 - 43,229,096 (+)NCBI
Cytogenetic Map10q11.22NCBI
HuRef1043,779,561 - 43,912,232 (+)NCBIHuRef
CHM1_11049,796,560 - 49,929,236 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences