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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621506
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk8
Name: mitogen-activated protein kinase 8
Acc ID: CHEBI:18723
Term: nicotine
Definition: A racemate composed of equimolar amounts of (R)- and (S)-nicotine.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk8increases activityEXP 6480464CTDNicotine results in increased activity of MAPK8 proteinPMID:17021677
Mapk8increases expressionEXP 6480464CTDNicotine results in increased expression of MAPK8 mRNAPMID:20426880
Mapk8multiple interactionsEXP 6480464CTDNicotine promotes the reaction [MAPK8 protein results in increased phosphorylation of JUN protein]PMID:17021677
Mapk8increases phosphorylationISOMAPK8 (Homo sapiens)6480464CTDNicotine results in increased phosphorylation of MAPK8 proteinPMID:20727180
Mapk8increases phosphorylationISOMapk8 (Mus musculus)6480464CTDNicotine results in increased phosphorylation of MAPK8 proteinPMID:21511693
Mapk8multiple interactionsISOMAPK8 (Homo sapiens)6480464CTDCurcumin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK8 protein]; Nicotine inhibits the reaction [Cisplatin results in increased phosphorylation of and results in increased activity of MAPK8 protein]; TP53 protein affects the reaction [Nicotine results in increased phosphorylation of MAPK8 protein]PMID:11592233 PMID:20727180
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